Release of cytokines induced by Salmonella typhimurium porins.

abstract：:Salmonella infections continue to cause substantial morbidity and mortality throughout the world. However, recent discoveries and new paradigms promise to lead to novel strategies to diagnose, treat, and prevent Salmonella infections. This review provides an update of the Salmonella field based on oral presentations g...

journal_title：Infection and immunity

authors： Andrews-Polymenis HL,Bäumler AJ,McCormick BA,Fang FC

更新日期：2010-06-01 00:00:00

abstract：:Poly-N-acetyl-glucosamine (PNAG) is a staphylococcal surface polysaccharide influencing biofilm formation that is also under investigation for its vaccine potential. Antibodies that bind to PNAG with either low (<15%) or high (>90%) levels of acetate are superior at opsonic and protective activity compared with antibo...

journal_title：Infection and immunity

authors： Cerca N,Jefferson KK,Maira-Litrán T,Pier DB,Kelly-Quintos C,Goldmann DA,Azeredo J,Pier GB

更新日期：2007-07-01 00:00:00

abstract：:The recombinant protective antigen (rPA) of Bacillus anthracis is a promising anthrax vaccine. We compared serum immunoglobulin G levels and toxin-neutralizing antibody titers in rabbits following delivery of various doses of vaccine by microneedle-based intradermal (i.d.) delivery or intramuscular (i.m.) injection us...

journal_title：Infection and immunity

authors： Mikszta JA,Dekker JP 3rd,Harvey NG,Dean CH,Brittingham JM,Huang J,Sullivan VJ,Dyas B,Roy CJ,Ulrich RG

更新日期：2006-12-01 00:00:00

abstract：:By subcutaneous treatment with an aqueous solution of 6-O-stearoyl-N-acetylmuramyl-L-alanyl-D-isoglutamine [6-O-CH3-(CH2)16-CO-MurNAc-L-Ala-D-isoGln] [referred to here as L18-MDP(Ala)], an augmentation of the resistance of mice to Escherichia coli, Pseudomonas aeruginosa. Staphylococcus aureus, and Candida albicans in...

journal_title：Infection and immunity

authors： Osada Y,Mitsuyama M,Une T,Matsumoto K,Otani T,Satoh M,Ogawa H,Nomoto K

更新日期：1982-07-01 00:00:00

abstract：:The protein P2 comprises a large proportion of the outer membrane of nontypable Haemophilus influenzae and functions as a porin. In view of the importance of the protein as a surface antigen, the present study was designed to purify and analyze P2 with particular emphasis on detection of antigenic determinants express...

journal_title：Infection and immunity

authors： Murphy TF,Bartos LC

更新日期：1988-05-01 00:00:00

abstract：:The immunostimulation provided by the mycobacterial cell wall has been exploited for many decades, e.g., in Freund's complete adjuvant. Recently, the underlying mechanism behind this adjuvant activity, including Toll receptor signaling, has begun to be unraveled, confirming the potential of mycobacterial constituents ...

journal_title：Infection and immunity

authors： Rosenkrands I,Agger EM,Olsen AW,Korsholm KS,Andersen CS,Jensen KT,Andersen P

更新日期：2005-09-01 00:00:00

abstract：:Depletion of dendritic cells (DC) in secondary lymphoid organs is a hallmark of sepsis-induced immune dysfunction. In this setting, we investigated if Toll-like receptor (TLR)-dependent signaling might modulate the maturation process and the survival of DC. Using a model of sublethal polymicrobial sepsis induced by ce...

journal_title：Infection and immunity

authors： Pène F,Courtine E,Ouaaz F,Zuber B,Sauneuf B,Sirgo G,Rousseau C,Toubiana J,Balloy V,Chignard M,Mira JP,Chiche JD

更新日期：2009-12-01 00:00:00

abstract：:The aroC gene of the facultative intracellular pathogen Brucella suis was cloned and sequenced. The cloned aroC gene complements Escherichia coli and Salmonella enterica serovar Typhimurium aroC mutants. A B. suis aroC mutant was found to be unable to grow in a defined medium without aromatic compounds. The mutant was...

journal_title：Infection and immunity

authors： Foulongne V,Walravens K,Bourg G,Boschiroli ML,Godfroid J,Ramuz M,O'Callaghan D

更新日期：2001-01-01 00:00:00

abstract：:The virulence and fitness in vivo of the major human pathogen Staphylococcus aureus are associated with a cell-to-cell signaling mechanism known as quorum sensing (QS). QS coordinates the production of virulence factors via the production and sensing of autoinducing peptide (AIP) signal molecules by the agr locus. Her...

journal_title：Infection and immunity

authors： Pollitt EJ,West SA,Crusz SA,Burton-Chellew MN,Diggle SP

更新日期：2014-03-01 00:00:00

abstract：:Cryptococcus neoformans is surrounded by a capsular polysaccharide. There are at least four known serotypes of the polysaccharide. The objective of this study was to produce monoclonal antibodies (MAbs) that could be used to study the distribution of epitopes among the serotypes of C. neoformans. BALB/c mice were immu...

