Characterization of a macrophage-specific infectivity locus (milA) of Legionella pneumophila.

abstract：:The effect of a standard regimen of cimetidine on the gastric flora of 20 male volunteers was studied in a double-blind manner and compared with the effects of a standard antacid regimen. Postprandial microbial titers in gastric aspirates were significantly higher at 4, 8, and 16 weeks of therapy in subjects taking an...

journal_title：Infection and immunity

authors： Snepar R,Poporad GA,Romano JM,Kobasa WD,Kaye D

更新日期：1982-05-01 00:00:00

abstract：:Nitration of protein A with tetranitromethane incompletely blocks its Fc-binding ability for immunoglobulin G when measured by more sensitive methods of immunoprecipitation and when tested in the enzyme-linked immunosorbent assay. In addition, binding of protein A and blockage by nitration is heterogeneous and depends...

journal_title：Infection and immunity

authors： Sloan GJ,Butler JE

更新日期：1978-08-01 00:00:00

abstract：:To determine optimal strategies to induce specific-antibody-secreting cells (specific ASC) in the rectal and vaginal mucosae, we immunized monkeys with a prototype mucosal immunogen, cholera toxin (CT), given locally or via gastric or parenteral administration. Repeated rectal or vaginal CT immunizations induced stron...

journal_title：Infection and immunity

authors： Eriksson K,Quiding-Järbrink M,Osek J,Möller A,Björk S,Holmgren J,Czerkinsky C

更新日期：1998-12-01 00:00:00

abstract：:Murine hybridoma cell lines were developed which synthesized monoclonal antibodies against Actinobacillus actinomycetemcomitans-associated antigens. Monoclonal antibodies specific for an antigen(s) common to all A. actinomycetemcomitans isolates tested but not detected on other gram-negative oral plaque microorganisms...

journal_title：Infection and immunity

authors： Place DA,Scidmore NC,McArthur WP

更新日期：1988-05-01 00:00:00

abstract：:In contrast to infection of superficial tissues, Streptococcus pyogenes infection of deeper tissue can be associated with a significantly diminished inflammatory response, suggesting that this bacterium has the ability to both promote and suppress inflammation. To examine this, we analyzed the behavior of an S. pyogen...

journal_title：Infection and immunity

authors： Lin A,Loughman JA,Zinselmeyer BH,Miller MJ,Caparon MG

更新日期：2009-11-01 00:00:00

abstract：:Experiments were performed to investigate the usefulness of an enzyme-linked immunosorbent assay utilizing avidin-biotin interaction as a diagnostic tool for detection of Toxoplasma antigen in blood. The lower limit of sensitivity of the assay by this method was ca. 4 ng/ml, and standard assays provided a linear plot ...

journal_title：Infection and immunity

authors： Ise Y,Iida T,Sato K,Suzuki T,Shimada K,Nishioka K

更新日期：1985-04-01 00:00:00

abstract：:Encapsulated Streptococcus pneumoniae of serotypes 2, 9N, 14, 21, and 23F and an unencapsulated variant of type 2 pneumococci were efficiently phagocytosed by both aerobically and anaerobically incubated human leukocytes. In the presence of O2, the pneumococci rapidly lost their viability, whereas during anaerobiosis,...

journal_title：Infection and immunity

authors： Thore M,Löfgren S,Tärnvik A,Monsen T,Selstam E,Burman LG

更新日期：1985-01-01 00:00:00

abstract：:Brucella abortus 2308 derivatives with mini-Tn5 insertions in purE, purL, and purD display significant attenuation in the BALB/c mouse model, while isogenic mutants with mini-Tn5 insertions in pheA, trpB, and dagA display little or no attenuation in cultured murine macrophages or mice. These experimental findings conf...

journal_title：Infection and immunity

authors： Alcantara RB,Read RD,Valderas MW,Brown TD,Roop RM 2nd

更新日期：2004-08-01 00:00:00

abstract：:Vibrio mimicus 61892, isolated in 1977 from a case of watery diarrhea in Bangladesh, produces an enterotoxin which possesses activity in Y-1 mouse adrenal cells and in rabbit ileal loops which is identical to the prototype cholera toxin (CT) produced by Vibrio cholerae 569B. The neutralization of the adrenal cell acti...

journal_title：Infection and immunity

authors： Spira WM,Fedorka-Cray PJ

更新日期：1983-11-01 00:00:00

abstract：:It was shown in this work that the infectivity of metacyclic forms of Trypanosoma cruzi was affected upon interaction with the monoclonal antibody (10D8), which reacts with a carbohydrate epitope of the 35- and 50-kilodalton (kDa) surface glycoconjugates. The invasion of Vero cells by metacyclic forms of strains Tulah...

