Type-specific capsular antigen is associated with virulence in late-onset group B Streptococcal type III disease.

abstract：:A recombinant 23-kDa protein (rBPI23) derived from human bactericidal/permeability-increasing protein (BPI) possesses potent endotoxin-neutralizing abilities in vitro and in vivo. Binding of rBPI23 to those endotoxins (lipopolysaccharides [LPSs]) encountered clinically would be a prerequisite for efficacy in decreasin...

journal_title：Infection and immunity

authors： Appelmelk BJ,An YQ,Thijs BG,MacLaren DM,de Graaff J

更新日期：1994-08-01 00:00:00

abstract：:The P2 porin protein is the major outer membrane protein of nontypeable Haemophilus influenzae and is a potential target of a protective immune response. Nine monoclonal antibodies (MAbs) to P2 were developed by immunizing mice with nontypeable H. influenzae whole organisms. Each MAb reacted exclusively with the homol...

journal_title：Infection and immunity

authors： Haase EM,Yi K,Morse GD,Murphy TF

更新日期：1994-09-01 00:00:00

abstract：:Tuberculosis continues to ravage humanity, killing 2 million people yearly. Most cases occur in areas of the world to which the disease is endemic, where almost everyone is vaccinated early in life with Mycobacterium bovis BCG, the currently available vaccine against tuberculosis. Thus, while more-potent vaccines are ...

journal_title：Infection and immunity

authors： Horwitz MA,Harth G,Dillon BJ,Maslesa-Galic S

更新日期：2005-08-01 00:00:00

abstract：:Infection by Shigella flexneri is characterized by infiltration of neutrophils in the intestinal mucosa and by a strong inflammatory reaction. Although neutrophils are constitutively programmed to die by apoptosis, we show that isolated human neutrophils undergo necrosis 2 h after infection with virulent S. flexneri s...

journal_title：Infection and immunity

authors： François M,Le Cabec V,Dupont MA,Sansonetti PJ,Maridonneau-Parini I

更新日期：2000-03-01 00:00:00

abstract：:Peptidoglycan (PG) turnover in exponentially growing Neisseria gonorrhoeae RD5 type 4 was accompanied by release of soluble PG fragments into the medium. Turnover of the D-[14C]glucosamine-labeled glycan moiety and of the meso-[3H]diaminopimelic acid (DAP)-labeled peptide region occurred at similar rates (ca. 35% per ...

journal_title：Infection and immunity

authors： Rosenthal RS

更新日期：1979-06-01 00:00:00

abstract：:Haemophilus influenzae is a commensal and opportunistic pathogen of the human airways. A number of surface molecules contribute to colonization of the airways by H. influenzae, such as adhesins, including structures found in the lipooligosaccharide (LOS). A human bronchiolar xenograft model was employed to investigate...

journal_title：Infection and immunity

authors： Swords WE,Chance DL,Cohn LA,Shao J,Apicella MA,Smith AL

更新日期：2002-08-01 00:00:00

abstract：:Allergic-type immune responses, particularly immunoglobulin E (IgE), correlate with protective immunity in human schistosomiasis. To better understand the mechanisms of parasite elimination we examined the immune correlates of protection in baboons (Papio cynocephalus anubis), which are natural hosts for Schistosoma m...

journal_title：Infection and immunity

authors： Nyindo M,Kariuki TM,Mola PW,Farah IO,Elson L,Blanton RE,King CL

更新日期：1999-02-01 00:00:00

abstract：:Cytokines such as tumor necrosis factor alpha (TNF-alpha), granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin 8 (IL-8), IL-6, IL-1 alpha, and IL-1 beta produced during the immune and inflammatory responses to bacterial stimuli have been reported to interact with polymorphonuclear neutrophil (PMN) a...

journal_title：Infection and immunity

authors： Elbim C,Bailly S,Chollet-Martin S,Hakim J,Gougerot-Pocidalo MA

更新日期：1994-06-01 00:00:00

abstract：:Phagosome acidification is an important component of the microbicidal response by infected eukaryotic cells. Thus, intracellular pathogens that reside within phagosomes must either block phagosome acidification or be able to survive at low pH. In this work, we studied the effect of phagosomal acidification on the surv...

journal_title：Infection and immunity

authors： Steele-Mortimer O,St-Louis M,Olivier M,Finlay BB

更新日期：2000-09-01 00:00:00

abstract：:Oropharyngeal candidiasis (OPC [thrush]) is an opportunistic infection caused by the commensal fungus Candida albicans. OPC is common in individuals with HIV/AIDS, infants, patients on chemotherapy, and individuals with congenital immune defects. Immunity to OPC is strongly dependent on the interleukin-23 (IL-23)/IL-1...