journal_title：Infection and immunity

authors： Eckert TF,Kozel TR

更新日期：1987-08-01 00:00:00

abstract：:Immune complexes have been partially purified from the serum of Plasmodium berghei-infected mice by ultracentrifugation on 10 to 40% linear sucrose gradients, by precipitation with polyethylene glycol, and by gel filtration through Sephacryl S-300. The complexes contain gamma 1, gamma 2a, gamma 2b, and gamma 3 subclas...

journal_title：Infection and immunity

authors： Shear HL

更新日期：1984-04-01 00:00:00

abstract：:The antigenic cross-reactivity between Treponema pallidum and several pathogenic members of the family Spirochaetaceae was examined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blotting techniques. Blots of T. pallidum antigens were incubated with antiserum from rabbits infected or immunize...

journal_title：Infection and immunity

authors： Baker-Zander SA,Lukehart SA

更新日期：1984-10-01 00:00:00

abstract：:Bacteroides spp. may contribute to the chronicity of mixed infections by affecting the normal functions of polymorphonuclear leukocytes (PMN). This study evaluated the physiologic and biochemical responses of human peripheral blood PMN to a variety of strains of the oral periodontal pathogen Porphyromonas (Bacteroides...

journal_title：Infection and immunity

authors： Novak MJ,Cohen HJ

更新日期：1991-09-01 00:00:00

abstract：:Counts of acid-fast bacilli were made on homogenates of whole liver, whole spleen, and two femurs of CBA mice killed at various time intervals after intravenous infection with Mycobacterium lepraemurium. The growth curves so obtained showed that the bacillus multiplied faster in bone marrow than in liver or spleen. No...

journal_title：Infection and immunity

authors： Brown IN,Krenzien HN

更新日期：1976-02-01 00:00:00

abstract：:EspG is a conserved protein encoded by the locus of enterocyte effacement (LEE) of attaching and effacing (A/E) pathogens, including enteropathogenic and enterohemorrhagic Escherichia coli and Citrobacter rodentium. EspG is delivered into infected host cells by a type III secretion system. The role of EspG in virulenc...

journal_title：Infection and immunity

authors： Hardwidge PR,Deng W,Vallance BA,Rodriguez-Escudero I,Cid VJ,Molina M,Finlay BB

更新日期：2005-05-01 00:00:00

abstract：:Mycoplasma hyorhinis organisms were fractionated into lipid, carbohydrate, and protein fractions by chemical and physiochemical procedures. When all fractions were tested for complement fixation and inhibition of growth inhibition activity, only the protein fractions possessed activity. Thus, it appears that the major...

journal_title：Infection and immunity

authors： Barden JA,Prescott B

更新日期：1973-06-01 00:00:00

abstract：:The purpose of this study was to determine the effects of human monocytes, macrophages, and polymorphonuclear neutrophils (PMN) on the fungal pathogen Blastomyces dermatitidis in vitro. Peripheral blood monocyte monolayers significantly inhibited the replication of a virulent strain (V) and an avirulent strain (AV) of...

journal_title：Infection and immunity

authors： Brummer E,Stevens DA

更新日期：1982-04-01 00:00:00

abstract：:The influence of the growth medium on the ability of strains of Streptococcus mutans, Actinomyces viscosus and A. naeslundii to attach to saliva-treated hydroxyapatite (S-HA) surfaces was studied. Preliminary experiments indicated that cells of each species harvested in lag, log, and early stationary phases of growth ...

journal_title：Infection and immunity

authors： Peros WJ,Gibbons RJ

更新日期：1981-04-01 00:00:00

abstract：:CC chemokine receptor 4 (CCR4) and its two ligands, CCL17 and CCL22, are critically involved in different immune processes. In models of lipopolysaccharide-induced shock, CCR4-deficient (CCR4(-/-)) mice showed improved survival rates associated with attenuated proinflammatory cytokine release. Using CCR4(-/-) mice wit...

journal_title：Infection and immunity

authors： Traeger T,Kessler W,Assfalg V,Cziupka K,Koerner P,Dassow C,Breitbach K,Mikulcak M,Steinmetz I,Pfeffer K,Heidecke CD,Maier S

更新日期：2008-11-01 00:00:00

abstract：:Stimulated polymorphonuclear leukocytes have been shown by this laboratory to release a reactive-oxygen species (ROS) which is detectable in the supernatant and is capable of oxidizing reduced glutathione and reacting with methionine (Sagone et al., Blood 63:96-104, 1984). This ROS is dependent on H2O2 and heme for it...

journal_title：Infection and immunity

authors： Rao MK,Sagone AL Jr

更新日期：1984-03-01 00:00:00

abstract：:Human granulocytic ehrlichiosis (HGE) is an emerging febrile systemic disease caused by the HGE agent, an obligatory intracellular bacterium of granulocytes. The pathogenicity- and immunity-related mechanisms of HGE are unknown. In this study, several cytokines generated in human peripheral blood leukocytes (PBLs) inc...

