E and P selectins are not required for resistance to severe murine lyme arthritis.

abstract：:Athymic BALB/c nude mice and euthymic BALB/c mice were infected with Rickettsia akari by the intraperitoneal route. The rickettsialpox infection was terminated in euthymic mice with only two intraperitoneal injections of the antibiotic oxytetracycline, whereas prolonged treatment was necessary to terminate the infecti...

journal_title：Infection and immunity

authors： Kenyon RH,Pedersen CE Jr

更新日期：1980-05-01 00:00:00

abstract：:A DNA microarray containing fragments of 137 Borrelia burgdorferi B31 putative lipoprotein genes was used to examine Lyme disease spirochetes. DNA from B. burgdorferi sensu stricto B31, 297, and N40; Borrelia garinii IP90; and Borrelia afzelii P/Gau was fluorescently labeled and hybridized to the microarray, demonstra...

journal_title：Infection and immunity

authors： Liang FT,Nelson FK,Fikrig E

更新日期：2002-06-01 00:00:00

abstract：:Understanding the regulation of human immune responses is critical for vaccine development and treating infectious diseases. We have previously shown that simultaneous engagement of the T cell receptor (TCR) and complement regulator CD46 on human CD4(+) T cells in the presence of interleukin-2 (IL-2) induces potent se...

journal_title：Infection and immunity

authors： Truscott SM,Abate G,Price JD,Kemper C,Atkinson JP,Hoft DF

更新日期：2010-12-01 00:00:00

abstract：:Bactericidal/permeability-increasing protein (BPI), a human neutrophil granule protein, has been shown to bind lipopolysaccharide (LPS) and neutralize LPS-mediated cytokine production in adherent monocytes and the whole-blood system. In this study we investigated the ability of recombinant human BPI (rBPI) to inhibit ...

journal_title：Infection and immunity

authors： Arditi M,Zhou J,Huang SH,Luckett PM,Marra MN,Kim KS

更新日期：1994-09-01 00:00:00

abstract：:Vibrio vulnificus is an oyster-associated bacterial pathogen that causes life-threatening fulminating septicemia and necrotizing wound infections in humans. The capsular polysaccharide of V. vulnificus (VvPS) is critical for virulence. Previously we showed that active immunization of mice with a VvPS-tetanus toxoid (V...

journal_title：Infection and immunity

authors： Devi SJ,Hayat U,Powell JL,Morris JG Jr

更新日期：1996-06-01 00:00:00

abstract：:The Yersinia high-pathogenicity island (HPI) is common to multiple virulence strategies used by Escherichia coli strains associated with urinary tract infection (UTI). Among the genes in this island are ybtP and ybtQ, encoding distinctive ATP binding cassette (ABC) proteins associated with iron(III)-yersiniabactin imp...

journal_title：Infection and immunity

authors： Koh EI,Hung CS,Henderson JP

更新日期：2016-04-22 00:00:00

abstract：:Association of Salmonella typhimurium with MDCK epithelial cells in monolayers, represented primarily by intracellular bacteria after 30 min of contact, with centrifugation followed by vigorous washing, was measured during aerobic and anaerobic growth of the bacteria in brain heart infusion broth. Cell association was...

journal_title：Infection and immunity

authors： Schiemann DA

更新日期：1995-04-01 00:00:00

abstract：:Several bacterial species recruit the complement regulators C4b-binding protein, factor H, and vitronectin, resulting in resistance against the bactericidal activity of human serum. It was recently demonstrated that bacteria also bind plasminogen, which is converted to plasmin that degrades C3b and C5. In this study, ...

journal_title：Infection and immunity

authors： Singh B,Al-Jubair T,Voraganti C,Andersson T,Mukherjee O,Su YC,Zipfel P,Riesbeck K

更新日期：2015-09-01 00:00:00

abstract：:Many of the proinflammatory effects of gram-negative bacteria are elicited by the interaction of bacterial lipopolysaccharide (LPS) with Toll-like receptor 4 (TLR4) expressed on host cells. TLR4 signaling leads to activation of NF-kappa B and transcription of many genes involved in the inflammatory response. In this s...

journal_title：Infection and immunity

authors： Li X,Tupper JC,Bannerman DD,Winn RK,Rhodes CJ,Harlan JM

更新日期：2003-08-01 00:00:00

abstract：:The serum antibody response to proteins encoded by the virulence-associated plasmid of Shigella flexneri was determined in monkeys challenged with virulent S. flexneri serotype 2a. With water-extractable antigen in an enzyme-linked immunosorbent assay, a significant increase in antibody titer against proteins from a p...