journal_title：Infection and immunity

authors： Bishu S,Hernández-Santos N,Simpson-Abelson MR,Huppler AR,Conti HR,Ghilardi N,Mamo AJ,Gaffen SL

更新日期：2014-03-01 00:00:00

abstract：:Salmonella typhimurium SH5014 porins induce the release of tumor necrosis factor alpha (TNF-alpha), interleukin 1 alpha (IL-1 alpha), and IL-6 by human monocytes and of gamma interferon (IFN-gamma) and IL-4 by human lymphocytes. Porins at 1 microgram/ml induce the greatest release of TNF-alpha, IL-1 alpha, and IL-6 by...

journal_title：Infection and immunity

authors： Galdiero F,de L'ero GC,Benedetto N,Galdiero M,Tufano MA

更新日期：1993-01-01 00:00:00

abstract：:The ability of hemagglutinating and poorly hemagglutinating strains of the gastroduodenal pathogen Helicobacter pylori to bind 125I-radiolabelled laminin was quantitated in a liquid phase assay. Although all strains bound laminin, some hemagglutinating strains were good binders of laminin (maximum of 31% binding), whe...

journal_title：Infection and immunity

authors： Valkonen KH,Wadström T,Moran AP

更新日期：1994-09-01 00:00:00

abstract：:Changes in cell viability and in factors affecting metabolic integrity were examined after exposure of Escherichia coli LP1092 to human serum. Antibody-dependent classical pathway activity accounted for the rapid killing of strain LP1092 by complement. Removal of serum lysozyme by bentonite absorption or by neutraliza...

journal_title：Infection and immunity

authors： Taylor PW,Kroll HP

更新日期：1983-01-01 00:00:00

abstract：:The cytotoxic effects of bacterial lipopolysaccharides (LPS) on mouse leukocytes have been examined in vivo and in vitro. Intraperitoneal injection of LPS into C57BL/6 mice greatly reduced the recovery of mononuclear cells; LPS was cytotoxic for macrophages, but had a mitogenic effect on lymphocytes. Similar effects o...

journal_title：Infection and immunity

authors： Peavy DL,Baughn RE,Musher DM

更新日期：1978-07-01 00:00:00

abstract：:Hybridomas secreting monoclonal antibodies against an apparent strain-specific cell surface antigen of Neisseria gonorrhoeae were produced. Spleen cells from BALB/c mice immunized with whole gonococci were fused with mouse myeloma cell line Sp2/0, and hybrid cells were selected in culture. One hybridoma that secreted ...

journal_title：Infection and immunity

authors： Nachamkin I,Cannon JG,Mittler RS

更新日期：1981-05-01 00:00:00

abstract：:Results from studies using mice deficient in specific complement factors and clinical data on patients with an inherited deficiency of the classical complement pathway component C2 suggest that the classical pathway is vital for immunity to Streptococcus pneumoniae. However, the consequences of defects in classical pa...

journal_title：Infection and immunity

authors： Yuste J,Sen A,Truedsson L,Jönsson G,Tay LS,Hyams C,Baxendale HE,Goldblatt F,Botto M,Brown JS

更新日期：2008-08-01 00:00:00

abstract：:We have focused on regions of staphylococcal enterotoxin C1 (SEC1) causing immunomodulation. N-terminal deletion mutants lacking residues 6 through 13 induced T-cell proliferation similar to that induced by native toxin. However, mutants with residues deleted between positions 19 and 33, although nonmitogenic themselv...

journal_title：Infection and immunity

authors： Hoffmann ML,Jablonski LM,Crum KK,Hackett SP,Chi YI,Stauffacher CV,Stevens DL,Bohach GA

更新日期：1994-08-01 00:00:00

abstract：:Streptococcus mutans Ingbritt was grown anaerobically in a chemostat, at a rate (mean generation time, 13 h) similar to that in dental plaque, in a complex medium with excess glucose and at pH values of 6.5, 6.0, and 5.5. The yield of cells was constant at pH 6.5 and 6.0 (2.00 mg/ml) but fell to 1.25 at pH 5.5; Y(gluc...

journal_title：Infection and immunity

authors： Hamilton IR,Ellwood DC

更新日期：1978-02-01 00:00:00

abstract：:Peptic ulcer disease (PUD) occurs after a long-term Helicobacter pylori infection. However, the disease can develop earlier, and rare cases have been observed in children, suggesting that these H. pylori strains may be more virulent. We used suppressive subtractive hybridization for comparative genomics between H. pyl...

journal_title：Infection and immunity

authors： Oleastro M,Monteiro L,Lehours P,Mégraud F,Ménard A

更新日期：2006-07-01 00:00:00

abstract：:Many of the virulence factors associated with fulminant group A streptococci (GAS) infection are expressed under in vitro exponential growth conditions. However, the survival of GAS in tissue and intracellularly, as well as colonization of asymptomatic carriers, has been reported for GAS. The bacteria associated with ...

