Hydrogen peroxide production from glycerol metabolism is dispensable for virulence of Mycoplasma gallisepticum in the tracheas of chickens.

abstract：:Genetically based natural resistance to brucellosis in cattle provides for novel strategies to control zoonotic diseases. Bovine NRAMP1, the homologue of a murine gene (Bcg), has been identified as a major candidate for controlling the in vivo resistant phenotype. We developed an in vitro model for expression of resis...

journal_title：Infection and immunity

authors： Barthel R,Feng J,Piedrahita JA,McMurray DN,Templeton JW,Adams LG

更新日期：2001-05-01 00:00:00

abstract：:In order to further characterize human host defenses against Coccidioides immitis, extracts of this fungus were tested in vitro for their ability to attract polymorphonuclear leukocytes derived from peripheral blood of uninfected subjects. Soluble substances prepared from the mycelial (saprophytic) and spherule (tissu...

journal_title：Infection and immunity

authors： Galgiani JN,Isenberg RA,Stevens DA

更新日期：1978-09-01 00:00:00

abstract：:Indomethacin, a nonsteroidal anti-inflammatory agent, will abolish salmonella-induced rabbit ileal secretion when given prior to the establishment of infection. In the present study, we assessed whether indomethacin can inhibit salmonella-induced intestinal secretion when administered after infection and net intestina...

journal_title：Infection and immunity

authors： Giannella RA,Rout WR,Formal SB

更新日期：1977-07-01 00:00:00

abstract：:Members of our group reported recently that neisseria infection of human epithelial cells results in accelerated degradation of the major lysosomal integral membrane protein LAMP1 and that this is due to hydrolysis of this glycoprotein at its immunoglobulin A1 (IgA1)-like hinge by the neisseria type 2 IgA1 protease (L...

journal_title：Infection and immunity

authors： Ayala P,Lin L,Hopper S,Fukuda M,So M

更新日期：1998-10-01 00:00:00

abstract：:Bactericidal activity and binding of a 57,000-dalton cationic antimicrobial neutrophil granule protein (CAP57) are determined by the presence on bacteria of O-antigen polysaccharide chains and the availability of negatively charged groups in the lipid A region, the inner core region, or both regions of lipopolysacchar...

journal_title：Infection and immunity

authors： Farley MM,Shafer WM,Spitznagel JK

更新日期：1988-06-01 00:00:00

abstract：:The amino acid sequence of heat-stable enterotoxin produced by enterotoxigenic Escherichia coli 18D has been revised. Amino acids originally assigned to positions 11 and 18, i.e., Tyr and Asn, respectively, were found to occupy positions 18 and 11, respectively. Thus all heat-stable enterotoxins composed of 18 amino a...

journal_title：Infection and immunity

authors： Thompson MR,Giannella RA

更新日期：1985-03-01 00:00:00

abstract：:Differences in infection kinetics and host response between Burkholderia multivorans and Burkholderia cenocepacia were demonstrated in a pulmonary infection model in BALB/c mice. B. multivorans persisted in the lung, while B. cenocepacia was cleared. Indirect immunofluorescence and electron microscopy of B. multivoran...

journal_title：Infection and immunity

authors： Chu KK,MacDonald KL,Davidson DJ,Speert DP

更新日期：2004-10-01 00:00:00

abstract：:Conjunctival infection of guinea pigs by the chlamydial agent of guinea pig inclusion conjunctivitis confers immunity. However, the mechanism of resistance to this intracellular pathogen is not yet defined. In the study reported here, serum immunoglobulin was passively transferred with resultant titers in excess of th...

journal_title：Infection and immunity

authors： Watson RR,Mull JD,MacDonald AB,Thompson SE 3rd,Bear SE

更新日期：1973-04-01 00:00:00

abstract：:Neonates are at increased risk for bacterial sepsis. We established that the immune-suppressive cytokine interleukin-27 (IL-27) is elevated in neonatal mice. Similarly, human cord blood-derived macrophages express IL-27 genes and secrete more cytokine than macrophages from adults. In the present work, we hypothesized ...

journal_title：Infection and immunity

authors： Seman BG,Vance JK,Rawson TW,Witt MR,Huckaby AB,Povroznik JM,Bradford SD,Barbier M,Robinson CM

更新日期：2020-02-20 00:00:00

abstract：:A study of the rise and fall in circulating tetanus antitoxin in a group of 15 adults after basic and booster immunization indicates that although individuals vary greatly in their responsiveness to toxoid, the falloff in antitoxin appears to be fractionally constant for each individual, and over periods of 5 to 6 yea...

