Intact purine biosynthesis pathways are required for wild-type virulence of Brucella abortus 2308 in the BALB/c mouse model.

abstract：:Outer membrane protein F (porin) was purified by extraction from polyacrylamide gels of cell envelope proteins of the Pseudomonas aeruginosa PAO1 strain. Rats were immunized intramuscularly with 25 micrograms of protein F on days 1 and 14 and then challenged on day 28 via intratracheal inoculation of bacterium-contain...

journal_title：Infection and immunity

authors： Gilleland HE Jr,Gilleland LB,Matthews-Greer JM

更新日期：1988-05-01 00:00:00

abstract：:Toxoplasma gondii infects both hematopoietic and nonhematopoietic cells and can cause cerebral and ocular toxoplasmosis, as a result of either congenital or postnatally acquired infections. Host protection likely acts at both cellular levels to control the parasite. CD40 is a key factor for protection against cerebral...

journal_title：Infection and immunity

authors： Van Grol J,Muniz-Feliciano L,Portillo JA,Bonilha VL,Subauste CS

更新日期：2013-06-01 00:00:00

abstract：:Studies were performed to determine the optimal sites for primary isolation of Mycoplasma pulmonis from the respiratory system of laboratory rats. In a preliminary study, a group of 42 rats was cultured for respiratory M. pulmonis at several sites. Tracheal washes yielded the highest number of positive cultures (61.9%...

journal_title：Infection and immunity

authors： Lentsch RH,Wagner JE,Owens DR

更新日期：1979-11-01 00:00:00

abstract：:Actinobacillus pleuropneumoniae serotype 7 strains are shown to spontaneously lose cytolytic activity with a frequency of approximately 10(-4). The phenotypic change is associated with the loss of approximately 8.5 kbp of chromosomal DNA. A genomic fragment encoding the cytolysin and its flanking sequences was cloned ...

journal_title：Infection and immunity

authors： Anderson C,Potter AA,Gerlach GF

更新日期：1991-11-01 00:00:00

abstract：:It is not clear how the host initially recognizes and responds to infection by gram-negative pathogenic Brucella spp. It was previously shown (D. S. Weiss, B. Raupach, K. Takeda, S. Akira, and A. Zychlinsky, J. Immunol. 172:4463-4469, 2004) that the early macrophage response against gram-negative bacteria is mediated ...

journal_title：Infection and immunity

authors： Weiss DS,Takeda K,Akira S,Zychlinsky A,Moreno E

更新日期：2005-08-01 00:00:00

abstract：:We have investigated the roles of gamma interferon (IFN-gamma) and interleukin-4 (IL-4) in host defense against Brugia malayi. Our data suggest that the lack of either IFN-gamma or IL-4 prolongs the time required to achieve sterile immunity, suggesting that both canonical type 1 and type 2 responses are involved in th...

journal_title：Infection and immunity

authors： Babu S,Ganley LM,Klei TR,Shultz LD,Rajan TV

更新日期：2000-05-01 00:00:00

abstract：:Cellular resistance to facultative intracellular parasites has been studied by determining the antimycobacterial activity and the amount of fatty acids in sera and in heptane extracts of freshly collected and 24-h-cultured normal and activated guinea pig alveolar macrophages and liver cells. The quantity and the antim...

journal_title：Infection and immunity

authors： Hemsworth GR,Kochan I

更新日期：1978-01-01 00:00:00

abstract：:Oligosaccharide (OS)-protein conjugates are promising candidate vaccines against encapsulated bacteria, such as Haemophilus influenzae, Neisseria meningitidis, and Streptococcus pneumoniae. Although the effects of several variables such as OS chain length and protein carrier have been studied, little is known about th...

journal_title：Infection and immunity

authors： Lefeber DJ,Benaissa-Trouw B,Vliegenthart JF,Kamerling JP,Jansen WT,Kraaijeveld K,Snippe H

更新日期：2003-12-01 00:00:00

abstract：:To assess the relationship between the within-host diversity of malaria infections and the susceptibility of the host to subsequent infection, we genotyped 60 children's successive infections from birth through 3 years of life. MSP-1 Block2 genotypes were used to estimate the complexity of infection (COI). Malaria tra...

journal_title：Infection and immunity

authors： Branch OH,Takala S,Kariuki S,Nahlen BL,Kolczak M,Hawley W,Lal AA

更新日期：2001-12-01 00:00:00

abstract：:The gene encoding a nitric oxide reductase has been identified in Neisseria gonorrhoeae. The norB gene product shares significant identity with the nitric oxide reductases in Ralstonia eutropha and Synechocystis sp. and, like those organisms, the gonococcus lacks a norC homolog. The gonococcal norB gene was found to b...

