Intraspleen delivery of a DNA vaccine coding for superoxide dismutase (SOD) of Brucella abortus induces SOD-specific CD4+ and CD8+ T cells.

abstract：:The compositions of lipopolysaccharides I and II, isolated from Coxiella burnetii phase I and pure phase II cells, respectively, showed drastic and clear-cut differences. Lipopolysaccharide II exhibited a comparatively simple composition. It contained, in addition to glucosamine (from lipid A) and a 2-keto-3-deoxyoctu...

journal_title：Infection and immunity

authors： Schramek S,Mayer H

更新日期：1982-10-01 00:00:00

abstract：:The susceptibility of a few strains of mice to a subcutaneous injection of Leishmania tropica major, the causative agent of cutaneous leishmaniasis in humans, was studied. The infection in six strains (CBA, AKR/J, AKR/cu, C57BL/6, A/J, and C3H) remained cutaneous, and the animals recovered within 3 to 4 months. In con...

journal_title：Infection and immunity

authors： Nasseri M,Modabber FZ

更新日期：1979-11-01 00:00:00

abstract：:Vaccine adjuvants exert critical and unique influences on the quality of immune responses induced during active immunizations. We investigated the mechanisms of action of immunological adjuvants in terms of their requirements for cytokine-mediated pathways for adjuvanticity. Antibody responses potentiated by several a...

journal_title：Infection and immunity

authors： Hui GS,Hashimoto CN

更新日期：1998-11-01 00:00:00

abstract：:The microbicidal myeloperoxidase (MPO)-H2O2-chloride system strongly inhibits Escherichia coli DNA synthesis. Also, cell envelopes from MPO-treated E. coli cells lose their ability to interact with hemimethylated DNA sequences of oriC, the chromosomal origin of replication, raising the prospect that suppression of DNA...

journal_title：Infection and immunity

authors： Rosen H,Michel BR,vanDevanter DR,Hughes JP

更新日期：1998-06-01 00:00:00

abstract：:The survival of Staphylococcus aureus in the lungs of mice was studied under various conditions. Doses of 10(7) to 10(9) washed staphylococci were quantitatively introduced into the lungs after intratracheal inoculation in mice under either ether or sodium pentobarbital anesthesia. Mice were sacrificed at intervals, t...

journal_title：Infection and immunity

authors： DeMaria TF,Kapral FA

更新日期：1978-07-01 00:00:00

abstract：:In Shigella flexneri a 220-kilobase plasmid encodes the ability to invade nonprofessional phagocytes by a mechanism similar to phagocytosis. In this report, the continuous macrophage cell line J774 was used to study the intracellular fate of both invasive and noninvasive strains. pWR100, the virulence plasmid of S. fl...

journal_title：Infection and immunity

authors： Clerc PL,Ryter A,Mounier J,Sansonetti PJ

更新日期：1987-03-01 00:00:00

abstract：:The gonococcal pilus is a primary virulence factor, providing the initial attachment of the bacterial cell to human mucosal tissues. Pilin, the major subunit of the pilus, can carry a wide spectrum of primary amino acid sequences which are generated by the action of a complex antigenic variation system. Changes in the...

journal_title：Infection and immunity

authors： Long CD,Madraswala RN,Seifert HS

更新日期：1998-05-01 00:00:00

abstract：:One rabbit pathogenic Escherichia coli strain, belonging to serogroup O103, harbors a self-transferable 117-kb plasmid (pREC-1) encoding resistance to several antibiotics. The role of this R plasmid in the colonization of the digestive tract in specific-pathogen-free (E. coli O103-free) rabbits was studied. Five-week-...

journal_title：Infection and immunity

authors： Reynaud A,Federighi M,Licois D,Guillot JF,Joly B

更新日期：1991-06-01 00:00:00

abstract：:In the present study, the roles of interleukin 12 (IL-12) and IL-18 and their possible interaction during superantigen-induced responses were studied by injection of staphylococcal enterotoxin B (SEB) into mice. These data suggest that the role of IL-12 in SEB-induced responses is limited to sustaining gamma interfero...

journal_title：Infection and immunity

authors： Lauw FN,Florquin S,Speelman P,van Deventer SJ,van der Poll T

更新日期：2001-09-01 00:00:00

abstract：:It has been shown previously that serum from chronically infected patients with cystic fibrosis inhibits the phagocytosis of Pseudomonas aeruginosa by both normal and cystic fibrosis alveolar macrophages. In the present study, the ability of peripheral monocytes and polymorphonuclear leukocytes from normal volunteers ...