journal_title：Infection and immunity

authors： Trinca JC

更新日期：1974-07-01 00:00:00

abstract：:HbhA of Mycobacterium tuberculosis is a multifunctional binding protein, binding to both sulfated sugars such as heparin and to human complement component C3. HbhA may therefore interact with host molecules and/or host cells during M. tuberculosis infection and play a role in the pathogenesis of this bacterium. The pu...

journal_title：Infection and immunity

authors： Mueller-Ortiz SL,Sepulveda E,Olsen MR,Jagannath C,Wanger AR,Norris SJ

更新日期：2002-12-01 00:00:00

abstract：:Neisseria meningitidis is a major cause of sepsis and meningitis but is also a common commensal, present in the nasopharynx of between 8 and 20% of healthy individuals. During carriage, the bacterium is found on the surface of the nasopharyngeal epithelium and in deeper tissues, while to develop disease the meningococ...

journal_title：Infection and immunity

authors： Sutherland TC,Quattroni P,Exley RM,Tang CM

更新日期：2010-09-01 00:00:00

abstract：:Curli are thin, coiled fibers expressed on the surface of Escherichia coli that bind several matrix and plasma proteins such as fibronectin, laminin, plasminogen, tissue plasminogen activator, and H-kininogen. In this work, we examined the interactions between curli-expressing E. coli and human major histocompatibilit...

journal_title：Infection and immunity

authors： Olsén A,Wick MJ,Mörgelin M,Björck L

更新日期：1998-03-01 00:00:00

abstract：:The effect of indomethacin on the net intestinal accumulation of fluid induced by Escherichia coli heat-stable (ST) enterotoxin in the infant mouse model was examined. Indomethacin, when administered with ST enterotoxin, caused a striking decrease in net intestinal fluid accumulation. This inhibition of ST activity wa...

journal_title：Infection and immunity

authors： Madsen GL,Knoop FC

更新日期：1978-10-01 00:00:00

abstract：:Intestinal mucus is postulated to play a role in preventing colonization of the gastrointestinal tract by microbial pathogens. To evaluate the ability of both crude mucus and purified mucin, a glycoprotein of goblet cell origin, to inhibit mucosal adherence of enteric pathogens, we examined whether mucus and mucin der...

journal_title：Infection and immunity

authors： Drumm B,Roberton AM,Sherman PM

更新日期：1988-09-01 00:00:00

abstract：:Both dextransucrase and mutansynthetase activities have been purified from the culture fluids of Streptococcus mutans GS-5 (serotype c). Although homogeneous dextransucrase preparations normally synthesize little insoluble glucan, essentially all of the glucan synthesized by this enzyme in the presence of 1.5 M (NH4)2...

journal_title：Infection and immunity

authors： Kuramitsu HK,Wondrack L

更新日期：1983-11-01 00:00:00

abstract：:A procedure is described for isolating a high-molecular-weight polysaccharide (PS) from the slime of Pseudomonas aeruginosa immunotype 1. The resultant material, obtained from the void volume of a Sephadex G-100 column, was composed of carbohydrate and water. No lipopolysaccharide (LPS), 2-keto-3-deoxyoctonoate, hepto...

journal_title：Infection and immunity

authors： Pier GB,Sidberry HF,Zolyomi S,Sadoff JC

更新日期：1978-12-01 00:00:00

abstract：:Cholera toxin (CT) and the type II heat-labile enterotoxins (HLT) LT-IIa and LT-IIb act as potent systemic and mucosal adjuvants and induce distinct T-helper (Th)-cell cytokine profiles. In the present study, CT and the type II HLT were found to differentially affect cytokine production by anti-CD3-stimulated human pe...

journal_title：Infection and immunity

authors： Martin M,Metzger DJ,Michalek SM,Connell TD,Russell MW

更新日期：2001-07-01 00:00:00

abstract：:Biomaterial-associated infections (BAI), which are predominantly caused by Staphylococcus epidermidis, are a significant problem in modern medicine. Biofilm formation is considered the pivotal element in the pathogenesis, but in previous mouse studies we retrieved S. epidermidis from peri-implant tissue. To assess the...

journal_title：Infection and immunity

authors： Broekhuizen CA,de Boer L,Schipper K,Jones CD,Quadir S,Feldman RG,Dankert J,Vandenbroucke-Grauls CM,Weening JJ,Zaat SA

更新日期：2007-03-01 00:00:00

abstract：:We previously reported that infection by Fusobacterium nucleatum strongly induced the expression of both human beta-defensin 2 (HBD-2) and HBD-3 by gingival epithelial cells. The aim of this study was to characterize the pattern recognition receptors (PRRs) and regulatory mechanisms involved in the induction of HBD-2 ...

