Unique and common protective epitopes among different serotypes of group A streptococcal M proteins defined with hybridoma antibodies.

abstract：:Natural-resistance-associated macrophage protein 1 (Nramp1) is a divalent cation transporter belonging to a family of transporter proteins highly conserved in eukaryotes and prokaryotes. Mammalian and bacterial transporters may compete for essential metal ions during mycobacterial infections. The mycobacterial Nramp h...

journal_title：Infection and immunity

authors： Boechat N,Lagier-Roger B,Petit S,Bordat Y,Rauzier J,Hance AJ,Gicquel B,Reyrat JM

更新日期：2002-08-01 00:00:00

abstract：:Streptococcus pneumoniae is a leading cause of bacterial pneumonia, meningitis, and sepsis in children. Human immunity to pneumococcal infections has been assumed to depend on anticapsular antibodies. However, recent findings from murine models suggest that alternative mechanisms, dependent on T helper cells, are also...

journal_title：Infection and immunity

authors： Olliver M,Hiew J,Mellroth P,Henriques-Normark B,Bergman P

更新日期：2011-10-01 00:00:00

abstract：:In this study we tested the in vitro and in vivo anti-Cryptococcus neoformans activity of an antilaminarin (anti-beta-glucan) monoclonal antibody (MAb 2G8) (immunoglobulin G2b) which was previously shown to inhibit the growth of beta-glucan-exposing Candida albicans cells. Here we show that MAb 2G8 binds to the cell w...

journal_title：Infection and immunity

authors： Rachini A,Pietrella D,Lupo P,Torosantucci A,Chiani P,Bromuro C,Proietti C,Bistoni F,Cassone A,Vecchiarelli A

更新日期：2007-11-01 00:00:00

abstract：:Mucosal exposure to Escherichia coli elicits an inflammatory response in the urinary tract. Interleukin-6 (IL-6) is secreted into the urine, and polymorphonuclear leukocytes (PMNLs) are recruited to the site of infection. This study analyzed the ability of mucosally administered bacterial components to activate IL-6 a...

journal_title：Infection and immunity

authors： Linder H,Engberg I,Hoschützky H,Mattsby-Baltzer I,Svanborg C

更新日期：1991-12-01 00:00:00

abstract：:In nature, mixed Borrelia burgdorferi infections are common and possibly can be acquired by either superinfection or coinfection. Superinfection by heterologous B. burgdorferi strains has been established experimentally, although the ability of homologous B. burgdorferi clones to superinfect a host has not been studie...

journal_title：Infection and immunity

authors： Rogovskyy AS,Bankhead T

更新日期：2014-11-01 00:00:00

abstract：:A gene bank of group A Streptococcus strain Manfredo (M protein serotype 5) was constructed with a bacteriophage lambda vector-Escherichia coli K-12 host system and screened by immunoblotting hybrid phage plaques with antisera raised to purified pep M5 (serotype 5 M protein fragment released from the streptococcal cel...

journal_title：Infection and immunity

authors： Kehoe MA,Poirier TP,Beachey EH,Timmis KN

更新日期：1985-04-01 00:00:00

abstract：:Pathogenicity of Rickettsia tsutsugamushi for laboratory mice is known to be influenced by at least three factors: (i) route of inoculation, (ii) antigenic strain, and (iii) natural resistance of the host. By using Karp, Gilliam, and Kato strains of R. tsutsugamushi, we examined the effect of these three pathogenicity...

journal_title：Infection and immunity

authors： Groves MG,Kelly DJ

更新日期：1989-05-01 00:00:00

abstract：:Antibodies against mumps virus have been studied by using immunoglobulin class-specific indicators labeled with (125)I in the radioimmunoassay (RIA) procedure. The immunoglobulins in paired acute and convalescent sera were allowed to react with mumps virus in a solid-phase RIA system. Class-specific immunoglobulin ind...

journal_title：Infection and immunity

authors： Daugharty H,Warfield DT,Hemingway WD,Casey HL

更新日期：1973-03-01 00:00:00

abstract：:Although protective immunity in C57BL/6 mice induced by a single dose of the radiation-attenuated schistosome vaccine is believed to be mediated by Th1-type immune responses, we here report that in BALB/c mice protection can also depend upon signaling via the interleukin-4 (IL-4) receptor which conventionally governs ...

journal_title：Infection and immunity

authors： Mountford AP,Hogg KG,Coulson PS,Brombacher F

更新日期：2001-01-01 00:00:00

abstract：:Aspergillus fumigatus produces conidia that are highly dispersable and resistant to degradation. We have sought to analyze these properties by studying the rodlets which form the outer spore coat protein. Degenerate primers based on hydrophobins in other fungi were applied to genomic DNA from A. fumigatus in PCR. A pr...

