Abstract:
:In nature, mixed Borrelia burgdorferi infections are common and possibly can be acquired by either superinfection or coinfection. Superinfection by heterologous B. burgdorferi strains has been established experimentally, although the ability of homologous B. burgdorferi clones to superinfect a host has not been studied in detail. Information regarding any potential immune barriers to secondary infection also currently is unavailable. In the present study, the ability to superinfect various mouse models by homologous wild-type clones was examined and compared to superinfection by heterologous strains. To assess the ability of homologous B. burgdorferi clones to successfully superinfect a mouse host, primary- and secondary-infecting spirochetes were recovered via in vitro cultivation of collected blood or tissue samples. This was accomplished by generating two different antibiotic-resistant versions of the wild-type B31-A3 clone in order to distinguish superinfecting B. burgdorferi from primary-infecting spirochetes. The data demonstrate an inability of homologous B. burgdorferi to superinfect immunocompetent mice as opposed to heterologous strains. Attempts to superinfect different types of immunodeficient mice with homologous B. burgdorferi indicate that the murine innate immune system represents a major barrier to intrastrain superinfection. Consequently, the possibility of innate immunity as a driving force for B. burgdorferi heterogeneity during the enzootic cycle is discussed.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Rogovskyy AS,Bankhead Tdoi
10.1128/IAI.01817-14subject
Has Abstractpub_date
2014-11-01 00:00:00pages
4542-52issue
11eissn
0019-9567issn
1098-5522pii
IAI.01817-14journal_volume
82pub_type
杂志文章abstract::Lipid extracts derived from a group A Streptococcus, when preincubated with tumor cells before inoculation, were shown to prevent completely the development of Ehrlich ascites tumor in mice. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.3.5.705-706.1971
更新日期:1971-05-01 00:00:00
abstract::Endocarditis isolates of Enterococcus faecalis produced biofilm significantly more often than nonendocarditis isolates, and 39% of 79 versus 6% of 84 isolates produced strong biofilm (P < 0.0001). esp was not required, but its presence was associated with higher amounts of biofilm (P < 0.001). Mutants disrupted in dlt...
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pub_type: 杂志文章
doi:10.1128/IAI.72.6.3658-3663.2004
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.3.785-790.1989
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abstract::Membrane and soluble fractions of Mycoplasma pneumoniae, M. pulmonis, and M. laidlawii B were prepared by hypotonic lysis of whole cells. The membranes of M. pneumoniae and M. laidlawii B contained, as percentage of dry weight: 34 to 37% protein, 59 to 61% lipid, 3 to 4% carbohydrate as hexose, and 0.2% ribonucleic ac...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.2.3.326-339.1970
更新日期:1970-09-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:
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abstract::Antigens shared between Streptococcus pyogenes and heart tissue may play an important role in autoimmune cardiac injury associated with acute rheumatic fever. Antiheart/antistreptococcal antibodies found in the disease react with antigens of S. pyogenes, including M protein and a 60-kDa antigen distinct from M protein...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.9.3932-3936.1992
更新日期:1992-09-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.30.1.147-149.1980
更新日期:1980-10-01 00:00:00
abstract::Salmonella enterica serovar Typhimurium causes self-limiting gastroenteritis in humans and a typhoid-like disease in mice that serves as a model for typhoid infections in humans. A critical step in Salmonella pathogenesis is the invasion of enterocytes and M cells of the small intestine via expression of a type III se...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.72.4.2002-2013.2004
更新日期:2004-04-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.9.4708-4712.1999
更新日期:1999-09-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1999-12-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.5.1631-1639.1997
更新日期:1997-05-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.1.143-149.1992
更新日期:1992-01-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.54.3.837-840.1986
更新日期:1986-12-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:2014-12-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.11.6461-6465.2000
更新日期:2000-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:2000-02-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.1.257-260.1997
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journal_title:Infection and immunity
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更新日期:2006-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.19.2.457-461.1978
更新日期:1978-02-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:2013-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.21.1.114-123.1978
更新日期:1978-07-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
pub_type: 杂志文章
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abstract::Infection with Histoplasma capsulatum results in a subclinical infection in immunocompetent hosts due to an effective cellular immune response. By contrast, immunodeficient individuals can have a severe disseminated and potentially fatal disease. In a previous study, it was demonstrated that normal mice infected intra...
journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:1997-03-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.11.4953-4956.1992
更新日期:1992-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:1971-01-01 00:00:00