Abstract:
:Representative strains of oral streptococci were tested for Fc immunoglobulin G (IgG) reactivity by two different techniques, agglutination of rabbit-IgG sensitized sheep erythrocytes and uptake of human and rabbit 125I-radiolabeled IgG. None of the S. mutans serotypes a through e reacted with the Fc region of either human or rabbit IgG. Additionally, other streptococci such as S. sanguis, S. salivarius, S. faecalis, and S. mitis failed to show appreciable Fc reactivity as assayed by these techniques. The group A, C, and G streptococci, previously shown to possess Fc reactivity, proved to be reactive in these experiments, as did a protein A-containing strain of Staphylococcus aureus.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Shea C,Ferretti JJdoi
10.1128/IAI.34.3.851-855.1981subject
Has Abstractpub_date
1981-12-01 00:00:00pages
851-5issue
3eissn
0019-9567issn
1098-5522journal_volume
34pub_type
杂志文章abstract::Uropathogenic Escherichia coli strain J96 carries multiple determinants for fimbrial adhesins. The regulatory protein PapB of P fimbriae has previously been implicated in potential coregulatory events. The focB gene of the F1C fimbria determinant is highly homologous to papB; the translated sequences share 81% identit...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01010-07
更新日期:2008-02-01 00:00:00
abstract::Henle 407 and HeLa cells were compared as hosts for Shigella dysenteriae at a low multiplicity of infection. Efficiency of attachment and invasion without centrifugation, as well as selectivity for pathogenic over nonpathogenic S. dysenteriae without Congo red, were much greater for Henle 407 cells than for HeLa cells...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.7.2401-2403.1990
更新日期:1990-07-01 00:00:00
abstract::Twenty monoclonal antibodies have been prepared to the erythrocytes from CBA/Ca mice infected with the rodent malaria Plasmodium chabaudi. By immunofluorescence, 15 of these antibodies recognized parasite antigens expressed only during the development of mature trophozoites to schizonts and merozoites, 2 recognized pa...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.38.1.94-102.1982
更新日期:1982-10-01 00:00:00
abstract::Macrophage recognition of Salmonella enterica serovar Typhimurium leads to a cascade of signaling events, including the activation of Src family and Syk kinases and the production of reactive oxygen species (ROS), which are critical for host innate defense during early stages of bacterial infection. ROS production dep...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00115-08
更新日期:2008-06-01 00:00:00
abstract::Once Candida albicans comes in contact with endothelial cells, it induces cellular injury. This endothelial cell injury may be a mechanism by which blood-borne organisms escape from the intravascular compartment and invade the tissue parenchyma during hematogenous infection. We have been investigating the ability of c...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.11.4714-4718.1996
更新日期:1996-11-01 00:00:00
abstract::The rat middle ear and lung clearance model has been used to show that the nontypeable Haemophilus influenzae 26-kDa outer membrane protein OMP26 is highly efficacious as a mucosal immunogen, inducing significantly enhanced clearance in immunized rats upon direct challenge of these two anatomic sites. Similarly, the c...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.8.4691-4699.2003
更新日期:2003-08-01 00:00:00
abstract::Bovine septicemic Escherichia coli 31A agglutinates bovine, rabbit, and human erythrocytes and adheres in vitro to the brush border of bovine or ovine intestinal epithelial cells and to the human colon carcinoma Caco-2 cell line. The adhesion and hemagglutination of E. coli 31A are mediated by a chromosome-encoded fim...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.1.332-342.1996
更新日期:1996-01-01 00:00:00
abstract::The effects of temperature and treatment with sodium dodecyl sulfate, Tween 20, dithiothreitol, trypsin, or guanidine on the hemagglutinating capacity of six strains of type A influenza virus (A(0)/PR8/34, A(1)/CAME/46, A(2)/J305/57, A(2)/Bethesda/63, A(2)/HK/Aichi/68, and A(2)/HK/80/68), one strain of swine virus (A/...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.5.3.324-331.1972
更新日期:1972-03-01 00:00:00
abstract::A differential-display PCR procedure identified the capsular assembly gene kpsD after Escherichia coli type 1 fimbrial binding to mannose-coated Sepharose beads. Limiting-dilution reverse-transcribed PCRs confirmed down-regulation of the kpsD gene, and Northern blot and lacZ fusion analyses showed down-regulation of t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.2.1226-1231.2005
