Synergistic effect of mutations in invA and lpfC on the ability of Salmonella typhimurium to cause murine typhoid.

abstract：:BALB/c mice were vaccinated by the intramuscular (i.m.) and subcutaneous (s.c.) routes with a native preparation of the Chlamydia trachomatis mouse pneumonitis (MoPn) major outer membrane protein (MOMP), using Montanide ISA 720 and CpG-1826 as adjuvants. A negative control group was immunized with ovalbumin and the tw...

journal_title：Infection and immunity

authors： Pal S,Peterson EM,de la Maza LM

更新日期：2005-12-01 00:00:00

abstract：:During infection, the Legionnaires' disease bacterium, Legionella pneumophila, survives and multiplies within a specialized phagosome that is near neutral pH and does not fuse with host lysosomes. In order to understand the molecular basis of this organism's ability to control its intracellular fate, we have isolated ...

journal_title：Infection and immunity

authors： Wiater LA,Dunn K,Maxfield FR,Shuman HA

更新日期：1998-09-01 00:00:00

abstract：:Mast cell-deficient W/Wv mice and their mast cell-sufficient littermates were given infections of Trichinella spiralis. W/Wv mice were slower than their littermates to expel adult T. spiralis. Repair of the mast cell deficiency of W/Wv mice by bone marrow grafting was accompanied by accelerated expulsion of T. spirali...

journal_title：Infection and immunity

authors： Ha TY,Reed ND,Crowle PK

更新日期：1983-07-01 00:00:00

abstract：:A hallmark of Bartonella henselae is persistent bacteremia in cats despite the presence of a vigorous host immune response. To understand better the long-term survival of B. henselae in cats, we examined the feline humoral immune response to B. henselae outer membrane (OM) proteins in naturally and experimentally infe...

journal_title：Infection and immunity

authors： Chenoweth MR,Greene CE,Krause DC,Gherardini FC

更新日期：2004-06-01 00:00:00

abstract：:Brucella spp. are intracellular bacteria that cause the most frequent zoonosis in the world. Although recent work has advanced the field of Brucella vaccine development, there remains no safe human vaccine. In order to produce a safe and effective human vaccine, the immune response to Brucella spp. requires greater un...

journal_title：Infection and immunity

authors： Durward MA,Harms J,Magnani DM,Eskra L,Splitter GA

更新日期：2010-01-01 00:00:00

abstract：:Piglets suckled by dams that had been vaccinated with K88 antigen were significantly more resistant to deaths caused by neonatal diarrhea after challenge with a large dose of a K88-positive enteropathogenic strain of Escherichia coli than piglets suckled by control dams. The factors most likely to be involved in prote...

journal_title：Infection and immunity

authors： Rutter JM,Jones GW,Brown GT,Burrows MR,Luther PD

更新日期：1976-03-01 00:00:00

abstract：:Nontypeable Haemophilus influenzae (NTHi) is a common cause of otitis media and respiratory tract infections. Outer membrane proteins (OMP) and lipooligosaccharide (LOS) are major surface antigens of NTHi and potential vaccine candidates. De-O-acylated LOS (dLOS) or oligosaccharide (OS) was coupled to total OMP to for...

journal_title：Infection and immunity

authors： Wu TH,Gu XX

更新日期：1999-10-01 00:00:00

abstract：:The smooth lipopolysaccharide complex of the outer surface of smooth Brucella abortus cells is believed to be the antigenic component involved in serological tests routinely used for the diagnosis of brucellosis. Sera from cattle vaccinated or infected with B. abortus generally contain antibody directed toward the smo...

journal_title：Infection and immunity

authors： Schurig GG,Jones LM,Speth SL,Berman DT

更新日期：1978-09-01 00:00:00

abstract：:Escherichia coli 536 (O6:K15:H31), which was isolated from a case of urinary tract infection, determines high nephropathogenicity in a rat pyelonephritis system as measured by renal bacterial counts 7 days after infection. The loss of S fimbrial adhesin formation (Sfa-) (mannose-resistant hemagglutination [Mrh-] and f...

journal_title：Infection and immunity

authors： Marre R,Hacker J,Henkel W,Goebel W

更新日期：1986-12-01 00:00:00

abstract：:Oxygen consumption by Treponema pallidum was observed to be glucose dependent. Treponemes consumed O2 to a low dissolved O2 concentration of 0.01 mumol of O2 per ml when respiration ceased. A fermentative degradation of glucose occurred during the maintenance of treponemes at 0.01 mumol of O2 per ml. Although the init...

