Antibodies to laminin in American cutaneous leishmaniasis.

abstract：:Haemophilus ducreyi, the etiologic agent of the sexually transmitted disease chancroid, has been shown to inhibit phagocytosis of both itself and secondary targets in vitro. Immunodepletion of LspA proteins from H. ducreyi culture supernatant fluid abolished this inhibitory effect, indicating that the LspA proteins ar...

journal_title：Infection and immunity

authors： Mock JR,Vakevainen M,Deng K,Latimer JL,Young JA,van Oers NS,Greenberg S,Hansen EJ

更新日期：2005-12-01 00:00:00

abstract：:Although the suckling mouse assay is widely used for the detection of heat-stable Escherichia coli enterotoxin (ST), few data have been published concerning the reproducibility, optimal growth, and test conditions of this assay. Four strains of toxigenic E. coli known to elaborate both heat-labile enterotoxin and ST o...

journal_title：Infection and immunity

authors： Giannella RA

更新日期：1976-07-01 00:00:00

abstract：:Interferon regulatory factor 1-deficient (IRF-1(-/-)) mice infected with virulent Brucella abortus 2308 at 5 x 10(5) CFU developed acute hepatitis similar to many natural hosts but, unlike natural hosts, IRF-1(-/-) mice were unable to resolve infection and died. In contrast, IRF-1(-/-) mice survived when infected at 5...

journal_title：Infection and immunity

authors： Ko J,Gendron-Fitzpatrick A,Ficht TA,Splitter GA

更新日期：2002-12-01 00:00:00

abstract：:Yersinia enterocolitica serotype 9 contained an antigenic component giving a reaction of total identity with Brucella native hapten and polysaccharide B. This component was present in a phenol-water extract (fraction 5; M. Redfearn, Ph.D. Thesis, University of Wisconsin, Madison, 1960) along with the smooth lipopolysa...

journal_title：Infection and immunity

authors： Fernandez-Lago L,Moriyon I,Toyos J,Diaz R

更新日期：1982-11-01 00:00:00

abstract：:Susceptibility of Syrian hamsters of the inbred LSH and MHA strains to injection of as few as 10 plaque-forming units of vesicular stomatitis virus (VSV) was shown to occur only after intraperitoneal and intrapleural injection and not after injection of VSV intravenously, intranasally, or in the footpads. Despite the ...

journal_title：Infection and immunity

authors： Fultz PN,Shadduck JA,Kang CY,Streilein JW

更新日期：1981-11-01 00:00:00

abstract：:Resequencing estA3, an allele of the methanol-soluble heat-stable enterotoxin of Escherichia coli showed that the proline triplet 19 is in fact an alanine codon; thus, estA alleles 3 and 4 were shown to be identical. Resequencing has also shown that the carboxy terminus of another allele, estA2, is not the previously ...

journal_title：Infection and immunity

authors： Guzman-Verduzco LM,Kupersztoch YM

更新日期：1989-02-01 00:00:00

abstract：:The interactions between Klebsiella pneumoniae and the host environment at the site of infection are largely unknown. Pulmonary surfactant serves as an initial point of contact for inhaled bacteria entering the lung and is thought to contain molecular cues that aid colonization and pathogenesis. To gain insight into t...

journal_title：Infection and immunity

authors： Willsey GG,Ventrone S,Schutz KC,Wallace AM,Ribis JW,Suratt BT,Wargo MJ

更新日期：2018-06-21 00:00:00

abstract：:A comparison of viral-induced unresponsiveness of phytohemagglutinin (PHA)-induced deoxyribonucleic acid (DNA) synthesis of mouse lymphocytes was made by culturing the cells under identical conditions in the presence of HEPES buffer in a humid-air atmosphere. The degree of PHA-induced DNA synthesis was found to vary, ...

journal_title：Infection and immunity

authors： Rogers HJ

更新日期：1973-03-01 00:00:00

abstract：:The antihistoplasma activity of recombinant murine gamma interferon (rMuIFN-gamma)-treated macrophages of the RAW 264.7 cell line depends on the generation of nitric oxide (NO.) from L-arginine. Macrophages of the P388D1 cell line treated with rMuIFN-gamma do not produce NO. or inhibit the intracellular growth of Hist...

journal_title：Infection and immunity

authors： Lane TE,Otero GC,Wu-Hsieh BA,Howard DH

更新日期：1994-04-01 00:00:00

abstract：:Chronic Helicobacter pylori infection is associated with mucosal inflammation. The aim of the present study was to assess human neutrophil and monocyte activation by H. pylori strains obtained from patients with different clinical presentations. Bacterial sonicates from 12 strains were used to stimulate phagocyte upre...

