Abstract:
:It is well established that activating-type Fc receptors for immunoglobulin G (FcgammaR), such as FcgammaRI and FcgammaRIII, are essential for inducing inflammatory responses. On the other hand, a unique inhibitory FcgammaR, FcgammaRIIB, inhibits intracellular signaling upon engagement of immunoglobulin G-immune complexes, suppressing inflammation and autoimmunity. The expression of FcgammaRIIB on B lymphocytes, natural killer cells, macrophages, mast cells, and a number of other cell types has been demonstrated for many years. However, the expression on T lymphocytes is probably restricted to activated cells in a narrow window of time. The controversy regarding the FcgammaR expression on T lymphocytes is attributable to considerable heterogeneity of cellular subpopulations and activation stages during immune responses in vivo. We addressed here this question by using mice experimentally infected with Trypanosoma cruzi, and we found an increase in the CD8(+) FcgammaR(+) population but not in the CD4(+) FcgammaR(+) population. Moreover, CD8(+) FcgammaR(+) T cells predominantly composed the cardiac inflammatory infiltration induced by the infection. These results indicate a novel pattern of FcgammaR expression on T cells in a pathological situation, and possible functional roles of this phenomenon are discussed.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Henriques-Pons A,Olivieri BP,Oliveira GM,Daëron M,de Araújo-Jorge TCdoi
10.1128/IAI.73.8.5048-5052.2005keywords:
subject
Has Abstractpub_date
2005-08-01 00:00:00pages
5048-52issue
8eissn
0019-9567issn
1098-5522pii
73/8/5048journal_volume
73pub_type
杂志文章abstract::Vibrio vulnificus causes rapidly progressing septicemia with an extremely high mortality rate (≥50%), even with aggressive antibiotic treatment. The bacteria secrete multifunctional autoprocessing repeats-in-toxin (MARTX) toxins, which are involved in the pathogenesis of Gram-negative Vibrio species. Recently, we repo...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02130-14
更新日期:2014-11-01 00:00:00
abstract::A genomic library of meningococcal DNA from a clinical isolate of Neisseria meningitidis was constructed in the expression vector lambda gt11. Outer membrane complex was prepared from the same strain and used to immunize rabbits to raise polyclonal anti-outer membrane complex serum. The amplified library was probed wi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.11.2734-2740.1987
更新日期:1987-11-01 00:00:00
abstract::Thrombin-induced platelet microbicidal protein 1 (tPMP-1) is a small, cationic peptide generated from rabbit platelets when they are exposed to thrombin in vitro. It has potent microbicidal activity against a broad spectrum of bacterial and fungal pathogens, including Staphylococcus aureus. Previous in vitro studies i...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.5.2475-2481.1999
更新日期:1999-05-01 00:00:00
abstract::Urinary tract infection (UTI) is the second most common infection in humans, making it a global health priority. Nearly half of all women will experience a symptomatic UTI, with uropathogenic Escherichia coli (UPEC) being the major causative agent of the infection. Although there has been extensive research on UPEC vi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00542-17
更新日期:2018-02-20 00:00:00
abstract::Analysis of the partition in a two-polymer phase system of Salmonella typhimurium R mutants with different susceptibility to phagocytosis distinguished between the mutants. Close to 80% of the R mutants least resistant to phagocytosis accumulated in the dextran-rich phase, whereas more phagocytosis-resistant mutants s...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.8.1.36-41.1973
更新日期:1973-07-01 00:00:00
abstract::The 120-kDa rickettsial outer membrane protein (rOmpB) is encoded by a gene with the capacity to encode a protein of approximately 168 kDa. The carboxy-terminal end of the molecule is apparently cleaved to yield 120- and 32-kDa products. Both polypeptides are surface exposed and remain associated with the outer membra...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.1.159-165.1992
更新日期:1992-01-01 00:00:00
abstract::In this study, we investigated the cell wall-anchored fibronectin-binding proteins SpsD and SpsL from the canine commensal and pathogen Staphylococcus pseudintermedius for their role in promoting bacterial invasion of canine progenitor epidermal keratinocytes (CPEK). Invasion was examined by the gentamicin protection ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00542-15
更新日期:2015-10-01 00:00:00
