Influence of oxygen on respiration and glucose catabolism by Treponema pallidum.

abstract：:Two proteins, HifD and HifE, have been identified as structural components of Haemophilus influenzae pili. Both are localized at the pilus tip, and HifE appears to mediate pilus adherence to host cells. In this study we examined the immunologic and structural diversity of these pilus subunits among type b H. influenza...

journal_title：Infection and immunity

authors： McCrea KW,Sauver JL,Marrs CF,Clemans D,Gilsdorf JR

更新日期：1998-10-01 00:00:00

abstract：:Staphylococcus aureus nasal carriage is a risk factor for infection in humans, particularly in the hospital environment. Attenuation of carriage has proven effective in reducing the prevalence of infection in some high-risk groups. To study staphylococcal factors that influence nasal colonization, a mouse model of S. ...

journal_title：Infection and immunity

authors： Kiser KB,Cantey-Kiser JM,Lee JC

更新日期：1999-10-01 00:00:00

abstract：:Helicobacter pylori secretes a pore-forming VacA toxin that has structural features and activities substantially different from those of other known bacterial toxins. VacA can assemble into multiple types of water-soluble flower-shaped oligomeric structures, and most VacA activities are dependent on its capacity to ol...

journal_title：Infection and immunity

authors： González-Rivera C,Campbell AM,Rutherford SA,Pyburn TM,Foegeding NJ,Barke TL,Spiller BW,McClain MS,Ohi MD,Lacy DB,Cover TL

更新日期：2016-08-19 00:00:00

abstract：:This study was designed to evaluate the immunogenicity and the protective efficacy of a divalent fusion DNA vaccine encoding both the Brucella abortus L7/L12 protein (ribosomal protein) and Omp16 protein (outer membrane lipoprotein), designated pcDNA3.1-L7/L12-Omp16. Intramuscular injection of this divalent DNA vaccin...

journal_title：Infection and immunity

authors： Luo D,Ni B,Li P,Shi W,Zhang S,Han Y,Mao L,He Y,Wu Y,Wang X

更新日期：2006-05-01 00:00:00

abstract：:The adhesion of gram-positive bacteria to extracellular matrix (ECM) proteins is regarded as an important determinant of pathogenicity. A comparison of the adhesion of Streptococcus agalactiae strain O90R to different ECM proteins showed that the most pronounced binding could be observed for immobilized fibrinogen. To...

journal_title：Infection and immunity

authors： Spellerberg B,Rozdzinski E,Martin S,Weber-Heynemann J,Lütticken R

更新日期：2002-05-01 00:00:00

abstract：:Polyprotein allergens are a family of structurally homologous molecules from parasitic nematodes which induce specific immunoglobulin E in infected individuals. We show here that both H-2 and non-H-2 factors determine the ability of mice to generate T- and B-cell responses to the filarial polyprotein allergen (Brugia ...

journal_title：Infection and immunity

authors： Allen JE,Lawrence RA,Maizels RM

更新日期：1995-08-01 00:00:00

abstract：:Intracellular bacterial infections affect all vertebrates. Cultured fish are particularly vulnerable because no effective protection measures have been established since such infections emerged approximately 50 years ago. As in other vertebrates, the induction of cell-mediated immunity (CMI) plays an important role in...

journal_title：Infection and immunity

authors： Matsumoto M,Kubota T,Fujita S,Shiozaki K,Kishida S,Yamamoto A

更新日期：2019-10-18 00:00:00

abstract：:The antigenically conserved proteins of Treponema pallidum subsp. pallidum and four nonpathogenic cultivatable treponemes were investigated by phase partitioning with the nonionic detergent Triton X-114 and immunoblot analysis. None of the T. pallidum integral membrane proteins identified by phase partitioning (deterg...

journal_title：Infection and immunity

authors： Radolf JD,Norgard MV

更新日期：1988-07-01 00:00:00

abstract：:Random-bred mice were immunized with a nonliving antigen prepared from mixed-blood forms of Plasmodium berghei, strain NYU-2, in combination with Corynebacterium parvum and/or living BCG. A high proportion of intravenously immunized mice survived virulent challenge, but subcutaneous vaccination was less effective. Vac...

journal_title：Infection and immunity

authors： Murphy JR,Lefford MJ

更新日期：1978-12-01 00:00:00

abstract：:Salmonella spp. and Shigella spp. are responsible for millions of cases of enteric disease each year worldwide. While these pathogens have evolved distinct strategies for interacting with the human intestinal epithelium, they both induce significant proinflammatory responses that result in massive transepithelial migr...