journal_title：Infection and immunity

authors： Thomassen MJ,Demko CA,Wood RE,Sherman JM

更新日期：1982-11-01 00:00:00

abstract：:In this study we found that serum inhibitory activity against Blastomyces dermatitidis was principally mediated by albumin. This was confirmed in experiments using albumin from several mammalian species. Analbuminemic rat serum did not inhibit B. dermatitidis growth in vivo; however, the addition of albumin restored i...

journal_title：Infection and immunity

authors： Giles S,Czuprynski C

更新日期：2003-11-01 00:00:00

abstract：:Exposure of PAM cells, a spontaneously transformed mouse cell line, to brain homogenates from mice infected with scrapie caused a relative decrease in total cell yield, which persisted from passage 2 or 3 to passage 18 after treatment. The effect was elicited by each of the eight independent scrapie isolates tested. L...

journal_title：Infection and immunity

authors： Carp RI,Merz GS,Licursi PC

更新日期：1976-07-01 00:00:00

abstract：:Apical membrane antigen 1 (AMA1) is expressed on the surfaces of Plasmodium falciparum merozoites and is thought to play an important role in the invasion of erythrocytes by malaria parasites. To select for peptides that mimic conformational B-cell epitopes on AMA1, we screened a phage display library of >10(8) indivi...

journal_title：Infection and immunity

authors： Casey JL,Coley AM,Anders RF,Murphy VJ,Humberstone KS,Thomas AW,Foley M

更新日期：2004-02-01 00:00:00

abstract：:Helicobacter pylori infection causes severe gastroduodenal diseases in humans. Its virulence is strongly increased by the presence of the cag pathogenicity island (cag PAI). It has been shown that CagA, a major antigen in humans, is translocated to the host cell via a secretion system encoded by the cag PAI. The roles...

journal_title：Infection and immunity

authors： Seydel A,Tasca E,Berti D,Rappuoli R,Del Giudice G,Montecucco C

更新日期：2002-11-01 00:00:00

abstract：:The involvement of tumor necrosis factor (TNF) in resistance to Toxoplasma gondii infection was examined by means of experiments in which mice were treated with anti-TNF antibodies prior to infection with ME49, a low-virulence Toxoplasma strain. In (BALB/cBy x C57BL/6J)F1 (CB6F1) mice, which are highly resistant to in...

journal_title：Infection and immunity

authors： Johnson LL

更新日期：1992-05-01 00:00:00

abstract：:The response of ferrets after intranasal inoculation of inactivated A/Hong Kong/68 (H3N2) influenza virus vaccines is reported. Normal ferrets given either saline vaccine in drops or freeze-dried vaccine in an aerosol intranasally did not produce detectable serum or nasal hemagglutination inhibiting antibody and were ...

journal_title：Infection and immunity

authors： McLaren C,Potter CW,Jennings R

更新日期：1974-06-01 00:00:00

abstract：:Mycobacterium leprae are killed by myeloperoxidase (or eosinophil peroxidase), H2O2, and a halide, thus suggesting a mechanism for their destruction by peroxidase-containing phagocytes. ...

journal_title：Infection and immunity

authors： Klebanoff SJ,Shepard CC

更新日期：1984-05-01 00:00:00

abstract：:Antigen 2 (Ag2), a major immunoreactive component of Coccidioides immitis mycelium- and spherule-phase cell walls, was recently cloned in our laboratory and was shown to elicit T-cell responses in Coccidioides-immune mice. In this investigation, we evaluated recombinant Ag2 (rAg2) and PCR-generated Ag2 truncations for...

journal_title：Infection and immunity

authors： Zhu Y,Tryon V,Magee DM,Cox RA

更新日期：1997-08-01 00:00:00

abstract：:P.69 pertactin (P.69 Prn), an adhesion molecule from the causative agent of pertussis, Bordetella pertussis, is present in cellular and most acellular vaccines that are currently used worldwide. Although both humoral immunity and cellular immunity directed against P.69 Prn have been implicated in protective immune mec...

journal_title：Infection and immunity

authors： Stenger RM,Poelen MC,Moret EE,Kuipers B,Bruijns SC,Hoogerhout P,Hijnen M,King AJ,Mooi FR,Boog CJ,van Els CA

更新日期：2009-02-01 00:00:00

abstract：:The ability of intracellular pathogens to sense and adapt to the hostile environment of the host is an important factor governing virulence. We have sequenced the operon encoding the major heat shock proteins GroES and GroEL in the gram-positive food-borne pathogen Listeria monocytogenes. The operon has a conserved or...

