Outer membrane protein D15 is conserved among Haemophilus influenzae species and may represent a universal protective antigen against invasive disease.

abstract：:Immunoprecipitation of radiolabeled antigens with bovine antisera indicated that many Babesia bigemina and Babesia bovis merozoite proteins contain isolate-common epitopes, while at least 16 B. bigemina and 8 B. bovis proteins contain species-cross-reactive epitopes. One immunogenic, isolate-common, and species-specif...

journal_title：Infection and immunity

authors： McElwain TF,Palmer GH,Goff WL,McGuire TC

更新日期：1988-06-01 00:00:00

abstract：:The role of the alternative sigma factor sigma(B) in Staphylococcus epidermidis was investigated by the construction, complementation, and characterization of a sigB deletion mutant. Electrophoretic analyses confirmed a profound influence of sigma(B) on the expression of exoproteins and cytoplasmic proteins. Detailed ...

journal_title：Infection and immunity

authors： Kies S,Otto M,Vuong C,Götz F

更新日期：2001-12-01 00:00:00

abstract：:Exoantigens of Plasmodium vivax-parasitized erythrocytes stimulated macrophages to secrete tumor necrosis factor, and antisera raised against the exoantigens inhibited this secretion. The antisera also inhibited the activity of Plasmodium falciparum and Plasmodium yoelii exoantigens, and conversely, antisera against t...

journal_title：Infection and immunity

authors： Bate CA,Taverne J,Karunaweera ND,Mendis KN,Kwiatkowski D,Playfair JH

更新日期：1992-03-01 00:00:00

abstract：:Preexisting antivector immunity can severely compromise the ability of Salmonella enterica serovar Typhimurium live vaccines to induce protective CD8 T-cell frequencies after type III secretion system-mediated heterologous protein translocation in orally immunized mice. To circumvent this problem, we injected CpG DNA ...

journal_title：Infection and immunity

authors： Berchtold C,Panthel K,Jellbauer S,Köhn B,Roider E,Partilla M,Heesemann J,Endres S,Bourquin C,Rüssmann H

更新日期：2009-12-01 00:00:00

abstract：:Utilization of heme-hemopexin as a source of heme by Haemophilus influenzae type b is dependent on expression by this bacterium of the 100-kDa HxuA protein, which is both present on the bacterial cell surface and released into the culture supernatant (L. D. Cope, R. Yogev, U. Muller-Eberhard, and E. J. Hansen, J. Bact...

journal_title：Infection and immunity

authors： Cope LD,Thomas SE,Hrkal Z,Hansen EJ

更新日期：1998-09-01 00:00:00

abstract：:As an intracellular protozoan parasite, Toxoplasma gondii is likely to exploit proteases for host cell invasion, acquisition of nutrients, avoidance of host protective responses, escape from the parasitophorous vacuole, differentiation, and other activities. T. gondii serine protease inhibitor 1 (TgPI1) is the most ab...

journal_title：Infection and immunity

authors： Pszenny V,Davis PH,Zhou XW,Hunter CA,Carruthers VB,Roos DS

更新日期：2012-03-01 00:00:00

abstract：:Candida-associated denture stomatitis (DS) is a persistent and chronic oral infection of the denture-bearing palatal mucosa. DS stems from the ability of the fungal opportunistic pathogen Candida albicans to adhere to denture material and invade palatal tissue. Although DS is the most prevalent form of oral candidiasi...

journal_title：Infection and immunity

authors： Sultan AS,Rizk AM,Vila T,Ji Y,Masri R,Jabra-Rizk MA

更新日期：2019-11-18 00:00:00

abstract：:There are no vaccines against boutonneuse fever and Rocky Mountain spotted fever. Previous studies have identified a Rickettsia rickettsii surface protein as a vaccine candidate and shown that an antigenically related protein is present in R. conorii, which causes boutonneuse fever. The gene encoding the R. rickettsii...

journal_title：Infection and immunity

authors： Vishwanath S,McDonald GA,Watkins NG

更新日期：1990-03-01 00:00:00

abstract：:Chromatographic analysis, coupled to mass spectrometry with a high-resolution mass spectrometer, of materials isolated from skin lesions of patients with lepromatous leprosy allows the recognition of characteristic mycobacterial products, mycolic acids. This finding indicates that the "noncultivable" bacteria responsi...

journal_title：Infection and immunity

authors： Etemadi AH,Convit J

更新日期：1974-07-01 00:00:00

abstract：:CD14, the leukocyte receptor for lipopolysaccharide (LPS), is important in the response of human polymorphonuclear leukocytes (PMNs) to infection with gram-negative bacteria. The level of CD14 on the PMN surface increases after exposure to some inflammatory stimuli such as N-formyl-methionyl-leucyl-phenylalanine (fMLP...