journal_title：Infection and immunity

authors： Householder TC,Fozo EM,Cardinale JA,Clark VL

更新日期：2000-09-01 00:00:00

abstract：:High-density oligonucleotide microarrays are widely used to study gene expression in cells exposed to a variety of pathogens. This study addressed the global genome-wide transcriptional activation of genes in hosts infected in vivo, which result in radically different clinical outcomes. We present an analysis of the g...

journal_title：Infection and immunity

authors： Schaecher K,Kumar S,Yadava A,Vahey M,Ockenhouse CF

更新日期：2005-09-01 00:00:00

abstract：:Genomic DNA fingerprint analysis was performed on 39 Staphylococcus aureus and 28 Enterococcus faecalis endophthalmitis isolates collected from multiple clinical centers. Among 21 S. aureus genomic DNA fingerprint patterns identified, five clonotypes were recovered from multiple unrelated patients and accounted for 58...

journal_title：Infection and immunity

authors： Booth MC,Hatter KL,Miller D,Davis J,Kowalski R,Parke DW,Chodosh J,Jett BD,Callegan MC,Penland R,Gilmore MS

更新日期：1998-01-01 00:00:00

abstract：:In an attempt to understand the mechanism of serum resistance in Actinobacillus pleuropneumoniae, in the present study we examined various interactions among the bacterial surface constituents, serum antibodies, and complement. Analysis of swine sera revealed the presence of anticapsular antibodies in convalescent-pha...

journal_title：Infection and immunity

authors： Udeze FA,Kadis S

更新日期：1992-09-01 00:00:00

abstract：:Antigen-specific T-cell responses and histopathological changes were studied in mice experimentally inoculated with Borrelia burgdorferi B31. Inbred mice with different H-2 haplotypes and/or different genetic backgrounds were inoculated with B. burgdorferi organisms and tested for antigen-specific T-cell responses in ...

journal_title：Infection and immunity

authors： Schaible UE,Kramer MD,Justus CW,Museteanu C,Simon MM

更新日期：1989-01-01 00:00:00

abstract：:Lipooligosaccharide (LOS) is a major surface component of Moraxella catarrhalis and a possible virulence factor in the pathogenesis of human infections caused by this organism. The presence of LOS on the bacterium is an obstacle to the development of vaccines derived from whole cells or outer membrane components of th...

journal_title：Infection and immunity

authors： Peng D,Hong W,Choudhury BP,Carlson RW,Gu XX

更新日期：2005-11-01 00:00:00

abstract：:Insertional mutagenesis studies of mrpB, a putative pilin-encoding open reading frame of the mrp gene cluster, which encodes mannose-resistant Proteus-like (MR/P) fimbriae of Proteus mirabilis, indicate that MrpB functions as the terminator for fimbrial assembly. ...

journal_title：Infection and immunity

authors： Li X,Mobley HL

更新日期：1998-04-01 00:00:00

abstract：:Peptic ulcer disease (PUD) occurs after a long-term Helicobacter pylori infection. However, the disease can develop earlier, and rare cases have been observed in children, suggesting that these H. pylori strains may be more virulent. We used suppressive subtractive hybridization for comparative genomics between H. pyl...

journal_title：Infection and immunity

authors： Oleastro M,Monteiro L,Lehours P,Mégraud F,Ménard A

更新日期：2006-07-01 00:00:00

abstract：:After intranasal inoculation, Brucella melitensis chronically infects the mononuclear phagocyte system in BALB/c mice, but it causes no apparent illness. Adaptive immunity, which can be transferred by either T cells or antibody from immune to naive animals, confers resistance to challenge infection. The role of innate...

journal_title：Infection and immunity

authors： Izadjoo MJ,Polotsky Y,Mense MG,Bhattacharjee AK,Paranavitana CM,Hadfield TL,Hoover DL

更新日期：2000-09-01 00:00:00

abstract：:Previous studies have suggested that the Pseudomonas aeruginosa PAK pilus adhesin moiety resides in an epithelial cell-binding domain located in the C-terminal region of the PAK pilin structural protein. Synthetic peptides Ac17red (a synthetic peptide with a sequence identical to that of PAK pilin residues 128 to 144,...

journal_title：Infection and immunity

authors： Irvin RT,Doig P,Lee KK,Sastry PA,Paranchych W,Todd T,Hodges RS

更新日期：1989-12-01 00:00:00

abstract：:A protein factor which induces high levels of gamma interferon (IFN-gamma) in resting splenic nonadherent cells was isolated from the sera of mice with generalized inflammation caused by endotoxic shock. The factor was highly purified by ammonium sulfate precipitation followed by ion-exchange column chromatography on ...

