Abstract:
:Immune and pathologic responses were measured for 20 weeks after infection of mice with Brucella abortus 19, RB51, or 2308. Live bacteria and bacterial antigens of 19 and RB51 persisted in spleens for 10 and 4 weeks after infection, respectively, whereas 2308 bacteria and bacterial antigens persisted for at least 20 weeks. Small germinal centers and profound lymphoid depletion occurred in spleens of mice during the first 4 weeks of infection with strain 19 or 2308; however, mice infected with strain RB51 had much larger germinal centers but no lymphoid depletion. At 4 weeks, only spleen cells from RB51-infected mice proliferated when incubated with 2308 bacteria. Large germinal centers in the spleen and spleen cell proliferative responses to 2308 did not appear in strain 19-infected mice until 6 weeks or in strain 2308-infected mice until 10 weeks. Similar proliferative responses to 2308 occurred in mice infected with strain 19 or RB51 at 6 weeks and in mice infected with strain 19, RB51, or 2308 at 10 weeks. However, at 20 weeks, spleen cell proliferative responses to 2308 occurred in mice infected with strain 19 or 2308 but not in mice infected with strain RB51. Mice infected with strain RB51 had lower and less persistent antibody titers to 2308 than did mice infected with strain 19 or 2308. Collectively, these results indicate that RB51-infected mice have less persistent immune responses to 2308 than do mice infected with 19 or 2308. The shorter duration of the responses probably resulted because RB51 is considerably less pathogenic and is cleared more rapidly from mice than are 19 and 2308.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Stevens MG,Olsen SC,Pugh GW Jr,Palmer MVdoi
10.1128/IAI.62.8.3206-3212.1994subject
Has Abstractpub_date
1994-08-01 00:00:00pages
3206-12issue
8eissn
0019-9567issn
1098-5522journal_volume
62pub_type
杂志文章abstract::Groups of female C57BL/6 and C3H/St mice were inoculated intraperitoneally (i.p.) with 10(9), 10(7), and 10(5) bacilli and into the right hind footpad with 10(7) and 10(5) bacilli of Mycobacterium lepraemurium. The incidence of death from leprosy and the mean survival time of leprous mice were recorded. In addition, t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1980-06-01 00:00:00
abstract::The results of a test of endotoxic potency based upon the development of histamine hypersensitivity in mice were compared with the results obtained by testing the same materials for pyrogenicity in rabbits and lethality for chicken embryos (CELD50). The results of the histamine hypersensitization test (HHT) correlated...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.18.2.352-355.1977
更新日期:1977-11-01 00:00:00
abstract::Candida albicans secreted aspartyl proteinases (Saps) are considered virulence-associated factors. Several members of the Sap family were claimed to play a significant role in the progression of candidiasis established by the hematogenous route. This assumption was based on the observed attenuated virulence of sap-nul...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00248-10
更新日期:2010-11-01 00:00:00
abstract::The response to reinfection with Ethiopian Leishmania donovani was evaluated in genetically determined noncure (H-2d) B10.D2 mice that are able to resolve infection due to sublethal irradiation pretreatment after inoculation with a low parasite dose and in C57BL/10 mice that demonstrate the genetically determined cure...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.9.2892-2899.1989
更新日期:1989-09-01 00:00:00
abstract::We studied the influence of staphylococcal toxic shock syndrome toxin 1 and streptococcal erythrogenic (pyrogenic) toxin A (ETA) on intact and digitonin-permeabilized human polymorphonuclear granulocytes (PMNs). As was shown by reversed-phase high-performance liquid chromatography analysis, toxic shock syndrome toxin ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.3.1055-1061.1993
更新日期:1993-03-01 00:00:00
abstract::In the present study, the role of virulence factors in and the effect of opsonization on the interactions between Bordetella pertussis and human monocytes were investigated. The methods used facilitated the distinction between attachment and ingestion of bacteria by monocytes. Nonopsonized virulent B. pertussis cells ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.11.4818-4824.1994
更新日期:1994-11-01 00:00:00
abstract::Coxiella burnetii is the causative agent of Q fever, a zoonotic disease that threatens both human and animal health. Due to the paucity of experimental animal models, little is known about how host factors interface with bacterial components and affect pathogenesis. Here, we used Drosophila melanogaster, in conjunctio...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00218-17
更新日期:2017-06-20 00:00:00
abstract::Pregnancy-associated malaria is a severe clinical syndrome associated with the sequestration of Plasmodium falciparum-infected erythrocytes in the placenta. Placental binding is mediated by VAR2CSA, a member of the large and diverse P. falciparum erythrocyte membrane 1 (PfEMP1) protein family. To better understand if ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00410-09
更新日期:2010-05-01 00:00:00
abstract::Identification of antigenically conserved surface components of Haemophilus ducreyi may facilitate the development of reagents to diagnose and prevent chancroid. A hybridoma derived from a mouse immunized with nontypeable Haemophilus influenzae produced a monoclonal antibody (MAb), designated 3B9, that bound to 35 of ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.2.385-391.1992
更新日期:1992-02-01 00:00:00