journal_title：Infection and immunity

authors： Rodeberg DA,Morris RE,Babcock GF

更新日期：1997-11-01 00:00:00

abstract：:The Th1/Th2 cytokines involved in human periodontitis remain unclear; therefore, we established a humanized mouse model to investigate this issue in Actinobacillus actinomycetemcomitans-mediated periodontal infection. Quantitative-PCR analysis clearly demonstrates a predominantly mixed Th1 and Th2 expression profile a...

journal_title：Infection and immunity

authors： Teng YT

更新日期：2002-09-01 00:00:00

abstract：:A total of 32 patients with Plasmodium falciparum malaria were studied. Of these, 23 had benign infections, and 9 had typical cerebral malaria. Cryoglobulins, circulating immune complexes detected by a C1q-binding assay, and hypocomplementemia were found in eight of nine patients with cerebral malaria. Raised levels o...

journal_title：Infection and immunity

authors： Adam C,Géniteau M,Gougerot-Pocidalo M,Verroust P,Lebras J,Gibert C,Morel-Maroger L

更新日期：1981-02-01 00:00:00

abstract：:The presence of soybean meal in the diet of gnotobiotic mice was shown to prevent the establishment of a clostridial strain in the gastrointestinal tract. Soybean meal did not inhibit the growth of Clostridium in vitro, suggesting that the host plays a role in the observed inhibition of bacterial growth. The inhibitor...

journal_title：Infection and immunity

authors： Lhuillery C,Demarne Y,Ducluzeau R,Clara A

更新日期：1982-05-01 00:00:00

abstract：:Toll-like receptors 2 and 4 (TLR2 and TLR4) have been found to transduce signals of peptidoglycan (PGN) and lipopolysaccharide (LPS), respectively, for NF-kappa B activation. However, little is known about the expression and regulation of the TLR2 gene in monocytes/macrophages in response to the two typical bacterial ...

journal_title：Infection and immunity

authors： Liu Y,Wang Y,Yamakuchi M,Isowaki S,Nagata E,Kanmura Y,Kitajima I,Maruyama I

更新日期：2001-05-01 00:00:00

abstract：:Inoculation of neonatal CD-1 mice by multiple routes with an amyocarditic temperature-sensitive (ts) mutant (ts 1) derived from a myocarditic parent variant of coxsackievirus B3 (CVB3(m)) resulted in approximately half of the neonates surviving to adolescence. Challenge of the ts 1 survivors with CVB3(m) did not induc...

journal_title：Infection and immunity

authors： Gauntt CJ,Paque RE,Trousdale MD,Gudvangen RJ,Barr DT,Lipotich GJ,Nealon TJ,Duffey PS

更新日期：1983-02-01 00:00:00

abstract：:Leishmania amastigotes are intracellular protozoan parasites of mononuclear phagocytes which reside within parasitophorous vacuoles of phagolysosomal origin. The pH of these compartments was studied with the aim of elucidating strategies used by these microorganisms to evade the microbicidal mechanisms of their host c...

journal_title：Infection and immunity

authors： Antoine JC,Prina E,Jouanne C,Bongrand P

更新日期：1990-03-01 00:00:00

abstract：:Anti-CD4 antibodies, which cause CD4(+) T-cell depletion, have been shown to increase susceptibility to infections in mice. Thus, development of anti-CD4 antibodies for clinical use raises potential concerns about suppression of host defense mechanisms against pathogens and tumors. The anti-human CD4 antibody kelixima...

journal_title：Infection and immunity

authors： Herzyk DJ,Gore ER,Polsky R,Nadwodny KL,Maier CC,Liu S,Hart TK,Harmsen AG,Bugelski PJ

更新日期：2001-02-01 00:00:00

abstract：:The protozoan parasite Cryptosporidium parvum is a significant cause of diarrheal disease worldwide. Attachment to and invasion of host intestinal epithelial cells by C. parvum sporozoites are crucial steps in the pathogenesis of cryptosporidiosis. The molecular basis of these initial interactions is unknown. In order...

journal_title：Infection and immunity

authors： Cevallos AM,Bhat N,Verdon R,Hamer DH,Stein B,Tzipori S,Pereira ME,Keusch GT,Ward HD

更新日期：2000-09-01 00:00:00

abstract：:Evidence showing that neutrophils play a protective role in the host response to infection by different intracellular parasites has been published in the past few years. We assessed this issue with regard to the infection of mice with Mycobacterium tuberculosis. We found a chronic recruitment of neutrophils to the inf...

journal_title：Infection and immunity

authors： Pedrosa J,Saunders BM,Appelberg R,Orme IM,Silva MT,Cooper AM

更新日期：2000-02-01 00:00:00

abstract：:Anopheles gambiae is the major African vector of Plasmodium falciparum, the most deadly species of human malaria parasite and the most prevalent in Africa. Several strategies are being developed to limit the global impact of malaria via reducing transmission rates, among which are transmission-blocking vaccines (TBVs)...

