Abstract:
:Protection against colibacillosis in neonatal piglets was obtained by immunization of pregnant dams with procholeragenoid. Procholeragenoid is a stable high-molecular-weight aggregate of cholera toxin formed during the heating of cholera toxin. Procholeragenoid retained approximately 1% of the toxicity of native toxin as determined in the rabbit ileal loop and Y-1 adrenal cell assays and 5% of the activity in the rabbit skin assay. Immunization of pregnant dams with 50 micrograms of procholeragenoid 5 and 2 weeks before the expected delivery date elicited high titers of antitoxic immunoglobulin G and toxin-neutralizing antibody in both the colostrum and serum. In three independent field trials, immunization with procholeragenoid resulted in a substantial decrease in diarrhea (73% in controls versus 11% in immunized) and death (4.7% in controls versus 0.77% in immunized) in neonatal piglets. The protection rate in the immunized population was approximately 85% for both diarrhea and death. In the following gestation period, reimmunization of dams with a single dose of procholeragenoid (50 micrograms) 2 weeks before delivery elicited titers of antitoxic immunoglobulin G and toxin-neutralizing antibody comparable to those obtained during the primary immunization. The death rate in neonatal piglets (0.86%) was comparable to that seen after immunization during the first gestation period (0.77%). These results indicate that substantial protection of neonatal piglets against colibacillosis can be obtained by immunization of dams with procholeragenoid. Protection was found to be based solely on antitoxic immunity.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Fürer E,Cryz SJ Jr,Dorner F,Nicolet J,Wanner M,Germanier Rdoi
10.1128/IAI.35.3.887-894.1982subject
Has Abstractpub_date
1982-03-01 00:00:00pages
887-94issue
3eissn
0019-9567issn
1098-5522journal_volume
35pub_type
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journal_title:Infection and immunity
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doi:10.1128/IAI.26.2.402-407.1979
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.7.2485-2493.1991
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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更新日期:1974-07-01 00:00:00
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pub_type: 杂志文章
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.14.3.671-679.1976
更新日期:1976-09-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:2001-02-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.46.1.74-80.1984
更新日期:1984-10-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.13.6.1549-1553.1976
更新日期:1976-06-01 00:00:00
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更新日期:2004-07-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.2.639-642.1989
更新日期:1989-02-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.46.1.98-104.1984
更新日期:1984-10-01 00:00:00
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journal_title:Infection and immunity
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.35.3.759-763.1982
更新日期:1982-03-01 00:00:00
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journal_title:Infection and immunity
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doi:10.1128/IAI.45.2.518-521.1984
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journal_title:Infection and immunity
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.7.1984-1989.1989
更新日期:1989-07-01 00:00:00
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journal_title:Infection and immunity
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更新日期:1994-08-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.26.2.547-553.1979
更新日期:1979-11-01 00:00:00
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doi:10.1128/IAI.28.1.54-64.1980
更新日期:1980-04-01 00:00:00
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journal_title:Infection and immunity
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:1996-12-01 00:00:00