Depolarization of polymorphonuclear leukocytes by Porphyromonas (Bacteroides) gingivalis 381 in the absence of respiratory burst activation.

abstract：:Mice (BALB/cJ, C3H/HeN, and C3H/HeJ) primed with actinomycin D became highly susceptible to lethal intoxication with staphylococcal enterotoxin B (SEB). The mice underwent toxicosis and toxic shock and died. Actinomycin D-primed C3H/HeN and C3H/HeJ mice showed equal sensitivity to SEB, suggesting that bacterial lipopo...

journal_title：Infection and immunity

authors： Chen JY,Qiao Y,Komisar JL,Baze WB,Hsu IC,Tseng J

更新日期：1994-10-01 00:00:00

abstract：:The mechanism by which recombinant murine gamma interferon (rMuIFN-gamma) and bacterial lipopolysaccharide (LPS) activate mouse resident splenic macrophages to inhibit the intracellular growth of the fungus Histoplasma capsulatum was examined. Growth inhibition depended on L-arginine metabolism. The growth inhibitory ...

journal_title：Infection and immunity

authors： Lane TE,Wu-Hsieh BA,Howard DH

更新日期：1994-05-01 00:00:00

abstract：:Candida albicans is a commensal organism that under certain circumstances can become pathogenic. During systemic infection C. albicans is disseminated via the circulation to distant organs, where it causes multiple organ failure. Despite the severity of systemic C. albicans infection, little is known about the mechani...

journal_title：Infection and immunity

authors： Grubb SE,Murdoch C,Sudbery PE,Saville SP,Lopez-Ribot JL,Thornhill MH

更新日期：2009-09-01 00:00:00

abstract：:In the murine model of urinary tract infections (UTI), cystitis by uropathogenic Escherichia coli (UPEC) occurs through an intimate relationship with the bladder superficial umbrella cell entailing cycles of adherence, invasion, intracellular bacterial community (IBC) formation, and dispersal (fluxing) from the intrac...

journal_title：Infection and immunity

authors： Wright KJ,Seed PC,Hultgren SJ

更新日期：2005-11-01 00:00:00

abstract：:The lack of specific T-cell help in immune responses to thymus-independent antigens results in weak, predominantly immunoglobulin M-mediated immunity with little or no memory. In the work presented here we show how the exogenous stimulation of CD40 by monoclonal antibodies can mimic T-cell help, resulting in enhanced ...

journal_title：Infection and immunity

authors： Barr TA,Heath AW

更新日期：1999-07-01 00:00:00

abstract：:Defining the pattern of lymphokine production associated with Brucella abortus is critical for advancing the development of B. abortus as a vaccine carrier. In the present study we investigated the ability of heat-inactivated B. abortus or lipopolysaccharide from B. abortus to induce lymphokine production from purifie...

journal_title：Infection and immunity

authors： Zaitseva MB,Golding H,Betts M,Yamauchi A,Bloom ET,Butler LE,Stevan L,Golding B

更新日期：1995-07-01 00:00:00

abstract：:An asd-stabilized plasmid carrying enterotoxigenic Escherichia coli cfaABCE genes was constructed and called pJGX15C-asd+. Expression of colonization factor antigen I (CFA/I) by this plasmid occurs independently of the cfaABCE positive regulator cfaR in attenuated Salmonella delta aro delta asd strain H683 and nonpath...

journal_title：Infection and immunity

authors： Wu S,Pascual DW,VanCott JL,McGhee JR,Maneval DR Jr,Levine MM,Hone DM

更新日期：1995-12-01 00:00:00

abstract：:The aroC gene of the facultative intracellular pathogen Brucella suis was cloned and sequenced. The cloned aroC gene complements Escherichia coli and Salmonella enterica serovar Typhimurium aroC mutants. A B. suis aroC mutant was found to be unable to grow in a defined medium without aromatic compounds. The mutant was...

journal_title：Infection and immunity

authors： Foulongne V,Walravens K,Bourg G,Boschiroli ML,Godfroid J,Ramuz M,O'Callaghan D

更新日期：2001-01-01 00:00:00

abstract：:The stimulation of mononuclear phagocytes by lipopolysaccharide (LPS) is facilitated by the binding of complexes of LPS and LPS-binding protein to CD14. Although it is clear that CD14 is involved in LPS-induced signaling, other investigators have hypothesized the existence of additional signaling pathways in macrophag...

journal_title：Infection and immunity

authors： Lynn WA,Liu Y,Golenbock DT

更新日期：1993-10-01 00:00:00

abstract：:Otitis media developed in 67% of chinchillas inoculated intranasally with type 7 Streptococcus pneumoniae and influenza A virus. Only 4% of chinchillas inoculated with influenza alone and 21% of chinchillas inoculated with S. pneumoniae alone developed otitis media. Among the chinchillas that developed otitis media af...

