Induction of neutralizing antibodies against diphtheria toxin by priming with recombinant Mycobacterium bovis BCG expressing CRM(197), a mutant diphtheria toxin.

abstract：:Streptococcus suis has received increasing attention for its involvement in severe human infections worldwide as well as in multidrug resistance. Two-component signaling systems (TCSSs) play important roles in bacterial adaptation to various environmental stimuli. In this study, we identified a novel TCSS located in S...

journal_title：Infection and immunity

authors： Zhong X,Zhang Y,Zhu Y,Dong W,Ma J,Pan Z,Roy S,Lu C,Yao H

更新日期：2018-06-21 00:00:00

abstract：:Clostridium perfringens is an anaerobic, Gram-positive bacterium that causes a range of diseases in humans, including lethal gas gangrene. We have recently shown that strains of C. perfringens move across the surface of agar plates by a unique type IV pilus (TFP)-mediated social motility that had not been previously d...

journal_title：Infection and immunity

authors： Rodgers K,Arvidson CG,Melville S

更新日期：2011-08-01 00:00:00

abstract：:Pregnancy-associated malaria is a severe clinical syndrome associated with the sequestration of Plasmodium falciparum-infected erythrocytes in the placenta. Placental binding is mediated by VAR2CSA, a member of the large and diverse P. falciparum erythrocyte membrane 1 (PfEMP1) protein family. To better understand if ...

journal_title：Infection and immunity

authors： Avril M,Cartwright MM,Hathaway MJ,Hommel M,Elliott SR,Williamson K,Narum DL,Duffy PE,Fried M,Beeson JG,Smith JD

更新日期：2010-05-01 00:00:00

abstract：:The naturally antibiotic-resistant bacterium Burkholderia pseudomallei is the causative agent of melioidosis, a disease with stubbornly high mortality and a complex, protracted treatment regimen. The worldwide incidence of melioidosis is likely grossly underreported, though it is known to be highly endemic in northern...

journal_title：Infection and immunity

authors： McMahon RM,Ireland PM,Sarovich DS,Petit G,Jenkins CH,Sarkar-Tyson M,Currie BJ,Martin JL

更新日期：2018-04-23 00:00:00

abstract：:Immunization with the B oligomer of pertussis toxin protected neonatal mice from a lethal respiratory challenge with Bordetella pertussis. All mice immunized with 8 micrograms of B oligomer survived aerosol challenge and had peripheral leukocyte counts and weight gains similar to those of mice immunized with pertussis...

journal_title：Infection and immunity

authors： Shahin RD,Witvliet MH,Manclark CR

更新日期：1990-12-01 00:00:00

abstract：:The NikR protein is a nickel-dependent regulatory protein which is a member of the ribbon-helix-helix family of transcriptional regulators. The gastric pathogen Helicobacter pylori expresses a NikR ortholog, which was previously shown to mediate regulation of metal metabolism and urease expression, but the mechanism g...

journal_title：Infection and immunity

authors： Ernst FD,Kuipers EJ,Heijens A,Sarwari R,Stoof J,Penn CW,Kusters JG,van Vliet AH

更新日期：2005-11-01 00:00:00

abstract：:An established cell line (Vero) defective in interferon production was used to evaluate the role of interferon in chronic rubella virus infections of cell cultures. Inoculation of Vero cells with a low multiplicity of virus resulted in the development of carrier cultures which had the characteristics of a regulated in...

journal_title：Infection and immunity

authors： Mifune K,Desmyter J,Rawls WE

更新日期：1970-08-01 00:00:00

abstract：:The serum opacity factor (SOF) of Streptococcus pyogenes is a serotyping tool and pathogenesis factor. Using SOF-coated latex beads in cell adherence assays and antiserum directed against SOF in S. pyogenes-HEp-2 cell adherence inhibition experiments, we demonstrate SOF involvement in the fibronectin-mediated adherenc...

journal_title：Infection and immunity

authors： Oehmcke S,Podbielski A,Kreikemeyer B

更新日期：2004-07-01 00:00:00

abstract：:Inactivated Marek's disease virus-infected chicken kidney cells and inactivated MSB-1 lymphoblastoid Marek's disease tumor cells were used to immunize chickens as virus- and tumor-associated antigens, respectively. Immune and nonimmune birds were then challenged by exposure to live virulent Marek's disease virus. Both...

journal_title：Infection and immunity

authors： Murthy KK,Calnek BW

更新日期：1979-11-01 00:00:00

abstract：:A key function of monocytes/macrophages (Mphi) is to present antigens to T cells. However, upon interaction with bacteria, Mphi lose their ability to effectively present soluble antigens. This functional loss was associated with alterations in the expression of adhesion molecules and CD14 and a reduction in the uptake...

