Abstract:
:The aroC gene of the facultative intracellular pathogen Brucella suis was cloned and sequenced. The cloned aroC gene complements Escherichia coli and Salmonella enterica serovar Typhimurium aroC mutants. A B. suis aroC mutant was found to be unable to grow in a defined medium without aromatic compounds. The mutant was highly attenuated in tissue culture (THP1 macrophages and HeLa cells) and murine virulence models.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Foulongne V,Walravens K,Bourg G,Boschiroli ML,Godfroid J,Ramuz M,O'Callaghan Ddoi
10.1128/IAI.69.1.547-550.2001keywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
547-50issue
1eissn
0019-9567issn
1098-5522journal_volume
69pub_type
杂志文章abstract::Efficient utilization of heme as an iron (Fe) source by Bordetella avium requires bhuR, an Fe-regulated gene which encodes an outer membrane heme receptor. Upstream of bhuR is a 507-bp open reading frame, hereby designated rhuI (for regulator of heme uptake), which codes for a 19-kDa polypeptide. Whereas the 19-kDa po...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.11.6951-6961.2001
更新日期:2001-11-01 00:00:00
abstract::Shiga toxigenic Escherichia coli (STEC) strains are a diverse group of organisms capable of causing severe gastrointestinal disease in humans. Within the STEC family, eae-positive STEC strains, particularly those belonging to serogroups O157 and O111, appear to have greater virulence for humans. However, in spite of b...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.11.5930-5937.1999
更新日期:1999-11-01 00:00:00
abstract::The scrub typhus 58-kilodalton (kDa) antigen (Sta58) of Rickettsia tsutsugamushi is a major protein antigen often recognized by humans infected with scrub typhus rickettsiae. A 2.9-kilobase HindIII fragment containing a complete sta58 gene was cloned in Escherichia coli and found to express the entire Sta58 antigen an...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.5.1360-1368.1990
更新日期:1990-05-01 00:00:00
abstract::The innate immune response in human tuberculosis is not completely understood. To improve our knowledge regarding the role of cathelicidin hCAP-18/LL37 in the innate immune response to tuberculosis infection, we used immunohistochemistry, immunoelectron microscopy, and gene expression to study the induction and produc...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01218-07
更新日期:2008-03-01 00:00:00
abstract::An apparent inhibition of induction of mouse hepatic tryptophan oxygenase by endotoxin has been reported previously, as evidenced by low catalytic activity. This could be due either to decreased tryptophan oxygenase levels or to inactivation of existing enzyme molecules. To resolve this question, the enzyme was quanti...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.8.4.534-539.1973
更新日期:1973-10-01 00:00:00
abstract::The nitrate dissimilation pathway is important for anaerobic growth in Pseudomonas aeruginosa. In addition, this pathway contributes to P. aeruginosa virulence by using the nematode Caenorhabditis elegans as a model host, as well as biofilm formation and motility. We used a set of nitrate dissimilation pathway mutants...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00822-09
更新日期:2009-10-01 00:00:00
abstract::Phenethyl alcohol, at the maximum concentration which did not inhibit growth (0.3% [vol/vol]), inhibited the production of alpha-lysin and exoproteases but not that of delta-lysin in Staphylococcus aureus Wood 46. The inhibition of alpha-lysin was reversible, and transient accumulation of cell-associated alpha-lysin o...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.47.1.112-117.1985
更新日期:1985-01-01 00:00:00
abstract::Pseudomallei group Burkholderia species are facultative intracellular parasites that spread efficiently from cell to cell by a mechanism involving the fusion of adjacent cell membranes. Intercellular fusion requires the function of the cluster 5 type VI secretion system (T6SS-5) and its associated valine-glycine repea...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01367-13
更新日期:2014-04-01 00:00:00
abstract::Sixty-one patients with a variety of different illnesses were studied with respect to skin test anergy and the presence of serum chemotactic inhibitors. In initial testing, 55% of the patient tests demonstrated negative skin test responses to all six test antigens. Sera from 65% of these anergic patients were capable ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.10.5.1003-1009.1974
更新日期:1974-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.39.1.132-136.1983
更新日期:1983-01-01 00:00:00
abstract::BCG, the attenuated strain of Mycobacterium bovis, has been widely used as a vaccine against tuberculosis and is thus an important candidate as a live carrier for multiple antigens. With the aim of developing a recombinant BCG (rBCG) vaccine against diphtheria, pertussis, and tetanus (DPT), we analyzed the potential o...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.2.869-874.2001
更新日期:2001-02-01 00:00:00
abstract::Inoculation of herpes simplex virus on the forehead and/or snout of hairless mice resulted in a significantly lower mortality rate than inoculation of the skin in the lumbosacral area. Latent herpes simplex virus infections were detected in all forehead-inoculated and in 90% of snout-inoculated mice. Phosphonoacetic a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.20.1.130-135.1978
更新日期:1978-04-01 00:00:00
abstract::Deciphering the mechanisms by which Borrelia burgdorferi controls the synthesis of proteins associated with mammalian infection will be an important step toward understanding the pathogenic properties of Lyme disease-causing bacteria. We present results of studies indicating that B. burgdorferi senses a wide variety o...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.6.4146-4153.2001
更新日期:2001-06-01 00:00:00
abstract::Brazilian purpuric fever (BPF)-associated Haemophilus influenzae biogroup aegyptius strain F3031 contains two identical copies of a five gene cluster (hifA to hifE) encoding pili similar to well-characterized Hif fimbriae of H. influenzae type b. HifE, the putative pilus tip adhesin of F3031, shares only 40% amino aci...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.4.1622-1631.1998
