Recognition of immunoglobulin A1 by oral actinomyces and streptococcal lectins.

abstract：:Actinobacillus actinomycetemcomitans SUNY 465, the invasion prototype strain, enters epithelial cells by an actin-dependent mechanism, escapes from the host cell vacuole, and spreads intracellularly and to adjacent epithelial cells via intercellular protrusions. Internalized organisms also egress from host cells into ...

journal_title：Infection and immunity

authors： Meyer DH,Rose JE,Lippmann JE,Fives-Taylor PM

更新日期：1999-12-01 00:00:00

abstract：:Escherichia coli O157:H7, a major Shiga toxin-producing pathogen, has a low infectious dose and causes serious illness in humans. The gastrointestinal tract of cattle is the primary reservoir of E. coli O157:H7, and thus, it is critical to eliminate or reduce E. coli O157:H7 gut colonization. Given that E. coli O157:H...

journal_title：Infection and immunity

authors： Xue Y,Zhang H,Wang H,Hu J,Du M,Zhu MJ

更新日期：2014-05-01 00:00:00

abstract：:Chronic lung infections with Pseudomonas aeruginosa biofilms are associated with refractory and fatal pneumonia in cystic fibrosis (CF). In this study, a group of genomically diverse P. aeruginosa isolates were compared with the reference strain PAO1 to assess the roles of motility, twitching, growth rate, and overpro...

journal_title：Infection and immunity

authors： Head NE,Yu H

更新日期：2004-01-01 00:00:00

abstract：:Isoelectric focusing and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) with acrylamide copolymerized with gelatin (substrate-SDS-PAGE) were combined to evaluate the proteinases of both long-term-grown and fresh isolates of Trichomonas vaginalis. This two-dimensional substrate-SDS-PAGE resolved a...

journal_title：Infection and immunity

authors： Neale KA,Alderete JF

更新日期：1990-01-01 00:00:00

abstract：:We have previously demonstrated that fibronectin mediates streptococcal adhesion to host cells and that streptococci interact primarily with the N-terminal domain of fibronectin. FBP54 is a 54-kDa protein from group A streptococci that binds fibronectin. In this report, we show that the N-terminal domain of fibronecti...

journal_title：Infection and immunity

authors： Courtney HS,Dale JB,Hasty DI

更新日期：1996-07-01 00:00:00

abstract：:Shiga toxigenic Escherichia coli (STEC) strains are a diverse group of organisms capable of causing severe gastrointestinal disease in humans. Within the STEC family, eae-positive STEC strains, particularly those belonging to serogroups O157 and O111, appear to have greater virulence for humans. However, in spite of b...

journal_title：Infection and immunity

authors： Paton AW,Paton JC

更新日期：1999-11-01 00:00:00

abstract：:The fibronectin-binding proteins (FnBPs) of Staphylococcus aureus are believed to be implicated in the pathogen's adherence to and colonization of bovine mammary glands, thus leading to infectious mastitis. In vitro studies have shown that FnBPs help the adhesion of the pathogen to bovine mammary epithelial cells. How...

journal_title：Infection and immunity

authors： Brouillette E,Talbot BG,Malouin F

更新日期：2003-04-01 00:00:00

abstract：:Immunologically competent mice and mice with defined immunological deficiencies were infected with Plasmodium yoelii. Splenomegaly, enhanced phagocytosis, and anemia were most marked in infected mice having intact thymic tissue. Whereas the spleens of infected nude mice increased minimally in size, the relative blood ...

journal_title：Infection and immunity

authors： Roberts DW,Weidanz WP

更新日期：1978-06-01 00:00:00

abstract：:We found that serum samples from patients with different clinical forms of American cutaneous leishmaniasis (ACL) contained immunoglobulin G and immunoglobulin M antibodies which reacted with laminin but not with various other purified connective tissue components, such as collagen types I, III, IV, and V and fibronec...

journal_title：Infection and immunity

authors： Avila JL,Rojas M,Rieber M

更新日期：1984-01-01 00:00:00

abstract：:The interferon-inducing capabilities of the three molecular segments of bacteriophage phi6 double-stranded ribonucleic acid increased with increasing molecular weight. ...

journal_title：Infection and immunity

authors： Kleinschmidt WJ,Van Etten JL,Vidaver AK

更新日期：1974-07-01 00:00:00

abstract：:The effects of pathologically relevant concentrations (0.38 to 12.5 microM) of the proinflammatory, Pseudomonas aeruginosa-derived pigment 1-hydroxyphenazine (1-hp) on Ca2+ metabolism and intracellular cyclic AMP (cAMP) in N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP; 1 microM)-activated human neutrophils, as w...