journal_title：Infection and immunity

authors： Yoshida N,Mortara RA,Araguth MF,Gonzalez JC,Russo M

更新日期：1989-06-01 00:00:00

abstract：:Treatment of mouse embryo fibroblasts (MEF) grown in vitro with purified staphylococcal exfoliative toxin (ET) increased the concanavalin A (Con A) agglutinability of MEF 3.5-fold over control cells. Possible explanations for this phenomenon were investigated. ET lacked proteolytic activity on denatured casein. Con A,...

journal_title：Infection and immunity

authors： Rogolsky M,Wiley BB,Keyhani M,Glasgow LA

更新日期：1974-12-01 00:00:00

abstract：:When immunocompetent mice are inoculated with Borrelia burgdorferi, they develop acute arthritis and carditis that undergo spontaneous regression despite the persistence of infection. Specific T- and/or B-cell immunity appears to be necessary for resolution of disease manifestations. Humoral immune responses to B. bur...

journal_title：Infection and immunity

authors： Bockenstedt LK,Barthold S,Deponte K,Marcantonio N,Kantor FS

更新日期：1993-05-01 00:00:00

abstract：:Murine monoclonal antibodies were generated against streptolysin O. One out of 10 tested immunoglobulin clones exhibited strong neutralizing activity; in solution, the presence of approximately two to four antibody molecules per toxin monomer effected 50% neutralization of hemolytic toxin activity. An enzyme-linked im...

journal_title：Infection and immunity

authors： Hugo F,Reichwein J,Arvand M,Krämer S,Bhakdi S

更新日期：1986-12-01 00:00:00

abstract：:Reverse transcriptase PCR analyses have demonstrated that open reading frames (ORFs) PM0298, PM0299, and PM0300 of the animal pathogen Pasteurella multocida constitute a single transcriptional unit. By cloning and overexpression studies in Escherichia coli cells, the product of ORF PM0300 was shown to bind hemoglobin ...

journal_title：Infection and immunity

authors： Bosch M,Garrido ME,Llagostera M,Pérez De Rozas AM,Badiola I,Barbé J

更新日期：2002-11-01 00:00:00

abstract：:A recombinant plasmid containing a 6.5-kb fragment of nontypeable Haemophilus influenzae (NTHI) chromosomal DNA was shown to confer a hemoglobin-haptoglobin-binding phenotype on Escherichia coli. Use of a mini-Tn10kan transposon for random insertion mutagenesis of this recombinant plasmid allowed localization of the N...

journal_title：Infection and immunity

authors： Maciver I,Latimer JL,Liem HH,Muller-Eberhard U,Hrkal Z,Hansen EJ

更新日期：1996-09-01 00:00:00

abstract：:Pseudomonas aeruginosa, an important opportunistic pathogen of humans, exploits epithelial damage to establish infection. We have rigorously explored the role of N-glycoproteins and heparan sulfate proteoglycans (HSPGs) in P. aeruginosa-mediated attachment and subsequent downstream events at the apical (AP) and basola...

journal_title：Infection and immunity

authors： Bucior I,Mostov K,Engel JN

更新日期：2010-03-01 00:00:00

abstract：:Culture supernatants from antigen-pulsed spleen cells of mice infected previously with either BCG or Plasmodium chabaudi were used to study macrophage activation as judged by phagocytosis of immunoglobulin G-sensitized erythrocytes and Plasmodium berghei- and P. chabaudi-infected erythrocytes. Resident peritoneal macr...

journal_title：Infection and immunity

authors： Ockenhouse CF,Shear HL

更新日期：1983-11-01 00:00:00

abstract：:Iron starvation conditions limited the growth of Salmonella typhi, as evidenced by an increase in the lag phase of a culture and a decrease in the number of bacteria reached in the stationary phase. The analysis of the outer membrane of bacteria grown under these conditions identified new protein components with appar...

journal_title：Infection and immunity

authors： Fernandez-Beros ME,Gonzalez C,McIntosh MA,Cabello FC

更新日期：1989-04-01 00:00:00

abstract：:In this work we immunized mice with DNA encoding full-length Tc52 or its amino- or carboxy-terminal (N- and C-term, respectively) domain carried by attenuated Salmonella as a DNA delivery system. As expected, Salmonella-mediated DNA delivery resulted in low antibody titers and a predominantly Th1 response, as shown by...

journal_title：Infection and immunity

authors： Matos MN,Cazorla SI,Bivona AE,Morales C,Guzmán CA,Malchiodi EL

更新日期：2014-10-01 00:00:00

abstract：:The efficacy of the innate immune system depends on its ability to mount an appropriate response to diverse infections and damaging agents. Key components of this system are pattern recognition receptors that detect pathogen-associated and damage-associated molecular patterns (PAMPs and DAMPs). Nlrp1b is a pattern rec...