journal_title：Infection and immunity

authors： Wyant TL,Tanner MK,Sztein MB

更新日期：1999-03-01 00:00:00

abstract：:Mice given Mycobacterium tuberculosis bacilli via the respiratory route succumbed much sooner to infection than mice given 1,000 times more bacilli via the intravenous route. Vaccination provided increased protection to an M. tuberculosis challenge infection; however, mice infected via the respiratory route remained m...

journal_title：Infection and immunity

authors： North RJ,LaCourse R,Ryan L

更新日期：1999-04-01 00:00:00

abstract：:An "immunogenic" ribonucleic acid (Im-RNA) has been extracted from peritoneal exudate (PE) cells of rats that were immunized with sheep erythrocytes (SRBC). Following multiple phenol extractions and deoxyribonuclease treatment, the material obtained from PE cells was eluted from diethylaminoethyl-cellulose at 0.55 M N...

journal_title：Infection and immunity

authors： Archer SJ,Wust CJ

更新日期：1973-08-01 00:00:00

abstract：:MAEBL is a type 1 membrane protein that is implicated in the merozoite invasion of erythrocytes and sporozoite invasion of mosquito salivary glands. This apical organelle protein is structurally similar to the ebl erythrocyte binding proteins, such as EBA-175, except that the tandem ligand domains of MAEBL are similar...

journal_title：Infection and immunity

authors： Preiser P,Rénia L,Singh N,Balu B,Jarra W,Voza T,Kaneko O,Blair P,Torii M,Landau I,Adams JH

更新日期：2004-06-01 00:00:00

abstract：:The effects of temperature and treatment with sodium dodecyl sulfate, Tween 20, dithiothreitol, trypsin, or guanidine on the hemagglutinating capacity of six strains of type A influenza virus (A(0)/PR8/34, A(1)/CAME/46, A(2)/J305/57, A(2)/Bethesda/63, A(2)/HK/Aichi/68, and A(2)/HK/80/68), one strain of swine virus (A/...

journal_title：Infection and immunity

authors： Cleeland R,Grunberg E,Prince HN

更新日期：1972-03-01 00:00:00

abstract：:Length and restriction site polymorphism within a 2.8-kb threonine-rich open reading frame from Cryptosporidium parvum was identified and used to determine the genotypes of isolates from calves and humans. In agreement with observations of other genetic loci, all calf isolates were identical at this locus. In contrast...

journal_title：Infection and immunity

authors： Carraway M,Tzipori S,Widmer G

更新日期：1997-09-01 00:00:00

abstract：:Legionella pneumophila has been shown to possess multiple genetic loci that play roles in its ability to survive within host cells. The mil (macrophage-specific infectivity loci) mutants of L. pneumophila exhibit a spectrum of defects in intracellular survival in and cytopathogenicity to macrophages and alveolar epith...

journal_title：Infection and immunity

authors： Harb OS,Abu Kwaik Y

更新日期：2000-01-01 00:00:00

abstract：:The Fcγ receptor IIIb (FcγRIIIb) is a low-affinity receptor of IgG and is essential in neutrophil-mediated effector functions. Different allelic forms of FcγRIIIb carrying human neutrophil antigen (HNA-1a, -1b, -1c, and -1d) have been identified. Here, we have generated stable transfected HEK293 cell lines expressing ...

journal_title：Infection and immunity

authors： Simtong P,Romphruk AV,Traum A,Burg-Roderfeld M,Bein G,Jakubowski K,Dominik A,Theisen M,Kana IH,Sachs UJ,Santoso S

更新日期：2018-07-23 00:00:00

abstract：:Female LSH hamsters infected with Treponema pallidum subsp, endemicum before pregnancy or during early pregnancy transmit a form of syphilis to the fetus that is similar to human congenital syphilis. The offspring develops rhinitis, skin rash, failure to thrive, and hepatosplenomegaly. T. pallidum is detectable in the...

journal_title：Infection and immunity

authors： Kajdacsy-Balla A,Howeedy A,Bagasra O

更新日期：1993-08-01 00:00:00

abstract：:Modulation of cytosolic (intracellular) Ca(2+) concentration (Ca(i)) may be an important host response when airway epithelial cells are exposed to Pseudomonas aeruginosa. We measured Ca(i) in Calu-3 cells exposed from the apical or basolateral surface to cytotoxic and noncytotoxic strains of P. aeruginosa. Apical addi...

journal_title：Infection and immunity

authors： Jacob T,Lee RJ,Engel JN,Machen TE

更新日期：2002-11-01 00:00:00

abstract：:Pertussis toxin is secreted from Bordetella pertussis with the assistance of the Ptl transport system, a member of the type IV family of macromolecular transporters. The S1 subunit and the B oligomer combine to form the holotoxin prior to export from the bacterial cell, although the site of assembly is not known. To b...

