Use of a monoclonal antibody to determine the mode of transmembrane pore formation by streptolysin O.

abstract：:The development of immunoglobulin-containing cells and antigen-specific plasma cells in retropharyngeal and bronchial lymph nodes, in lung tissue, and in nasal mucous membrane was followed during an experimental infection of pigs with Mycoplasma hyopneumoniae. An enzyme-linked immunosorbent assay was used to follow st...

journal_title：Infection and immunity

authors： Suter M,Kobisch M,Nicolet J

更新日期：1985-09-01 00:00:00

abstract：:The outcome of infection is determined by both the quantity and the quality of an induced immune response. In particular, it has been demonstrated for selected pathogens that induction of TH1 or TH2 type helper T-cell subsets determines whether an immune response gives rise to protective immunity or disease-associated...

journal_title：Infection and immunity

authors： Westbay TD,Dascher CC,Hsia RC,Zauderer M,Bavoil PM

更新日期：1995-04-01 00:00:00

abstract：:The kinetics of attachment and ingestion of Chlamydia trachomatis serotype L1 by monolayers of McCoy cells were studied by using a method that discriminated between attachment and uptake. When about 1% of the McCoy cells was infected, the proteinase K-resistant chlamydial fraction, regarded as ingested chlamydiae, rea...

journal_title：Infection and immunity

authors： Söderlund G,Kihlström E

更新日期：1983-12-01 00:00:00

abstract：:Antibodies to Escherichia coli O and K antigens were raised in rabbits by repeated immunizations with whole, Formalin-killed and, later, liver bacteria. The serum antibody levels were determined with the ammonium sulfate precipitation technique after radioiodinating the antigens. The K antigens had to be conjugated to...

journal_title：Infection and immunity

authors： Kaijser B,Ahlstedt S

更新日期：1977-08-01 00:00:00

abstract：:The interferon-inducing capabilities of the three molecular segments of bacteriophage phi6 double-stranded ribonucleic acid increased with increasing molecular weight. ...

journal_title：Infection and immunity

authors： Kleinschmidt WJ,Van Etten JL,Vidaver AK

更新日期：1974-07-01 00:00:00

abstract：:In 2001, a bioterrorism attack involving Bacillus anthracis spore-laced letters resulted in 22 cases of inhalation anthrax, with five fatalities. This incident identified gaps in our health care system and precipitated a renewed interest in identifying both therapeutics and rapid diagnostic assays. To address those ga...

journal_title：Infection and immunity

authors： Rossi CA,Ulrich M,Norris S,Reed DS,Pitt LM,Leffel EK

更新日期：2008-12-01 00:00:00

abstract：:Yersinia pestis, the causative agent of plague, autoaggregates within a few minutes of cessation of shaking when grown at 28 degrees C. To identify the autoaggregation factor of Y. pestis, we performed mariner-based transposon mutagenesis. Autoaggregation-defective mutants from three different pools were identified, e...

journal_title：Infection and immunity

authors： Felek S,Muszyński A,Carlson RW,Tsang TM,Hinnebusch BJ,Krukonis ES

更新日期：2010-03-01 00:00:00

abstract：:Legionella pneumophila is the predominant cause of Legionnaires' disease in the United States and Europe, while Legionella longbeachae is the common cause of the disease in Western Australia. Although clinical manifestations by both intracellular pathogens are very similar, recent studies have shown that phagosome bio...

journal_title：Infection and immunity

authors： Asare R,Santic M,Gobin I,Doric M,Suttles J,Graham JE,Price CD,Abu Kwaik Y

更新日期：2007-04-01 00:00:00

abstract：:Borrelia burgdorferi elicits a potent cytokine response through activation of multiple signaling receptors on innate immune cells. Spirochetal lipoproteins initiate expression of NF-κB-dependent cytokines primarily via TLR2, whereas type I interferon (IFN) production is induced through the endosomal receptors TLR7 and...

journal_title：Infection and immunity

authors： Love AC,Schwartz I,Petzke MM

更新日期：2014-06-01 00:00:00

abstract：:The rate of clearance of Vibrio fetus var. venerealis was measured by using in vivo and in vitro methods. The rate of clearance from the circulating blood increased in immune rabbits and reached a plateau 4 days after immunization. Thereafter in vivo clearance did not increase further despite rising agglutinin titers....

journal_title：Infection and immunity

authors： Carrier SP,Kramer TT

更新日期：1971-06-01 00:00:00

abstract：:Tubercle bacilli failed to grow in iron-void media enriched with solutions of iron-containing transferrin (Tr) or ferritin (F) because these substances do not provide the bacilli with iron, which is essential for their growth. Animal serum and macrophages possessed no iron carrier with an ability to satisfy the need o...