journal_title：Infection and immunity

authors： Mumy KL,Bien JD,Pazos MA,Gronert K,Hurley BP,McCormick BA

更新日期：2008-08-01 00:00:00

abstract：:Outer membrane porin genes of Salmonella typhimurium, including ompC, ompF, and tppB, are regulated by the products of ompB, a two-component regulatory locus encoding OmpR and EnvZ. S. typhimurium ompR mutants are attenuated in mice, but to date no one has studied the intracellular trafficking of S. typhimurium porin-...

journal_title：Infection and immunity

authors： Mills SD,Ruschkowski SR,Stein MA,Finlay BB

更新日期：1998-04-01 00:00:00

abstract：:Mucosal exposure to Escherichia coli elicits an inflammatory response in the urinary tract. Interleukin-6 (IL-6) is secreted into the urine, and polymorphonuclear leukocytes (PMNLs) are recruited to the site of infection. This study analyzed the ability of mucosally administered bacterial components to activate IL-6 a...

journal_title：Infection and immunity

authors： Linder H,Engberg I,Hoschützky H,Mattsby-Baltzer I,Svanborg C

更新日期：1991-12-01 00:00:00

abstract：:Studies with animal models have demonstrated that viral respiratory tract infections suppress bacterial clearance processes in the lung and that this alteration in host defenses appears to explain the excessive mortality from bacterial pneumonia during influenza epidemics. However, since the pathogenesis of postinflue...

journal_title：Infection and immunity

authors： Nugent KM,Pesanti EL

更新日期：1983-12-01 00:00:00

abstract：:In C3H gnotobiotic mice, no significant difference was observed between the translocation of nine clinical isolates of enteropathogenic Campylobacter spp. and that of seven nonisogeneic Escherichia coli strains with or without various determinants of pathogenicity. In addition, there was no correlation found between t...

journal_title：Infection and immunity

authors： Youssef M,Corthier G,Goossens H,Tancrede C,Henry-Amar M,Andremont A

更新日期：1987-04-01 00:00:00

abstract：:The macrophage migration inhibition test was applied to the study of delayed hypersensitivity in mice vaccinated intravenously with oil-treated cell walls of Mycobacterium bovis BCG. Migration inhibition of peritoneal exudate cells from sensitized mice was demonstrated directly upon incubation of the cells with purifi...

journal_title：Infection and immunity

authors： Yamamoto K,Anacker RL

更新日期：1970-06-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF) is thought to play a major role in the pathogenesis of septic shock. Anti-TNF antibody was preadministered in low-dose endotoxin lethality models in which BALB/c mice were challenged with small amounts of lipopolysaccharide following their sensitization with either carrageenan (CAR) o...

journal_title：Infection and immunity

authors： Franks AK,Kujawa KI,Yaffe LJ

更新日期：1991-08-01 00:00:00

abstract：:Rickettsia rickettsii and R. australis formed infectious antibody complexes when reacted with homologous convalescent serum. The addition of antiglobulin to these complexes showed neutralization of plaques proportional to the concentration of rickettsial immune serum. ...

journal_title：Infection and immunity

authors： Kenyon RH,McManus AT

更新日期：1974-05-01 00:00:00

abstract：:Serial passage of Cryptococcus neoformans in mice increases virulence relative to the nonpassaged line. Postpassaged lines showed no difference in the expression of most known virulence factors, with the exception that the more virulent lines had smaller capsules in vitro. These data imply that other mechanisms of vir...

journal_title：Infection and immunity

authors： McClelland EE,Perrine WT,Potts WK,Casadevall A

更新日期：2005-10-01 00:00:00

abstract：:Pseudomonas aeruginosa invades various epithelial cell types in vitro and in vivo. The P. aeruginosa genome possesses a gene (flhA) which encodes a protein that is believed to be part of the export apparatus for flagellum assembly and which is homologous to invA of Salmonella spp. Because invA is required for invasion...

journal_title：Infection and immunity

authors： Fleiszig SM,Arora SK,Van R,Ramphal R

更新日期：2001-08-01 00:00:00

abstract：:Scrub typhus immunogens were prepared by exposing infected yolk sac suspensions of Rickettsia tsutsugamushi to various doses of gamma radiation. Mouse lethality was abolished at doses greater than 200 krads, whereas immunogenicity of the suspensions, as shown by mouse protection tests, was diminished relatively little...