更新日期:1998-04-01 00:00:00
abstract::An enterotoxic factor isolated from cultures of Salmonella yielded reproducible results in the suckling mouse model in contrast to other animal models. The enterotoxin appears to possess properties similar to both the heat-stable and heat-labile enterotoxins of Escherichia coli. Preliminary results indicate that the t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.11.1.14-22.1975
更新日期:1975-01-01 00:00:00
abstract::Outbred Swiss mice were inoculated intraperitoneally or intravenously with one 90 to 100% lethal dose of Escherichia coli O:18, Proteus mirabilis, or Klebsiella pneumoniae. After carefully timed intervals, aminoglycoside antibiotics were begun at dosages nnd intervals predetermined to constitute optimal therapy. With ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.25.2.538-557.1979
更新日期:1979-08-01 00:00:00
abstract::Pathogenic species of the spotted fever group Rickettsia are subjected to repeated exposures to the host complement system through cyclic infections of mammalian and tick hosts. The serum complement machinery is a formidable obstacle for bacteria to overcome if they endeavor to endure this endozoonotic cycle. We have ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00349-12
更新日期:2012-08-01 00:00:00
abstract::The localization and population levels of the indigenous bacterial flora of conventional rats were investigated by cultural and histological techniques. Lactobacilli predominate in the stomach and upper part of the small intestine and associate with keratinized cells of the nonglandular portion of stomach. Mixtures of...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.11.5.962-968.1975
更新日期:1975-05-01 00:00:00
abstract::Streptococcus agalactiae (group B Streptococcus or GBS) is a common colonizer of the gastrointestinal and genital tracts and an important cause of invasive infections in newborn infants and in adults with predisposing chronic conditions or advanced age. Attachment to epithelial surfaces at mucosal sites is a critical ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00699-12
更新日期:2012-11-01 00:00:00
abstract::Ultrastructural immunoperoxidase studies were done in spinal cords of mice infected with wild type vesicular stomatitis virus or its temperature-sensitive (ts) mutant G31. Infected neurons showed subplasmalemmal staining of viral antigen and staining of viral particles budding from the neuronal membrane in wild-type v...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.24.1.276-281.1979
更新日期:1979-04-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.9.5312-5315.2002
更新日期:2002-09-01 00:00:00
abstract::Yersinia enterocolitica, Yersinia pseudotuberculosis, and Yersinia pestis deliver different Yop (Yersinia outer proteins) effector proteins into mammalian cells by a type III secretion mechanism. Recently, it was shown that Yersinia producing YopT leads to disruption of the actin cytoskeleton of HeLa cells (M. Iriarte...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.12.7535-7543.2001
更新日期:2001-12-01 00:00:00
abstract::Most children and adults living in areas where the endemicity of Plasmodium falciparum malaria is high have significantly elevated levels of both total immunoglobulin E (IgE) and IgE antimalarial antibodies in blood. This elevation is highest in patients with cerebral malaria, suggesting a pathogenic role for this imm...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.1.116-121.1997
更新日期:1997-01-01 00:00:00
abstract::Sera from adult periodontitis patients were analyzed for antibody activity against surface antigens of Bacteroides gingivalis by immunoblotting analysis. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.3.832-834.1987
更新日期:1987-03-01 00:00:00
abstract::Sepsis and lipopolysaccharide (LPS) trigger the systemic release of both cytokines and catecholamines. Cytokines are known to be capable of eliciting a stress hormone response in vivo. The present study sought insight into the effect of noradrenaline on LPS-induced release of tumor necrosis factor alpha (TNF) and inte...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.5.2046-2050.1994
更新日期:1994-05-01 00:00:00
abstract::Mesophilic Aeromonas hydrophila strains of serotype O34 typically express smooth lipopolysaccharide (LPS) on their surface. A single mutation in the gene that codes for UDP N-acetylgalactosamine 4-epimerase (gne) confers the O(-) phenotype (LPS without O-antigen molecules) on a strain in serotypes O18 and O34, but not...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.74.1.537-548.2006
更新日期:2006-01-01 00:00:00
abstract::Ehrlichia chaffeensis, an obligatory intracellular bacterium of monocytes or macrophages, is the etiologic agent of human monocytic ehrlichiosis. Our previous study showed that gamma interferon (IFN-gamma) added prior to or at early stage of infection inhibited infection of human monocytes with E. chaffeensis; however...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.6.2514-2520.1998
更新日期:1998-06-01 00:00:00
abstract::Borrelia burgdorferi spirochetes that do not cause arthritis or carditis were developed and used to investigate Lyme disease pathogenesis. A clonal isolate of B. burgdorferi N40 (cN40), which induces disease in C3H/HeN (C3H) mice, was repeatedly passaged in vitro to generate nonpathogenic spirochetes. The passage 75 i...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.3.1222-1230.2000
更新日期:2000-03-01 00:00:00
abstract::Most vaccines are still given parenterally. Mucosal vaccination would offer different advantages over parenteral immunization, including blocking of the pathogens at the portal of entry. In this paper, nontoxic Escherichia coli heat-labile enterotoxin (LT) mutants and Supramolecular Biovector systems (SMBV) were evalu...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.9.4785-4790.2002
更新日期:2002-09-01 00:00:00
abstract::Escherichia coli O157:H7 is an important pathogen of humans. Cattle are most frequently identified as the primary source of infection, and therefore, reduction in E. coli O157:H7 prevalence in cattle by vaccination represents an attractive strategy for reducing the incidence of human disease. H7 flagella have been imp...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01452-07
更新日期:2008-06-01 00:00:00