Abstract:
:The fibronectin-binding proteins (FnBPs) of Staphylococcus aureus are believed to be implicated in the pathogen's adherence to and colonization of bovine mammary glands, thus leading to infectious mastitis. In vitro studies have shown that FnBPs help the adhesion of the pathogen to bovine mammary epithelial cells. However, the importance of FnBPs for the infection of mammary glands has never been directly established in vivo. In this study with a mouse model of mastitis, the presence of FnBPs on the surface of S. aureus increased the capacity of the bacterium to colonize mammary glands under suckling pressure compared to that of a mutant lacking FnBPs.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Brouillette E,Talbot BG,Malouin Fdoi
10.1128/iai.71.4.2292-2295.2003keywords:
subject
Has Abstractpub_date
2003-04-01 00:00:00pages
2292-5issue
4eissn
0019-9567issn
1098-5522journal_volume
71pub_type
杂志文章abstract::While the pathological events evoked by infection are commonly described, effective host responses to bacteria and their products should primarily be protective. Heat shock protein (Hsp) expression is upregulated by many stimuli and serves to maintain intracellular protein integrity. The ability of the prototypic supe...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.6.3187-3194.2004
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abstract::An LT-B-ST (LT-B/ST) fusion peptide was constructed by genetically joining the 5' terminus of a synthetic gene coding for the heat-stable enterotoxin (ST) of Escherichia coli to the 3' terminus of the gene coding for the binding subunit of the heat-labile enterotoxin (LT-B) of E. coli. An eight-amino-acid, proline-con...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.11.4629-4636.1993
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.9.5107-5114.2002
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abstract::Infectious agents are often considered potential triggers of chronic inflammatory disease, including autoimmunity; however, direct evidence is usually lacking. Here we show that following control of acute infection of mice with the myotropic Colombiana strain of Trypanosoma cruzi, parasites persisted in tissue at low ...
journal_title:Infection and immunity
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doi:10.1128/IAI.01497-15
更新日期:2016-03-24 00:00:00
abstract::Oral or intravenous inoculation of previously unexposed juvenile and adult ferrets with Campylobacter jejuni uniformly resulted in intestinal colonization lasting 2 to 12 days. Disease varied from mild to moderate diarrhea, which resolved in 2 to 3 days. Orally infected animals developed agglutinin titers of 8 to 256 ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.6.1848-1852.1990
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abstract::During the process of phagocytosis, human leukocytes emit a burst of luminescence which can be measured in a liquid scintillation spectrometer. The enzyme superoxide dismutase, which removes superoxide anions (O(2.)), inhibited this chemiluminescence by 70% at a concentration of 100 mug/ml. The enzyme did not inhibit ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1974-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.39.2.779-784.1983
更新日期:1983-02-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.8.4736-4745.2000
更新日期:2000-08-01 00:00:00
abstract::Suppression of the host defense is one of the hallmarks of Yersinia enterocolitica infection. This enteric pathogen resists phagocytosis and interferes with macrophage functions from an extracellular localization (oxidative-burst generation and tumor necrosis factor alpha production). In this study, we investigated th...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.11.4813-4821.1997
更新日期:1997-11-01 00:00:00
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journal_title:Infection and immunity
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doi:10.1128/IAI.01230-13
更新日期:2015-02-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.3.785-790.1989
更新日期:1989-03-01 00:00:00
abstract::Oral inoculation of 5-day-old gnotobiotic pigs with Salmonella enterica serovar Typhimurium strain F98 resulted in severe enteritis and invasive disease. Preinoculation 24 h earlier with an avirulent mutant of Salmonella enterica serovar Infantis (1326/28) completely prevented disease for up to 14 days (when the exper...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.4.2182-2191.2003
更新日期:2003-04-01 00:00:00
abstract::Conjunctival infection of guinea pigs by the chlamydial agent of guinea pig inclusion conjunctivitis confers immunity. However, the mechanism of resistance to this intracellular pathogen is not yet defined. In the study reported here, serum immunoglobulin was passively transferred with resultant titers in excess of th...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.7.4.597-599.1973
更新日期:1973-04-01 00:00:00
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doi:10.1128/IAI.02208-14
更新日期:2014-12-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00849-17
更新日期:2018-02-20 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01117-06
更新日期:2007-01-01 00:00:00
abstract::Several studies have demonstrated roles for eosinophils during innate and adaptive immune responses to helminth infections. However, evidence that eosinophils are capable of initiating an immune response to parasite antigens is lacking. The goal of the present in vitro study was to investigate the potential of eosinop...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02067-05
更新日期:2006-06-01 00:00:00
abstract::A nonclonal population of Borrelia burgdorferi N40 (passage 3) that survived protective immunity following challenge inoculation of outer surface protein (Osp) A- or B-hyperimmunized mice were characterized for the molecular basis of evasion of immunity. Two of six B. burgdorferi isolates, cultured from OspA-immunized...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.5.1658-1662.1995
更新日期:1995-05-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.38.3.860-864.1982
更新日期:1982-12-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.1.157-162.1990
更新日期:1990-01-01 00:00:00
abstract::Sixty-one Burkholderia cepacia isolates from patients with cystic fibrosis (CF) and four plant isolates were screened for production of the siderophores salicylic acid (SA), pyochelin, cepabactin, and ornibactins and fingerprinted by a PCR-based randomly amplified polymorphic DNA (RAPD) method. Of the 24 RAPD types de...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.2.874-877.1998
更新日期:1998-02-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.72.4.2170-2176.2004
更新日期:2004-04-01 00:00:00
abstract::Humoral immunity does not play a prominent role during experimental cryptococcosis. However, previous studies have shown that immunoglobulin G (IgG) anti-Cryptococcus neoformans antibodies can mediate cell-dependent yeast killing in vitro. Therefore, the protective effect of a previously described monoclonal IgG1 anti...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.3.749-752.1987
更新日期:1987-03-01 00:00:00
abstract::The ScpC protease of Streptococcus pyogenes degrades interleukin-8 (IL-8), a chemokine that mediates neutrophil transmigration and activation. The ability to degrade IL-8 differs dramatically among clinical isolates of S. pyogenes. Bacteria expressing ScpC overcome immune clearance by preventing the recruitment of neu...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00128-08
更新日期:2008-09-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.1.363-365.1995
更新日期:1995-01-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.7.3566-3570.1999
更新日期:1999-07-01 00:00:00
abstract::Because of the unavailability of a suitable antigen, specific in vitro lymphocyte reactivity has not been investigated in persons who have had systemic blastomycosis. Twelve persons who had recovered from blastomycosis were evaluated, and all were found to exhibit strongly positive and apparently specific in vitro cel...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.33.2.485-490.1981
更新日期:1981-08-01 00:00:00
abstract::Bacillus anthracis, the causative agent of anthrax, relies on multiple virulence factors to subvert the host immune defense. Using Caenorhabditis elegans as an infection model, we screened approximately 5,000 transposon mutants of B. anthracis Sterne for decreased virulence. One of the attenuated mutants resulted in l...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01614-13
更新日期:2014-03-01 00:00:00