journal_title：Infection and immunity

authors： Parta M,Chang Y,Rulong S,Pinto-DaSilva P,Kwon-Chung KJ

更新日期：1994-10-01 00:00:00

abstract：:Saccharomyces boulardii is a nonpathogenic yeast used in the treatment of Clostridium difficile diarrhea and colitis. We have reported that S. boulardii inhibits C. difficile toxin A enteritis in rats by releasing a 54-kDa protease which digests the toxin A molecule and its brush border membrane (BBM) receptor (I. Cas...

journal_title：Infection and immunity

authors： Castagliuolo I,Riegler MF,Valenick L,LaMont JT,Pothoulakis C

更新日期：1999-01-01 00:00:00

abstract：:Infections caused by organisms of the Mycobacterium avium complex occur in approximately 50 to 60% of patients with AIDS. M. avium is an intracellular pathogen that survives and multiplies within mononuclear phagocytes. In this study, we investigated the uptake of M. avium grown within macrophages (intracellular growt...

journal_title：Infection and immunity

authors： Bermudez LE,Parker A,Goodman JR

更新日期：1997-05-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is an inflammatory disease that has been linked to several risk factors, including periodontitis. Identification of new anti-inflammatory compounds to treat arthritis is needed. We had previously demonstrated the beneficial effect of Kava-241, a kavain-derived compound, in the management of P...

journal_title：Infection and immunity

authors： Huck O,You J,Han X,Cai B,Panek J,Amar S

更新日期：2018-08-22 00:00:00

abstract：:Pseudomonas aeruginosa bacteremia in cancer patients develops from initial gastrointestinal (GI) colonization with translocation into the bloodstream in the setting of chemotherapy-induced neutropenia and GI mucosal damage. We established a reproducible mouse model of P. aeruginosa GI colonization and systemic spread ...

journal_title：Infection and immunity

authors： Koh AY,Priebe GP,Pier GB

更新日期：2005-04-01 00:00:00

abstract：:The obligate intracellular parasite Toxoplasma gondii can actively infect any nucleated cell type, including cells from the immune system. The rapid transfer of T. gondii from infected dendritic cells to effector natural killer (NK) cells may contribute to the parasite's sequestration and shielding from immune recogni...

journal_title：Infection and immunity

authors： Sultana MA,Du A,Carow B,Angbjär CM,Weidner JM,Kanatani S,Fuks JM,Muliaditan T,James J,Mansfield IO,Campbell TM,Liu L,Kadri N,Lambert H,Barragan A,Chambers BJ

更新日期：2017-09-20 00:00:00

abstract：:Brucella abortus is a facultative intracellular bacterial pathogen that causes abortion in domestic animals and undulant fever in humans. The mechanism of virulence of Brucella spp. is not fully understood yet. Furthermore, genes that allow Brucella to reach the intracellular niche and to interact with host cells need...

journal_title：Infection and immunity

authors： Rosinha GM,Freitas DA,Miyoshi A,Azevedo V,Campos E,Cravero SL,Rossetti O,Splitter G,Oliveira SC

更新日期：2002-09-01 00:00:00

abstract：:In mammals, the natural resistance-associated macrophage protein 1 gene, Nramp1, plays a major role in resistance to mycobacterial infections. Chesapeake Bay striped bass (Morone saxatilis) is currently experiencing an epizootic of mycobacteriosis that threatens the health of this ecologically and economically importa...

journal_title：Infection and immunity

authors： Burge EJ,Gauthier DT,Ottinger CA,Van Veld PA

更新日期：2004-03-01 00:00:00

abstract：:The purpose of this study was to determine the effects of human monocytes, macrophages, and polymorphonuclear neutrophils (PMN) on the fungal pathogen Blastomyces dermatitidis in vitro. Peripheral blood monocyte monolayers significantly inhibited the replication of a virulent strain (V) and an avirulent strain (AV) of...

journal_title：Infection and immunity

authors： Brummer E,Stevens DA

更新日期：1982-04-01 00:00:00

abstract：:A receptor specific for lipoglycans from Acholeplasma axanthum and Acholeplasma granularum was isolated from sheep erythrocyte stroma by extraction with n-pentanol and permeation chromatography. The purified receptor appeared as one band on sodium dodecyl sulfate-polyacrylamide gels and stained with Coomassie blue, pe...

journal_title：Infection and immunity

authors： Al-Samarrai TH,Smith PF,Lynn RJ

更新日期：1982-12-01 00:00:00

abstract：:The structural gene of pneumolysin was randomly mutagenized. A screen, developed to identify mutants with reduced hemolytic activity, identified substitutions within the cysteine-containing region and also at residues toward the N terminus of the toxin. These are the first reported changes within the N-terminal region...