journal_title：Infection and immunity

authors： Kim HY,Rikihisa Y

更新日期：2000-06-01 00:00:00

abstract：:We have cloned and sequenced the d15 gene from two strains of Haemophilus influenzae type b (Hib) and two strains of nontypeable H. influenzae (NTHI). The nucleotide and deduced protein sequences of d15 are highly conserved, with only a small variable region identified near the carboxyl terminus of the protein. Analys...

journal_title：Infection and immunity

authors： Loosmore SM,Yang YP,Coleman DC,Shortreed JM,England DM,Klein MH

更新日期：1997-09-01 00:00:00

abstract：:The biological activity of C-ASWS, an alkali-soluble, water-soluble cell wall antigen isolated from mycelial-phase cells of Coccidioides immitis, was compared with that of a commercial coccidioidin (CDN; Cutter Laboratories); CDN-TS, a toluene-induced lysate of mycelial-phase cells; and spherulin, a spherule-derived e...

journal_title：Infection and immunity

authors： Cox RA,Brummer E,Lecara G

更新日期：1977-03-01 00:00:00

abstract：:Whooping cough results from infection of the respiratory tract with Bordetella pertussis, and the secreted adenylate cyclase toxin (ACT) is essential for the bacterium to establish infection. Despite extensive study of the mechanism of ACT cytotoxicity and its effects over a range of concentrations in vitro, ACT has n...

journal_title：Infection and immunity

authors： Eby JC,Gray MC,Warfel JM,Paddock CD,Jones TF,Day SR,Bowden J,Poulter MD,Donato GM,Merkel TJ,Hewlett EL

更新日期：2013-05-01 00:00:00

abstract：:Targeting an antigen to Fc receptors (FcR) can enhance the immune response to the antigen in the absence of adjuvant. Furthermore, we recently demonstrated that intranasal immunization with an FcγR-targeted antigen enhances protection against a category A intracellular mucosal pathogen, Francisella tularensis. To dete...

journal_title：Infection and immunity

authors： Bitsaktsis C,Iglesias BV,Li Y,Colino J,Snapper CM,Hollingshead SK,Pham G,Gosselin DR,Gosselin EJ

更新日期：2012-03-01 00:00:00

abstract：:Helicobacter pylori is an important human pathogen that causes gastritis and is strongly associated with gastric ulcers, gastric adenocarcinomas, and mucosa-associated lymphoid tissue lymphomas. In response to H. pylori, interleukin-8 (IL-8) is secreted from host cells to attract components of the innate and adaptive ...

journal_title：Infection and immunity

authors： Torok AM,Bouton AH,Goldberg JB

更新日期：2005-03-01 00:00:00

abstract：:A recent study found that group A Streptococcus (GAS) expresses a cell surface protein with similarity to human collagen (S. Lukomski, K. Nakashima, I. Abdi, V. J. Cipriano, R. M. Ireland, S. R. Reid, G. G. Adams, and J. M. Musser, Infect. Immun. 68:6542-6553, 2000). This streptococcal collagen-like protein (Scl) cont...

journal_title：Infection and immunity

authors： Lukomski S,Nakashima K,Abdi I,Cipriano VJ,Shelvin BJ,Graviss EA,Musser JM

更新日期：2001-03-01 00:00:00

abstract：:Four pneumococcal genes (phtA, phtB, phtD, and phtE) encoding a novel family of homologous proteins (32 to 87% identity) were identified from the Streptococcus pneumoniae genomic sequence. These open reading frames were selected as potential vaccine candidates based upon their possession of hydrophobic leader sequence...

journal_title：Infection and immunity

authors： Adamou JE,Heinrichs JH,Erwin AL,Walsh W,Gayle T,Dormitzer M,Dagan R,Brewah YA,Barren P,Lathigra R,Langermann S,Koenig S,Johnson S

更新日期：2001-02-01 00:00:00

abstract：:A fibronectin (Fn)-binding adhesin of Staphylococcus aureus contains three tandem 37- or 38-amino-acid motifs (D1, D2, and D3), which function to bind Fn. Plasma from patients with S. aureus infections contain antibodies that preferentially recognize ligand induced binding sites in the D motifs and do not inhibit Fn b...

journal_title：Infection and immunity

authors： Huesca M,Sun Q,Peralta R,Shivji GM,Sauder DN,McGavin MJ

更新日期：2000-03-01 00:00:00

abstract：:Pathogenicities of 10 temperature-sensitive mutants of Venezuelan encephalitis virus were studied using the hamster model of human virulence. The parental strain and nine of the temperature-sensitive mutants produced lethal infections in hamsters. Strain ts 126 showed reduced hamster virulence. Deaths with the lethal ...

journal_title：Infection and immunity

authors： Krieger JN,Scherer WF,Wiebe ME,Pancake BA,Harsanyi ZP

更新日期：1979-09-01 00:00:00