Pneumocystis carinii activates the NF-kappaB signaling pathway in alveolar epithelial cells.

abstract：:Glucose metabolism and respiration of Candida albicans were compared under conditions which permitted either maximal filamentous or maximal yeast growth. Changes in metabolism were monitored by comparing the quantities of ethanol produced, CO2 evolved, and oxygen consumed. Filamenting cultures produced more ethanol an...

journal_title：Infection and immunity

authors： Land GA,McDonald WC,Stjernholm RL,Friedman L

更新日期：1975-07-01 00:00:00

abstract：:We have determined the nucleotide sequence of the 1.4-kilobase DNA fragment containing the plasminogen activator gene (pla) of Yersinia pestis, which determines both plasminogen activator and coagulase activities of the species. The sequence revealed the presence of a 936-base-pair open reading frame that constitutes ...

journal_title：Infection and immunity

authors： Sodeinde OA,Goguen JD

更新日期：1989-05-01 00:00:00

abstract：:Group A streptococcal pyrogenic exotoxins A, B, and C (also known as scarlet fever toxins and erythrogenic toxins) were evaluated for relatedness to another streptococcus-derived lymphocyte mitogen, blastogen A. Streptococcal pyrogenic exotoxin A and blastogen A were immunologically cross-reactive and shared the same ...

journal_title：Infection and immunity

authors： Schlievert PM,Gray ED

更新日期：1989-06-01 00:00:00

abstract：:The innate and the adaptive arms of the mucosal immune system must be coordinated to facilitate the control of pathogenic invasion while maintaining immune homeostasis. Toll-like receptors, able to activate the cell to produce bactericidal and inflammatory cytokines but also able to upregulate antigen (Ag)-presenting ...

journal_title：Infection and immunity

authors： Muthukuru M,Cutler CW

更新日期：2008-02-01 00:00:00

abstract：:The results show that Listeria monocytogenes, Francisella tularensis, and Salmonella typhimurium are facultative intracellular bacteria with a capacity to invade and grow in nonphagocytic cells in vivo. In the liver, all of these pathogens were seen to invade and to multiply extensively in hepatocytes. In all three ca...

journal_title：Infection and immunity

authors： Conlan JW,North RJ

更新日期：1992-12-01 00:00:00

abstract：:Ocular exposure of mice to live elementary bodies of Chlamydia trachomatis serovar A results in immunological sensitization of the mice. This reactivity is manifested by the development of early (5 h) and delayed-type (24 h) dermal reactivity and serovar-specific antibody formation against either live or irradiated (1...

journal_title：Infection and immunity

authors： Colley DG,Goodman TG,Barsoum IS

更新日期：1986-10-01 00:00:00

abstract：:The UspA1 and UspA2 proteins of Moraxella catarrhalis are potential vaccine candidates for preventing disease caused by this organism. We have characterized both proteins and evaluated their vaccine potential using both in vitro and in vivo assays. Both proteins were purified from the O35E isolate by Triton X-100 extr...

journal_title：Infection and immunity

authors： McMichael JC,Fiske MJ,Fredenburg RA,Chakravarti DN,VanDerMeid KR,Barniak V,Caplan J,Bortell E,Baker S,Arumugham R,Chen D

更新日期：1998-09-01 00:00:00

abstract：:Plasma cells are common in chronically inflamed sites, including periodontal lesions. The aim of this study was to determine which factors contribute to this local accumulation of plasma cells. Specifically, we sought to evaluate the effects of specific antigen and nonspecific activators from an infectious agent assoc...

journal_title：Infection and immunity

authors： Mallison SM 3rd,Smith JP,Schenkein HA,Tew JG

更新日期：1991-11-01 00:00:00

abstract：:Two inbred mouse strains, derived from feral founders, are susceptible to experimental leishmaniasis due to Leishmania major and support a disease of a severity intermediate between those observed in strains C57BL/6 and BALB/c. Mice of the MAI strain develop a severe, nonhealing, but nonfatal disease with no resistanc...

journal_title：Infection and immunity

authors： Babay BE,Louzir H,Kebaïer C,Boubaker S,Dellagi K,Cazenave PA

更新日期：2004-08-01 00:00:00

abstract：:The effects of Mycoplasma pneumoniae on host cell metabolism were studied by using two types of host cells, MRC-5 human lung fibroblasts, a normal cell line, and Lesch-Nyhan fibroblasts, a cell line deficient in hypoxanthine-guanine phosphoribosyl transferase (EC 2.4.2.8). The susceptibilities of the two cell types we...

