Abstract:
:Human galectin-3 binds to the surface of Trypanosoma cruzi trypomastigotes and human coronary artery smooth muscle (CASM) cells. CASM cells express galectin-3 on their surface and secrete it. Exogenous galectin-3 increased the binding of T. cruzi to CASM cells. Trypanosome binding to CASM cells was enhanced when either T. cruzi or CASM cells were preincubated with galectin-3. Cells stably transfected with galectin-3 antisense show a dramatic decrease in galectin-3 expression and very little T. cruzi adhesion to cells. The addition of galectin-3 to these cells restores their initial capacity to bind to trypanosomes. Thus, host galectin-3 expression is required for T. cruzi adhesion to human cells and exogenous galectin-3 enhances this process, leading to parasite entry.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Kleshchenko YY,Moody TN,Furtak VA,Ochieng J,Lima MF,Villalta Fdoi
10.1128/IAI.72.11.6717-6721.2004keywords:
subject
Has Abstractpub_date
2004-11-01 00:00:00pages
6717-21issue
11eissn
0019-9567issn
1098-5522pii
72/11/6717journal_volume
72pub_type
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journal_title:Infection and immunity
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