Phosphoglucomutase of Yersinia pestis is required for autoaggregation and polymyxin B resistance.

abstract：:The binding of (125)I-labeled S component to rabbit polymorphonuclear leukocytes was found to be concentration dependent and saturable at 37 degrees C. Scatchard analysis of the binding curve gave a straight line, indicating that S component binds to a single population of sites. The dissociation constant, K(D), deriv...

journal_title：Infection and immunity

authors： Noda M,Kato I,Matsuda F,Hirayama T

更新日期：1981-11-01 00:00:00

abstract：:Antigens shared between Streptococcus pyogenes and heart tissue may play an important role in autoimmune cardiac injury associated with acute rheumatic fever. Antiheart/antistreptococcal antibodies found in the disease react with antigens of S. pyogenes, including M protein and a 60-kDa antigen distinct from M protein...

journal_title：Infection and immunity

authors： Barnett LA,Cunningham MW

更新日期：1992-09-01 00:00:00

abstract：:Mannheimia haemolytica, a commensal organism of the upper respiratory tract in cattle, is the principal bacterial pathogen associated with the bovine respiratory disease complex. Adherence to the respiratory mucosa is a crucial event in its pathogenesis. However, the bacterial components that contribute to this proces...

journal_title：Infection and immunity

authors： Kisiela DI,Czuprynski CJ

更新日期：2009-01-01 00:00:00

abstract：:We have previously identified mgrA (rat) as a regulator of autolysis in Staphylococcus aureus. Besides its effect on autolytic activity, we recently found alterations in the expression of regulator and target virulence genes in the mgrA mutant. Northern analysis and transcription fusion assays showed that inactivation...

journal_title：Infection and immunity

authors： Ingavale S,van Wamel W,Luong TT,Lee CY,Cheung AL

更新日期：2005-03-01 00:00:00

abstract：:Using fluorescent antibody techniques (FA) and light microscopy (LM) and electron microscopy (EM), this paper describes the morphological features of the ileum in the DK1 mouse orally challenged with adenovirus K87. At the peak of infection, virus is easily identified by FA in the epithelium of the villi and crypts of...

journal_title：Infection and immunity

authors： Takeuchi A,Hashimoto K

更新日期：1976-02-01 00:00:00

abstract：:The P2 porin protein is the major outer membrane protein of nontypeable Haemophilus influenzae and is a potential target of a protective immune response. Nine monoclonal antibodies (MAbs) to P2 were developed by immunizing mice with nontypeable H. influenzae whole organisms. Each MAb reacted exclusively with the homol...

journal_title：Infection and immunity

authors： Haase EM,Yi K,Morse GD,Murphy TF

更新日期：1994-09-01 00:00:00

abstract：:Trefoil family factor 2 (TFF2), also known as spasmolytic peptide, is a low-molecular-weight protein that is upregulated in gastric tissues infected with Helicobacter or having other inflammatory conditions, but a precise function is yet to be elucidated. The role of TFF2 in the development of gastritis, colitis, and ...

journal_title：Infection and immunity

authors： Kurt-Jones EA,Cao L,Sandor F,Rogers AB,Whary MT,Nambiar PR,Cerny A,Bowen G,Yan J,Takaishi S,Chi AL,Reed G,Houghton J,Fox JG,Wang TC

更新日期：2007-01-01 00:00:00

abstract：:An "immunogenic" ribonucleic acid (Im-RNA) has been extracted from peritoneal exudate (PE) cells of rats that were immunized with sheep erythrocytes (SRBC). Following multiple phenol extractions and deoxyribonuclease treatment, the material obtained from PE cells was eluted from diethylaminoethyl-cellulose at 0.55 M N...

journal_title：Infection and immunity

authors： Archer SJ,Wust CJ

更新日期：1973-08-01 00:00:00

abstract：:Active immunization with Porphyromonas gingivalis whole-cell preparations has been shown to prevent P. gingivalis infection and oral bone loss. Employing passive antibody transfer and opsonization, we demonstrate with this study that immunization-elicited P. gingivalis-specific immunoglobulin G facilitates clearance o...

journal_title：Infection and immunity

authors： Gibson FC 3rd,Gonzalez DA,Wong J,Genco CA

更新日期：2004-04-01 00:00:00

abstract：:Because of the association of the group A streptococcal pyrogenic exotoxins (SPEs) with erythrogenic toxin used in the classical Dick test, the involvement of the SPEs in production of erythematous skin reactions was assessed. Unless they had been presensitized, young adult rabbits failed to show skin reactions after ...

