Antigenic determinants in influenza virus hemagglutinin.

abstract：:Previous studies have indicated that the ability to bind to fibronectin is a key feature in successful cell invasion by Campylobacter jejuni. Given the spatial distribution of fibronectin and the architecture of the epithelium, this suggests the possibility that C. jejuni cell invasion might preferentially occur at th...

journal_title：Infection and immunity

authors： Monteville MR,Konkel ME

更新日期：2002-12-01 00:00:00

abstract：:Inbred mouse strains differ in their susceptibility to infection with the facultative intracellular bacterium Listeria monocytogenes, largely due to delayed or deficient innate immune responses. Previous antibody depletion studies suggested that neutrophils (polymorphonuclear leukocytes [PMN]) were particularly import...

journal_title：Infection and immunity

authors： Pitts MG,Combs TA,D'Orazio SEF

更新日期：2018-03-22 00:00:00

abstract：:The American Heart Association supports an association between periodontal diseases and atherosclerosis but not a causal association. This study explores the use of the integrin β6(-/-) mouse model to study the causality. We investigated the ability of a polymicrobial consortium of Porphyromonas gingivalis, Treponema ...

journal_title：Infection and immunity

authors： Velsko IM,Chukkapalli SS,Rivera-Kweh MF,Zheng D,Aukhil I,Lucas AR,Larjava H,Kesavalu L

更新日期：2015-12-01 00:00:00

abstract：:A set of four monoclonal antibodies was produced against a highly purified pepsin extract of type 5 streptococcal M protein. Three of the four antibodies cross-reacted with purified M proteins from heterologous serotypes and opsonized the respective heterologous organisms. Our studies suggest that monoclonal antibodie...

journal_title：Infection and immunity

authors： Dale JB,Beachey EH

更新日期：1984-10-01 00:00:00

abstract：:The human pathogen enterohemorrhagic Escherichia coli (EHEC) O157:H7 has two histidine sensor kinases, QseC and QseE, which respond to the mammalian adrenergic hormones epinephrine and norepinephrine by increasing their autophosphorylation. Although QseC and QseE are present in nonpathogenic strains of E. coli, EHEC e...

journal_title：Infection and immunity

authors： Njoroge J,Sperandio V

更新日期：2012-02-01 00:00:00

abstract：:The adherence of Plasmodium falciparum-infected red blood cells (IRBCs) in the human placenta is mediated by chondroitin-4-sulfate (C4S). Although IRBC binding to C4S has been unequivocally established, the adherence characteristics of IRBCs at different stages of parasite development and through successive parasite g...

journal_title：Infection and immunity

authors： Madhunapantula SV,Achur RN,Gowda DC

更新日期：2007-09-01 00:00:00

abstract：:An effective vaccine for Vibrio cholerae is not yet available for use in the developing world, where the burden of cholera disease is highest. Characterizing the proteins that are expressed by V. cholerae in the human host environment may provide insight into the pathogenesis of cholera and assist with the development...

journal_title：Infection and immunity

authors： LaRocque RC,Krastins B,Harris JB,Lebrun LM,Parker KC,Chase M,Ryan ET,Qadri F,Sarracino D,Calderwood SB

更新日期：2008-09-01 00:00:00

abstract：:Yersinia pestis KIM5 was found to be cytotoxic for the IC21 and P388D1 mouse macrophage cell lines, as well as for resident peritoneal macrophages from C57BL/6 mice. Affected cells phagocytosed KIM5 inefficiently, became spherical, detached readily from culture dishes, and retained 51Cr poorly. The cytotoxic effect wa...

journal_title：Infection and immunity

authors： Goguen JD,Walker WS,Hatch TP,Yother J

更新日期：1986-03-01 00:00:00

abstract：:Outer membrane protein F (porin) was purified by extraction from polyacrylamide gels of cell envelope proteins of the Pseudomonas aeruginosa PAO1 strain. Rats were immunized intramuscularly with 25 micrograms of protein F on days 1 and 14 and then challenged on day 28 via intratracheal inoculation of bacterium-contain...

journal_title：Infection and immunity

authors： Gilleland HE Jr,Gilleland LB,Matthews-Greer JM

更新日期：1988-05-01 00:00:00

abstract：:A C3d-binding glycoprotein was purified from the culture filtrate of Candida albicans by preparative isoelectric focusing. The protein possessed a pI of 3.9 to 4.1 and could inhibit rosetting of EAC3d (sheep erythrocytes conjugated to C3d) by pseudohyphae of C. albicans. When analyzed by polyacrylamide gel electrophor...

