Acidic pH changes receptor binding specificity of Helicobacter pylori: a binary adhesion model in which surface heat shock (stress) proteins mediate sulfatide recognition in gastric colonization.

abstract：:Pretreatment with multiple doses of polymyxin B and colistimethate was evaluated as to its ability to sequester sufficient antibiotic in tissues to neutralize the effects of endotoxin in three animal models. Animals were challenged with endotoxin 24, 48, or 72 h after the last dose of antibiotic when there was minimal...

journal_title：Infection and immunity

authors： Craig WA,Turner JH,Kunin CM

更新日期：1974-08-01 00:00:00

abstract：:Clostridium difficile is the leading cause of nosocomial bacterial diarrhea. Glutamine and its stable and highly soluble derivative alanyl-glutamine, have been beneficial in models of intestinal injury. In this study, we extend our work on the mechanisms of Clostridium difficile toxin A (TxA)-induced apoptosis in huma...

journal_title：Infection and immunity

authors： Carneiro BA,Fujii J,Brito GA,Alcantara C,Oriá RB,Lima AA,Obrig T,Guerrant RL

更新日期：2006-01-01 00:00:00

abstract：:Lymphocytes derived from 72- to 90-day-old fetal piglet thymuses respond in vitro to phytohemagglutinin quantitatively greater than do spleen cell lymphocytes. ...

journal_title：Infection and immunity

authors： Rodey GE,Day N,Holmes-Gray B,Good RA

更新日期：1972-03-01 00:00:00

abstract：:Treatment with nontoxic monophosphoryl lipid A (MPL), which was derived from a polysaccharide-deficient, heptoseless Re mutant of Salmonella typhimurium, was found to inactivate suppressor T-cell activity, as evidenced by a decrease in the degree of low-dose immunological paralysis expressed and an increase in the mag...

journal_title：Infection and immunity

authors： Baker PJ,Hiernaux JR,Fauntleroy MB,Prescott B,Cantrell JL,Rudbach JA

更新日期：1988-05-01 00:00:00

abstract：:PspC was found to bind human complement factor H (FH) by Western blot analysis of D39 (pspC(+)) and an isogenic mutant TRE108 (pspC). We confirmed that PspA does not bind FH, while purified PspC binds FH very strongly. The binding of FH to exponentially growing pneumococci varied among different isolates when analyzed...

journal_title：Infection and immunity

authors： Dave S,Brooks-Walter A,Pangburn MK,McDaniel LS

更新日期：2001-05-01 00:00:00

abstract：:This longitudinal prospective study shows that antibodies to the N-terminal block 2 region of the Plasmodium falciparum merozoite surface protein 1 (MSP-1) are associated with protection against clinical malaria in an area of stable but seasonal malaria transmission of Ghana. Antibodies to the block 2 region of MSP-1 ...

journal_title：Infection and immunity

authors： Cavanagh DR,Dodoo D,Hviid L,Kurtzhals JA,Theander TG,Akanmori BD,Polley S,Conway DJ,Koram K,McBride JS

更新日期：2004-11-01 00:00:00

abstract：:Members of our group reported recently that neisseria infection of human epithelial cells results in accelerated degradation of the major lysosomal integral membrane protein LAMP1 and that this is due to hydrolysis of this glycoprotein at its immunoglobulin A1 (IgA1)-like hinge by the neisseria type 2 IgA1 protease (L...

journal_title：Infection and immunity

authors： Ayala P,Lin L,Hopper S,Fukuda M,So M

更新日期：1998-10-01 00:00:00

abstract：:Cryptococcal meningoencephalitis develops as a result of hematogenous dissemination of inhaled Cryptococcus neoformans from the lung to the brain. The mechanism(s) by which C. neoformans crosses the blood-brain barrier (BBB) is a key unresolved issue in cryptococcosis. We used both an in vivo mouse model and an in vit...

journal_title：Infection and immunity

authors： Chang YC,Stins MF,McCaffery MJ,Miller GF,Pare DR,Dam T,Paul-Satyaseela M,Kim KS,Kwon-Chung KJ

更新日期：2004-09-01 00:00:00

abstract：:In this report, we demonstrate that the variable antigens present on the surface of Plasmodium knowlesi-infected erythrocytes could not be found on the surface of merozoites. A number of technical problems had to be solved to make such a comparative study possible, including the purification of merozoites by affinity ...

journal_title：Infection and immunity

authors： Hommel M,David PH

更新日期：1981-07-01 00:00:00

abstract：:Gamma interferon (IFN-gamma)-activated macrophages use an alternative processing mechanism to present Salmonella antigens to CD8(+) T lymphocytes. This pathway involves processing of antigen in a vacuolar compartment followed by secretion and loading of antigenic peptides to major histocompatibility complex class I (M...