journal_title：Infection and immunity

authors： Oaks EV,Hale TL,Formal SB

更新日期：1986-07-01 00:00:00

abstract：:Enterohemorrhagic Escherichia coli (EHEC) is a noninvasive food-borne pathogen that colonizes the distal ileum and colon. Proteins encoded in the EHEC locus of enterocyte effacement (LEE) pathogenicity island are known to contribute to this pathogen's adherence to epithelial cells and intestinal colonization. The role...

journal_title：Infection and immunity

authors： Ho TD,Davis BM,Ritchie JM,Waldor MK

更新日期：2008-05-01 00:00:00

abstract：:Pneumolysin (PLY), an important virulence factor of Streptococcus pneumoniae, is known to exert various effects on the host immune cells, including cytokine induction, in addition to its known cytolytic activity as a member of the thiol-activated cytolysins. It is of interest to determine whether cytolytic activity is...

journal_title：Infection and immunity

authors： Baba H,Kawamura I,Kohda C,Nomura T,Ito Y,Kimoto T,Watanabe I,Ichiyama S,Mitsuyama M

更新日期：2002-01-01 00:00:00

abstract：:Antigen-presenting cells (APCs) are key players in the induction and regulation of immune responses. In Plasmodium falciparum malaria, determination of which cells and pathways are activated in the network of APCs remains elusive. We therefore investigated the effects of a controlled human malaria infection in healthy...

journal_title：Infection and immunity

authors： Teirlinck AC,Roestenberg M,Bijker EM,Hoffman SL,Sauerwein RW,Scholzen A

更新日期：2015-09-01 00:00:00

abstract：:The effects of passive administration of neutralizing monoclonal antibodies (MAB) to respiratory syncytial virus glycoproteins (GP90 and VP70) was evaluated in cotton rats challenged with respiratory syncytial virus. Animals injected with MAB to VP70 had lower mean viral titers in lung tissues than did controls (log10...

journal_title：Infection and immunity

authors： Walsh EE,Schlesinger JJ,Brandriss MW

更新日期：1984-02-01 00:00:00

abstract：:The humoral and cell-mediated immune responses of murine lymphocytes exposed to lead in vivo and in vitro were investigated. In vivo Pb was administered via the drinking water (0 to 10 mM) for 1 to 10 weeks. In vivo exposure of the mice to Pb did not alter significantly their plaque-forming cell response to sheep eryt...

journal_title：Infection and immunity

authors： Lawrence DA

更新日期：1981-01-01 00:00:00

abstract：:G protein-coupled receptor kinase 5 (GRK5) is a serine/threonine kinase previously shown to mediate polymicrobial sepsis-induced inflammation. The goal of the present study was to examine the role of GRK5 in monomicrobial pulmonary infection by using an intratracheal Escherichia coli infection model of pneumonia. We u...

journal_title：Infection and immunity

authors： Packiriswamy N,Steury M,McCabe IC,Fitzgerald SD,Parameswaran N

更新日期：2016-04-22 00:00:00

abstract：:Although protective immunity in C57BL/6 mice induced by a single dose of the radiation-attenuated schistosome vaccine is believed to be mediated by Th1-type immune responses, we here report that in BALB/c mice protection can also depend upon signaling via the interleukin-4 (IL-4) receptor which conventionally governs ...

journal_title：Infection and immunity

authors： Mountford AP,Hogg KG,Coulson PS,Brombacher F

更新日期：2001-01-01 00:00:00

abstract：:Escherichia coli strains produce at least two heat-stable enterotoxins, STa and STb. STa is well known to be important in the pathogenesis of human diarrheal disease; the role of STb has not been defined. Fifty-two E. coli strains recovered from human diarrheal illness in northeast Brazil or Bangladesh were examined i...

journal_title：Infection and immunity

authors： Weikel CS,Tiemens KM,Moseley SL,Huq IM,Guerrant RL

更新日期：1986-04-01 00:00:00

abstract：:Antibodies directed against Pfs25, a protein present on the surface of zygotes and ookinetes of Plasmodium falciparum, completely block pathogen transmission. We evaluated the immunomodulatory effect of CpG oligodeoxynucleotides (ODN) on the immunogenicity of recombinant Pfs25 (rPfs25) formulated in alum (Al). Immuniz...

journal_title：Infection and immunity

authors： Coban C,Ishii KJ,Stowers AW,Keister DB,Klinman DM,Kumar N

更新日期：2004-01-01 00:00:00

abstract：:Strain differences have been postulated to explain the observation that group B Streptococcus type III (GBS III) late-onset disease occurs in only a fraction of colonized infants. To determine the distribution of type-specific polysaccharide antigen (Ag) in GBS III, Ag was measured by rocket immunoelectrophoresis in b...

