Abstract:
:Ultrastructural changes in cells of the mouse footpad are described which occurred during the log phase of multiplication, the plateau, and the stationary phase of growth of Mycobacterium leprae.BALB/c mice were inoculated in the right hind footpad with 5 x 10(3) organisms and sacrificed in pairs at 86 to 173 days after inoculation. Tissue samples were prepared for electron microscopy by standard techniques. During the early growth phase of M. leprae in the mouse footpad, few organisms can be detected. Those present are in macrophages and are bound by a single membrane. The cytoplasm of the macrophage is less dense around the organism. There are few lysosomes, and the bacteria do not appear to be degenerating. At the peak of the growth phase, the organisms within a macrophage are bound by either a single or double membrane. There is an increased number of vacuoles, which are also bound by a double membrane, and lysosomes. During the stationary phase, most of the macrophages have taken on a vacuolar appearance and contain lysosomes. The vacuoles are bound by a double membrane, as are most of the organisms within the macrophage. Many of these organisms appear to be degenerating. Occasionally, organisms are encountered in the sarcoplasm of striated muscle. They are usually bound by a single membrane and do not appear to be degenerating.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Evans MJ,Levy Ldoi
10.1128/IAI.5.2.238-247.1972subject
Has Abstractpub_date
1972-02-01 00:00:00pages
238-47issue
2eissn
0019-9567issn
1098-5522journal_volume
5pub_type
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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doi:10.1128/IAI.41.2.482-487.1983
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journal_title:Infection and immunity
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.40.2.670-674.1983
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.36.3.1028-1035.1982
更新日期:1982-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.6.1656-1662.1989
更新日期:1989-06-01 00:00:00
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journal_title:Infection and immunity
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.6.2284-2288.1993
更新日期:1993-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00909-19
更新日期:2020-02-20 00:00:00
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pub_type: 杂志文章
doi:10.1128/iai.70.3.1518-1529.2002
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journal_title:Infection and immunity
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doi:10.1128/IAI.31.2.571-573.1981
更新日期:1981-02-01 00:00:00
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doi:10.1128/IAI.23.3.737-742.1979
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:2001-03-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.4.1538-1543.1993
更新日期:1993-04-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.6.2120-2125.1995
更新日期:1995-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:2017-10-18 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.2.2.201-208.1970
更新日期:1970-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/IAI.00077-16
更新日期:2016-06-23 00:00:00