journal_title：Infection and immunity

authors： Golden CA,Kochan I,Spriggs DR

更新日期：1974-01-01 00:00:00

abstract：:A monoclonal antibody (MAb) was raised against Shiga toxin 2 (Stx2) of Escherichia coli O157:H7. MAb VTm1.1 belonged to the immunoglobulin G1 subclass and had a kappa light chain, and it could neutralize the cytotoxic activity of Stx2 and variants derived from patient strains but not that of variants derived from anim...

journal_title：Infection and immunity

authors： Nakao H,Kiyokawa N,Fujimoto J,Yamasaki S,Takeda T

更新日期：1999-11-01 00:00:00

abstract：:The literature on chronic mucocutaneous candidiasis contains multiple reports which suggest that loss of cell-mediated immunity in this disease may be related in part to the presence of an inhibitory factor(s) present in patient plasma. One such inhibitory factor has been suggested to be mannan polysaccharide released...

journal_title：Infection and immunity

authors： Nelson RD,Herron MJ,McCormack RT,Gehrz RC

更新日期：1984-03-01 00:00:00

abstract：:The adherence of Treponema denticola GM-1, TD-4, and MS25 to human gingival fibroblasts (HGFs) was studied to serve as an introduction to investigations into the interactions of these oral bacteria with human host cells. Under both aerobic (5% CO2) and anaerobic (85% N2 plus 10% H2 plus 5% CO2) environments, the inter...

journal_title：Infection and immunity

authors： Weinberg A,Holt SC

更新日期：1990-06-01 00:00:00

abstract：:Attaching and effacing adhesion to epithelial cells is a pathognomonic feature of infection by both enteropathogenic Escherichia coli (EPEC) and certain strains of verocytotoxin-producing E. coli (VTEC). EPEC adhesion to tissue culture epithelial cells results in activation of the phosphatidylinositol pathway, with el...

journal_title：Infection and immunity

authors： Ismaili A,Philpott DJ,Dytoc MT,Sherman PM

更新日期：1995-09-01 00:00:00

abstract：:The oral streptococcal group (mitis phylogenetic group) currently consists of nine recognized species, although the group has been traditionally difficult to classify, with frequent changes in nomenclature over the years. The pneumococcus (Streptococcus pneumoniae), an important human pathogen, is traditionally distin...

journal_title：Infection and immunity

authors： Whatmore AM,Efstratiou A,Pickerill AP,Broughton K,Woodard G,Sturgeon D,George R,Dowson CG

更新日期：2000-03-01 00:00:00

abstract：:Current evidence indicates that Mycobacterium avium infection in patients with AIDS is acquired mostly through the gastrointestinal (GI) tract and that M. avium binds to and invades GI mucosal cells in vitro. Since M. avium is exposed to specific environmental conditions in the GI tract such as changes in pH, low oxyg...

journal_title：Infection and immunity

authors： Bermudez LE,Petrofsky M,Goodman J

更新日期：1997-09-01 00:00:00

abstract：:An immunoregulatory mechanism involving release of neutralizing autoantibodies (Aabs) to self cytokines during bacterial infections is presented herein. Intraperitoneal inoculation of Haemophilus influenzae type b into Sprague-Dawley rats resulted in a self-limiting meningitis. High levels of cells expressing mRNA for...

journal_title：Infection and immunity

authors： Bakhiet M,Diab A,Mahamustafa,Jiezhu,Lindqvist L,Link H

更新日期：1997-08-01 00:00:00

abstract：:Groups of specific pathogen-free Hartley strain guinea pigs were vaccinated with viable Mycobacterium bovis BCG and maintained on isocaloric purified diets containing either 30 or 10% protein (ovalbumin) combined with either 50 ppm (microgram/g) or no added zinc. Seven weeks later the guinea pigs were skin tested with...

journal_title：Infection and immunity

authors： McMurray DN,Yetley EA

更新日期：1983-02-01 00:00:00

abstract：:Invasive aspergillosis is a major threat for patients suffering from chronic granulomatous disease (CGD). Although Aspergillus fumigatus is the most commonly encountered Aspergillus species, the presence of A. nidulans appears to be disproportionately high in CGD patients. The purpose of this study was to investigate ...

journal_title：Infection and immunity

authors： Henriet SS,Hermans PW,Verweij PE,Simonetti E,Holland SM,Sugui JA,Kwon-Chung KJ,Warris A

更新日期：2011-02-01 00:00:00

abstract：:In this work, apolipoprotein A-I (ApoA-I) was purified from pig sera. The responses of this protein after sterile inflammation and in animals infected with Actinobacillus pleuropneumoniae or Streptococcus suis were investigated. Decreases in the concentrations of ApoA-I, two to five times lower than the initial values...