journal_title：Infection and immunity

authors： Upchurch S,Gabridge MG

更新日期：1983-01-01 00:00:00

abstract：:Upon infection of a host, the pathogenic fungus Aspergillus fumigatus is attacked by the reactive oxygen species produced by phagocytic cells. Detoxification of hydrogen peroxide by catalases was proposed as a way to overcome this host response. A. fumigatus produces three active catalases; one is produced by conidia,...

journal_title：Infection and immunity

authors： Paris S,Wysong D,Debeaupuis JP,Shibuya K,Philippe B,Diamond RD,Latgé JP

更新日期：2003-06-01 00:00:00

abstract：:Nonspecific interactions related to physicochemical properties of bacterial cell surfaces, such as hydrophobicity and electrostatic charge, are known to have important roles in bacterium-host cell encounters. Streptococcus pneumoniae (pneumococcus) expresses multiple, surface-exposed, choline-binding proteins (CBPs) w...

journal_title：Infection and immunity

authors： Swiatlo E,Champlin FR,Holman SC,Wilson WW,Watt JM

更新日期：2002-01-01 00:00:00

abstract：:Continuous virus production is a characteristic of chicken embryo fibroblasts (CEF) infected and transformed by a nondefective Schmidt-Ruppin subgroup A Rous sarcoma virus. This virus production has been examined with particular attention to the amount of newly budded virus which remained cell-associated, and to the a...

journal_title：Infection and immunity

authors： Volkmann KR,Morgan HR

更新日期：1974-10-01 00:00:00

abstract：:The hallmarks of enteropathogenic Escherichia coli (EPEC) infection are formation of attaching and effacing (A/E) lesions on mucosal surfaces and actin-rich pedestals on cultured cells, both of which are dependent on the type III secretion system effector Tir. Following translocation into cultured cells and clustering...

journal_title：Infection and immunity

authors： Crepin VF,Habibzay M,Glegola-Madejska I,Guenot M,Collins JW,Frankel G

更新日期：2015-09-01 00:00:00

abstract：:We examined the immunobiological responses to Histoplasma capsulatum in lungs of gamma interferon (IFN-gamma) knockout mice (GKO mice). Naive GKO mice succumbed by day 9 to intranasal challenge with 2.5 x 10(6) yeasts, whereas all wild-type (WT) mice survived for 45 days. Compared to lungs of WT mice, the lungs of acu...

journal_title：Infection and immunity

authors： Allendoerfer R,Deepe GS Jr

更新日期：1997-07-01 00:00:00

abstract：:In experimental Leishmania donovani infection in BALB/c mice, initial susceptibility gives way to T-cell-dependent acquired resistance and eventual control over visceral infection. Since various cytokines appear to underlie the host response to Leishmania infection, we examined infected liver tissue for gene expressio...

journal_title：Infection and immunity

authors： Miralles GD,Stoeckle MY,McDermott DF,Finkelman FD,Murray HW

更新日期：1994-03-01 00:00:00

abstract：:Serine proteases and serine protease homologs form the second largest gene family in the Drosophila melanogaster genome. Certain genes in the Jonah multigene family encoding serine proteases have been implicated in the fly antiviral immune response. Here, we report the involvement of Jonah66Ci in the Drosophila immune...

journal_title：Infection and immunity

authors： Yadav S,Eleftherianos I

更新日期：2019-08-21 00:00:00

abstract：:Moraxella catarrhalis expresses surface receptor proteins that specifically bind host transferrin (Tf) and lactoferrin (Lf) in the first step of the iron acquisition pathway. Acute- and convalescent-phase antisera from a series of patients with M. catarrhalis pulmonary infections were tested against Tf and Lf receptor...

journal_title：Infection and immunity

authors： Yu RH,Bonnah RA,Ainsworth S,Schryvers AB

更新日期：1999-08-01 00:00:00

abstract：:Streptococcus pneumoniae cell wall and pneumolysin are important contributors to pneumococcal pathogenicity in some animal models. To further explore these factors in middle ear inflammation caused by pneumococci, penicillin-induced inflammatory acceleration was studied by using three closely related pneumococcal stra...

journal_title：Infection and immunity

authors： Sato K,Quartey MK,Liebeler CL,Le CT,Giebink GS

更新日期：1996-04-01 00:00:00

abstract：:Toll-like receptor 4 (TLR4), which recognizes lipopolysaccharide from Gram-negative bacteria, plays a major role in resistance of mice and humans to Salmonella infection. In chickens, Salmonella may establish a carrier state whereby bacteria are able to persist in the host organism without triggering clinical signs. B...

journal_title：Infection and immunity

authors： Chaussé AM,Grépinet O,Bottreau E,Le Vern Y,Menanteau P,Trotereau J,Robert V,Wu Z,Kerboeuf D,Beaumont C,Velge P

