Abstract:
:Galectin-3 (Gal-3) is a multifunctional beta-galactoside-binding lectin that senses self-derived and microbial glycoconjugates. Although Gal-3 is important in immune reactions and host defense in some experimental models, the function of Gal-3 during helminthic diseases (e.g., schistosomiasis) is still elusive. We show that, compared to wild-type Schistosoma mansoni-infected mice, infected Gal-3-/- mice have a reduced number of T and B lymphocytes in the spleen, develop reduced liver granulomas at 7 weeks (acute phase) and 14 weeks (chronic phase) postinfection, and mount a biased cellular and humoral Th1 response. In an attempt to understand this latter phenomenon, we studied the role of endogenous Gal-3 in dendritic cells (DCs), the most potent antigen-presenting cells, both in vitro and in vivo. Although Gal-3 deficiency in DCs does not impact their differentiation and maturation processes, it greatly influences the strength (but not the nature) of the adaptive immune response that they trigger, suggesting that Gal-3 deficiency in some other cell types may be important during murine schistosomiasis. As a whole, this study implies that Gal-3 is a modulator of the immune/inflammatory responses during helminthic infection and reveals for the first time that Gal-3 expression in DCs is pivotal to control the magnitude of T-lymphocyte priming.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Breuilh L,Vanhoutte F,Fontaine J,van Stijn CM,Tillie-Leblond I,Capron M,Faveeuw C,Jouault T,van Die I,Gosset P,Trottein Fdoi
10.1128/IAI.02006-06subject
Has Abstractpub_date
2007-11-01 00:00:00pages
5148-57issue
11eissn
0019-9567issn
1098-5522pii
IAI.02006-06journal_volume
75pub_type
杂志文章abstract::Streptococcus pneumoniae is a major cause of illness and death in children in developing countries. In these children, zinc deficiency is associated with an increased risk of acute respiratory tract infections, which can be reduced by daily zinc administration. Severe infections decrease zinc levels in plasma and may ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.4.2009-2013.2003
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journal_title:Infection and immunity
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doi:10.1128/IAI.39.3.1147-1154.1983
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pub_type: 杂志文章
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journal_title:Infection and immunity
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doi:10.1128/IAI.8.4.534-539.1973
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:2000-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/IAI.27.2.297-301.1980
更新日期:1980-02-01 00:00:00
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更新日期:1996-08-01 00:00:00
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journal_title:Infection and immunity
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更新日期:2003-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-02-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.9.3705-3710.1995
更新日期:1995-09-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.74.2.1032-1042.2006
更新日期:2006-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-05-23 00:00:00