Abstract:
:The zoopathogenic fungus Histoplasma capsulatum requires iron for growth. Intracellular growth of the fungus within mouse peritoneal macrophages is inhibited by recombinant murine gamma interferon (IFN-gamma). Such treatment of mouse peritoneal macrophages induces a marked downshift in transferrin receptors. We tested whether the antihistoplasma effect of IFN-gamma-treated macrophages is the result of iron deprivation. Treatment of mouse peritoneal macrophages with the intracellular iron chelator deferoxamine inhibits the intracellular growth of H. capsulatum. Exposure of macrophages to holotransferrin antagonizes the effect of both recombinant murine IFN-gamma and deferoxamine treatments. These results suggest that iron restriction may be one of the bases for the IFN-gamma-induced antihistoplasma effect of mouse macrophages.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Lane TE,Wu-Hsieh BA,Howard DHdoi
10.1128/IAI.59.7.2274-2278.1991subject
Has Abstractpub_date
1991-07-01 00:00:00pages
2274-8issue
7eissn
0019-9567issn
1098-5522journal_volume
59pub_type
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journal_title:Infection and immunity
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1990-06-01 00:00:00
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pub_type: 杂志文章
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