更新日期:2005-02-01 00:00:00
abstract::In previous studies, we reported that fibronectin (FN) markedly enhances phagocytic uptake of antibody-coated group B streptococci (GBS) by human polymorphonuclear leukocytes. Furthermore, administration of FN along with a GBS type-specific monoclonal or polyclonal antibody to infected neonatal rats significantly enha...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.6.2334-2339.1993
更新日期:1993-06-01 00:00:00
abstract::We have reported that P388D1 cell line murine macrophages stimulated with lipopolysaccharide (LPS) from Actinobacillus actinomycetemcomitans release interleukin-1 (IL-1) inhibitor. The IL-1 inhibitor was purified from conditioned media of P388D1 cells stimulated with A. actinomycetemcomitans LPS for 72 h to homogeneit...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.2.390-397.1994
更新日期:1994-02-01 00:00:00
abstract::We have developed a novel ileal loop model for use in calves to analyze the contribution of Salmonella enterica serovar Typhimurium type III secretion systems to disease processes in vivo. Our model involves constructing ileal loops with end-to-end anastamoses to restore the patency of the small intestine, thereby all...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.11.7161-7169.2005
更新日期:2005-11-01 00:00:00
abstract::Immunization of monkeys with the 82-kDa rhoptry protein (p82) of Plasmodium falciparum can protect them against a lethal blood stage challenge, and monoclonal antibodies to p82 inhibit parasite growth in vitro. The role that a p82-specific immune response might play in human immunity to the parasite is not known. To d...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.7.2960-2965.1993
更新日期:1993-07-01 00:00:00
abstract::Erysipelothrix rhusiopathiae is a primary pathogen of swine and turkeys and sporadic cause of disease in a variety of other hosts, including humans. A genomic library of the highly virulent strain of E. rhusiopathiae E1-6P was constructed in the expression-cloning vector lambda gt11 and screened with serum from a pig ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.9.3116-3121.1990
更新日期:1990-09-01 00:00:00
abstract::Establishment and maintenance of chronic lung infections with mucoid Pseudomonas aeruginosa in patients with cystic fibrosis (CF) require that the bacteria avoid host defenses. Elaboration of the extracellular, O-acetylated mucoid exopolysaccharide, or alginate, is a major microbial factor in resistance to immune effe...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.3.1895-1901.2001
更新日期:2001-03-01 00:00:00
abstract::We have focused on regions of staphylococcal enterotoxin C1 (SEC1) causing immunomodulation. N-terminal deletion mutants lacking residues 6 through 13 induced T-cell proliferation similar to that induced by native toxin. However, mutants with residues deleted between positions 19 and 33, although nonmitogenic themselv...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.8.3396-3407.1994
更新日期:1994-08-01 00:00:00
abstract::Mucosal immune responses to fungal infection range from T helper type 2 (Th2) cell-directed allergic inflammation to Th1-predominant neutrophilic inflammation, but the mechanisms directing these divergent mucosal immune outcomes and the role of T cells in host defense against mucosal fungal infections are not known. H...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.05209-11
更新日期:2011-11-01 00:00:00
abstract::Antigen-specific T-cell responses and histopathological changes were studied in mice experimentally inoculated with Borrelia burgdorferi B31. Inbred mice with different H-2 haplotypes and/or different genetic backgrounds were inoculated with B. burgdorferi organisms and tested for antigen-specific T-cell responses in ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.1.41-47.1989
更新日期:1989-01-01 00:00:00
abstract::Protection against colibacillosis in neonatal piglets was obtained by immunization of pregnant dams with procholeragenoid. Procholeragenoid is a stable high-molecular-weight aggregate of cholera toxin formed during the heating of cholera toxin. Procholeragenoid retained approximately 1% of the toxicity of native toxin...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.35.3.887-894.1982
更新日期:1982-03-01 00:00:00
