Influence of origin of isolates, especially endocarditis isolates, and various genes on biofilm formation by Enterococcus faecalis.

Abstract:

:Endocarditis isolates of Enterococcus faecalis produced biofilm significantly more often than nonendocarditis isolates, and 39% of 79 versus 6% of 84 isolates produced strong biofilm (P < 0.0001). esp was not required, but its presence was associated with higher amounts of biofilm (P < 0.001). Mutants disrupted in dltA, efaA, ace, lsa, and six two-component regulatory systems were largely unaltered, while disruptions in epa (encoding enterococcal polysaccharide antigen), atn (encoding an autolysin), gelE (encoding gelatinase), and fsr (encoding the E. faecalis regulator) [corrected] resulted in fewer attached bacteria, as determined using phase-contrast microscopy, and less biofilm (P < 0.0001).

journal_name

Infect Immun

journal_title

Infection and immunity

authors

Mohamed JA,Huang W,Nallapareddy SR,Teng F,Murray BE

doi

10.1128/IAI.72.6.3658-3663.2004

keywords:

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

3658-63

issue

6

eissn

0019-9567

issn

1098-5522

pii

72/6/3658

journal_volume

72

pub_type

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