journal_title：Infection and immunity

authors： Barbieri JT,Cox CD

更新日期：1981-03-01 00:00:00

abstract：:Pneumonic tularemia is a life-threatening disease caused by inhalation of the highly infectious intracellular bacterium Francisella tularensis. The most serious form of the disease associated with the type A strains can be prevented in experimental animals through vaccination with the attenuated live vaccine strain (L...

journal_title：Infection and immunity

authors： Mara-Koosham G,Hutt JA,Lyons CR,Wu TH

更新日期：2011-04-01 00:00:00

abstract：:The contribution of murine Toll-like receptors 2 and 4 (TLR2 and -4, respectively) to cytokine induction by heat-killed bacteria was analyzed in vitro and in vivo. Gram-negative bacteria induced cytokines primarily via TLR4; the contribution of TLR2 was only minor. Neither TLR4 nor, surprisingly, TLR2 was required in ...

journal_title：Infection and immunity

authors： Lembo A,Kalis C,Kirschning CJ,Mitolo V,Jirillo E,Wagner H,Galanos C,Freudenberg MA

更新日期：2003-10-01 00:00:00

abstract：:Mutant cultures that lacked the ability to produce filamentous hemagglutinin were obtained by UV irradiation of Bordetella pertussis strain 18-323. Various biological activities of these mutants were compared with those of the parent culture. It was found that the leukocytosis-promoting, histamine-sensitizing, and mou...

journal_title：Infection and immunity

authors： Watanabe M,Nakase Y

更新日期：1982-03-01 00:00:00

abstract：:Clostridium difficile toxins A and B (TcdA and TcdB) are the causative agents of antibiotic-associated pseudomembranous colitis. Mucosal mast cells play a crucial role in the inflammatory processes underlying this disease. We studied the direct effects of TcdA and TcdB on the human mast cell line HMC-1 with respect to...

journal_title：Infection and immunity

authors： Meyer GK,Neetz A,Brandes G,Tsikas D,Butterfield JH,Just I,Gerhard R

更新日期：2007-08-01 00:00:00

abstract：:Chronic helminth infections are known to be associated with the modulation of antigen-specific T-cell responses. Strongyloides stercoralis infection is characterized by the downmodulation of antigen-specific Th1 and Th17 responses and the upregulation of Th2 and Th9 responses. Immune homeostasis is partially maintaine...

journal_title：Infection and immunity

authors： Rajamanickam A,Munisankar S,Dolla C,Nutman TB,Babu S

更新日期：2019-11-18 00:00:00

abstract：:Endotoxin-treated mice exhibit a rapid rise in the level of the serum amyloid A (SAA) protein, but this effect is not observed in endotoxin-resistant C3H/HeJ mice. To evaluate the role of lymphoid cells in the production of SAA protein, C3H/HeJ mice were adoptively transfused with endotoxin-sensitive (C3H/HeN) bone ma...

journal_title：Infection and immunity

authors： Rosenstreich DL,McAdam KP

更新日期：1979-01-01 00:00:00

abstract：:Lung dendritic cells were identified by immunohistochemistry in lung tissue sections from C57BL/6 mice. Following isolation from the lungs using CD11c magnetic beads, the flow cytometric analysis of I-A(b+) and CD11c(+) cells indicated a mixed population of dendritic cells at different stages of maturation, with most ...

journal_title：Infection and immunity

authors： Gonzalez-Juarrero M,Orme IM

更新日期：2001-02-01 00:00:00

abstract：:It is proposed that binding of oral streptococci to saliva-coated hydroxylapatite (SHA) surfaces is a multifactorial process involving both specific and nonspecific receptors. In this context, specific binding is described as a high-affinity, saturable interaction between the cell and binding surface. Conversely, nons...

journal_title：Infection and immunity

authors： Staat RH,Peyton JC

更新日期：1984-06-01 00:00:00

abstract：:The capacity of the intracellular pathogen Listeria monocytogenes to activate the alternative pathway of human complement was examined. Incubation of L. monocytogenes with human serum in optimal conditions (20% Mg2+EGTA [ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid]-chelated serum) consumed (3...

journal_title：Infection and immunity

authors： Croize J,Arvieux J,Berche P,Colomb MG

更新日期：1993-12-01 00:00:00

abstract：:Moraxella catarrhalis is a causative agent of otitis media in children and lower respiratory tract infections in adults suffering from chronic obstructive pulmonary disease (COPD). This strict human pathogen continues to be a significant cause of disease in this broad spectrum of patients because there is no available...

journal_title：Infection and immunity

authors： Schwingel JM,Edwards KJ,Cox AD,Masoud H,Richards JC,St Michael F,Tekwe CD,Sethi S,Murphy TF,Campagnari AA