journal_title：Infection and immunity

authors： Gahan CG,O'Mahony J,Hill C

更新日期：2001-06-01 00:00:00

abstract：:Current evidence indicates that Mycobacterium avium infection in patients with AIDS is acquired mostly through the gastrointestinal (GI) tract and that M. avium binds to and invades GI mucosal cells in vitro. Since M. avium is exposed to specific environmental conditions in the GI tract such as changes in pH, low oxyg...

journal_title：Infection and immunity

authors： Bermudez LE,Petrofsky M,Goodman J

更新日期：1997-09-01 00:00:00

abstract：:The role of the spleen in hepatic amoebiasis in hamsters was studied. In hamsters receiving an intrahepatic inoculation of 10(5) trophozoites of axenic Entamoeba histolytica at 7 or 14 days postsplenectomy, the mean weight of metastatic foci increased significantly when compared with sham-splenectomized or intact cont...

journal_title：Infection and immunity

authors： Ghadirian E,Meerovitch E

更新日期：1981-02-01 00:00:00

abstract：:Purified Escherichia coli type 1 fimbriae have been shown previously to stimulate T-cell-independent proliferation of human B lymphocytes. The response is mediated by the mannose-specific, lectin-like adhesin protein FimH. Here we show that type 1 fimbriae also stimulate immunoglobulin (Ig) secretion by B cells. The r...

journal_title：Infection and immunity

authors： Ponniah S,Abraham SN,Endres RO

更新日期：1992-12-01 00:00:00

abstract：:The effects of infection with Rowson-Parr virus (RPV), an associated virus present in Friend virus (FV) preparations, on the splenic plaque-forming cell response to sheep red cells in adult mice and on the plaque-forming cell response of peritoneal cells in vitro have been investigated. The results support the hypothe...

journal_title：Infection and immunity

authors： Bendinelli M,Nardini L

更新日期：1973-02-01 00:00:00

abstract：:Two fragments with molecular weights of 111,000 (fragment I) and 59,000 (fragment II) were separated from each other by gel filtration of dithiothreitol and urea-treated, trypsinized derivative toxin (molecular weight, 170,000) of the proteolytic Okra strain of Clostridium botulinum type B on a column of Sephadex G-20...

journal_title：Infection and immunity

authors： Kozaki S,Miyazaki S,Sakaguchi G

更新日期：1977-12-01 00:00:00

abstract：:Two hybrid clones producing monoclonal antibodies (MAbs) raised against the purified enterotoxic hemolysin-phospholipase C (HlyPC) bifunctional molecule of a Vibrio cholerae O139 strain were used to study its enterotoxicity in relation to its hemolytic and enzymatic activities. Fab fragments of MAbs from ascites produ...

journal_title：Infection and immunity

authors： Pal S,Datta A,Nair GB,Guhathakurta B

更新日期：1998-08-01 00:00:00

abstract：:Outbred Swiss mice were inoculated intraperitoneally or intravenously with one 90 to 100% lethal dose of Escherichia coli O:18, Proteus mirabilis, or Klebsiella pneumoniae. After carefully timed intervals, aminoglycoside antibiotics were begun at dosages nnd intervals predetermined to constitute optimal therapy. With ...

journal_title：Infection and immunity

authors： Greisman SE,DuBuy JB,Woodward CL

更新日期：1979-08-01 00:00:00

abstract：:An asd-stabilized plasmid carrying enterotoxigenic Escherichia coli cfaABCE genes was constructed and called pJGX15C-asd+. Expression of colonization factor antigen I (CFA/I) by this plasmid occurs independently of the cfaABCE positive regulator cfaR in attenuated Salmonella delta aro delta asd strain H683 and nonpath...

journal_title：Infection and immunity

authors： Wu S,Pascual DW,VanCott JL,McGhee JR,Maneval DR Jr,Levine MM,Hone DM

更新日期：1995-12-01 00:00:00

abstract：:B-cell-deficient mice were prepared by administration of rabbit anti-mouse-mu antiserum to newborn animals within 12 h of birth onwards. Such immunodeficient animals, along with the normal controls, were infected intravenously with Cryptococcus neoformans. There was no difference in the mortality pattern, viable count...

journal_title：Infection and immunity

authors： Monga DP,Kumar R,Mohapatra LN,Malaviya AN

更新日期：1979-10-01 00:00:00

abstract：:Sequestration of Plasmodium falciparum-infected erythrocytes to the capillary endothelium can cause obstruction and localized tissue damage. Occlusion of vessels in falciparum malaria infection has been related to two properties of the parasite: adhesion to endothelial cells and rosette formation. Our study on P. falc...

journal_title：Infection and immunity

authors： Udomsangpetch R,Webster HK,Pattanapanyasat K,Pitchayangkul S,Thaithong S

更新日期：1992-11-01 00:00:00