abstract::Porphyromonas gingivalis has been implicated as an etiologic agent of adult periodontitis. We have previously shown that P. gingivalis can degrade the epithelial cell-cell junction complexes, thus suggesting that this bacterium can invade the underlying connective tissues via a paracellular pathway. However, the preci...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.5.2512-2518.2002
更新日期:2002-05-01 00:00:00
abstract::Pathogenic species of the spotted fever group Rickettsia are subjected to repeated exposures to the host complement system through cyclic infections of mammalian and tick hosts. The serum complement machinery is a formidable obstacle for bacteria to overcome if they endeavor to endure this endozoonotic cycle. We have ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00349-12
更新日期:2012-08-01 00:00:00
abstract::We isolated a monoclonal antibody directed against the ferric complex of aerobactin purified from Escherichia coli KH576. This antibody, which we designated MAb AERO1, was identified as an immunoglobulin G, subtype 2. A competitive enzyme-linked immunosorbent assay with MAb AERO1 had a limit of 10 nM for the detection...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.3.768-772.1992
更新日期:1992-03-01 00:00:00
abstract::We have previously shown that a pneumococcal surface protein A (PspA)-based vaccine containing DNA plasmid encoding the Flt3 ligand (FL) gene (pFL) as a nasal adjuvant prevented nasal carriage of Streptococcus pneumoniae. In this study, we further investigated the safety and efficacy of this nasal vaccine for the indu...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01360-10
更新日期:2011-07-01 00:00:00
abstract::Antibodies against mumps virus have been studied by using immunoglobulin class-specific indicators labeled with (125)I in the radioimmunoassay (RIA) procedure. The immunoglobulins in paired acute and convalescent sera were allowed to react with mumps virus in a solid-phase RIA system. Class-specific immunoglobulin ind...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.7.3.380-385.1973
更新日期:1973-03-01 00:00:00
abstract::Recent preclinical and epidemiologic studies have suggested that certain Mycobacterium tuberculosis genotypes (in particular, Beijing lineage strains) may be resistant to Mycobacterium bovis BCG vaccine-induced antituberculosis protective immunity. To investigate the strain specificity of BCG-induced protective respon...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00019-08
更新日期:2008-11-01 00:00:00
abstract::The bacterial pathogen Listeria monocytogenes causes foodborne systemic disease in pregnant women, which can lead to preterm labor, stillbirth, or severe neonatal disease. Colonization of the maternal decidua appears to be an initial step in the maternal component of the disease as well as bacterial transmission to th...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00153-17
更新日期:2017-07-19 00:00:00
abstract::Three open reading frames (ORFs) were identified by a genome walking strategy in the genomes of serotype M49 group A streptococcal (GAS) strains CS101 and 591. These ORFs were located between the mga core regulon and the dipeptide permease operon. The deduced amino acid (aa) sequences contained signature sequences ind...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.9.4859-4869.2002
更新日期:2002-09-01 00:00:00
abstract::Chlamydia trachomatis serovar E, the leading bacterial agent responsible for sexually transmitted diseases, is required to invade genital epithelial cells for its growth and survival, yet little is known about the adhesin-receptor interactions promoting its entry. In contrast, much has been published on the heparan su...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.7.3413-3418.2002
更新日期:2002-07-01 00:00:00
abstract::Fibrosis is a significant complication of intestinal disorders associated with microbial dysbiosis and pathobiont expansion, notably Crohn's disease (CD). Mechanisms that favor fibrosis are not well understood, and therapeutic strategies are limited. Here we demonstrate that colitis-susceptible Il10-deficient mice dev...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00587-19
更新日期:2019-10-18 00:00:00
abstract::In order to deploy virulence factors at appropriate times and locations, microbes must rapidly sense and respond to various metabolite signals. Previously, we showed a transient elevation of the methionine-derived metabolite methylthioadenosine (MTA) concentration in serum during systemic Salmonella enterica serovar T...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00429-18
更新日期:2018-08-22 00:00:00