Phagocytosis of virulent Porphyromonas gingivalis by human polymorphonuclear leukocytes requires specific immunoglobulin G.

abstract：:The Lyme disease spirochete, Borrelia burgdorferi, exists in a zoonotic cycle involving an arthropod tick and mammalian host. Dissemination of the organism within and between these hosts depends upon the spirochete's ability to traverse through complex tissues. Additionally, the spirochete outruns the host immune cell...

journal_title：Infection and immunity

authors： Sultan SZ,Manne A,Stewart PE,Bestor A,Rosa PA,Charon NW,Motaleb MA

更新日期：2013-06-01 00:00:00

abstract：:Resistance against acute and chronic infection with Taxoplasma gondii in BALB/c and CBA/Ca mice was compared. Intraperitoneal inoculation of either 20, 40, or 80 cysts of the ME49 strain resulted in mortality rates in BALB/c mice of 12% (2 of 17), 50% (6 of 12), and 75% (9 of 12), respectively, within 3 weeks after in...

journal_title：Infection and immunity

authors： Suzuki Y,Orellana MA,Wong SY,Conley FK,Remington JS

更新日期：1993-06-01 00:00:00

abstract：:The expression of T cell differentiation markers is known to increase during Mycobacterium tuberculosis infection, and yet the biological role of such markers remains unclear. We examined the requirement of the T cell differentiation marker killer cell lectin-like receptor G1 (KLRG1) during M. tuberculosis infection u...

journal_title：Infection and immunity

authors： Cyktor JC,Carruthers B,Stromberg P,Flaño E,Pircher H,Turner J

更新日期：2013-04-01 00:00:00

abstract：:Earlier work had shown that a collection of anaerobic bacteria, in conjunction with facultative anaerobes, may be implanted into germfree mice, thereby rendering the animals "normal" with respect to a variety of parameters tested. The present experiments indicate that a different collection of anaerobic bacteria, isol...

journal_title：Infection and immunity

authors： Freter R,Abrams GD

更新日期：1972-08-01 00:00:00

abstract：:Three antigenic determinants were revealed in H3 hemagglutinin of influenza A viruses isolated from 1968 to 1975. One of them was common for all viruses, and two others specified differences between the viruses possessing H3 hemagglutinin. ...

journal_title：Infection and immunity

authors： Rovnova ZI,Kosyakov PN,Berezina ON,Isayeva EI,Zhdanov VM

更新日期：1979-06-01 00:00:00

abstract：:Protamines (salmine prepared from sperm DNA of salmon and clupeine from herring sperm), which are basic peptides rich in arginine, were found to inhibit the proteolytic activity of arginine-specific cysteine protease (RC-protease) from Porphyromonas gingivalis. Lineweaver-Burk plot analysis revealed that the protamine...

journal_title：Infection and immunity

authors： Kontani M,Amano A,Nakamura T,Nakagawa I,Kawabata S,Hamada S

更新日期：1999-09-01 00:00:00

abstract：:Secreted and surface-exposed antigens of intracellular pathogens are thought to provide target structures for detection by the host immune system. The major secreted product of intracellular Leishmania mexicana amastigotes, a proteophosphoglycan (aPPG), is known to contribute to the establishment of the parasitophorou...

journal_title：Infection and immunity

authors： Aebischer T,Harbecke D,Ilg T

更新日期：1999-10-01 00:00:00

abstract：:While the pathological events evoked by infection are commonly described, effective host responses to bacteria and their products should primarily be protective. Heat shock protein (Hsp) expression is upregulated by many stimuli and serves to maintain intracellular protein integrity. The ability of the prototypic supe...

journal_title：Infection and immunity

authors： Musch MW,Petrof EO,Kojima K,Ren H,McKay DM,Chang EB

更新日期：2004-06-01 00:00:00

abstract：:The pulmonary immune response protects healthy individuals against Pneumocystis pneumonia (PcP). However, the immune response also drives immunopathogenesis in patients who develop severe PcP, and it is generally accepted that optimal treatment requires combination strategies that promote fungal killing and also provi...

journal_title：Infection and immunity

authors： Hoy Z,Wright TW,Elliott M,Malone J,Bhagwat S,Wang J,Gigliotti F

更新日期：2020-01-22 00:00:00

abstract：:Once Candida albicans comes in contact with endothelial cells, it induces cellular injury. This endothelial cell injury may be a mechanism by which blood-borne organisms escape from the intravascular compartment and invade the tissue parenchyma during hematogenous infection. We have been investigating the ability of c...

