Protection against Streptococcus suis Serotype 2 Infection Using a Capsular Polysaccharide Glycoconjugate Vaccine.

abstract：:We have shown that a member of the 70-kDa heat shock protein (Hsp70) family is a major target of the humoral immune response during Leishmania donovani infection. A recombinant fusion protein was recognized by sera from 92% (35 of 38) of patients with visceral leishmaniasis, including representatives from each of the ...

journal_title：Infection and immunity

authors： Wallace GR,Ball AE,MacFarlane J,el Safi SH,Miles MA,Kelly JM

更新日期：1992-07-01 00:00:00

abstract：:Helicobacter pylori mutants deficient in 6-phosphogluconate dehydratase (6PGD) were constructed. Colonization densities were lower and minimum infectious doses were higher for mutant strains than for wild-type strains. In spite of better colonization, however, wild-type strains did not displace the mutant in cocoloniz...

journal_title：Infection and immunity

authors： Wanken AE,Conway T,Eaton KA

更新日期：2003-05-01 00:00:00

abstract：:The regulation of innate immune responses to pathogens occurs through the interaction of Toll-like receptors (TLRs) with pathogen-associated molecular patterns and the activation of several signaling pathways whose contribution to the overall innate immune response to pathogens is poorly understood. We demonstrate a m...

journal_title：Infection and immunity

authors： Izadi H,Motameni AT,Bates TC,Olivera ER,Villar-Suarez V,Joshi I,Garg R,Osborne BA,Davis RJ,Rincón M,Anguita J

更新日期：2007-10-01 00:00:00

abstract：:We have identified a Crp/Fnr-like transcriptional regulator of Streptococcus pyogenes that when inactivated attenuates virulence. The gene, named srv for streptococcal regulator of virulence, encodes a 240-amino-acid protein with 53% amino acid similarity to PrfA, a transcriptional activator of virulence in Listeria m...

journal_title：Infection and immunity

authors： Reid SD,Montgomery AG,Musser JM

更新日期：2004-03-01 00:00:00

abstract：:Enterohemorrhagic Escherichia coli (EHEC) is a noninvasive food-borne pathogen that colonizes the distal ileum and colon. Proteins encoded in the EHEC locus of enterocyte effacement (LEE) pathogenicity island are known to contribute to this pathogen's adherence to epithelial cells and intestinal colonization. The role...

journal_title：Infection and immunity

authors： Ho TD,Davis BM,Ritchie JM,Waldor MK

更新日期：2008-05-01 00:00:00

abstract：:Deoxyribonucleic acid (DNA) base composition, as measured by guanine plus cytosine (G + C) content, was determined in 17 strains of Sporothrix schenckii and Ceratocystis species. The average G + C content for S. schenckii was 54.7 +/- 0.2 mol%. No strain of Ceratocystis, with the exception of C. minor, gave values for...

journal_title：Infection and immunity

authors： Mendonça-Hagler LC,Travassos LR,Lloyd KO,Phaff HJ

更新日期：1974-05-01 00:00:00

abstract：:Cyclic dimeric GMP (c-di-GMP), a bacterial second messenger, is known to regulate bacterial biofilm and sessility. Replication of an obligatory intracellular pathogen, Ehrlichia chaffeensis, is characterized by formation of bacterial aggregates called morulae inside membrane-bound inclusions. When E. chaffeensis matur...

journal_title：Infection and immunity

authors： Kumagai Y,Matsuo J,Cheng Z,Hayakawa Y,Rikihisa Y

更新日期：2011-10-01 00:00:00

abstract：:Interleukin-10 (IL-10)-producing B cells (B10 cells) play a critical role in the immune system balance by negatively regulating inflammatory responses. This study was conducted to determine the effect of local B10 cell induction on periodontal inflammation and bone loss in ligature-induced experimental periodontitis i...

journal_title：Infection and immunity

authors： Yu P,Hu Y,Liu Z,Kawai T,Taubman MA,Li W,Han X

更新日期：2016-12-29 00:00:00

abstract：:Staphylococcus aureus nitric oxide synthase (saNOS) is a major contributor to virulence, stress resistance, and physiology, yet the specific mechanism(s) by which saNOS intersects with other known regulatory circuits is largely unknown. The SrrAB two-component system, which modulates gene expression in response to the...

journal_title：Infection and immunity

authors： James KL,Mogen AB,Brandwein JN,Orsini SS,Ridder MJ,Markiewicz MA,Bose JL,Rice KC

更新日期：2019-01-24 00:00:00

abstract：:The toxicity of Chlamydia trachomatis was studied with mouse peritoneal macrophage culture. Inoculation of 30 inclusion-forming units of trachoma B/TW-5/OT organisms and 250 inclusion-forming units of lymphogranuloma venereum L2/434/Bu organisms per cell caused immediated toxicity, with the killing of 40 to 90% of the...

journal_title：Infection and immunity

authors： Kuo CC

更新日期：1978-06-01 00:00:00

abstract：:Antimicrobial peptides play an important role in host defense against Vibrio cholerae Generally, the V. cholerae O1 classical biotype is polymyxin B (PB) sensitive and El Tor is relatively resistant. Detection of classical biotype traits like the production of classical cholera toxin and PB sensitivity in El Tor strai...