abstract::Iron acquisition from the host is an important step in the pathogenic process. While Yersinia pestis has multiple iron transporters, the yersiniabactin (Ybt) siderophore-dependent system plays a major role in iron acquisition in vitro and in vivo. In this study, we determined that the Ybt system is required for the us...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01236-09
更新日期:2010-05-01 00:00:00
abstract::We have previously shown that a pneumococcal surface protein A (PspA)-based vaccine containing DNA plasmid encoding the Flt3 ligand (FL) gene (pFL) as a nasal adjuvant prevented nasal carriage of Streptococcus pneumoniae. In this study, we further investigated the safety and efficacy of this nasal vaccine for the indu...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01360-10
更新日期:2011-07-01 00:00:00
abstract::Human defensins play a fundamental role in the initiation of innate immune responses to some microbial pathogens. Here we show that colonic epithelial model HCT116 cells respond to Trypanosoma cruzi infection by secreting defensin α-1, which reduces infection. We also report the early effects of defensin α-1 on invasi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01459-12
更新日期:2013-11-01 00:00:00
abstract::An immune response (fluorescent antibody to membrane antigen) was detected in guinea pigs inoculated with varicella-zoster virus (VZV) adapted to guinea pig embryonic cells, including the Oka vaccine strain, even when inoculation was by an external route, i.e., nasal or corneal. Live or UV-inactivated virus having the...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.37.2.407-412.1982
更新日期:1982-08-01 00:00:00
abstract::Susceptibility to Coccidioides spp. varies widely in humans and other mammals and also among individuals within a species. Among strains of mice with various susceptibilities, immunohistopathology revealed that C57BL/6 mice were highly susceptible to the disease following intranasal infection, DBA/2n mice were interme...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00885-08
更新日期:2008-12-01 00:00:00
abstract::Female guinea pigs were immunized with viable or UV light-inactivated chlamydiae (agent of guinea pig inclusion conjunctivitis), belonging to the species Chlamydia psittaci, by intravenous, subcutaneous, oral, or ocular routes. All animals were then inoculated vaginally with viable chlamydiae to determine the extent o...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.8.2599-2605.1990
更新日期:1990-08-01 00:00:00
abstract::LipL32 is the major outer membrane protein in pathogenic Leptospira. It is highly conserved throughout pathogenic species and is expressed in vivo during human infection. While these data suggest a role in pathogenesis, a function for LipL32 has not been defined. Outer membrane proteins of gram-negative bacteria are t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01643-07
更新日期:2008-05-01 00:00:00
abstract::Antibodies induced in sera and saliva of rats and rabbits immunized with ribosomal preparations from Streptococcus mutans 6715 inhibited transport of glucose by the phosphotransferase system by greater than 60%, acid production from sucrose by greater than 95%, and growth of the homologous S. mutans by greater than 59...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.45.1.286-289.1984
更新日期:1984-07-01 00:00:00
abstract::We developed an in vitro model to study the temperature-regulated cytotoxicity and intracellular growth of Mycobacterium haemophilum in cultured human epithelial and endothelial cells. M. haemophilum associated with human epithelial and endothelial cells at similar rates when incubated at 33 and 37 degrees C, but only...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.1.269-276.1996
更新日期:1996-01-01 00:00:00
abstract::The cyst cell wall β-glucans of Pneumocystis have been shown to stimulate immune responses in lung epithelial cells, dendritic cells, and alveolar macrophages. Little is known about how the trophic life forms, which do not have a fungal cell wall, interact with these innate immune cells. Here, we report differences in...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00519-16
更新日期:2016-11-01 00:00:00
abstract::Neutrophil serine proteases cathepsin G (CG), neutrophil elastase (NE), and proteinase 3 (PR3) have recently been shown to contribute to killing of Streptococcus pneumoniae in vitro. However, their relevance in lung-protective immunity against different serotypes of S. pneumoniae in vivo has not been determined so far...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.05593-11
更新日期:2011-12-01 00:00:00
abstract::This study compared infection and transformation of peripheral blood mononuclear cells (PBM) of Boran cattle and African buffalo in vitro to determine whether differences occurred which could account for the greater susceptibility of Boran cattle to infection with Theileria parva subsp. parva and T. parva subsp. lawre...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.53.1.186-191.1986