journal_title：Infection and immunity

authors： Saxena A,Calderone R

更新日期：1990-02-01 00:00:00

abstract：:Shigella flexneri 2a is an invasive enteric pathogen that may produce diarrhea when ingested by human beings and subhuman primates. We have previously shown that shigella diarrhea correlates with water and electrolyte transport abnormalities in the jejunum and colon. Dysentery alone is associated only with colonic tra...

journal_title：Infection and immunity

authors： Kinsey MD,Formal SB,Dammin GJ,Giannella RA

更新日期：1976-08-01 00:00:00

abstract：:The interaction of plasma fibronectin with C1q of the complement system has been demonstrated in the past several years. In addition, the antibody-independent binding of C1q to bacteria, as well as the binding of plasma fibronectin to bacteria, is well documented. This study examines whether the binding of C1q to bact...

journal_title：Infection and immunity

authors： Sorvillo JM,Pearlstein E

更新日期：1985-09-01 00:00:00

abstract：:A DNA microarray containing fragments of 137 Borrelia burgdorferi B31 putative lipoprotein genes was used to examine Lyme disease spirochetes. DNA from B. burgdorferi sensu stricto B31, 297, and N40; Borrelia garinii IP90; and Borrelia afzelii P/Gau was fluorescently labeled and hybridized to the microarray, demonstra...

journal_title：Infection and immunity

authors： Liang FT,Nelson FK,Fikrig E

更新日期：2002-06-01 00:00:00

abstract：:Fasciola hepatica is a prevalent helminth parasite of livestock. Infection results in polarization of the host's immune response and generation of type 2 helper (Th2) immune responses, which are known to be inhibitory to Th1 responses. Bovine tuberculosis (BTB) is a bacterial disease of economic and zoonotic importanc...

journal_title：Infection and immunity

authors： Flynn RJ,Mannion C,Golden O,Hacariz O,Mulcahy G

更新日期：2007-03-01 00:00:00

abstract：:Eight chlamydial isolates of ovine origin were tested in a plaque reduction system using homologous and heterologous rooster antisera. The eight isolates could be separated into two separate immunotypes. Type 1 included isolates associated with ovine abortion and one agent recovered from the feces of an apparently nor...

journal_title：Infection and immunity

authors： Schachter J,Banks J,Sugg N,Sung M,Storz J,Meyer KF

更新日期：1974-01-01 00:00:00

abstract：:Escherichia coli strains that cause nonbloody diarrhea in infants are known to present three distinct patterns of adherence to epithelial cells, namely, localized (LA), diffuse (DA), and aggregative (AA) adherence. Strains with LA (typical Enteropathogenic Escherichia coli [EPEC]) are well recognized as a cause of sec...

journal_title：Infection and immunity

authors： Scaletsky IC,Pedroso MZ,Oliva CA,Carvalho RL,Morais MB,Fagundes-Neto U

更新日期：1999-07-01 00:00:00

abstract：:The diarrheagenic pathogen enteropathogenic Escherichia coli (EPEC) is responsible for significant infant mortality and morbidity, particularly in developing countries. EPEC pathogenesis relies on a type III secretion system-mediated transfer of virulence effectors into host cells. EPEC modulates host cell survival an...

journal_title：Infection and immunity

authors： Roxas JL,Koutsouris A,Viswanathan VK

更新日期：2007-05-01 00:00:00

abstract：:A monoclonal antibody was used to characterize a 135-kDa surface-located membrane protein (Lmp1) generally present in Mycoplasma hominis strains. The monoclonal antibody, 552, was applied to identify the corresponding gene in an expression library of M. hominis PG21 DNA. The M. hominis PG21 lmp1 gene was sequenced, an...

journal_title：Infection and immunity

authors： Ladefoged SA,Birkelund S,Hauge S,Brock B,Jensen LT,Christiansen G

更新日期：1995-01-01 00:00:00

abstract：:Salmonella is a widespread zoonotic enteropathogen that causes gastroenteritis and fatal typhoidal disease in mammals. During systemic infection of mice, Salmonella enterica serovar Typhimurium resides and replicates in macrophages within the "Salmonella-containing vacuole" (SCV). It is surprising that the substrates ...

journal_title：Infection and immunity

authors： Bowden SD,Rowley G,Hinton JC,Thompson A

更新日期：2009-07-01 00:00:00

abstract：:In experimental Leishmania donovani infection in BALB/c mice, initial susceptibility gives way to T-cell-dependent acquired resistance and eventual control over visceral infection. Since various cytokines appear to underlie the host response to Leishmania infection, we examined infected liver tissue for gene expressio...

journal_title：Infection and immunity

authors： Miralles GD,Stoeckle MY,McDermott DF,Finkelman FD,Murray HW

更新日期：1994-03-01 00:00:00

abstract：:Cholera enterotoxin and the related heat-labile enterotoxins of Escherichia coli enter their target cells through noncoated vesicles, but how the toxins are processed intracellularly and how they get to their targeted enzyme, adenylate cyclase, remain to be defined. Brefeldin A, an inhibitor of the trans-Golgi network...