journal_title：Infection and immunity

authors： Giebink GS,Berzins IK,Marker SC,Schiffman G

更新日期：1980-11-01 00:00:00

abstract：:The microbicidal myeloperoxidase (MPO)-H2O2-chloride system strongly inhibits Escherichia coli DNA synthesis. Also, cell envelopes from MPO-treated E. coli cells lose their ability to interact with hemimethylated DNA sequences of oriC, the chromosomal origin of replication, raising the prospect that suppression of DNA...

journal_title：Infection and immunity

authors： Rosen H,Michel BR,vanDevanter DR,Hughes JP

更新日期：1998-06-01 00:00:00

abstract：:Immunoglobulin A1 (IgA1) proteases are produced by a number of different species of bacteria which cause infection at human mucosal surfaces. The sole substrate of these proteases is human IgA1. Cleavage is within the hinge region of IgA1, although there is variability in the exact peptide bond within the hinge region...

journal_title：Infection and immunity

authors： Grundy FJ,Plaut AG,Wright A

更新日期：1990-02-01 00:00:00

abstract：:Macrophage ribonucleic acid (RNA) synthesis is an important metabolic process intimately related to the function of these cells. Mouse peritoneal macrophage RNA was extracted with phenol in the presence of bentonite and electrophoresed on composite agarose-polyacrylamide gels. The pulse-chase technique was used to fol...

journal_title：Infection and immunity

authors： Soderberg LS,Tewari RP,Solotorovsky M

更新日期：1976-06-01 00:00:00

abstract：:Candida-associated denture stomatitis (DS) is a persistent and chronic oral infection of the denture-bearing palatal mucosa. DS stems from the ability of the fungal opportunistic pathogen Candida albicans to adhere to denture material and invade palatal tissue. Although DS is the most prevalent form of oral candidiasi...

journal_title：Infection and immunity

authors： Sultan AS,Rizk AM,Vila T,Ji Y,Masri R,Jabra-Rizk MA

更新日期：2019-11-18 00:00:00

abstract：:Candida albicans serotype A (C. albicans A) possesses a specific antigen, designated antigen 6, which resides in mannans on the cell surface. To determine the role of the mannan moiety of the C. albicans cell wall in adherence to buccal epithelial cells, we used antigen 6-deficient mutants which had been isolated by s...

journal_title：Infection and immunity

authors： Miyakawa Y,Kuribayashi T,Kagaya K,Suzuki M,Nakase T,Fukazawa Y

更新日期：1992-06-01 00:00:00

abstract：:Salmonella infection can cause gastroenteritis in healthy individuals or a serious, systemic infection in immunocompromised patients and has a global impact. CD4 Th1 cells represent the main lymphocyte population that participates in bacterial clearance during both primary and secondary infections in mice of the H-2b ...

journal_title：Infection and immunity

authors： Labuda JC,Depew CE,Pham OH,Benoun JM,Ramirez NA,McSorley SJ

更新日期：2019-10-18 00:00:00

abstract：:Studies were carried out to determine whether treatment of mice with the synthetic adjuvant muramyl dipeptide afforded any resistance to infection with the obligate intracellular protozoan Toxoplasma gondii. Marked resistance to lethal challenge infection was observed in CBA but not C57BL/6 mice pretreated with muramy...

journal_title：Infection and immunity

authors： Krahenbuhl JL,Sharma SD,Ferraresi RW,Remington JS

更新日期：1981-02-01 00:00:00

abstract：:Diverse pathogens have evolved to survive and replicate in the endosomes or phagosomes of the host cells and establish persistent infection. Ehrlichiae are Gram-negative, intracellular bacteria that are transmitted by ticks. Ehrlichiae reside in the endosomes of the host phagocytic or endothelial cells and establish p...

journal_title：Infection and immunity

authors： Singh AK,Thirumalapura NR

更新日期：2014-10-01 00:00:00

abstract：:Oral treponemes are considered to be important in the development and progression of periodontal diseases. We investigated the mechanisms of recognition and activation of human gingival epithelial cells (HGEC) with the oral treponemes Treponema denticola, Treponema vincentii, and Treponema medium and their outer membr...

journal_title：Infection and immunity

authors： Asai Y,Jinno T,Ogawa T

更新日期：2003-02-01 00:00:00

abstract：:Lewis (Le) antigens have been implicated in the pathogenesis of atrophic gastritis and gastric cancer in the setting of Helicobacter pylori infection, and H. pylori-induced anti-Le antibodies have been described that cross-react with the gastric mucosa of both mice and humans. The aim of this study was to examine the ...

journal_title：Infection and immunity

authors： Heneghan MA,McCarthy CF,Janulaityte D,Moran AP

更新日期：2001-08-01 00:00:00

abstract：:A major obstacle to studying the functions of particular gene products in the mouse-tick infectious cycle of Borrelia burgdorferi has been an inability to knock out genes in pathogenic strains. Here, we investigated conditions for site-directed mutagenesis in B31 MI, the low-passage-number, infectious B. burgdorferi s...