journal_title：Infection and immunity

authors： Eisenberg GH Jr,Osterman JV

更新日期：1977-01-01 00:00:00

abstract：:Natural killer (NK) cells are considered to be key players in the early innate responses to protozoan infections, primarily indirectly by producing gamma interferon (IFN-gamma) in response to cytokines, like interleukin 12 (IL-12). We demonstrate that live, as well as heat-inactivated, tachyzoites of Neospora caninum,...

journal_title：Infection and immunity

authors： Boysen P,Klevar S,Olsen I,Storset AK

更新日期：2006-02-01 00:00:00

abstract：:Escherichia coli isolates from patients with bacteriuria of pregnancy were compared by PCR with isolates from patients with community-acquired cystitis for the presence of established virulence determinants. The strains from patients with bacteriuria of pregnancy were less likely to carry genes for P-family, S-family,...

journal_title：Infection and immunity

authors： Graham JC,Leathart JB,Keegan SJ,Pearson J,Bint A,Gally DL

更新日期：2001-02-01 00:00:00

abstract：:Previous data from our laboratory suggest that the transitional epithelium of the urinary bladder secretes and binds to its surface a glycosaminoglycan. The presence of this substance at the bladder surface markedly reduces the ability of microorganisms to adhere to the mucosa. Furthermore, this glycosaminoglycan can ...

journal_title：Infection and immunity

authors： Parsons CL,Pollen JJ,Anwar H,Stauffer C,Schmidt JD

更新日期：1980-03-01 00:00:00

abstract：:Enterohemorrhagic Escherichia coli (EHEC) is a noninvasive food-borne pathogen that colonizes the distal ileum and colon. Proteins encoded in the EHEC locus of enterocyte effacement (LEE) pathogenicity island are known to contribute to this pathogen's adherence to epithelial cells and intestinal colonization. The role...

journal_title：Infection and immunity

authors： Ho TD,Davis BM,Ritchie JM,Waldor MK

更新日期：2008-05-01 00:00:00

abstract：:The Pseudomonas aeruginosa quorum-sensing systems, las and rhl, control the production of numerous virulence factors. In this study, we have used the burned-mouse model to examine the contribution of quorum-sensing systems to the pathogenesis of P. aeruginosa infections in burn wounds. Different quorum-sensing mutants...

journal_title：Infection and immunity

authors： Rumbaugh KP,Griswold JA,Iglewski BH,Hamood AN

更新日期：1999-11-01 00:00:00

abstract：:Vibrio cholerae is a monoflagellated gram-negative bacterium that causes the severe diarrheal disease cholera. In contrast to Salmonella enterica serovar Typhimurium infection, which is accompanied by both acute diarrhea and high-level inflammation, V. cholerae infection is largely noninflammatory in human hosts. Bact...

journal_title：Infection and immunity

authors： Yoon SS,Mekalanos JJ

更新日期：2008-03-01 00:00:00

abstract：:Challenges with the production and suboptimal immunogenicity of malaria vaccine candidates have slowed the development of a Plasmodium falciparum multiantigen vaccine. Attempting to resolve these issues, we focused on the use of highly immunogenic merozoite surface protein 8 (MSP8) as a vaccine carrier protein. Previo...

journal_title：Infection and immunity

authors： Parzych EM,Miura K,Ramanathan A,Long CA,Burns JM Jr

更新日期：2017-12-19 00:00:00

abstract：:We investigated the cytokine/chemokine secretions and alteration of protein expression from peripheral blood mononuclear cells (PBMCs) cocultured with adult liver flukes (Opisthorchis viverrini) for 6 to 24 h. PBMC-derived proteins were identified by two-dimensional electrophoresis and mass spectrometry, and the cytok...

journal_title：Infection and immunity

authors： Hongsrichan N,Intuyod K,Pinlaor P,Khoontawad J,Yongvanit P,Wongkham C,Roytrakul S,Pinlaor S

更新日期：2014-05-01 00:00:00

abstract：:Serotypes A and B of the relapsing fever spirochete Borrelia turicatae produce different disease manifestations in infected mice. Whereas serotype B causes more severe arthritis and reaches higher densities in the blood of mice than serotype A, serotype A invades the central nervous system earlier than serotype B duri...

journal_title：Infection and immunity

authors： Pennington PM,Cadavid D,Barbour AG

更新日期：1999-09-01 00:00:00

abstract：:Sublethal infection of mice with recombinant Listeria monocytogenes expressing a model epitope in either secreted or nonsecreted form results in similar CD8(+) T-cell priming. Since nonsecreted bacterial proteins have no obvious access to the endogenous major histocompatibility complex (MHC) class I presentation pathw...

journal_title：Infection and immunity

authors： Tvinnereim AR,Harty JT

更新日期：2000-04-01 00:00:00