journal_title：Infection and immunity

authors： Samanta P,Mandal RS,Saha RN,Shaw S,Ghosh P,Dutta S,Ghosh A,Imamura D,Morita M,Ohnishi M,Ramamurthy T,Mukhopadhyay AK

更新日期：2020-04-20 00:00:00

abstract：:We have cloned and sequenced the d15 gene from two strains of Haemophilus influenzae type b (Hib) and two strains of nontypeable H. influenzae (NTHI). The nucleotide and deduced protein sequences of d15 are highly conserved, with only a small variable region identified near the carboxyl terminus of the protein. Analys...

journal_title：Infection and immunity

authors： Loosmore SM,Yang YP,Coleman DC,Shortreed JM,England DM,Klein MH

更新日期：1997-09-01 00:00:00

abstract：:Actinomyces naeslundii and Streptococcus gordonii, oral bacteria that possess Gal/GalNAc- and sialic acid-reactive lectins, respectively, were adherent to immobilized secretory immunoglobulin A (IgA) and two IgA1 myeloma proteins but not to two IgA2 myeloma proteins. Apparently, O-linked oligosaccharides at the hinge ...

journal_title：Infection and immunity

authors： Ruhl S,Sandberg AL,Cole MF,Cisar JO

更新日期：1996-12-01 00:00:00

abstract：:While several diseases associated with Chlamydia psittaci infection have been reported in Phascolarctos cinereus (koala), it is still unclear whether one or more chlamydial strains are responsible. In this study, we provide evidence, obtained by restriction enzyme and gene probe analysis, that two quite distinct strai...

journal_title：Infection and immunity

authors： Girjes AA,Hugall AF,Timms P,Lavin MF

更新日期：1988-08-01 00:00:00

abstract：:Acquisition of immunity to Plasmodium falciparum sexual stages is a key determinant for reducing human-mosquito transmission by preventing the fertilization and the development of the parasite in the mosquito midgut. Naturally acquired immunity against sexual stages may therefore form the basis for the development of ...

journal_title：Infection and immunity

authors： Ouédraogo AL,Roeffen W,Luty AJ,de Vlas SJ,Nebie I,Ilboudo-Sanogo E,Cuzin-Ouattara N,Teleen K,Tiono AB,Sirima SB,Verhave JP,Bousema T,Sauerwein R

更新日期：2011-12-01 00:00:00

abstract：:The zoopathogenic fungus Histoplasma capsulatum requires iron for growth. Intracellular growth of the fungus within mouse peritoneal macrophages is inhibited by recombinant murine gamma interferon (IFN-gamma). Such treatment of mouse peritoneal macrophages induces a marked downshift in transferrin receptors. We tested...

journal_title：Infection and immunity

authors： Lane TE,Wu-Hsieh BA,Howard DH

更新日期：1991-07-01 00:00:00

abstract：:The glucosyltransferases (GTFs) of viridans streptococci, common pathogens of infective endocarditis, are extracellular proteins that convert sucrose into exopolysaccharides and glucans. GTFs B, C, and D of Streptococcus mutans are modulins that induce, in vitro and in vivo, the production of cytokines, in particular ...

journal_title：Infection and immunity

authors： Shun CT,Lu SY,Yeh CY,Chiang CP,Chia JS,Chen JY

更新日期：2005-06-01 00:00:00

abstract：:Human galectin-3 binds to the surface of Trypanosoma cruzi trypomastigotes and human coronary artery smooth muscle (CASM) cells. CASM cells express galectin-3 on their surface and secrete it. Exogenous galectin-3 increased the binding of T. cruzi to CASM cells. Trypanosome binding to CASM cells was enhanced when eithe...

journal_title：Infection and immunity

authors： Kleshchenko YY,Moody TN,Furtak VA,Ochieng J,Lima MF,Villalta F

更新日期：2004-11-01 00:00:00

abstract：:The disruption of a specific gene in Candida albicans is commonly used to determine the function of the gene product. We disrupted AAF1, a gene of C. albicans that causes Saccharomyces cerevisiae to flocculate and adhere to endothelial cells. We then characterized multiple heterozygous and homozygous mutants. These nu...

journal_title：Infection and immunity

authors： Rieg G,Fu Y,Ibrahim AS,Zhou X,Filler SG,Edwards JE Jr

更新日期：1999-07-01 00:00:00

abstract：:Pneumonic plague, caused by inhalation of Yersinia pestis, represents a major bioterrorism threat for which no vaccine is available. Based on the knowledge that genetic delivery of monoclonal antibodies (MAbs) with adenovirus (Ad) gene transfer vectors results in rapid, high-level antibody expression, we evaluated the...

journal_title：Infection and immunity

authors： Sofer-Podesta C,Ang J,Hackett NR,Senina S,Perlin D,Crystal RG,Boyer JL

更新日期：2009-04-01 00:00:00

abstract：:Host-adapted Gram-negative bacterial pathogens from the Pasteurellaceae, Neisseriaceae, and Moraxellaceae families normally reside in the upper respiratory or genitourinary tracts of their hosts and rely on utilizing iron from host transferrin (Tf) for growth and survival. The surface receptor proteins that mediate th...