journal_title：Infection and immunity

authors： Ramafi G,Anderson R,Theron A,Feldman C,Taylor GW,Wilson R,Cole PJ

更新日期：1999-10-01 00:00:00

abstract：:Q fever has been associated with granulomatous changes in clinical biopsy material obtained from liver and bone marrow. Local reactions to skin testing have been described in previously sensitized humans, but histological studies of such reactions have not been reported. We note that delayed hypersensitivity reactions...

journal_title：Infection and immunity

authors： Ascher MS,Berman MA,Parker D,Turk JL

更新日期：1983-01-01 00:00:00

abstract：:The development of a vaccine is essential for the elimination of malaria. However, despite many years of effort, a successful vaccine has not been achieved. Most subunit vaccine candidates tested in clinical trials have provided limited efficacy, and thus attenuated whole-parasite vaccines are now receiving close scru...

journal_title：Infection and immunity

authors： Raja AI,Cai Y,Reiman JM,Groves P,Chakravarty S,McPhun V,Doolan DL,Cockburn I,Hoffman SL,Stanisic DI,Good MF

更新日期：2016-07-21 00:00:00

abstract：:The Lyme disease spirochete Borrelia burgdorferi reduces the expression of outer surface protein C (OspC) in response to the development of an anti-OspC humoral response, leading to the hypothesis that the ability to repress OspC expression is critical for the pathogen to proceed to chronic infection. B. burgdorferi w...

journal_title：Infection and immunity

authors： Xu Q,Seemanapalli SV,McShan K,Liang FT

更新日期：2006-09-01 00:00:00

abstract：:The pattern of meningococcal surface structure expression in different microenvironments following bloodstream invasion in vivo is not known. We used immunohistochemistry to determine the expression of capsule, type IV pili, and PorA by meningococci residing in the skin lesions of children with purpura fulminans. All ...

journal_title：Infection and immunity

authors： Harrison OB,Robertson BD,Faust SN,Jepson MA,Goldin RD,Levin M,Heyderman RS

更新日期：2002-09-01 00:00:00

abstract：:The gastric pathogen helicobacter pylori is one of a number of bacteria which bind specifically to gangliotetraosylceramide, gangliotriaosylceramide, and phosphatidylethanolamine in vitro at neutral pH. Since this organism encounters an acid pH during initial infection of the stomach, we have monitored the effect of p...

journal_title：Infection and immunity

authors： Huesca M,Borgia S,Hoffman P,Lingwood CA

更新日期：1996-07-01 00:00:00

abstract：:Major research efforts are directed towards the development of a better antimycobacterial vaccine. But progress in the field of tuberculosis vaccine development has been hampered by the lack of human in vitro models to assess vaccine immunogenicity and efficacy. New candidate vaccines will have to be evaluated against...

journal_title：Infection and immunity

authors： Kampmann B,Tena GN,Mzazi S,Eley B,Young DB,Levin M

更新日期：2004-11-01 00:00:00

abstract：:Pathogenic leptospires have the ability to survive and disseminate to multiple organs after penetrating the host. Several pathogens, including spirochetes, have been shown to express surface proteins that interact with the extracellular matrix (ECM). This adhesin-mediated binding process seems to be a crucial step in ...

journal_title：Infection and immunity

authors： Barbosa AS,Abreu PA,Neves FO,Atzingen MV,Watanabe MM,Vieira ML,Morais ZM,Vasconcellos SA,Nascimento AL

更新日期：2006-11-01 00:00:00

abstract：:The hydrolysis of urea by ureases of oral bacteria in dental plaque can cause a considerable increase in plaque pH, which can inhibit the development of dental caries. There is also indirect evidence that urea metabolism may promote the formation of calculus and that ammonia release from urea could exacerbate periodon...

journal_title：Infection and immunity

authors： Morou-Bermudez E,Burne RA

更新日期：2000-12-01 00:00:00

abstract：:Phase 1 and 2 clinical trials of group B streptococcal (GBS) capsular polysaccharide (CPS)-protein conjugate vaccines in healthy adults have demonstrated their safety and improved immunogenicity compared with uncoupled CPSs. Two recent trials sought to determine (i) whether adsorption of conjugate vaccine to aluminum ...