更新日期:1986-07-01 00:00:00
abstract::Staphylococcal alpha-toxin was purified from Staphylococcus aureus growth medium using adsorption chromatography on controlled pore glass beads. Elution of alpha-toxin from the unmodified glass surface of the beads with various anions generally followed the chaotropic series. Alpha-toxin, purified by glass bead chroma...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.13.3.982-986.1976
更新日期:1976-03-01 00:00:00
abstract::An immunogenic aminopeptidase was purified from Brucella melitensis strain VTRM1. The purification procedure consisted of ammonium sulfate fractionation and three chromatographic steps. This procedure resulted in a yield of 29% and a 144-fold increase in specific activity. The aminopeptidase appeared to be a monomeric...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.9.5238-5244.2003
更新日期:2003-09-01 00:00:00
abstract::Investigating the innate immune response mediators released in milk has manifold implications, spanning from elucidation of the role played by mammary epithelial cells (MECs) in fighting microbial infections to the discovery of novel diagnostic markers for monitoring udder health in dairy animals. Here, we investigate...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00291-13
更新日期:2013-09-01 00:00:00
abstract::Coxiella burnetii is an intracellular pathogen that replicates in a lysosome-derived vacuole. A determinant necessary for C. burnetii virulence is the Dot/Icm type IVB secretion system (T4SS). The Dot/Icm system delivers more than 100 proteins, called type IV effectors (T4Es), across the vacuolar membrane into the hos...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00758-17
更新日期:2018-03-22 00:00:00
abstract::Hydrogen peroxide (H2O2) is a by-product of glycerol metabolism in mycoplasmas and has been shown to cause cytotoxicity for cocultured eukaryotic cells. There appears to be selective pressure for mycoplasmas to retain the genes needed for glycerol metabolism. This has generated interest and speculation as to their fun...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02208-14
更新日期:2014-12-01 00:00:00
abstract::Schistosoma mansoni-infected wild-type (WT) mice develop a Th2 response and chronic disease. In contrast, infected interleukin-4 double-deficient (IL-4(-/-)) mice develop a Th1-like response and an acute, lethal syndrome. Disease severity in these animals correlates with excessive and prolonged production of nitric ox...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.1.177-184.2002
更新日期:2002-01-01 00:00:00
abstract::A murine respiratory infection model was used to study the mechanism of protective immunity to Bordetella pertussis. We found that nude mice, which are deficient in T cells, developed a persistent infection and failed to clear the bacteria after aerosol inoculation. In contrast, normal adult nonimmune mice cleared a r...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.2.399-410.1993
更新日期:1993-02-01 00:00:00
abstract::Previous work in our laboratory has shown that corticosterone increases the susceptibility of macrophages from Bcgs mice to the growth of Mycobacterium avium. The innate antimycobacterial activity of macrophages from Bcgr mice was not affected by corticosterone. In contrast to the differential effect of corticosterone...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.8.2983-2988.1995
更新日期:1995-08-01 00:00:00
abstract::This work evaluated the kinetics of events that occur in the placenta of Calomys callosus after Toxoplasma gondii infection. Animals on the first day of pregnancy (dop) and virgin nonpregnant females were perorally infected with 20 cysts of T. gondii strain ME49. After 100 days of infection, the virgin animals were ma...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.12.7089-7094.2002
更新日期:2002-12-01 00:00:00
abstract::This study examined apoptotic cell death associated with Shiga-like toxin (Stx)-producing Escherichia coli. Renal cortices from three children with postenteropathic hemolytic-uremic syndrome (HUS) and from mice infected with E. coli O157:H7 and pediatric renal tubular epithelial cells stimulated with Stx and E. coli O...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.2.636-644.1998
更新日期:1998-02-01 00:00:00
abstract::The Streptococcus mutans serotype c gtfA gene encodes a 55-kilodalton sucrose-hydrolyzing enzyme. Analysis of S. mutans gtfA mutants revealed that the mutant strains were specifically impaired in the ability to use melibiose as a sole carbon source. S. mutans gtfA mutant strains synthesized less alpha-galactosidase ac...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.3.992-995.1989
更新日期:1989-03-01 00:00:00