journal_title：Infection and immunity

authors： Ji S,Shin JE,Kim YS,Oh JE,Min BM,Choi Y

更新日期：2009-03-01 00:00:00

abstract：:In this study we used Escherichia coli strain F11(P155) of porcine origin. The heat-stable enterotoxin (ST) was produced with a batch fermentor under agitation (500 rpm) and forced aeration (5 liters/min) in Casamino Acids yeast extract medium containing 0.2% glucose. The pH varied from 7.2 to 7.8. The maximum amount ...

journal_title：Infection and immunity

authors： Lallier R,Lariviere S,St-Pierre S

更新日期：1980-05-01 00:00:00

abstract：:Vibrio cholerae neuraminidase (NANase) is hypothesized to act synergistically with cholera toxin (CT) and increase the severity of a secretory response by increasing the binding and penetration of CT to enterocytes. To test this hypothesis, the NANase gene (nanH) from V. cholerae Ogawa 395 was first cloned and sequenc...

journal_title：Infection and immunity

authors： Galen JE,Ketley JM,Fasano A,Richardson SH,Wasserman SS,Kaper JB

更新日期：1992-02-01 00:00:00

abstract：:A plaque assay system for pathogenic rickettsiae, which utilizes primary chick embryo tissue cultures, is described. It proved to be a highly reproducible measure of infectiousness for Rickettsia rickettsi and R. typhi, which were employed in most studies; as well as for R. canada, R. prowazeki, R. sibirica, R. akari,...

journal_title：Infection and immunity

authors： Wike DA,Tallent G,Peacock MG,Ormsbee RA

更新日期：1972-05-01 00:00:00

abstract：:The lack of specific T-cell help in immune responses to thymus-independent antigens results in weak, predominantly immunoglobulin M-mediated immunity with little or no memory. In the work presented here we show how the exogenous stimulation of CD40 by monoclonal antibodies can mimic T-cell help, resulting in enhanced ...

journal_title：Infection and immunity

authors： Barr TA,Heath AW

更新日期：1999-07-01 00:00:00

abstract：:The concept of translational research, which aims to facilitate the application of basic scientific discoveries in clinical and community settings, is currently in vogue. While there are powerful forces driving this trend, support for translational research must be accompanied by a robust investment in basic science, ...

journal_title：Infection and immunity

authors： Fang FC,Casadevall A

更新日期：2010-02-01 00:00:00

abstract：:To characterize the roles of Porphyromonas gingivalis and its components in disease processes, we investigated the cytokine profiles induced by live P. gingivalis, its lipopolysaccharide (LPS), and its major fimbrial protein, fimbrillin (FimA). A cytokine antibody array revealed that human monocyte-derived macrophages...

journal_title：Infection and immunity

authors： Zhou Q,Amar S

更新日期：2006-02-01 00:00:00

abstract：:The adherence of 58 nontypeable Haemophilus influenzae isolates obtained from patients with otitis media or chronic obstructive pulmonary disease (COPD) and obtained from the throats of healthy individuals to Chang and NCI-H292 epithelial cells was compared. Otitis media isolates, but not COPD isolates, adhered signif...

journal_title：Infection and immunity

authors： van Schilfgaarde M,van Ulsen P,Eijk P,Brand M,Stam M,Kouame J,van Alphen L,Dankert J

更新日期：2000-08-01 00:00:00

abstract：:In this study we demonstrate the capability of Chlamydia trachomatis to infect cultured human mesothelial cell (MC) monolayers and to induce the production of the proinflammatory cytokines interleukin 1beta (IL-1beta) and IL-8. Seventy-two hours after initial infection, both the procoagulant activity of MC and the act...

journal_title：Infection and immunity

authors： van Westreenen M,Pronk A,Diepersloot RJ,de Groot PG,Leguit P

更新日期：1998-05-01 00:00:00

abstract：:Penetration of the intestinal mucosa at areas of Peyer's patches is an important first step for Salmonella typhimurium to produce lethal systemic disease in mice. However, mutations in genes that are important for intestinal invasion result in only moderately decreased virulence of S. typhimurium for mice. Here we rep...

journal_title：Infection and immunity

authors： Bäumler AJ,Tsolis RM,Valentine PJ,Ficht TA,Heffron F

更新日期：1997-06-01 00:00:00

abstract：:The ultrastructural appearance of the "halozone" formed at the interface between the spotted fever agent Rickettsia rickettsii and the cytoplasm of persistently infected cultured vole cells (Microtus pennsylvanicus) was studied by transmission electron microscopy. In sections of epoxy-embedded specimens stained with u...

journal_title：Infection and immunity

authors： Todd WJ,Burgdorfer W,Wray GP

更新日期：1983-09-01 00:00:00