journal_title：Infection and immunity

authors： Hansen PS,Go MF,Varming K,Andersen LP,Genta RM,Graham DY,Nielsen H

更新日期：1999-06-01 00:00:00

abstract：:Brucella spp. are intracellular bacteria that cause the most frequent zoonosis in the world. Although recent work has advanced the field of Brucella vaccine development, there remains no safe human vaccine. In order to produce a safe and effective human vaccine, the immune response to Brucella spp. requires greater un...

journal_title：Infection and immunity

authors： Durward MA,Harms J,Magnani DM,Eskra L,Splitter GA

更新日期：2010-01-01 00:00:00

abstract：:Buruli ulcer, caused by Mycobacterium ulcerans, is characterized by deep and necrotizing skin lesions, mostly on the arms and legs. Together with tuberculosis and leprosy, this mycobacterial disease has become a major health problem in tropical and subtropical regions, particularly in central and western Africa. No sp...

journal_title：Infection and immunity

authors： Tanghe A,Content J,Van Vooren JP,Portaels F,Huygen K

更新日期：2001-09-01 00:00:00

abstract：:Tox-+ staphylococcal strains, as opposed to Tox-minus strains, produce epidermal exfoliation within 18 h after direct subcutaneous or intraperitoneal injection into newborn mice. The extracellular product responsible for exfoliation is termed exfoliative toxin (ET). When culture supernatant fluid from the plasmid-cure...

journal_title：Infection and immunity

authors： Keyhani M,Rogolsky M,Wiley BB,Glasgow LA

更新日期：1975-07-01 00:00:00

abstract：:A common concern with many autoimmune diseases of unknown etiology is the extent to which tissue T-lymphocyte infiltrates, versus a nonspecific infiltrate, reflect a response to the causative agent. Lyme arthritis can histologically resemble rheumatoid synovitis, particularly the prominent infiltration by T lymphocyte...

journal_title：Infection and immunity

authors： Roessner K,Trivedi H,Gaur L,Howard D,Aversa J,Cooper SM,Sigal LH,Budd RC

更新日期：1998-03-01 00:00:00

abstract：:Inflammatory cytokines play an important role in human immune responses to malarial disease. However, the role of these mediators in disease pathogenesis, and the relationship between host protection and injury remains unclear. A total of 248 cases of severe Plasmodium falciparum malaria among children aged 3 months t...

journal_title：Infection and immunity

authors： Lyke KE,Burges R,Cissoko Y,Sangare L,Dao M,Diarra I,Kone A,Harley R,Plowe CV,Doumbo OK,Sztein MB

更新日期：2004-10-01 00:00:00

abstract：:Polymicrobial intra-abdominal infections (IAIs) are a significant cause of morbidity and mortality, particularly when fungal pathogens are involved. Our experimental murine model of IAI involving intraperitoneal inoculation of Candida albicans and Staphylococcus aureus results in synergistic lethality (∼80%) due to ex...

journal_title：Infection and immunity

authors： Ikeh MAC,Fidel PL Jr,Noverr MC

更新日期：2018-06-21 00:00:00

abstract：:Secreted and surface-exposed antigens of intracellular pathogens are thought to provide target structures for detection by the host immune system. The major secreted product of intracellular Leishmania mexicana amastigotes, a proteophosphoglycan (aPPG), is known to contribute to the establishment of the parasitophorou...

journal_title：Infection and immunity

authors： Aebischer T,Harbecke D,Ilg T

更新日期：1999-10-01 00:00:00

abstract：:Immunofluorescence microscopy demonstrated that laminin bound to the surface of Penicillium marneffei conidia. Attachment of P. marneffei conidia in an adherence assay was inhibited by soluble laminin and anti-laminin antibody. N-Acetylneuraminic acid abolished adherence, indicating an interaction mediated by a sialic...

journal_title：Infection and immunity

authors： Hamilton AJ,Jeavons L,Youngchim S,Vanittanakom N,Hay RJ

更新日期：1998-12-01 00:00:00

abstract：:The relationship between the sequence of Neisseria gonorrhoeae pilin and its quaternary assembly into pilus fibers was studied with a set of site-directed antibody probes and by mapping the specificities of antipilus antisera with peptides. Buried and exposed peptides in assembled pili were identified by competitive i...

journal_title：Infection and immunity

authors： Forest KT,Bernstein SL,Getzoff ED,So M,Tribbick G,Geysen HM,Deal CD,Tainer JA

更新日期：1996-02-01 00:00:00

abstract：:Protective immunity to Plasmodium falciparum malaria acquired after natural exposure is largely antibody mediated. IgG-specific P. falciparum EMP1 (PfEMP1) proteins on the infected erythrocyte surface are particularly important. The transient antibody responses and the slowly acquired protective immunity probably refl...

