Function of the fibronectin-binding serum opacity factor of Streptococcus pyogenes in adherence to epithelial cells.

abstract：:Spleen cells from BALB/c mice infected with 2 X 10(7) L. major promastigotes and developing progressive disease produced significantly lower levels of interleukin-2 (IL-2) in response to concanavalin A stimulation than did spleen cells from uninfected mice. In contrast, spleen cells from sublethally irradiated and inf...

journal_title：Infection and immunity

authors： Cillari E,Liew FY,Lelchuk R

更新日期：1986-11-01 00:00:00

abstract：:A solid-phase radioimmunoassay, applying whole Mycobacterium leprae as antigen and radiolabeled protein A from Staphylococcus aureus as antibody-detecting reagent, was used for the determination of specific immunoglobulin G (IgG) and IgM antibody responses in leprosy patients. High IgG anti-M. leprae antibody levels w...

journal_title：Infection and immunity

authors： Touw J,Langendijk EM,Stoner GL,Belehu A

更新日期：1982-06-01 00:00:00

abstract：:Toxicity of lipopolysaccharide (LPS) (endotoxin) is, to a large extent, mediated by the activation of monocytes/macrophages and subsequent release of monokines, such as interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-alpha). It is known that LPS binds readily to serum lipoproteins and that LPS-lipoprotein co...

journal_title：Infection and immunity

authors： Flegel WA,Wölpl A,Männel DN,Northoff H

更新日期：1989-07-01 00:00:00

abstract：:Direct instillation of coxsackievirus B1 into the gastrointestinal tracts of albino mice caused viremia in more than 85% of the animals within 1 day. In pregnant mice infected early in gestation (7 days), the geometric mean titer of virus in the blood was lower (P = 0.02) and the duration of viremia was shorter (P = 0...

journal_title：Infection and immunity

authors： Modlin JF,Crumpacker CS

更新日期：1982-07-01 00:00:00

abstract：:Murine cerebral malaria (CM) induced by Plasmodium berghei ANKA kills susceptible mice within 24 to 48 h of onset of symptoms and is characterized by the production of inflammatory cytokines in the brain. C57BL/6J mice are sensitive to lethal CM, while A/J mice are resistant. These strains of mice were immunized with ...

journal_title：Infection and immunity

authors： Jennings VM,Lal AA,Hunter RL

更新日期：1998-12-01 00:00:00

abstract：:Yersinia pseudotuberculosis inv mutant strains cured of the virulence plasmid exhibit thermoinducible adhesion to cultured mammalian cells. To identify the genes responsible for this phenotype, Y. pseudotuberculosis homologs of the Y. enterocolitica ail and the Y. pestis psa loci were identified. Mutations in the Y. p...

journal_title：Infection and immunity

authors： Yang Y,Merriam JJ,Mueller JP,Isberg RR

更新日期：1996-07-01 00:00:00

abstract：:Restoration of the ability of hypogammaglobulinemic serum to support opsonophagocytosis and intracellular killing of Bacteroides fragilis and Bacteroides thetaiotaomicron by human polymorphonuclear leukocytes was achieved by supplementation with normal human immunoglobulin M, but not with normal human immunoglobulin G...

journal_title：Infection and immunity

authors： Bjornson AB,Bjornson HS,Kitko BP

更新日期：1980-05-01 00:00:00

abstract：:After uptake and retrograde transport pertussis toxin acts by ADP-ribosylating alpha-Gi proteins. We show that uptake via many different receptor proteins followed by retrograde transport and intoxication is not restricted to a particular cell type. The efficiency of cellular intoxication, however, was found to be cel...

journal_title：Infection and immunity

authors： el Bayâ A,Brückener K,Schmidt MA

更新日期：1999-01-01 00:00:00

abstract：:The effects of pathologically relevant concentrations (0.38 to 12.5 microM) of the proinflammatory, Pseudomonas aeruginosa-derived pigment 1-hydroxyphenazine (1-hp) on Ca2+ metabolism and intracellular cyclic AMP (cAMP) in N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP; 1 microM)-activated human neutrophils, as w...

journal_title：Infection and immunity

authors： Ramafi G,Anderson R,Theron A,Feldman C,Taylor GW,Wilson R,Cole PJ

更新日期：1999-10-01 00:00:00

abstract：:An asd-stabilized plasmid carrying enterotoxigenic Escherichia coli cfaABCE genes was constructed and called pJGX15C-asd+. Expression of colonization factor antigen I (CFA/I) by this plasmid occurs independently of the cfaABCE positive regulator cfaR in attenuated Salmonella delta aro delta asd strain H683 and nonpath...