journal_title：Infection and immunity

authors： Klegerman ME,Boyer KM,Papierniak CK,Levine L,Gotoff SP

更新日期：1984-04-01 00:00:00

abstract：:A model of invasive Haemophilus influenzae type b disease in rats was used to compare the net in vivo and in vitro multiplication rates of this bacterium. In both the blood of rats and in vitro cultures (fresh rat blood or enriched broth) there was an exponential increase in the number of CFU per milliliter with calcu...

journal_title：Infection and immunity

authors： Rubin LG

更新日期：1986-06-01 00:00:00

abstract：:There is an emerging paradigm shift from coronary heart disease having a purely hereditary and nutritional causation to possibly having an infectious etiology. Recent epidemiological studies have shown a correlation between periodontal disease and coronary heart disease. However, to date, there is minimal information ...

journal_title：Infection and immunity

authors： Dorn BR,Dunn WA Jr,Progulske-Fox A

更新日期：1999-11-01 00:00:00

abstract：:Our knowledge of pathogenesis has benefited from a better understanding of the roles of specific virulence factors in disease. To determine the role of the virulence factor ZapA, a 54-kDa metalloproteinase of Proteus mirabilis, in prostatitis, rats were infected with either wild-type (WT) P. mirabilis or its isogenic ...

journal_title：Infection and immunity

authors： Phan V,Belas R,Gilmore BF,Ceri H

更新日期：2008-11-01 00:00:00

abstract：:Three types of caseinolytic proteases (Pase-A, Pase-B, and Pase-C) were isolated and purified from culture supernatants of Porphyromonas gingivalis 381 by the combined procedures of acetone precipitation, gel filtration, solubilization with octylthioglucoside followed by affinity chromatography on arginine-Sepharose 4...

journal_title：Infection and immunity

authors： Hinode D,Hayashi H,Nakamura R

更新日期：1991-09-01 00:00:00

abstract：:Repeated immunizations of CF1 mice with irradiated noninfectious Trypanosoma cruzi trypomastigotes resulted in partial protection against infection with live parasites. It also induced a limited number of antibody species that were reactive in Western blots with trypomastigote but not with epimastigote or amastigote p...

journal_title：Infection and immunity

authors： Zweerink HJ,Weston HD,Andersen OF,Garber SS,Hayes EC

更新日期：1984-12-01 00:00:00

abstract：:Cholera toxin (CT) is a potent adjuvant for mucosal vaccination; however, its mechanism of action has not been clarified completely. It is well established that peripheral monocytes differentiate into dendritic cells (DCs) both in vitro and in vivo and that monocytes are the in vivo precursors of mucosal CD103(-) proi...

journal_title：Infection and immunity

authors： Veglia F,Sciaraffia E,Riccomi A,Pinto D,Negri DR,De Magistris MT,Vendetti S

更新日期：2011-03-01 00:00:00

abstract：:Meningococcal sodC encodes periplasmic copper- and zinc-cofactored superoxide dismutase (Cu,Zn SOD) which catalyzes the conversion of the superoxide radical anion to hydrogen peroxide, preventing a sequence of reactions leading to production of toxic hydroxyl free radicals. From its periplasmic location, Cu,Zn SOD was...

journal_title：Infection and immunity

authors： Wilks KE,Dunn KL,Farrant JL,Reddin KM,Gorringe AR,Langford PR,Kroll JS

更新日期：1998-01-01 00:00:00

abstract：:Genetically based natural resistance to brucellosis in cattle provides for novel strategies to control zoonotic diseases. Bovine NRAMP1, the homologue of a murine gene (Bcg), has been identified as a major candidate for controlling the in vivo resistant phenotype. We developed an in vitro model for expression of resis...

journal_title：Infection and immunity

authors： Barthel R,Feng J,Piedrahita JA,McMurray DN,Templeton JW,Adams LG

更新日期：2001-05-01 00:00:00

abstract：:Tuberculosis (TB) is a leading cause worldwide of human mortality attributable to a single infectious agent. Recent studies targeting candidate genes and "case-control" association have revealed numerous polymorphisms implicated in host susceptibility to TB. Here, we review current progress in the understanding of cau...

journal_title：Infection and immunity

authors： Azad AK,Sadee W,Schlesinger LS

更新日期：2012-10-01 00:00:00

abstract：:Human gamma delta T cells are known to respond at high frequencies to pathogenic mycobacteria. Here we show that opportunistic strains of mycobacteria share with pathogenic mycobacteria the ability to trigger at high frequencies human V gamma 9V delta 2 T-cell-receptor-positive T lymphocytes. Stimulating ligands were ...

journal_title：Infection and immunity

authors： Häcker G,Kromer S,Heeg K,Ivanyi J,Wagner H,Pfeffer K

更新日期：1992-07-01 00:00:00