journal_title：Infection and immunity

authors： Donta ST,Beristain S,Tomicic TK

更新日期：1993-08-01 00:00:00

abstract：:Clostridium perfringens type B and type C isolates, which produce beta-toxin (CPB), cause fatal diseases originating in the intestines of humans or livestock. Our previous studies demonstrated that CPB is necessary for type C isolate CN3685 to cause bloody necrotic enteritis in a rabbit ileal loop model and also showe...

journal_title：Infection and immunity

authors： Vidal JE,McClane BA,Saputo J,Parker J,Uzal FA

更新日期：2008-10-01 00:00:00

abstract：:The Bordetella pertussis BrkA protein protects against the bactericidal activity of complement and antibody; however, some individuals mount an immune response that overcomes this bacterial defense. To further characterize this process, the bactericidal activities of sera from 13 adults with different modes of exposur...

journal_title：Infection and immunity

authors： Weiss AA,Mobberley PS,Fernandez RC,Mink CM

更新日期：1999-03-01 00:00:00

abstract：:The interactions between Klebsiella pneumoniae and the host environment at the site of infection are largely unknown. Pulmonary surfactant serves as an initial point of contact for inhaled bacteria entering the lung and is thought to contain molecular cues that aid colonization and pathogenesis. To gain insight into t...

journal_title：Infection and immunity

authors： Willsey GG,Ventrone S,Schutz KC,Wallace AM,Ribis JW,Suratt BT,Wargo MJ

更新日期：2018-06-21 00:00:00

abstract：:Rheumatoid arthritis (RA) is an inflammatory disease that has been linked to several risk factors, including periodontitis. Identification of new anti-inflammatory compounds to treat arthritis is needed. We had previously demonstrated the beneficial effect of Kava-241, a kavain-derived compound, in the management of P...

journal_title：Infection and immunity

authors： Huck O,You J,Han X,Cai B,Panek J,Amar S

更新日期：2018-08-22 00:00:00

abstract：:Tissue macrophages are the obligatory host cells for Leishmania donovani, the causative agent of visceral leishmaniasis. In this study we sought to determine whether activated macrophages, as defined by the functional criterion of tumor cell cytotoxicity, were also able to exert a microbicidal effect on ingested L. do...

journal_title：Infection and immunity

authors： Haidaris CG,Bonventre PF

更新日期：1981-09-01 00:00:00

abstract：:Individuals living in areas where malaria is endemic are repeatedly exposed to many different malaria parasite antigens. Studies on naturally acquired antibody-mediated immunity to clinical malaria have largely focused on the presence of responses to individual antigens and their associations with decreased morbidity....

journal_title：Infection and immunity

authors： Osier FH,Fegan G,Polley SD,Murungi L,Verra F,Tetteh KK,Lowe B,Mwangi T,Bull PC,Thomas AW,Cavanagh DR,McBride JS,Lanar DE,Mackinnon MJ,Conway DJ,Marsh K

更新日期：2008-05-01 00:00:00

abstract：:The contribution of murine Toll-like receptors 2 and 4 (TLR2 and -4, respectively) to cytokine induction by heat-killed bacteria was analyzed in vitro and in vivo. Gram-negative bacteria induced cytokines primarily via TLR4; the contribution of TLR2 was only minor. Neither TLR4 nor, surprisingly, TLR2 was required in ...

journal_title：Infection and immunity

authors： Lembo A,Kalis C,Kirschning CJ,Mitolo V,Jirillo E,Wagner H,Galanos C,Freudenberg MA

更新日期：2003-10-01 00:00:00

abstract：:Four glycoproteins of Treponema pallidum were identified by intrinsic [14C]glucosamine labeling. Only two glycoproteins were demonstrated in T. phagedenis biotype Reiter with the same technique. Glycoproteins of both treponemes were characterized as antigens and shown to be localized within the outer membranes of the ...

journal_title：Infection and immunity

authors： Moskophidis M,Müller F

更新日期：1984-12-01 00:00:00

abstract：:In the lungs of mice vaccinated with Mycobacterium bovis BCG, there was an accumulation of CD4 cells expressing the activated effector phenotype CD44hi CD62 ligandlo) (CD62Llo) which were capable of secreting gamma interferon. Upon cell transfer, however, cells expressing a resting/naïve phenotype (CD44lo CD62Lhi) wer...

journal_title：Infection and immunity

authors： Kipnis A,Irwin S,Izzo AA,Basaraba RJ,Orme IM

更新日期：2005-11-01 00:00:00