journal_title：Infection and immunity

authors： Elias AF,Stewart PE,Grimm D,Caimano MJ,Eggers CH,Tilly K,Bono JL,Akins DR,Radolf JD,Schwan TG,Rosa P

更新日期：2002-04-01 00:00:00

abstract：:A cytotoxigenic Clostridium difficile strain that fails to produce toxin A but causes hemorrhage and bloody fluid accumulation in ligated ileal loops of rabbits and hemorrhage and diarrhea in hamsters is described. The lack of reaction of DNA from this strain in hybridization studies with a toxin A gene-specific 4.5-k...

journal_title：Infection and immunity

authors： Borriello SP,Wren BW,Hyde S,Seddon SV,Sibbons P,Krishna MM,Tabaqchali S,Manek S,Price AB

更新日期：1992-10-01 00:00:00

abstract：:Salmonella enterica serovar Typhi is a human-restricted Gram-negative bacterial pathogen responsible for causing an estimated 27 million cases of typhoid fever annually, leading to 217,000 deaths, and current vaccines do not offer full protection. The O-antigen side chain of the lipopolysaccharide is an immunodominant...

journal_title：Infection and immunity

authors： Kintz E,Heiss C,Black I,Donohue N,Brown N,Davies MR,Azadi P,Baker S,Kaye PM,van der Woude M

更新日期：2017-03-23 00:00:00

abstract：:The actions of polymyxin B, rabbit polymorphonuclear lysosome extracts, 14 polycationic peptides (including defensin NP-2, cecropin P1, lactoferricin B, and active peptides from cationic protein 18 and bactenecin), EDTA, and Tris on Brucella spp. were studied, with other gram-negative bacteria as controls. Brucella sp...

journal_title：Infection and immunity

authors： Martínez de Tejada G,Pizarro-Cerdá J,Moreno E,Moriyón I

更新日期：1995-08-01 00:00:00

abstract：:Nasopharyngeal colonization is a necessary first step in the pathogenesis of Streptococcus pneumoniae. Using isolates containing defined mutations in the S. pneumoniae capsule locus, we found that expression of the capsular polysaccharide is essential for colonization by the type 2 strain D39 and the type 3 strains A6...

journal_title：Infection and immunity

authors： Magee AD,Yother J

更新日期：2001-06-01 00:00:00

abstract：:Streptococcus suis serotype 2 is an encapsulated bacterium and one of the most important bacterial pathogens in the porcine industry. Despite decades of research for an efficient vaccine, none is currently available. Based on the success achieved with other encapsulated pathogens, a glycoconjugate vaccine strategy was...

journal_title：Infection and immunity

authors： Goyette-Desjardins G,Calzas C,Shiao TC,Neubauer A,Kempker J,Roy R,Gottschalk M,Segura M

更新日期：2016-06-23 00:00:00

abstract：:The mouse humoral immune response toward native or detergent-extracted outer membrane vesicles (NOMVs and DOMVs, respectively) from Neisseria meningitidis was determined after intranasal immunization. Both preparations elicited high frequencies of NOMV-specific antibody-forming cells (AFCs) locally in the nasal associ...

journal_title：Infection and immunity

authors： Guthrie T,Wong SY,Liang B,Hyland L,Hou S,Høiby EA,Andersen SR

更新日期：2004-05-01 00:00:00

abstract：:Killing of Salmonella minnesota and Salmonella typhimurium S and R strains in serum of nonimmune humans and guinea pigs was drastically reduced in the selective absence of C1q, C1r, Ca2+, C4, or C2, the components of the classical complement pathway. Binding of C1 and C1q to the S form and six different core-deficient...

journal_title：Infection and immunity

authors： Clas F,Loos M

更新日期：1982-09-01 00:00:00

abstract：:Ultrastructural changes in cells of the mouse footpad are described which occurred during the log phase of multiplication, the plateau, and the stationary phase of growth of Mycobacterium leprae.BALB/c mice were inoculated in the right hind footpad with 5 x 10(3) organisms and sacrificed in pairs at 86 to 173 days aft...

journal_title：Infection and immunity

authors： Evans MJ,Levy L

更新日期：1972-02-01 00:00:00

abstract：:Trypanosoma cruzi is a protozoan parasite that causes human Chagas' disease, a leading source of congestive heart failure in Central and South America. CD8+ T cells are critical for control of T. cruzi infection, and CD8+ T cells recognizing the immunodominant trans-sialidase gene-encoded peptide TSKB20 (ANYKFTLV) acc...

journal_title：Infection and immunity

authors： Martin DL,Murali-Krishna K,Tarleton RL

更新日期：2010-07-01 00:00:00