journal_title：Infection and immunity

authors： Leonard BA,Woischnik M,Podbielski A

更新日期：1998-08-01 00:00:00

abstract：:The intravenous administration of hydrogen peroxide has been reported to benefit patients with pneumonia and to reduce Plasmodium parasitemia in experimentally infected mice. We assessed the antibacterial activity of intravenously infused hydrogen peroxide against hydrogen peroxide-susceptible Escherichia coli (MBC of...

journal_title：Infection and immunity

authors： Shenep JL,Stokes DC,Hughes WT

更新日期：1985-06-01 00:00:00

abstract：:The energy-dependent adsorption of radioiodinated rickettsiae to sheep erythrocytes was demonstrated. The iodination procedure, however, decreased the hemolytic activity of the rickettsiae. No desorption of rickettsiae from isolated rickettsia-erythrocyte complexes (prevented from lysing by NaF) could be measured. On ...

journal_title：Infection and immunity

authors： Winkler HH

更新日期：1977-09-01 00:00:00

abstract：:The complement system plays an important role in the host defense against infection, and the formation of the terminal complement complex on the bacterial surface has been shown to be particularly important in killing of gram-negative bacteria. The gram-negative periodontal pathogen Porphyromonas gingivalis is resista...

journal_title：Infection and immunity

authors： Slaney JM,Gallagher A,Aduse-Opoku J,Pell K,Curtis MA

更新日期：2006-09-01 00:00:00

abstract：:The 9.5-kilobase plasmid of Yersinia pestis determines plasminogen activator, coagulase, pesticin, and pesticin immunity activities. We have mapped and cloned the loci encoding these activities and demonstrated that both plasminogen activator and coagulase were determined by the same gene, designated pla. The primary ...

journal_title：Infection and immunity

authors： Sodeinde OA,Goguen JD

更新日期：1988-10-01 00:00:00

abstract：:Although periodontal treatment by scaling and root planing (SCRP) is known to induce bacteremia, the effect of this procedure on the host immune response is not known. We have determined pre- and post-SCRP immunoglobulin G antibody titers to antigens of Actinobacillus actinomycetemcomitans in the sera of 22 patients w...

journal_title：Infection and immunity

authors： Sjöström K,Ou J,Whitney C,Johnson B,Darveau R,Engel D,Page RC

更新日期：1994-01-01 00:00:00

abstract：:Chlamydia pneumoniae is a causative agent for many respiratory infections and has been associated with cardiovascular diseases in humans. The pathogenicity of C. pneumoniae is thought to depend on its ability to cause persistent infection and to evade host defense. Genome sequence analysis indicates that C. pneumoniae...

journal_title：Infection and immunity

authors： Fan P,Dong F,Huang Y,Zhong G

更新日期：2002-01-01 00:00:00

abstract：:L-phase variants and small colony (G-phase) variants derived from penicillinase-producing Staphylococcus aureus strains were tested for penicillinase (beta lactamase) production. A refined variation of the modified Gots test for penicillinase was used to demonstrate penicillinase synthesis. Penicillinase synthesis was...

journal_title：Infection and immunity

authors： Simon HJ,Yin EJ

更新日期：1970-11-01 00:00:00

abstract：:A large-scale DNA vaccination trial was performed with sheep to investigate whether an antigen targeted by CTLA-4 enhanced and accelerated the humoral immune response. Vaccination with genetically detoxified phospholipase D (DeltaPLD) has been shown to be effective, at least partially, against Corynebacterium pseudotu...

journal_title：Infection and immunity

authors： Chaplin PJ,De Rose R,Boyle JS,McWaters P,Kelly J,Tennent JM,Lew AM,Scheerlinck JP

更新日期：1999-12-01 00:00:00

abstract：:The Legionella pneumophila major secretory protein (Msp) is a Zn2+ metalloprotease whose function in pathogenesis is unknown. The structural gene for the Msp protease, mspA, was isolated from an L. pneumophila genomic library. In Escherichia coli which contain plasmids with the mspA gene, Msp protein and activity are ...

journal_title：Infection and immunity

authors： Szeto L,Shuman HA

更新日期：1990-08-01 00:00:00

abstract：:We have isolated plasma cell hybridomas which secrete monoclonal antibodies directed against Haemophilus ducreyi. Two of these monoclonal antibodies recognize all strains of H. ducreyi tested to date and are capable of detecting the presence of H. ducreyi in skin lesions produced by this pathogen in experimental anima...

journal_title：Infection and immunity

authors： Hansen EJ,Loftus TA

更新日期：1984-04-01 00:00:00