journal_title：Infection and immunity

authors： Wu S,Pascual DW,VanCott JL,McGhee JR,Maneval DR Jr,Levine MM,Hone DM

更新日期：1995-12-01 00:00:00

abstract：:Malaria toxin causes hypoglycemia and induction of tumor necrosis factor. Extracts of parasitized erythrocytes which were coeluted and copurified with one of the two subtypes of mammalian insulin-mimetic inositolphosphoglycans similarly induced fibroblast proliferation in the absence of serum. In addition, induction o...

journal_title：Infection and immunity

authors： Caro HN,Sheikh NA,Taverne J,Playfair JH,Rademacher TW

更新日期：1996-08-01 00:00:00

abstract：:Membrane and soluble fractions of Mycoplasma pneumoniae, M. pulmonis, and M. laidlawii B were prepared by hypotonic lysis of whole cells. The membranes of M. pneumoniae and M. laidlawii B contained, as percentage of dry weight: 34 to 37% protein, 59 to 61% lipid, 3 to 4% carbohydrate as hexose, and 0.2% ribonucleic ac...

journal_title：Infection and immunity

authors： Pollack JD,Somerson NL,Senterfit LB

更新日期：1970-09-01 00:00:00

abstract：:We reexamined the binding specificity of the Shiga-like toxin variant associated with porcine edema disease, SLT2e, which is reported to be more cytotoxic for Vero cells than for HeLa cells, by using receptor-deficient cells and a liposomal insertion system for purified glycolipids. We found that SLT2e preferentially ...

journal_title：Infection and immunity

authors： Keusch GT,Jacewicz M,Acheson DW,Donohue-Rolfe A,Kane AV,McCluer RH

更新日期：1995-03-01 00:00:00

abstract：:Bacillus cereus causes exotoxin-mediated diarrheal food poisoning. Hemolysin BL (HBL) is a well-characterized B. cereus toxin composed of three components (B, L1, and L2) that together possess hemolytic, cytotoxic, dermonecrotic, and vascular permeability activities. Here, we show that HBL causes fluid accumulation in...

journal_title：Infection and immunity

authors： Beecher DJ,Schoeni JL,Wong AC

更新日期：1995-11-01 00:00:00

abstract：:Exposure of hamster tracheal rings in organ culture to virulent Mycoplasma pneumoniae organisms leads to alterations in macromolecular biosynthesis and metabolic activity of the respiratory epithelial cells. Avirulent organisms derived from the same parent strain do not produce these effects. During the course of infe...

journal_title：Infection and immunity

authors： Hu PC,Collier AM,Baseman JB

更新日期：1975-04-01 00:00:00

abstract：:A virus, 78-238, isolated from the cerebrospinal fluid of a dog with neurological dysfunction, was characterized as a paramyxovirus. This conclusion was supported by viral cytopathic effects and morphological appearance of virions and nucleocapsids in infected cells. Nucleocapsids were found in the cytoplasm of all in...

journal_title：Infection and immunity

authors： Baumgärtner WK,Metzler AE,Krakowka S,Koestner A

更新日期：1981-03-01 00:00:00

abstract：:Immunochemically identical components were isolated from water-soluble phases of five Staphylococcus aureus strains by affinity chromatography on fibrinogen-linked Sepharose 4B. The elution was performed with 1 M MgCl2. The component could be isolated from sonicated preparations of whole cells, cell walls, and extrace...

journal_title：Infection and immunity

authors： Espersen F,Clemmensen I,Barkholt V

更新日期：1985-09-01 00:00:00

abstract：:The invasion of red blood cells (RBCs) by Plasmodium falciparum is dependent on multiple molecular interactions between erythrocyte receptors and parasite ligands. Invasion studies using culture-adapted parasite strains have indicated significant receptor heterogeneity. It is not known whether this heterogeneity refle...

journal_title：Infection and immunity

authors： Lobo CA,de Frazao K,Rodriguez M,Reid M,Zalis M,Lustigman S

更新日期：2004-10-01 00:00:00

abstract：:Anopheles gambiae is the major African vector of Plasmodium falciparum, the most deadly species of human malaria parasite and the most prevalent in Africa. Several strategies are being developed to limit the global impact of malaria via reducing transmission rates, among which are transmission-blocking vaccines (TBVs)...

journal_title：Infection and immunity

authors： Lavazec C,Boudin C,Lacroix R,Bonnet S,Diop A,Thiberge S,Boisson B,Tahar R,Bourgouin C

更新日期：2007-04-01 00:00:00

abstract：:We found that when group A streptococci are cocultured with human pharyngeal cells, they upregulate and secrete a 25-kDa toxin, determined to be the bacteriophage-encoded streptococcal pyrogenic exotoxin C (SpeC). This prompted us to determine if the bacteriophage themselves are induced during coculture conditions. We...