journal_title：Infection and immunity

authors： Schlievert PM,Bettin KM,Watson DW

更新日期：1979-11-01 00:00:00

abstract：:Pregnant mice, guinea pigs, rats, and rabbits responded to injections of Moraxella bovis strain EPP-63(300) with abortion, death, embryo resorption, and production of small litters. The nature of response appeared to depend primarily on the number of viable cells injected and to some extent on the species of animal an...

journal_title：Infection and immunity

authors： Norman JO,Elissalde MH

更新日期：1979-05-01 00:00:00

abstract：:Legionella pneumophila is the predominant cause of Legionnaires' disease in the United States and Europe, while Legionella longbeachae is the common cause of the disease in Western Australia. Although clinical manifestations by both intracellular pathogens are very similar, recent studies have shown that phagosome bio...

journal_title：Infection and immunity

authors： Asare R,Santic M,Gobin I,Doric M,Suttles J,Graham JE,Price CD,Abu Kwaik Y

更新日期：2007-04-01 00:00:00

abstract：:Bordetella pertussis was grown in iron (Fe)-free defined medium to limit the growth of the organism. Doubling times of the Fe-starved organism increased by approximately 1 h, and a 40% reduction in the final extent of growth in Fe-depleted medium was observed. Under these conditions, a hydroxamate siderophore named bo...

journal_title：Infection and immunity

authors： Agiato LA,Dyer DW

更新日期：1992-01-01 00:00:00

abstract：:The gene products from an 8-kb region adjacent to the 3' end of the ptx operon are required by Bordetella pertussis for the export of pertussis holotoxin. At least one of these gene products (PtlC) is specifically required for the export of assembled holotoxin from the periplasmic space. ptlC mutants exhibit a 20-fold...

journal_title：Infection and immunity

authors： Baker SM,Masi A,Liu DF,Novitsky BK,Deich RA

更新日期：1995-10-01 00:00:00

abstract：:In order to deploy virulence factors at appropriate times and locations, microbes must rapidly sense and respond to various metabolite signals. Previously, we showed a transient elevation of the methionine-derived metabolite methylthioadenosine (MTA) concentration in serum during systemic Salmonella enterica serovar T...

journal_title：Infection and immunity

authors： Bourgeois JS,Zhou D,Thurston TLM,Gilchrist JJ,Ko DC

更新日期：2018-08-22 00:00:00

abstract：:Nonspecific cross-reacting antigen (NCA) is a well-characterized membrane glycoprotein on granulocytes, macrophages, and lung epithelium. Structural studies at the protein and genomic levels have revealed that NCA is a member of the immunoglobulin supergene family, and hybridization studies showed that the transcript ...

journal_title：Infection and immunity

authors： Sauter SL,Rutherfurd SM,Wagener C,Shively JE,Hefta SA

更新日期：1991-07-01 00:00:00

abstract：:Mucin glycoproteins are secreted in large amounts by the intestinal epithelium and constitute an efficient component of innate immune defenses to promote homeostasis and protect against enteric pathogens. In this study, our objective was to investigate how the bacterial enteropathogen Shigella flexneri, which causes b...

journal_title：Infection and immunity

authors： Sperandio B,Fischer N,Joncquel Chevalier-Curt M,Rossez Y,Roux P,Robbe Masselot C,Sansonetti PJ

更新日期：2013-10-01 00:00:00

abstract：:We have reported that P388D1 cell line murine macrophages stimulated with lipopolysaccharide (LPS) from Actinobacillus actinomycetemcomitans release interleukin-1 (IL-1) inhibitor. The IL-1 inhibitor was purified from conditioned media of P388D1 cells stimulated with A. actinomycetemcomitans LPS for 72 h to homogeneit...

journal_title：Infection and immunity

authors： Nishihara T,Ohsaki Y,Ueda N,Saito N,Mundy GR

更新日期：1994-02-01 00:00:00

abstract：:The Duffy binding protein (DBP) is a vital ligand for Plasmodium vivax blood-stage merozoite invasion, making the molecule an attractive vaccine candidate against vivax malaria. Similar to other blood-stage vaccine candidates, DBP allelic variation eliciting a strain-specific immunity may be a major challenge for deve...

journal_title：Infection and immunity

authors： Ntumngia FB,Schloegel J,Barnes SJ,McHenry AM,Singh S,King CL,Adams JH

更新日期：2012-03-01 00:00:00

abstract：:Staphylococcus aureus can produce a wide variety of exotoxins, including toxic shock syndrome toxin 1 (TSST-1), staphylococcal enterotoxins, and staphylococcal enterotoxin-like toxins. These toxins share superantigenic activity. To investigate the beta chain (Vbeta) specificities of each of these toxins, TSST-1 and al...

journal_title：Infection and immunity

authors： Thomas D,Dauwalder O,Brun V,Badiou C,Ferry T,Etienne J,Vandenesch F,Lina G