journal_title：Infection and immunity

authors： Nakamura K,Okamura H,Nagata K,Komatsu T,Tamura T

更新日期：1993-01-01 00:00:00

abstract：:Susceptibility to Coccidioides spp. varies widely in humans and other mammals and also among individuals within a species. Among strains of mice with various susceptibilities, immunohistopathology revealed that C57BL/6 mice were highly susceptible to the disease following intranasal infection, DBA/2n mice were interme...

journal_title：Infection and immunity

authors： Shubitz LF,Dial SM,Perrill R,Casement R,Galgiani JN

更新日期：2008-12-01 00:00:00

abstract：:A nonproteolytic strain of Clostridium botulinum type B produces two toxins of different molecular weight (16S and 12S) that are indistinguishable from the corresponding toxins of a proteolytic strain in molecular weight and construction but differ in potential toxicity, activation ratio, and hemagglutinability. Succe...

journal_title：Infection and immunity

authors： Miyazaki S,Kozaki S,Sakaguchi S,Sakaguchi G

更新日期：1976-03-01 00:00:00

abstract：:The rationale for the present study was to determine how different species of bacteria interact with cells of the human meninges in order to gain information that would have broad relevance to understanding aspects of the innate immune response in the brain. Neisseria lactamica is an occasional cause of meningitis in ...

journal_title：Infection and immunity

authors： Fowler MI,Yin KY,Humphries HE,Heckels JE,Christodoulides M

更新日期：2006-11-01 00:00:00

abstract：:Clostridium perfringens enterotoxin (CPE), a single polypeptide of 319 amino acids, has a unique multistep mechanism of action. In the first step, CPE binds to claudin proteins and/or a 50-kDa eukaryotic membrane protein receptor, forming a small ( approximately 90-kDa) complex. This small complex apparently then asso...

journal_title：Infection and immunity

authors： Kokai-Kun JF,Benton K,Wieckowski EU,McClane BA

更新日期：1999-11-01 00:00:00

abstract：:Capsular glucuronoxylomannans (GXM) of Cryptococcus neoformans var. neoformans isolates from patients with recurrent cryptococcal meningitis were analyzed by 1H nuclear magnetic resonance spectroscopy and for reactivity with factor sera (Iatron, Tokyo, Japan). For each patient the initial and relapse isolates had prev...

journal_title：Infection and immunity

authors： Cherniak R,Morris LC,Belay T,Spitzer ED,Casadevall A

更新日期：1995-05-01 00:00:00

abstract：:Pneumolysin, the cholesterol-dependent cytolysin of Streptococcus pneumoniae, induces inflammatory and apoptotic events in mammalian cells. Toll-like receptor 4 (TLR4) confers resistance to pneumococcal infection via its interaction with pneumolysin, but the underlying mechanisms remain to be identified. In the presen...

journal_title：Infection and immunity

authors： Srivastava A,Henneke P,Visintin A,Morse SC,Martin V,Watkins C,Paton JC,Wessels MR,Golenbock DT,Malley R

更新日期：2005-10-01 00:00:00

abstract：:Ehrlichia chaffeensis is a recently isolated minute gram-negative obligatory intracellular bacterium of monocytes/macrophages and is the etiologic agent of human monocytic ehrlichiosis. It is not known how macrophages respond when they encounter ehrlichiae in terms of cytokine production. In this study, we examined cy...

journal_title：Infection and immunity

authors： Lee EH,Rikihisa Y

更新日期：1996-10-01 00:00:00

abstract：:The nonacylated form of protein D (PDm) of Haemophilus influenzae has been shown to induce the production of antibodies that are bactericidal to homologous and heterologous nontypeable H. influenzae (NTHi) strains. In this study, immunization of rats with lipoprotein D (LPD) induced higher levels of anti-protein D imm...

journal_title：Infection and immunity

authors： Akkoyunlu M,Melhus A,Capiau C,van Opstal O,Forsgren A

更新日期：1997-12-01 00:00:00

abstract：:Infection with gram-negative monocytotropic Ehrlichia strains results in a fatal toxic shock-like syndrome characterized by a decreased number of Ehrlichia-specific CD4(+) Th1 cells, the expansion of tumor necrosis factor alpha (TNF-alpha)-producing CD8(+) T cells, and the systemic overproduction of interleukin-10 (IL...

journal_title：Infection and immunity

authors： Ismail N,Crossley EC,Stevenson HL,Walker DH

更新日期：2007-09-01 00:00:00

abstract：:Strains of Corynebacterium ulcerans and Corynebacterium pseudotuberculosis (Corynebacterium ovis) were examined for the production of diphtheria toxin. A majority of C. ulcerans strains (25 of 37) and 1 C. pseudotuberculosis strain (1 of 14) gave a positive Elek test for diphtheria toxin, and for all strains but 1, pr...

journal_title：Infection and immunity

authors： Groman N,Schiller J,Russell J

更新日期：1984-08-01 00:00:00