journal_title：Infection and immunity

authors： Liao KC,Mogridge J

更新日期：2013-02-01 00:00:00

abstract：:In vitro or animal models have been used to investigate the pathogenesis of Helicobacter pylori infection. However, extrapolation to humans of results obtained with these heterologous models remains difficult. We have developed a new model for the study of H. pylori infection that uses human entire embryonic stomachs ...

journal_title：Infection and immunity

authors： Lozniewski A,Muhale F,Hatier R,Marais A,Conroy MC,Edert D,le Faou A,Weber M,Duprez A

更新日期：1999-04-01 00:00:00

abstract：:A hemolysin that appears to be responsible for the zones of beta-hemolysis surrounding colonies of group B streptococci (Streptococcus agalactiae) on blood agar plates has been isolated and partially purified. No soluble hemolysin was detectable in the supernatants of streptococcal cultures grown in several types of m...

journal_title：Infection and immunity

authors： Marchlewicz BA,Duncan JL

更新日期：1980-12-01 00:00:00

abstract：:Trypanosoma cruzi is a protozoan parasite that can initiate mucosal infection after conjunctival exposure. The anatomical route of T. cruzi invasion and spread after conjunctival parasite contamination remains poorly characterized. In the present work we have identified the sites of initial invasion and replication af...

journal_title：Infection and immunity

authors： Giddings OK,Eickhoff CS,Smith TJ,Bryant LA,Hoft DF

更新日期：2006-10-01 00:00:00

abstract：:Passive transfer of antibody may be useful for preexposure prophylaxis against biological agents used as weapons of terror, such as Bacillus anthracis. Studies were performed to evaluate the ability of anthrax antiprotective antigen (anti-PA) and antilethal factor (anti-LF) neutralizing monoclonal antibodies (mAbs) to...

journal_title：Infection and immunity

authors： Staats HF,Alam SM,Scearce RM,Kirwan SM,Zhang JX,Gwinn WM,Haynes BF

更新日期：2007-11-01 00:00:00

abstract：:Fifteen clinical isolates of Trichomonas vaginalis were evaluated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis with transfer to nitrocellulose and by immunoblots probed with human sera. All T. vaginalis isolates showed similar banding patterns by Coomassie brilliant blue and silver staining of the elec...

journal_title：Infection and immunity

authors： Garber GE,Proctor EM,Bowie WR

更新日期：1986-01-01 00:00:00

abstract：:ZnCl2 over a very narrow concentration range was found to be mitogenic for hamster lymph node cells but not for thymocytes or splenocytes. Maximal leucine, [3H]uridine, and [3H]thymidine incorporation. Addition of 10 micron ZnCl2 was found to greatly enhance the stimulation observed with the B-lymphocyte mitogen lipop...

journal_title：Infection and immunity

authors： Hart DA

更新日期：1978-02-01 00:00:00

abstract：:Changes in periodontal status are associated with shifts in the composition of the bacterial community in the periodontal pocket. The relative abundances of several newly recognized microbial species, including Filifactor alocis, as-yet-unculturable organisms, and other fastidious organisms have raised questions on th...

journal_title：Infection and immunity

authors： Aruni AW,Zhang K,Dou Y,Fletcher H

更新日期：2014-08-01 00:00:00

abstract：:The important veterinary pathogen Clostridium perfringens type B is unique for producing the two most lethal C. perfringens toxins, i.e., epsilon-toxin and beta-toxin. Our recent study (K. Miyamoto, J. Li, S. Sayeed, S. Akimoto, and B. A. McClane, J. Bacteriol. 190:7178-7188, 2008) showed that most, if not all, type B...

journal_title：Infection and immunity

authors： Sayeed S,Li J,McClane BA

更新日期：2010-01-01 00:00:00

abstract：:Since the pH of the gingival crevice increases from below neutrality in health to above pH 8 in disease, we decided to investigate the effect of environmental pH on the growth and enzyme activity of Bacteroides gingivalis W50. Cells were grown in a chemostat under hemin-excess conditions over a range of pH values; sta...

journal_title：Infection and immunity

authors： McDermid AS,McKee AS,Marsh PD

更新日期：1988-05-01 00:00:00

abstract：:Hybridoma cell lines which produced monoclonal antibodies against cholera toxin were isolated. These cell lines were detected with an enzyme-linked immunosorbent assay screening procedure with purified cholera toxin or subunit A of cholera toxin. Seven cell lines were characterized with respect to their reactivity wit...

journal_title：Infection and immunity

authors： Robb M,Nichols JC,Whoriskey SK,Murphy JR

更新日期：1982-10-01 00:00:00