journal_title：Infection and immunity

authors： Broudy TB,Pancholi V,Fischetti VA

更新日期：2001-03-01 00:00:00

abstract：:The enteric pathogens enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli employ a type 3 secretion system (T3SS) to manipulate the host inflammatory response during infection. Previously, it has been reported that EPEC, in a T3SS-dependent manner, induces an early proinflammatory response through a...

journal_title：Infection and immunity

authors： Pallett MA,Berger CN,Pearson JS,Hartland EL,Frankel G

更新日期：2014-11-01 00:00:00

abstract：:Protective immunity against Toxoplasma gondii is known to be mediated mainly by T lymphocytes and gamma interferon (IFN-gamma). The contribution of CD4(+) and CD8(+) T-lymphocyte subsets to protective immune responses against T. gondii infection, triggered by a GRA1 (p24) DNA vaccine, was assessed in this study. In vi...

journal_title：Infection and immunity

authors： Scorza T,D'Souza S,Laloup M,Dewit J,De Braekeleer J,Verschueren H,Vercammen M,Huygen K,Jongert E

更新日期：2003-01-01 00:00:00

abstract：:Campylobacter rectus is a putative periodontopathogen which expresses a proteinaceous surface layer (S-layer) external to the outer membrane. S-layers are considered to play a protective role for the microorganism in hostile environments. The S-layer proteins from six different C. rectus strains (five human isolates a...

journal_title：Infection and immunity

authors： Nitta H,Holt SC,Ebersole JL

更新日期：1997-02-01 00:00:00

abstract：:The human pathogen enterohemorrhagic Escherichia coli (EHEC) O157:H7 has two histidine sensor kinases, QseC and QseE, which respond to the mammalian adrenergic hormones epinephrine and norepinephrine by increasing their autophosphorylation. Although QseC and QseE are present in nonpathogenic strains of E. coli, EHEC e...

journal_title：Infection and immunity

authors： Njoroge J,Sperandio V

更新日期：2012-02-01 00:00:00

abstract：:Brucella abortus injected into CBA mice replicated primarily in the spleen and liver, reaching a peak bacterial count in both organs about 7 days postinfection. The organism was eliminated from the liver but declined to a chronic phase in the spleen. The infection caused hepatosplenomegaly. An influx of macrophages in...

journal_title：Infection and immunity

authors： Doyle AG,Halliday WJ,Barnett CJ,Dunn TL,Hume DA

更新日期：1992-04-01 00:00:00

abstract：:Amastigotes obtained from spleens of mice infected with different strains of Trypanosoma cruzi were examined for their ability to invade macrophages and L929 cells and to initiate infection in mice. Both types of cells were readily invaded by organisms of the strains Y, MR, and Tulahuen. Organisms of the CL strain wer...

journal_title：Infection and immunity

authors： McCabe RE,Remington JS,Araujo FG

更新日期：1984-11-01 00:00:00

abstract：:In contrast to infection of superficial tissues, Streptococcus pyogenes infection of deeper tissue can be associated with a significantly diminished inflammatory response, suggesting that this bacterium has the ability to both promote and suppress inflammation. To examine this, we analyzed the behavior of an S. pyogen...

journal_title：Infection and immunity

authors： Lin A,Loughman JA,Zinselmeyer BH,Miller MJ,Caparon MG

更新日期：2009-11-01 00:00:00

abstract：:Antibody rises to various virus subcomponents were measured by enzyme-linked immunosorbent assay in the paired sera of volunteers experimentally infected with human coronavirus 229E group viruses. Most of the antibody made during infection was directed against the virus surface projections, with only small amounts of ...

journal_title：Infection and immunity

authors： Macnaughton MR,Hasony HJ,Madge MH,Reed SE

更新日期：1981-03-01 00:00:00

abstract：:We have investigated the role of lipoteichoic acid in mediating the adherence of different serotypes of group B streptococci to human adult and neonatal epithelial cells. Pretreatment of neonatal buccal and vaginal epithelial cells with lipoteichoic acid, but not with deacylated lipoteichoic acid, induced a marked inh...

journal_title：Infection and immunity

authors： Teti G,Tomasello F,Chiofalo MS,Orefici G,Mastroeni P

更新日期：1987-12-01 00:00:00

abstract：:A major problem in the study of chlamydial genital infections in animal models has been the use of varied doses of chlamydiae for infection in different laboratories. It is clearly desirable to use a dose which approximates that of natural sexual infection, but that dose to date has not been determined because of the ...

journal_title：Infection and immunity

authors： Rank RG,Bowlin AK,Reed RL,Darville T

更新日期：2003-11-01 00:00:00