journal_title：Infection and immunity

authors： Paoletti LC,Rench MA,Kasper DL,Molrine D,Ambrosino D,Baker CJ

更新日期：2001-11-01 00:00:00

abstract：:Toxin preparations were obtained by growing Clostridium difficile VPI strain 10463 in 2-liter brain heart infusion dialysis flasks at 37 degrees C for 3 days. The initial step of the purification scheme involved ultrafiltration through an XM-100 membrane filter. Two toxic activities, designated toxins A and B, were se...

journal_title：Infection and immunity

authors： Sullivan NM,Pellett S,Wilkins TD

更新日期：1982-03-01 00:00:00

abstract：:Infections caused by organisms of the Mycobacterium avium complex occur in approximately 50 to 60% of patients with AIDS. M. avium is an intracellular pathogen that survives and multiplies within mononuclear phagocytes. In this study, we investigated the uptake of M. avium grown within macrophages (intracellular growt...

journal_title：Infection and immunity

authors： Bermudez LE,Parker A,Goodman JR

更新日期：1997-05-01 00:00:00

abstract：:Mouse peritoneal macrophages were infected with varying numbers of Nocardia asteroides 10905, and the fate of the ingested organisms was determined by viable plate count (VPC), light microscopy (LM), immunofluorescent microscopy (IM), and electron microscopy (EM). The results obtained with these methods differed. VPC ...

journal_title：Infection and immunity

authors： Bourgeois L,Beaman BL

更新日期：1974-03-01 00:00:00

abstract：:A GroEL-like protein from Bordetella pertussis was purified. This protein was found to have the tetradecameric subunit structure typical of the GroEL family of proteins and to contain epitopes similar to those of other members of this family, including a human GroEL-like protein. Active immunization of neonatal mice w...

journal_title：Infection and immunity

authors： Burns DL,Gould-Kostka JL,Kessel M,Arciniega JL

更新日期：1991-04-01 00:00:00

abstract：:The possibility that gonococcal energy might play a role in the interaction of Neisseria gonorrhoeae with both phagocytic and nonphagocytic cells was examined. Respiratory chain inhibitors including KCN and amobarbital resulted in reduction in gonococcal association with human neutrophils. Similar results were seen wi...

journal_title：Infection and immunity

authors： Weber RD,Britigan BE,Svendsen T,Cohen MS

更新日期：1989-03-01 00:00:00

abstract：:In the development of vaccines capable of providing immunity against brucellosis, Cu-Zn superoxide dismutase (SOD) has been demonstrated to be one of the protective immunogens of Brucella abortus. In an earlier study, we provided strong evidence that intramuscular injection with a plasmid DNA carrying the SOD gene (pc...

journal_title：Infection and immunity

authors： Muñoz-Montesino C,Andrews E,Rivers R,González-Smith A,Moraga-Cid G,Folch H,Céspedes S,Oñate AA

更新日期：2004-04-01 00:00:00

abstract：:The vast majority of cases of gram-negative meningitis in neonates are caused by K1-encapsulated Escherichia coli. The role of the K1 capsule in the pathogenesis of E. coli meningitis was examined with an in vivo model of experimental hematogenous E. coli K1 meningitis and an in vitro model of the blood-brain barrier....

journal_title：Infection and immunity

authors： Hoffman JA,Wass C,Stins MF,Kim KS

更新日期：1999-07-01 00:00:00

abstract：:We examined the way the major outer membrane protein OmpA of Salmonella enterica serovar Typhimurium is recognized by the mouse immune system, by raising a panel of 12 monoclonal antibodies (MAbs) against this protein. Interaction between OmpA and these MAbs is competitively inhibited with several-hundredfold dilution...

journal_title：Infection and immunity

authors： Singh SP,Williams YU,Miller S,Nikaido H

更新日期：2003-07-01 00:00:00

abstract：:A main feature in the pathogenesis of bacterial endocarditis is the activation of the coagulation system via the extrinsic pathway, resulting in the formation of infected endocardial vegetations. Earlier studies gave indirect evidence that monocytes play an important role in the procoagulant response during the course...

journal_title：Infection and immunity

authors： Bancsi MJ,Veltrop MH,Bertina RM,Thompson J

更新日期：1996-02-01 00:00:00

abstract：:Toxin A (TcdA) and toxin B (TcdB) are major virulence factors of Clostridium difficile. These two toxins intoxicate cultured cells by similar mechanisms, and TcdB generally is more potent than TcdA in cultured cells. The exact reason for this difference is unclear. Here, we report that the cellular effects of TcdA can...

journal_title：Infection and immunity

authors： He X,Sun X,Wang J,Wang X,Zhang Q,Tzipori S,Feng H

更新日期：2009-06-01 00:00:00