journal_title：Infection and immunity

authors： Fratti RA,Ghannoum MA,Edwards JE Jr,Filler SG

更新日期：1996-11-01 00:00:00

abstract：:A procedure is described for isolating a high-molecular-weight polysaccharide (PS) from the slime of Pseudomonas aeruginosa immunotype 1. The resultant material, obtained from the void volume of a Sephadex G-100 column, was composed of carbohydrate and water. No lipopolysaccharide (LPS), 2-keto-3-deoxyoctonoate, hepto...

journal_title：Infection and immunity

authors： Pier GB,Sidberry HF,Zolyomi S,Sadoff JC

更新日期：1978-12-01 00:00:00

abstract：:Cell-mediated immunity plays an important role in immunity to the pathogenic fungus Cryptococcus neoformans. However, the antigen specificity of the T-cell response to C. neoformans remains largely unknown. In this study, we used two approaches to determine the antigen specificity of the T-cell response to C. neoforma...

journal_title：Infection and immunity

authors： Lindell DM,Ballinger MN,McDonald RA,Toews GB,Huffnagle GB

更新日期：2006-08-01 00:00:00

abstract：:Hydrosalpinx induction in mice by Chlamydia muridarum infection, a model that has been used to study C. trachomatis pathogenesis in women, is known to depend on the cryptic plasmid that encodes eight genes designated pgp1 to pgp8. To identify the plasmid-encoded pathogenic determinants, we evaluated C. muridarum trans...

journal_title：Infection and immunity

authors： Liu Y,Huang Y,Yang Z,Sun Y,Gong S,Hou S,Chen C,Li Z,Liu Q,Wu Y,Baseman J,Zhong G

更新日期：2014-12-01 00:00:00

abstract：:Variation has been observed in the structural polypeptides of swine vesicular disease viruses isolated from the United Kingdom and Hong Kong. Despite the limited number of isolates examined, several distinct polypeptide patterns were obtained when the virus structural proteins were examined by polyacrylamide gel elect...

journal_title：Infection and immunity

authors： Harris TJ,Underwood BO,Knowles NJ,Crowther JR,Brown F

更新日期：1979-06-01 00:00:00

abstract：:The virulence of Neisseria gonorrhoeae for chicken embryos can be modified in a predictable manner by the addition of microbial siderophores to the inoculum. "Meningobactin" and "gonobactin," siderophores isolated from iron-limited cultures of meningococci and gonococci, respectively, enhance the virulence of the rela...

journal_title：Infection and immunity

authors： Finkelstein RA,Yancey RJ

更新日期：1981-05-01 00:00:00

abstract：:A gene from Haemophilus influenzae encoding an outer membrane lipoprotein of about 15,000 daltons and which comigrates with the peptidoglycan-associated lipoprotein (PAL) of H. influenzae on sodium dodecyl sulfate-polyacrylamide gel electrophoresis has been previously reported and designated pcp gene, and its product ...

journal_title：Infection and immunity

authors： Deich RA,Anilionis A,Fulginiti J,Metcalf BJ,Quataert S,Quinn-Dey T,Zlotnick GW,Green BA

更新日期：1990-10-01 00:00:00

abstract：:Brucella abortus endotoxin preparations, containing approximately 5 to 6% protein, induce strong immune and adjuvant immunoglobulin G (IgG) responses as compared with Escherichia coli endotoxin preparations, with equivalent amounts of protein, which induce responses in which IgM antibody predominates. Using an enzyme-...

journal_title：Infection and immunity

authors： Kurtz RS,Berman DT

更新日期：1986-12-01 00:00:00

abstract：:A gene encoding the cytotoxic enterotoxin (Act) from Aeromonas hydrophila was hyperexpressed with the pET, pTRX, and pGEX vector systems. Maximum toxin yield was obtained with the pTRX vector. Approximately 40 to 60% of Act was in a soluble form with the pTRX and pET vector systems. The toxin protein was purified to h...

journal_title：Infection and immunity

authors： Ferguson MR,Xu XJ,Houston CW,Peterson JW,Coppenhaver DH,Popov VL,Chopra AK

更新日期：1997-10-01 00:00:00

abstract：:The enzymes responsible for reducing H2O2 were surveyed in 49 strains of Leptospira by using semiquantitative assays for catalase and peroxidase. The survey revealed a differential distribution of catalase and peroxidase activities between the two leptospiral complexes. The pathogenic Leptospira interrogans strains ga...

journal_title：Infection and immunity

authors： Corin RE,Boggs E,Cox CD

更新日期：1978-12-01 00:00:00

abstract：:Previous studies have indicated that the ability to bind to fibronectin is a key feature in successful cell invasion by Campylobacter jejuni. Given the spatial distribution of fibronectin and the architecture of the epithelium, this suggests the possibility that C. jejuni cell invasion might preferentially occur at th...