journal_title：Infection and immunity

authors： Ampomah P,Stevenson L,Ofori MF,Barfod L,Hviid L

更新日期：2014-05-01 00:00:00

abstract：:We have previously shown that Bacillus anthracis lethal toxin represses glucocorticoid receptor (GR) transactivation. We now report that repression of GR activity also occurs with the large clostridial toxins produced by Clostridium sordellii and C. difficile. This was demonstrated using a transient transfection assay...

journal_title：Infection and immunity

authors： Tait AS,Dalton M,Geny B,D'Agnillo F,Popoff MR,Sternberg EM

更新日期：2007-08-01 00:00:00

abstract：:The immunogenic and adjuvant properties of Brucella abortus and Escherichia coli lipopolysaccharides (LPSs) were studied in endotoxin-responsive, athymic, and euthymic BALB/c mice and in responsive C3H/HeAu mice and congenic nonresponsive C3H/HeJ mice. Consistent with previous reports, E. coli LPS did not stimulate si...

journal_title：Infection and immunity

authors： Moreno E,Kurtz RS,Berman DT

更新日期：1984-10-01 00:00:00

abstract：:Results from studies using mice deficient in specific complement factors and clinical data on patients with an inherited deficiency of the classical complement pathway component C2 suggest that the classical pathway is vital for immunity to Streptococcus pneumoniae. However, the consequences of defects in classical pa...

journal_title：Infection and immunity

authors： Yuste J,Sen A,Truedsson L,Jönsson G,Tay LS,Hyams C,Baxendale HE,Goldblatt F,Botto M,Brown JS

更新日期：2008-08-01 00:00:00

abstract：:In mammalian hosts, Leishmania sp. parasites are obligatory intracellular organisms that invade macrophages and dendritic cells (DC), where they reside in endocytic organelles termed parasitophorous vacuoles (PV). Most of the present knowledge of the characteristics of PV harboring Leishmania sp. is derived from studi...

journal_title：Infection and immunity

authors： Körner U,Fuss V,Steigerwald J,Moll H

更新日期：2006-02-01 00:00:00

abstract：:Pneumonic plague, caused by inhalation of Yersinia pestis, represents a major bioterrorism threat for which no vaccine is available. Based on the knowledge that genetic delivery of monoclonal antibodies (MAbs) with adenovirus (Ad) gene transfer vectors results in rapid, high-level antibody expression, we evaluated the...

journal_title：Infection and immunity

authors： Sofer-Podesta C,Ang J,Hackett NR,Senina S,Perlin D,Crystal RG,Boyer JL

更新日期：2009-04-01 00:00:00

abstract：:The mechanism by which bacterial heat-stable enterotoxins (ST I STA) cause diarrhea in humans and animals has been linked to the activation of an intestinal membrane-bound guanylate cyclase. Guanylin, a recently discovered rat intestinal peptide, is homologous in structure to ST I and can activate guanylate cyclase pr...

journal_title：Infection and immunity

authors： Carpick BW,Gariépy J

更新日期：1993-11-01 00:00:00

abstract：:After aerosol deposition of Serratia marcescens in mice, initial delayed pulmonary clearance was followed between 4 and 24 hr later by progressive elimination. ...

journal_title：Infection and immunity

authors： Southern PM,Pierce AK,Sanford JP

更新日期：1971-01-01 00:00:00

abstract：:F1651 and the pyelonephritis-associated pili (Pap) are two members of the type P family of adhesive factors. They play a key role in establishing disease caused by extraintestinal pathogenic Escherichia coli (ExPEC) strains in animals and humans. Both F1651 and Pap are under the control of an epigenetic and reversible...

journal_title：Infection and immunity

authors： Graveline R,Lavoie R,Garneau P,Daigle F,Sénéchal S,Martin C,Harel J

更新日期：2015-05-01 00:00:00

abstract：:Rhodococcus equi is a facultative intracellular pathogen of macrophages, relying on the presence of a conjugative virulence plasmid harboring a 21-kb pathogenicity island (PAI) for growth in host macrophages. The PAI encodes a family of 6 virulence-associated proteins (Vaps) in addition to 20 other proteins. The contr...

journal_title：Infection and immunity

authors： Coulson GB,Miranda-CasoLuengo AA,Miranda-CasoLuengo R,Wang X,Oliver J,Willingham-Lane JM,Meijer WG,Hondalus MK

更新日期：2015-08-01 00:00:00

abstract：:Streptococcus iniae causes systemic infection characterized by meningitis and sepsis. Here, we report a larval zebrafish model of S. iniae infection. Injection of wild-type S. iniae into the otic vesicle induced a lethal infection by 24 h postinfection. In contrast, an S. iniae mutant deficient in polysaccharide capsu...

journal_title：Infection and immunity

authors： Harvie EA,Green JM,Neely MN,Huttenlocher A

更新日期：2013-01-01 00:00:00