journal_title：Infection and immunity

authors： Hill J,Andrew PW,Mitchell TJ

更新日期：1994-02-01 00:00:00

abstract：:The serum opacity factor (SOF) of Streptococcus pyogenes is a serotyping tool and pathogenesis factor. Using SOF-coated latex beads in cell adherence assays and antiserum directed against SOF in S. pyogenes-HEp-2 cell adherence inhibition experiments, we demonstrate SOF involvement in the fibronectin-mediated adherenc...

journal_title：Infection and immunity

authors： Oehmcke S,Podbielski A,Kreikemeyer B

更新日期：2004-07-01 00:00:00

abstract：:Heterogeneic autoantibodies against axonal neurofilament proteins of mature mouse neurons grown in vitro were detected by the indirect immunofluorescence technique in 12.7% (9 of 71) of the sera from nonhuman primates infected with kuru, in 14.5% (17 of 117) and 4% (1 of 25), respectively, of the sera from nonhuman pr...

journal_title：Infection and immunity

authors： Aoki T,Gibbs CJ Jr,Sotelo J,Gajdusek DC

更新日期：1982-10-01 00:00:00

abstract：:In Vibrio cholerae, the transmembrane DNA binding proteins, ToxR and TcpP, activate expression of the regulatory gene toxT in response to specific environmental signals. The resulting enhanced level of ToxT leads to a coordinated increase in the production of a subset of virulence factors, including cholera toxin (CT)...

journal_title：Infection and immunity

authors： Krishnan HH,Ghosh A,Paul K,Chowdhury R

更新日期：2004-07-01 00:00:00

abstract：:An enzyme from Treponema denticola that hydrolyzes a synthetic trypsin substrate, N-alpha-benzoyl-L-arginine-p-nitroanilide (BAPNA), was purified to near homogeneity, as judged by gel electrophoresis. The molecular weight of the enzyme was estimated to be ca. 69,000 by sodium dodecyl sulfate-polyacrylamide gel electro...

journal_title：Infection and immunity

authors： Ohta K,Makinen KK,Loesche WJ

更新日期：1986-07-01 00:00:00

abstract：:Mice with a null deletion mutation in the gamma interferon (IFN-gamma) receptor gene were used to study the role of IFN-gamma responsiveness during experimental pulmonary cryptococcosis. Cryptococcus neoformans was inoculated intratracheally into mice lacking the IFN-gamma receptor gene (IFN-gammaR-/-) and into contro...

journal_title：Infection and immunity

authors： Chen GH,McDonald RA,Wells JC,Huffnagle GB,Lukacs NW,Toews GB

更新日期：2005-03-01 00:00:00

abstract：:Adhesion of Trichomonas vaginalis is believed to be dependent on four adhesion proteins, which are thought to bind to vaginal epithelial cells in a specific manner with a ligand-receptor type of interaction. However, the specific receptors on the host cell have not yet been identified. In this work, the ability of the...

journal_title：Infection and immunity

authors： Addis MF,Rappelli P,Fiori PL

更新日期：2000-07-01 00:00:00

abstract：:Five mutagens were used to induce mutants of Candida albicans. Ultraviolet light, N-nitroso-N'-methyl-N-nitrosoguanidine, and N-nitroso-N-methylurethane were effective mutagens which induced stable auxotrophs. N-nitroso-N-methylurethane produced the largest number and variety of mutants. Nitrous acid and hydroxylamine...

journal_title：Infection and immunity

authors： Savage N,Balish E

更新日期：1971-01-01 00:00:00

abstract：:Schistosomiasis affects nearly 40 million women of reproductive age. Many of these women are infected while pregnant and lactating. Several studies have demonstrated transplacental trafficking of schistosome antigens; however, little is known regarding how these antigens affect the developing fetus and placenta. To ev...

journal_title：Infection and immunity

authors： McDonald EA,Kurtis JD,Acosta L,Gundogan F,Sharma S,Pond-Tor S,Wu HW,Friedman JF

更新日期：2013-03-01 00:00:00

abstract：:Capsular types 5 and 8, which account for about 70% of Staphylococcus aureus strains isolated from the blood of patients, resisted in vitro phagocytosis by human polymorphonuclear leukocytes (PMN). Antisera and monoclonal antibody to type 5 and 8 capsular polysaccharides (CPS) induced type-specific in vitro phagocytos...

journal_title：Infection and immunity

authors： Karakawa WW,Sutton A,Schneerson R,Karpas A,Vann WF

更新日期：1988-05-01 00:00:00

abstract：:Gram-negative bacteria have been shown to activate human natural killer (NK) cells. In this report, we show that the gram-positive bacterium Listeria monocytogenes can also activate human NK cells with regard to non-major histocompatibility complex (MHC)-restricted killing and the production of cytokines. Overnight in...

journal_title：Infection and immunity

authors： Guo Y,Niesel DW,Ziegler HK,Klimpel GR

更新日期：1992-05-01 00:00:00