journal_title：Infection and immunity

authors： Monteville MR,Konkel ME

更新日期：2002-12-01 00:00:00

abstract：:Members of our group reported recently that neisseria infection of human epithelial cells results in accelerated degradation of the major lysosomal integral membrane protein LAMP1 and that this is due to hydrolysis of this glycoprotein at its immunoglobulin A1 (IgA1)-like hinge by the neisseria type 2 IgA1 protease (L...

journal_title：Infection and immunity

authors： Ayala P,Lin L,Hopper S,Fukuda M,So M

更新日期：1998-10-01 00:00:00

abstract：:We have shown that a member of the 70-kDa heat shock protein (Hsp70) family is a major target of the humoral immune response during Leishmania donovani infection. A recombinant fusion protein was recognized by sera from 92% (35 of 38) of patients with visceral leishmaniasis, including representatives from each of the ...

journal_title：Infection and immunity

authors： Wallace GR,Ball AE,MacFarlane J,el Safi SH,Miles MA,Kelly JM

更新日期：1992-07-01 00:00:00

abstract：:Porphyromonas gingivalis is a gram-negative anaerobic bacterium that is considered the key etiologic agent of chronic periodontitis. Arg- and Lys-gingipain cysteine proteinases produced by P. gingivalis are key virulence factors and are believed to be essential for significant tissue component degradation, leading to ...

journal_title：Infection and immunity

authors： Andrian E,Grenier D,Rouabhia M

更新日期：2004-08-01 00:00:00

abstract：:Nerve damage is a clinical hallmark of leprosy and a major source of patient morbidity. We investigated the possibility that human Schwann cells are susceptible to cell death through the activation of Toll-like receptor 2 (TLR2), a pattern recognition receptor of the innate immune system. TLR2 was detected on the surf...

journal_title：Infection and immunity

authors： Oliveira RB,Ochoa MT,Sieling PA,Rea TH,Rambukkana A,Sarno EN,Modlin RL

更新日期：2003-03-01 00:00:00

abstract：:Representative strains of oral streptococci were tested for Fc immunoglobulin G (IgG) reactivity by two different techniques, agglutination of rabbit-IgG sensitized sheep erythrocytes and uptake of human and rabbit 125I-radiolabeled IgG. None of the S. mutans serotypes a through e reacted with the Fc region of either ...

journal_title：Infection and immunity

authors： Shea C,Ferretti JJ

更新日期：1981-12-01 00:00:00

abstract：:The diarrheagenic pathogen enteropathogenic Escherichia coli (EPEC) is responsible for significant infant mortality and morbidity, particularly in developing countries. EPEC pathogenesis relies on a type III secretion system-mediated transfer of virulence effectors into host cells. EPEC modulates host cell survival an...

journal_title：Infection and immunity

authors： Roxas JL,Koutsouris A,Viswanathan VK

更新日期：2007-05-01 00:00:00

abstract：:Transposon Tn916 was used to insertionally inactivate a coaggregation-relevant locus of Streptococcus gordonii DL1 (Challis). One mutant (F11) was isolated that lost the ability to coaggregate with the streptococcal partners of DL1 but retained the ability to coaggregate with partners belonging to other genera. A prob...

journal_title：Infection and immunity

authors： Whittaker CJ,Clemans DL,Kolenbrander PE

更新日期：1996-10-01 00:00:00

abstract：:Recruitment of neutrophils to lung tissue and airspaces is a hallmark of inflammatory events following inhalation of endotoxins. We studied the role of different lymphocyte subsets in this inflammation, which is assumed to primarily involve the innate immune system. Inhalation of aerosolized Escherichia coli lipopolys...

journal_title：Infection and immunity

authors： Larsson R,Rocksén D,Lilliehöök B,Jonsson A,Bucht A

更新日期：2000-12-01 00:00:00

abstract：:Immunoglobulin class-specific antibodies were measured by a solid-phase radioimmunoassay in serum, bronchoalveolar washings (BAW), lung cell lysates, and spleen cell lysates in germfree mice after intranasal (i.n.) and intraperitoneal (i.p.) primary and secondary 10(5), 10(4), and 10(3) mean tissue culture infective d...

journal_title：Infection and immunity

authors： Charlton D,Blandford G

更新日期：1977-09-01 00:00:00

abstract：:Inoculation of neonatal CD-1 mice by multiple routes with an amyocarditic temperature-sensitive (ts) mutant (ts 1) derived from a myocarditic parent variant of coxsackievirus B3 (CVB3(m)) resulted in approximately half of the neonates surviving to adolescence. Challenge of the ts 1 survivors with CVB3(m) did not induc...

journal_title：Infection and immunity

authors： Gauntt CJ,Paque RE,Trousdale MD,Gudvangen RJ,Barr DT,Lipotich GJ,Nealon TJ,Duffey PS

更新日期：1983-02-01 00:00:00