更新日期：2009-10-01 00:00:00

abstract：:The protozoan parasite Giardia duodenalis (Giardia lamblia) is one of the most commonly found intestinal pathogens in mammals, including humans. In the current study, a Giardia muris-mouse model was used to analyze cytokine transcription patterns and histological changes in intestinal tissue at different time points d...

journal_title：Infection and immunity

authors： Dreesen L,De Bosscher K,Grit G,Staels B,Lubberts E,Bauge E,Geldhof P

更新日期：2014-08-01 00:00:00

abstract：:Inbred strain 2 guinea pigs were vaccinated with Mycobacterium bovis BCG or were left unvaccinated and challenged 6 weeks later by the respiratory route with virulent Mycobacterium tuberculosis. By using a double rosette assay with isotype-specific antibody-coated ox and uncoated rabbit erythrocytes, the proportions o...

journal_title：Infection and immunity

authors： Bartow RA,McMurray DN

更新日期：1989-05-01 00:00:00

abstract：:Cell wall lytic enzyme (Kyowa lytic no. 2 enzyme) liberated arthritogenic hydrosoluble peptidoglycans from both arthritogenic and non-arthritogenic bacterial cell walls. From these cell walls, mutanolysin (peptidoglycan-degrading enzyme) also liberated hydrosoluble peptidoglycans which, however, lacked arthritogenicit...

journal_title：Infection and immunity

authors： Kohashi O,Pearson CM,Watanabe Y,Kotani S

更新日期：1977-06-01 00:00:00

abstract：:Local passive immunization with monoclonal antibodies (Mc Ab) to Streptococcus mutans was attempted as an alternative approach to active systemic immunization. We prepared an immunoglobulin G class Mc Ab to the cell surface protein determinant of streptococcal antigen I/II and applied it repeatedly to the teeth of rhe...

journal_title：Infection and immunity

authors： Lehner T,Caldwell J,Smith R

更新日期：1985-12-01 00:00:00

abstract：:Clostridium difficile causes pseudomembranous colitis in humans. The enterotoxin (i.e., toxin A) from this organism is believed to be responsible for the initial intestinal pathology associated with this disease. Previous work shows that this toxin binds to carbohydrates that contain Gal alpha 1-3Gal beta 1-4GlcNAc. H...

journal_title：Infection and immunity

authors： Tucker KD,Wilkins TD

更新日期：1991-01-01 00:00:00

abstract：:Exoenzyme S (ExoS), an ADP-ribosylating enzyme produced by the opportunistic pathogen Pseudomonas aeruginosa, is directly translocated into eukaryotic cells by bacterial contact. Within the cell, ExoS ADP-ribosylates the cell signaling protein Ras and causes inhibition of DNA synthesis and alterations in cytoskeletal ...

journal_title：Infection and immunity

authors： Olson JC,Fraylick JE,McGuffie EM,Dolan KM,Yahr TL,Frank DW,Vincent TS

更新日期：1999-06-01 00:00:00

abstract：:Toxoplasma gondii infects both hematopoietic and nonhematopoietic cells and can cause cerebral and ocular toxoplasmosis, as a result of either congenital or postnatally acquired infections. Host protection likely acts at both cellular levels to control the parasite. CD40 is a key factor for protection against cerebral...

journal_title：Infection and immunity

authors： Van Grol J,Muniz-Feliciano L,Portillo JA,Bonilha VL,Subauste CS

更新日期：2013-06-01 00:00:00

abstract：:Biofilm formation by the periodontal pathogen Aggregatibacter actinomycetemcomitans is dependent upon autoinducer-2 (AI-2)-mediated quorum sensing. However, the components that link the detection of the AI-2 signal to downstream gene expression have not been determined. One potential regulator is the QseBC two-compone...

journal_title：Infection and immunity

authors： Novak EA,Shao H,Daep CA,Demuth DR

更新日期：2010-07-01 00:00:00

abstract：:In the present investigation we studied the nature of a Shigella flexneri O antigen, the type III antigen. No structural entity has yet been attributed to this antigen. Phenol-water-extracted lipopolysaccharides (LPSs) from all S. flexneri serotypes possessing either group 6 antigen or both type III antigen and group ...

journal_title：Infection and immunity

authors： Carlin NI,Wehler T,Lindberg AA

更新日期：1986-07-01 00:00:00

abstract：:Understanding the regulation of human immune responses is critical for vaccine development and treating infectious diseases. We have previously shown that simultaneous engagement of the T cell receptor (TCR) and complement regulator CD46 on human CD4(+) T cells in the presence of interleukin-2 (IL-2) induces potent se...

journal_title：Infection and immunity

authors： Truscott SM,Abate G,Price JD,Kemper C,Atkinson JP,Hoft DF

更新日期：2010-12-01 00:00:00