journal_title：Infection and immunity

authors： Rosales-Reyes R,Alpuche-Aranda C,Ramírez-Aguilar Mde L,Castro-Eguiluz AD,Ortiz-Navarrete V

更新日期：2005-07-01 00:00:00

abstract：:Streptococcus mutans Ingbritt was grown anaerobically in a chemostat, at a rate (mean generation time, 13 h) similar to that in dental plaque, in a complex medium with excess glucose and at pH values of 6.5, 6.0, and 5.5. The yield of cells was constant at pH 6.5 and 6.0 (2.00 mg/ml) but fell to 1.25 at pH 5.5; Y(gluc...

journal_title：Infection and immunity

authors： Hamilton IR,Ellwood DC

更新日期：1978-02-01 00:00:00

abstract：:Purified R-28 antigen from an M-protein-poor, R-antigen-rich strain of group A Streptococcus was prepared by sequential treatment of an acid extract of whole cells with ammonium sulfate fractionation and hydroxylapatite (HA) column chromatography. Purified R-28 antigen was eluted only with 0.10 M sodium phosphate, pH ...

journal_title：Infection and immunity

authors： Johnson RH

更新日期：1975-10-01 00:00:00

abstract：:Haemophilus influenzae type b infection of immersed and air interface organ cultures for 24 h caused significant epithelial damage. Bacterial association with mucus, damaged epithelium, and unciliated cells was significantly higher in air interface than immersed organ cultures, and total bacterial association was 55.8...

journal_title：Infection and immunity

authors： Jackson AD,Cole PJ,Wilson R

更新日期：1996-06-01 00:00:00

abstract：:Specific proteolytic destruction of the human chemotaxin, C5a, is a property of group A and B streptococcal pathogens. Here we show that virulent group G streptococci from human sources also express C5a peptidase activity. The enzyme responsible for this activity is approximately the same size as and is antigenically ...

journal_title：Infection and immunity

authors： Cleary PP,Peterson J,Chen C,Nelson C

更新日期：1991-07-01 00:00:00

abstract：:Staphylococcus aureus is an important pathogen of humans and other animals, causing bacteremia, abscesses, endocarditis, and other infectious syndromes. A signature-tagged mutagenesis (STM) system was adapted for use in studying the genes required for in vivo survival of S. aureus. An STM library was ultimately create...

journal_title：Infection and immunity

authors： Schwan WR,Coulter SN,Ng EY,Langhorne MH,Ritchie HD,Brody LL,Westbrock-Wadman S,Bayer AS,Folger KR,Stover CK

更新日期：1998-02-01 00:00:00

abstract：:We have previously described (L. M. Vaughan, P. R. Smith, and T. J. Foster, Infect. Immun. 61:2172-2181, 1993) the construction of a kanamycin-resistant aromatic-dependent mutant of Aeromonas salmonicida, the causative agent of furunculosis, and its use as a live vaccine. Here we describe the construction of an unmark...

journal_title：Infection and immunity

authors： Marsden MJ,Vaughan LM,Foster TJ,Secombes CJ

更新日期：1996-09-01 00:00:00

abstract：:Previous studies have reported that human vascular endothelial cells lack the membrane-bound lipopolysaccharide (LPS) receptor, CD14 (mCD14). By optimizing assay conditions, including the selection of anti-CD14 monoclonal antibody, we now demonstrate that human umbilical vein endothelial cells (HUVEC) express CD14 on ...

journal_title：Infection and immunity

authors： Jersmann HP,Hii CS,Hodge GL,Ferrante A

更新日期：2001-01-01 00:00:00

abstract：:The blood-stage development of malaria parasites is initiated by the invasion of merozoites into susceptible erythrocytes. Specific receptor-ligand interactions must occur for the merozoites to first attach to and then invade erythrocytes. Because the invasion process is essential for the parasite's survival and the m...

journal_title：Infection and immunity

authors： Tsuboi T,Kappe SH,al-Yaman F,Prickett MD,Alpers M,Adams JH

更新日期：1994-12-01 00:00:00

abstract：:Production of group A streptococcal pyrogenic exotoxins (SPE) type A and C was transferred from toxigenic streptococcal strains to nontoxigenic strains by lysogeny. Lysogens were tested for SPE with Ouchterlony immunodiffusion on Todd-Hewitt agar plates; toxin diffusing from isolated colonies reacted with specific hyp...

journal_title：Infection and immunity

authors： Johnson LP,Schlievert PM,Watson DW

更新日期：1980-04-01 00:00:00

abstract：:Oral or intravenous inoculation of previously unexposed juvenile and adult ferrets with Campylobacter jejuni uniformly resulted in intestinal colonization lasting 2 to 12 days. Disease varied from mild to moderate diarrhea, which resolved in 2 to 3 days. Orally infected animals developed agglutinin titers of 8 to 256 ...