journal_title：Infection and immunity

authors： Lavazec C,Boudin C,Lacroix R,Bonnet S,Diop A,Thiberge S,Boisson B,Tahar R,Bourgouin C

更新日期：2007-04-01 00:00:00

abstract：:The mechanisms for acquisition of iron by Haemophilus influenzae and their role in pathogenesis are not known. Heme and nonheme sources of iron were evaluated for their effect on growth of type b and nontypable strains of H. influenzae in an iron-restricted, defined medium. All 13 strains acquired iron from heme, hemo...

journal_title：Infection and immunity

authors： Pidcock KA,Wooten JA,Daley BA,Stull TL

更新日期：1988-04-01 00:00:00

abstract：:Heart and muscle tissues appear to be specific target organs for the in vivo inhibition of protein synthesis by diphtheria toxin. ...

journal_title：Infection and immunity

authors： Bowman CG,Imhoff JG,Bonventre PF

更新日期：1970-11-01 00:00:00

abstract：:Recent evidence suggests that immune-mediated gastric epithelial cell apoptosis through Fas-Fas ligand interactions participates in Helicobacter pylori disease pathogenesis. To define the role of Fas signaling in vivo, H. pylori strain SS1 infection in C57BL/6 mice was compared to that in mice deficient in the Fas lig...

journal_title：Infection and immunity

authors： Jones NL,Day AS,Jennings H,Shannon PT,Galindo-Mata E,Sherman PM

更新日期：2002-05-01 00:00:00

abstract：:Improvement of antibody responses to polysaccharides through their linkage to proteins is thought to be mediated by protein-specific T helper (Th) cells. To investigate whether the carrier protein of a conjugate could be substituted by a Th epitope, Streptococcus pneumoniae type 17F polysaccharide (PS) was bromoacetyl...

journal_title：Infection and immunity

authors： de Velasco EA,Merkus D,Anderton S,Verheul AF,Lizzio EF,Van der Zee R,Van Eden W,Hoffman T,Verhoef J,Snippe H

更新日期：1995-03-01 00:00:00

abstract：:The ultrastructural appearance of the "halozone" formed at the interface between the spotted fever agent Rickettsia rickettsii and the cytoplasm of persistently infected cultured vole cells (Microtus pennsylvanicus) was studied by transmission electron microscopy. In sections of epoxy-embedded specimens stained with u...

journal_title：Infection and immunity

authors： Todd WJ,Burgdorfer W,Wray GP

更新日期：1983-09-01 00:00:00

abstract：:We have previously shown that chinchillas infected with a multiply passaged laboratory strain of influenza A/NWS/33 (H1N1) develop negative middle-ear pressure; polymorphonuclear leukocyte oxidative, bactericidal, and chemotactic dysfunction; and increased susceptibility to pneumococcal otitis media. Because influenza...

journal_title：Infection and immunity

authors： Giebink GS,Wright PF

更新日期：1983-09-01 00:00:00

abstract：:Recent studies have shown that probiotics are beneficial in T-cell-mediated inflammatory diseases. The molecular mechanism by which probiotics work remains elusive, but accumulating evidence indicates that probiotics can modulate immune cell responses. Since T cells express receptors for bacterial products or componen...

journal_title：Infection and immunity

authors： Peluso I,Fina D,Caruso R,Stolfi C,Caprioli F,Fantini MC,Caspani G,Grossi E,Di Iorio L,Paone FM,Pallone F,Monteleone G

更新日期：2007-04-01 00:00:00

abstract：:Pathogenic Yersinia species utilize a type III secretion system (T3SS) to translocate effectors called Yersinia outer proteins (Yops) into infected host cells. Previous studies demonstrated a role for effector Yops in the inhibition of caspase-1-mediated cell death and secretion of interleukin-1beta (IL-1beta) in naïv...

journal_title：Infection and immunity

authors： Lilo S,Zheng Y,Bliska JB

更新日期：2008-09-01 00:00:00

abstract：:By using a suckling mouse assay, heat-stable enterotoxin (ST) was purified from the culture filtrate of Yersinia enterocolitica isolated from a diarrheal patient. The purification procedures involve ultrafiltration with an Amicon HIP-10 hollow fiber, ethanol fractionation, protamine sulfate treatment, diethylaminoethy...

journal_title：Infection and immunity

authors： Okamoto K,Inoue T,Ichikawa H,Kawamoto Y,Miyama A

更新日期：1981-02-01 00:00:00

abstract：:CmeABC functions as a multidrug efflux pump contributing to the resistance of Campylobacter to a broad range of antimicrobials. In this study, we examined the role of CmeABC in bile resistance and its contribution to the adaptation of Campylobacter jejuni in the intestinal tract of the chicken, a natural host and a ma...

journal_title：Infection and immunity

authors： Lin J,Sahin O,Michel LO,Zhang Q

更新日期：2003-08-01 00:00:00