更新日期：2011-08-01 00:00:00

abstract：:It is well established that activating-type Fc receptors for immunoglobulin G (FcgammaR), such as FcgammaRI and FcgammaRIII, are essential for inducing inflammatory responses. On the other hand, a unique inhibitory FcgammaR, FcgammaRIIB, inhibits intracellular signaling upon engagement of immunoglobulin G-immune compl...

journal_title：Infection and immunity

authors： Henriques-Pons A,Olivieri BP,Oliveira GM,Daëron M,de Araújo-Jorge TC

更新日期：2005-08-01 00:00:00

abstract：:Thirteen Habs-serotype strains could be classified into 11 groups depending on the characteristic patterns of 2-amino sugar composition; strains of serotypes 2, 5, and 7 had the same pattern, and each other serotype strain had its own distinctive pattern. In our classification, fucosamine and quinovosamine were of imp...

journal_title：Infection and immunity

authors： Suzuki N,Tsunematsu Y,Matsumoto H,Tazaki T

更新日期：1977-03-01 00:00:00

abstract：:Cutaneous lesions of the human sexually transmitted genital ulcer disease chancroid are characterized by the presence of intraepidermal pustules, keratinocyte cytopathology, and epidermal and dermal erosion. These lesions are replete with neutrophils, macrophages, and CD4(+) T cells and contain very low numbers of cel...

journal_title：Infection and immunity

authors： San Mateo LR,Toffer KL,Orndorff PE,Kawula TH

更新日期：1999-09-01 00:00:00

abstract：:The Yersinia enterocolitica gsrA gene is a stress protein gene which was originally identified as essential for protecting cells under both extracellular environmental stress and intracellular stress in macrophages due to phagocytosis. The gsrA gene was shown to be a member of the htrA class of genes and to possess a ...

journal_title：Infection and immunity

authors： Yamamoto T,Hanawa T,Ogata S,Kamiya S

更新日期：1997-06-01 00:00:00

abstract：:We purified three proline-rich antimicrobial peptides from elastase-treated extracts of sheep and goat leukocytes and subjected two of them, OaBac5alpha and ChBac5, to detailed analysis. OaBac5alpha and ChBac5 were homologous to each other and to bovine Bac5. Both exhibited potent, broad-spectrum antimicrobial activit...

journal_title：Infection and immunity

authors： Shamova O,Brogden KA,Zhao C,Nguyen T,Kokryakov VN,Lehrer RI

更新日期：1999-08-01 00:00:00

abstract：:Streptococcus pneumoniae infections of the lung are associated with significant damage to the alveolar epithelium. Host phagocytes and pneumolysin, a cytolytic toxin of S. pneumoniae, are believed to contribute to this cellular damage, yet experiments in which these elements are absent demonstrate the presence of an a...

journal_title：Infection and immunity

authors： Duane PG,Rubins JB,Weisel HR,Janoff EN

更新日期：1993-10-01 00:00:00

abstract：:Adult murine models of Cryptosporidium infection involving Cryptosporidium muris and C. parvum were used to study immunity to cryptosporidiosis in the mammalian host. Immunocompetent BALB/c or C57BL/6 mice developed a highly patent infection with the RN 66 strain of C. muris but overcame the infection and were immune ...

journal_title：Infection and immunity

authors： McDonald V,Deer R,Uni S,Iseki M,Bancroft GJ

更新日期：1992-08-01 00:00:00

abstract：:Malaria infection treatment vaccine (ITV) is a promising strategy to induce homologous and heterologous protective immunity against the blood stage of the parasite. However, the underlying mechanism of protection remains largely unknown. Here, we found that a malaria-specific antibody (Ab) could mediate the protective...

journal_title：Infection and immunity

authors： Liu T,Lu X,Zhao C,Fu X,Zhao T,Xu W

更新日期：2015-05-01 00:00:00

abstract：:Many pathogenic microbes have multiple virulence factors that can cause damage to the host and thus contribute to an overall virulence phenotype for that organism. Although current techniques are suitable for demonstrating that a particular microbial characteristic contributes to virulence, no formal approach for defi...

journal_title：Infection and immunity

authors： McClelland EE,Bernhardt P,Casadevall A

更新日期：2006-03-01 00:00:00

abstract：:Oral or intravenous inoculation of previously unexposed juvenile and adult ferrets with Campylobacter jejuni uniformly resulted in intestinal colonization lasting 2 to 12 days. Disease varied from mild to moderate diarrhea, which resolved in 2 to 3 days. Orally infected animals developed agglutinin titers of 8 to 256 ...

journal_title：Infection and immunity

authors： Bell JA,Manning DD

更新日期：1990-06-01 00:00:00