journal_title：Infection and immunity

authors： Farizo KM,Fiddner S,Cheung AM,Burns DL

更新日期：2002-03-01 00:00:00

abstract：:Forty-seven bacterial strains representing four different group C streptococcal species were tested for binding of human and bovine immunoglobulin G (IgG) subclasses. Specific binding sites for IgG were found in all bacterial species studied. The four species included differed, however, in their capacities to interact...

journal_title：Infection and immunity

authors： Myhre EB,Kronvall G

更新日期：1980-03-01 00:00:00

abstract：:Escherichia coli and other members of the family Enterobacteriaceae express surface fibrillar structures, fimbriae, that promote bacterial adhesion to host receptors. Type 1 fimbriae possess a lectinlike component, FimH, that is commonly thought to cause binding to mannose-containing oligosaccharides of host receptors...

journal_title：Infection and immunity

authors： Sokurenko EV,Courtney HS,Abraham SN,Klemm P,Hasty DL

更新日期：1992-11-01 00:00:00

abstract：:Adhesion of Trichomonas vaginalis is believed to be dependent on four adhesion proteins, which are thought to bind to vaginal epithelial cells in a specific manner with a ligand-receptor type of interaction. However, the specific receptors on the host cell have not yet been identified. In this work, the ability of the...

journal_title：Infection and immunity

authors： Addis MF,Rappelli P,Fiori PL

更新日期：2000-07-01 00:00:00

abstract：:Pseudomonas aeruginosa is considered an extracellular pathogen. Using assays to determine intracellular survival in the presence of gentamicin, we have demonstrated that some strains of P. aeruginosa are able to invade corneal cells during experimental bacterial keratitis in mice. Although intracellular bacteria were ...

journal_title：Infection and immunity

authors： Fleiszig SM,Zaidi TS,Fletcher EL,Preston MJ,Pier GB

更新日期：1994-08-01 00:00:00

abstract：:The enterotoxin of Shigella dysenteriae I produces fluid and electrolyte secretion in the rabbit ileum. These present studies were designed to evaluate nonelectrolyte transport in rabbit ileal mucosa exposed to Shigella enterotoxin. Both 10 mM galactose and 5 mM L-alanine absorptions were significantly impaired in ent...

journal_title：Infection and immunity

authors： Binder HJ,Whiting DS

更新日期：1977-05-01 00:00:00

abstract：:Salmonella infection can cause gastroenteritis in healthy individuals or a serious, systemic infection in immunocompromised patients and has a global impact. CD4 Th1 cells represent the main lymphocyte population that participates in bacterial clearance during both primary and secondary infections in mice of the H-2b ...

journal_title：Infection and immunity

authors： Labuda JC,Depew CE,Pham OH,Benoun JM,Ramirez NA,McSorley SJ

更新日期：2019-10-18 00:00:00

abstract：:Four isolates of Staphylococcus aureus from patients with endocarditis and bacteremia were capable of secreting high-molecular-weight soluble peptidoglycans when grown in a minimal cell wall medium containing penicillin G. Vancomycin was not able to substitute for penicillin G in triggering this secretion. Secretion r...

journal_title：Infection and immunity

authors： Zeiger AR,Wong W,Chatterjee AN,Young FE,Tuazon CU

更新日期：1982-09-01 00:00:00

abstract：:Clostridium perfringens delta toxin was selectively cytotoxic for various rabbit leukocyte populations. The sensitivity of these populations to the toxin varied, depending on the tissue from which they were derived, from 28% (appendix) to 41% (bone marrow) and 32% (spleen). Macrophages were uniformly killed by delta t...

journal_title：Infection and immunity

authors： Jolivet-Reynaud C,Cavaillon JM,Alouf JE

更新日期：1982-12-01 00:00:00

abstract：:Hematogenous infections caused by Candida krusei have been noted with increasing frequency, particularly in cancer patients receiving prophylaxis with antifungal triazoles. Progress in understanding the pathogenesis of this emerging infection has been limited by the lack of an animal model. We developed a CF1 mouse in...

journal_title：Infection and immunity

authors： Anaissie E,Hachem R,K-Tin-U C,Stephens LC,Bodey GP

更新日期：1993-04-01 00:00:00

abstract：:Host-adapted Gram-negative bacterial pathogens from the Pasteurellaceae, Neisseriaceae, and Moraxellaceae families normally reside in the upper respiratory or genitourinary tracts of their hosts and rely on utilizing iron from host transferrin (Tf) for growth and survival. The surface receptor proteins that mediate th...

journal_title：Infection and immunity

authors： Frandoloso R,Martínez-Martínez S,Calmettes C,Fegan J,Costa E,Curran D,Yu RH,Gutiérrez-Martín CB,Rodríguez-Ferri EF,Moraes TF,Schryvers AB

更新日期：2015-03-01 00:00:00