journal_title：Infection and immunity

authors： Carpintero R,Piñeiro M,Andrés M,Iturralde M,Alava MA,Heegaard PM,Jobert JL,Madec F,Lampreave F

更新日期：2005-05-01 00:00:00

abstract：:Ers has been qualified as the PrfA-like transcriptional regulator of Enterococcus faecalis. In a previous study we reported that Ers is important for the survival within macrophages of this opportunist pathogenic bacterium. In the present work we have used proteomic and microarray expression profiling of E. faecalis J...

journal_title：Infection and immunity

authors： Riboulet-Bisson E,Sanguinetti M,Budin-Verneuil A,Auffray Y,Hartke A,Giard JC

更新日期：2008-07-01 00:00:00

abstract：:Scrub typhus is a potentially lethal infection that is caused by the obligate intracellular bacterium Orientia tsutsugamushi The roles of Toll-like receptor 2 (TLR2) and TLR4 in innate recognition of O. tsutsugamushi have not been elucidated. By overexpression of TLR2 or TLR4 in HEK293 cells, we demonstrated that TLR2...

journal_title：Infection and immunity

authors： Gharaibeh M,Hagedorn M,Lilla S,Hauptmann M,Heine H,Fleischer B,Keller C

更新日期：2016-11-18 00:00:00

abstract：:The immunogenic and adjuvant properties of Brucella abortus and Escherichia coli lipopolysaccharides (LPSs) were studied in endotoxin-responsive, athymic, and euthymic BALB/c mice and in responsive C3H/HeAu mice and congenic nonresponsive C3H/HeJ mice. Consistent with previous reports, E. coli LPS did not stimulate si...

journal_title：Infection and immunity

authors： Moreno E,Kurtz RS,Berman DT

更新日期：1984-10-01 00:00:00

abstract：:Lipopolysaccharide (LPS) binding protein (LBP) is an acute-phase protein that enhances the responsiveness of immune cells to LPS by virtue of its capacity to transfer LPS to CD14. To determine the role of LBP in the innate immune response to peritonitis, LBP gene-deficient (LBP(-/-)) and normal wild-type mice were int...

journal_title：Infection and immunity

authors： Knapp S,de Vos AF,Florquin S,Golenbock DT,van der Poll T

更新日期：2003-12-01 00:00:00

abstract：:Streptococcus suis serotype 2 is an encapsulated bacterium and one of the most important bacterial pathogens in the porcine industry. Despite decades of research for an efficient vaccine, none is currently available. Based on the success achieved with other encapsulated pathogens, a glycoconjugate vaccine strategy was...

journal_title：Infection and immunity

authors： Goyette-Desjardins G,Calzas C,Shiao TC,Neubauer A,Kempker J,Roy R,Gottschalk M,Segura M

更新日期：2016-06-23 00:00:00

abstract：:Trefoil family factor 2 (TFF2), also known as spasmolytic peptide, is a low-molecular-weight protein that is upregulated in gastric tissues infected with Helicobacter or having other inflammatory conditions, but a precise function is yet to be elucidated. The role of TFF2 in the development of gastritis, colitis, and ...

journal_title：Infection and immunity

authors： Kurt-Jones EA,Cao L,Sandor F,Rogers AB,Whary MT,Nambiar PR,Cerny A,Bowen G,Yan J,Takaishi S,Chi AL,Reed G,Houghton J,Fox JG,Wang TC

更新日期：2007-01-01 00:00:00

abstract：:EspG is a conserved protein encoded by the locus of enterocyte effacement (LEE) of attaching and effacing (A/E) pathogens, including enteropathogenic and enterohemorrhagic Escherichia coli and Citrobacter rodentium. EspG is delivered into infected host cells by a type III secretion system. The role of EspG in virulenc...

journal_title：Infection and immunity

authors： Hardwidge PR,Deng W,Vallance BA,Rodriguez-Escudero I,Cid VJ,Molina M,Finlay BB

更新日期：2005-05-01 00:00:00

abstract：:Anaplasma marginale subsp. centrale was the first vaccine used to protect against a rickettsial disease and is still in widespread use a century later. As its use preceded development of either cryopreservation or cell culture, the vaccine strain was maintained for decades by sequential passage among donor animals, ex...

journal_title：Infection and immunity

authors： Herndon DR,Ueti MW,Reif KE,Noh SM,Brayton KA,Agnes JT,Palmer GH

更新日期：2013-05-01 00:00:00

abstract：:The effect of indomethacin on the net intestinal accumulation of fluid induced by Escherichia coli heat-stable (ST) enterotoxin in the infant mouse model was examined. Indomethacin, when administered with ST enterotoxin, caused a striking decrease in net intestinal fluid accumulation. This inhibition of ST activity wa...

journal_title：Infection and immunity

authors： Madsen GL,Knoop FC

更新日期：1978-10-01 00:00:00