更新日期：2009-05-01 00:00:00

abstract：:Nitric oxide (NO) produced by inducible NO synthase (iNOS) mediates hypotension in endotoxemia. In this study, NO induction by a toxin-producing Streptococcus pyogenes isolate, H250, and by recombinant streptococcal pyrogenic exotoxin A (rSPEA) has been examined, both in vitro and in vivo. Streptococcal supernatants, ...

journal_title：Infection and immunity

authors： Sriskandan S,Moyes D,Buttery LK,Wilkinson J,Evans TJ,Polak J,Cohen J

更新日期：1997-05-01 00:00:00

abstract：:Enterotoxigenic Escherichia coli (ETEC) is a major cause of traveler's diarrhea as well as of endemic diarrhea and stunting in children in developing areas. However, a small-mammal model has been badly needed to better understand and assess mechanisms, vaccines, and interventions. We report a murine model of ETEC diar...

journal_title：Infection and immunity

authors： Bolick DT,Medeiros PHQS,Ledwaba SE,Lima AAM,Nataro JP,Barry EM,Guerrant RL

更新日期：2018-06-21 00:00:00

abstract：:The antigenic cross-reactivity between Treponema pallidum and several pathogenic members of the family Spirochaetaceae was examined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blotting techniques. Blots of T. pallidum antigens were incubated with antiserum from rabbits infected or immunize...

journal_title：Infection and immunity

authors： Baker-Zander SA,Lukehart SA

更新日期：1984-10-01 00:00:00

abstract：:Porphyromonas gingivalis has been implicated as an etiologic agent of adult periodontitis. We have previously shown that P. gingivalis can degrade the epithelial cell-cell junction complexes, thus suggesting that this bacterium can invade the underlying connective tissues via a paracellular pathway. However, the preci...

journal_title：Infection and immunity

authors： Katz J,Yang QB,Zhang P,Potempa J,Travis J,Michalek SM,Balkovetz DF

更新日期：2002-05-01 00:00:00

abstract：:The porcine immunoglobulins M (IgM), A (IgA), and G (IgG) were isolated and purified and some of the properties of the porcine milk IgA were examined. Monospecific antisera which were prepared against these immunoglobulins in rabbits were then used to absorb a particular class of immunoglobulin from sow serum, colostr...

journal_title：Infection and immunity

authors： Saif LJ,Bohl EH,Gupta RK

更新日期：1972-10-01 00:00:00

abstract：:A purified human granulocyte colony-stimulating factor (hG-CSF) was studied for its protective effect on the induction of neutropenia and enhanced susceptibility to microbial infections in mice receiving cyclophosphamide (CPA). A severe reduction in peripheral blood neutrophils was induced 4 days after injection with ...

journal_title：Infection and immunity

authors： Matsumoto M,Matsubara S,Matsuno T,Tamura M,Hattori K,Nomura H,Ono M,Yokota T

更新日期：1987-11-01 00:00:00

abstract：:A method for stimulating sensitized lymphocytes by inactivated herpes simplex virus was established by using cultures of washed whole blood cells. The development of the immune response of herpes simplex virus-infected guinea pigs was examined at different times in the 4-month period after infection. Humoral and cellu...

journal_title：Infection and immunity

authors： Scriba M

更新日期：1974-09-01 00:00:00

abstract：:The importance of CD4+ cells and gamma interferon (IFN-gamma) in the resolution of established Cryptosporidium parvum infection was investigated with a murine model of cryptosporidiosis in severe combined immunodeficient (SCID) mice. C. parvum-infected SCID mice were reconstituted with spleen cells from immunocompeten...

journal_title：Infection and immunity

authors： Chen W,Harp JA,Harmsen AG

更新日期：1993-09-01 00:00:00

abstract：:Endotoxemia in rats is associated with the accumulation of neutrophils (polymorphonuclear leukocytes) within the airspaces of the lung. Polymorphonuclear leukocyte influx appears to be regulated by the intrapulmonary accumulation of chemotactic activity. Since alveolar macrophages (AMS) are prevalent cells in the airs...

journal_title：Infection and immunity

authors： Christman JW,Petras SF,Vacek PM,Davis GS

更新日期：1989-03-01 00:00:00

abstract：:Ehrlichia chaffeensis is a recently isolated minute gram-negative obligatory intracellular bacterium of monocytes/macrophages and is the etiologic agent of human monocytic ehrlichiosis. It is not known how macrophages respond when they encounter ehrlichiae in terms of cytokine production. In this study, we examined cy...

journal_title：Infection and immunity

authors： Lee EH,Rikihisa Y

更新日期：1996-10-01 00:00:00