journal_title：Infection and immunity

authors： Frandoloso R,Martínez-Martínez S,Calmettes C,Fegan J,Costa E,Curran D,Yu RH,Gutiérrez-Martín CB,Rodríguez-Ferri EF,Moraes TF,Schryvers AB

更新日期：2015-03-01 00:00:00

abstract：:Herein we characterized various genetic markers and the biological behavior of a natural recombinant strain of Toxoplasma gondii (P-Br). From nine genetic markers analyzed, three (B1, ROP1, and SAG1) and three (cS10-A6, GRA6, and SAG3) markers belong to parasites from the type I and type III lineages, respectively. Th...

journal_title：Infection and immunity

authors： Fux B,Rodrigues CV,Portela RW,Silva NM,Su C,Sibley D,Vitor RW,Gazzinelli RT

更新日期：2003-11-01 00:00:00

abstract：:Salmonella enterica serovar Enteritidis (S. Enteritidis) is a major etiologic agent of nontyphoid salmonellosis in the United States. S. Enteritidis persistently and silently colonizes the intestinal and reproductive tract of laying hens, resulting in contaminated poultry products. The consumption of contaminated poul...

journal_title：Infection and immunity

authors： McKelvey JA,Yang M,Jiang Y,Zhang S

更新日期：2014-12-01 00:00:00

abstract：:Cell-mediated immunity is critical in host resistance against the pathogenic fungus Histoplasma capsulatum. To explore the role of L3T4+ T cells in protection of mice against H. capsulatum infection, we examined the effect of in vivo treatment with anti-L3T4 monoclonal antibody (MAb) GK1.5 on the course of murine diss...

journal_title：Infection and immunity

authors： Gomez AM,Bullock WE,Taylor CL,Deepe GS Jr

更新日期：1988-07-01 00:00:00

abstract：:Rabbit-specific enteropathogenic Escherichia coli (REPEC) is an attaching and effacing pathogen of young rabbits. Using signature-tagged mutagenesis, we identified several known colonization factors of REPEC as well as a gene predicted to encode a novel autotransporter protein. This novel gene was termed rpeA for REPE...

journal_title：Infection and immunity

authors： Leyton DL,Adams LM,Kelly M,Sloan J,Tauschek M,Robins-Browne RM,Hartland EL

更新日期：2007-09-01 00:00:00

abstract：:Antigen preparations derived from Plasmodium falciparum-infected erythrocytes (but not from uninfected erythrocytes) can stimulate the in vitro proliferation of peripheral blood lymphocytes from malaria-sensitized as well as nonsensitized donors. The possibility that the nonspecific responses might be due to a parasit...

journal_title：Infection and immunity

authors： Wyler DJ,Herrod HG,Weinbaum FI

更新日期：1979-04-01 00:00:00

abstract：:Internalization of Staphylococcus aureus in bovine endothelial cells (BEC) is increased by tumor necrosis factor alpha stimulation and NF-κB activation. Because the phosphoinositide-3-kinase (PI3K)-Akt signaling pathway also modulates NF-κB activity, we considered whether the internalization of S. aureus by BEC is ass...

journal_title：Infection and immunity

authors： Oviedo-Boyso J,Cortés-Vieyra R,Huante-Mendoza A,Yu HB,Valdez-Alarcón JJ,Bravo-Patiño A,Cajero-Juárez M,Finlay BB,Baizabal-Aguirre VM

更新日期：2011-11-01 00:00:00

abstract：:Seven cathepsin B-like cysteine proteases (CBLs) were identified from the immunoprotective excretory-secretory products of Haemonchus contortus. Two-dimensional (2-D) zymography and biotinylated inhibitors were employed to localize active CBLs in 2-D protein gels. Mass spectrometry provided the identification of AC-4,...

journal_title：Infection and immunity

authors： Yatsuda AP,Bakker N,Krijgsveld J,Knox DP,Heck AJ,de Vries E

更新日期：2006-03-01 00:00:00

abstract：:We investigated the effects of peripheral blood mononuclear cells expanded with irrelevant control and mycobacterial antigens on the intracellular growth of Mycobacterium bovis bacillus Calmette-Guérin (BCG) in human macrophages. More than 90% of the cells present after 1 week of in vitro expansion were CD3(+). T cell...

journal_title：Infection and immunity

authors： Worku S,Hoft DF

更新日期：2003-04-01 00:00:00

abstract：:No effective therapy exists for Cryptosporidium parvum, a coccidial protozoan parasite that causes severe diarrhea in patients with AIDS. The role of microtubules in parasite invasion of host cells was investigated by incubating 10(7) oocysts with a HT 29.74 cell line for 24 h in the presence of microtubule-disrupting...

journal_title：Infection and immunity

authors： Wiest PM,Johnson JH,Flanigan TP

更新日期：1993-11-01 00:00:00