journal_title：Infection and immunity

authors： Bell JA,Manning DD

更新日期：1990-06-01 00:00:00

abstract：:A gene encoding a heat-stable enterotoxin (ST) from an Escherichia coli strain isolated from a human with diarrhea was cloned and characterized by nucleotide sequence analysis. The gene was found to be partially homologous to a previously characterized ST gene from an E. coli strain of bovine origin. Hybridization stu...

journal_title：Infection and immunity

authors： Moseley SL,Hardy JW,Hug MI,Echeverria P,Falkow S

更新日期：1983-03-01 00:00:00

abstract：:Periodontitis is a disease of polymicrobial etiology characterized by inflammation, degradation of host tissue, and bone that irreversibly destroys the supporting apparatus of teeth. Porphyromonas gingivalis contains lipid A with structural heterogeneity that has been postulated to contribute to the initiation of dysb...

journal_title：Infection and immunity

authors： Zenobia C,Hasturk H,Nguyen D,Van Dyke TE,Kantarci A,Darveau RP

更新日期：2014-02-01 00:00:00

abstract：:Murine embryo fibroblasts (MEF) were found to secrete tumor necrosis factor (TNF) in response to stimulation with endotoxin. Endotoxin-induced TNF production by MEF was inhibited by cycloheximide. However, reversal of the effect of this inhibitor on protein synthesis results in TNF being secreted in amounts equivalent...

journal_title：Infection and immunity

authors： Havell EA,Rogerson BJ

更新日期：1993-05-01 00:00:00

abstract：:The urease gene of Staphylococcus saprophyticus CCM883 was cloned and expressed in Staphylococcus carnosus TM300. In vitro translation of the cloned DNA sequences revealed six polypeptides (of 70, 47, 29, 27, 20, and 17 kilodaltons) that were associated with enzyme activity. Introduction of the cloned genes into a ure...

journal_title：Infection and immunity

authors： Gatermann S,Marre R

更新日期：1989-10-01 00:00:00

abstract：:Antisera were produced by inoculation of mycoplasma cells grown in PPLO broth supplemented with rabbit serum alone or rabbit serum plus Freund complete or incomplete adjuvant. By using an enzyme-linked immunosorbent assay, immunoglobulin G antibodies to cholesterol were detected in antisera to mycoplasmas (Mycoplasma ...

journal_title：Infection and immunity

authors： Watanabe T,Kumazawa T

更新日期：1991-06-01 00:00:00

abstract：:Synthetic peptides and murine monoclonal antibodies were used to map cross-reactive chlamydial epitopes. A species-specific epitope in the central region of variable sequence region 4 abuts the amino-terminal end of a B-serogroup-specific or F/G-serogroup-specific epitope, which in turn abuts known serovar-specific ep...

journal_title：Infection and immunity

authors： Batteiger BE,Lin PM,Jones RB,Van Der Pol BJ

更新日期：1996-07-01 00:00:00

abstract：:Sixty-one patients with a variety of different illnesses were studied with respect to skin test anergy and the presence of serum chemotactic inhibitors. In initial testing, 55% of the patient tests demonstrated negative skin test responses to all six test antigens. Sera from 65% of these anergic patients were capable ...

journal_title：Infection and immunity

authors： Van Epps DE,Frierson JA,Williams RC

更新日期：1974-11-01 00:00:00

abstract：:There are no vaccines against boutonneuse fever and Rocky Mountain spotted fever. Previous studies have identified a Rickettsia rickettsii surface protein as a vaccine candidate and shown that an antigenically related protein is present in R. conorii, which causes boutonneuse fever. The gene encoding the R. rickettsii...

journal_title：Infection and immunity

authors： Vishwanath S,McDonald GA,Watkins NG

更新日期：1990-03-01 00:00:00

abstract：:Strain superinfection occurs when a second pathogen strain infects a host already infected with a primary strain. The selective pressures that drive strain divergence, which underlies superinfection, and allow penetration of a new strain into a host population are critical knowledge gaps relevant to shifts in infectio...

journal_title：Infection and immunity

authors： Vallejo Esquerra E,Herndon DR,Alpirez Mendoza F,Mosqueda J,Palmer GH

更新日期：2014-12-01 00:00:00

abstract：:Complement-fixing antibodies were first detected in mice 7 days after intravenous injection with Mycoplasma arthritidis. Peak titers were observed at 21 days, and high levels of antibody persisted through 293 days. The metabolism-inhibiting antibody response was minimal. On fractionation of mouse sera, only 7S antibod...

journal_title：Infection and immunity

authors： Coke BC,Ward JR,Golightly-Rowland C,Trapp GA

更新日期：1971-10-01 00:00:00