abstract::Infection with gram-negative monocytotropic Ehrlichia strains results in a fatal toxic shock-like syndrome characterized by a decreased number of Ehrlichia-specific CD4(+) Th1 cells, the expansion of tumor necrosis factor alpha (TNF-alpha)-producing CD8(+) T cells, and the systemic overproduction of interleukin-10 (IL...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00198-07
更新日期:2007-09-01 00:00:00
abstract::Only listeriolysin O (LLO)-producing strains of Listeria monocytogenes generate protective immunity in mice. Based on the findings that endogenous gamma interferon (IFN-gamma) production was induced only by such strains and that purified LLO could induce IFN-gamma from NK cells, we have postulated that LLO may play a ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.2.568-575.1999
更新日期:1999-02-01 00:00:00
abstract::Despite the high prevalence of cutaneous infections, little is known about the role of host immune responsiveness during Staphylococcus aureus dermatitis. We have recently described a murine model of infectious dermatitis induced by superantigen-producing S. aureus. To assess the role of neutrophils in staphylococcal ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.11.6162-6167.2000
更新日期:2000-11-01 00:00:00
abstract::Clostridium perfringens enterotoxin (CPE), a single polypeptide of 319 amino acids, has a unique multistep mechanism of action. In the first step, CPE binds to claudin proteins and/or a 50-kDa eukaryotic membrane protein receptor, forming a small ( approximately 90-kDa) complex. This small complex apparently then asso...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.11.5634-5641.1999
更新日期:1999-11-01 00:00:00
abstract::With large amounts of parasite gene sequence available, additional bioinformatic tools to screen these sequences for identifying genes encoding antigens are needed. Proteins containing tandem repeat (TR) domains are often B-cell antigens, and antibody responses toward TR domains of the proteins are dominant in human i...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01205-06
更新日期:2007-02-01 00:00:00
abstract::The ocular damage in young adult mice produced by purified Pseudomonas aeruginosa exotoxin A was microscopically characterized at 1 and 5 h and at 1, 3, 5, 7, 10, 14, and 21 days after toxin A challenge, using light, transmission, and scanning electron microscopic techniques. Similarly to previously described infectio...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.34.3.1025-1035.1981
更新日期:1981-12-01 00:00:00
abstract::A gene from Haemophilus influenzae encoding an outer membrane lipoprotein of about 15,000 daltons and which comigrates with the peptidoglycan-associated lipoprotein (PAL) of H. influenzae on sodium dodecyl sulfate-polyacrylamide gel electrophoresis has been previously reported and designated pcp gene, and its product ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.10.3388-3393.1990
更新日期:1990-10-01 00:00:00
abstract::Adult murine models of Cryptosporidium infection involving Cryptosporidium muris and C. parvum were used to study immunity to cryptosporidiosis in the mammalian host. Immunocompetent BALB/c or C57BL/6 mice developed a highly patent infection with the RN 66 strain of C. muris but overcame the infection and were immune ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.8.3325-3331.1992
更新日期:1992-08-01 00:00:00
abstract::Cells in the Brucella spp. are intracellular pathogens that survive and replicate within host monocytes. Brucella maintains persistent infections in animals despite the production of high levels of anti-Brucella-specific antibodies. To determine the effect of antibody opsonization on the ability of Brucella to establi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.6.3702-3713.2005
更新日期:2005-06-01 00:00:00
abstract::The objective of this study was to identify disease-related changes in lymphocyte populations within ileal mucosae of calves with cryptosporidiosis. Groups of five neonatal calves were orally infected at 3 days of age with 10(8) oocysts and maintained in enteric-pathogen-free conditions until clinical disease was esta...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.1.185-190.1997
更新日期:1997-01-01 00:00:00
abstract::We have performed microarray hybridization studies on 40 clinical isolates from 12 common serovars within Salmonella enterica subspecies I to identify the conserved chromosomal gene pool. We were able to separate the core invariant portion of the genome by a novel mathematical approach using a decision tree based on g...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.12.7894-7905.2005
更新日期:2005-12-01 00:00:00
abstract::Advanced human periodontitis is considered to be a B-cell lesion, but the cellular infiltrate contains several cell types, the distribution of which has not been determined. This experiment was designed to characterize and identify the immunocompetent cells on histological sections and in eluates from diseased human g...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.41.1.365-374.1983
更新日期:1983-07-01 00:00:00
abstract::Bile aspirated from chicken gall bladders was found to contain substances neutralizing Newcastle disease virus (NDV). Nonspecific factors were present in the bile, probably the bile acids, which caused a reduction in the infectivity of the virus. Specific anti-NDV activity was found in the bile of birds that had been ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.11.4.692-697.1975
更新日期:1975-04-01 00:00:00
abstract::Immunization of monkeys with the 82-kDa rhoptry protein (p82) of Plasmodium falciparum can protect them against a lethal blood stage challenge, and monoclonal antibodies to p82 inhibit parasite growth in vitro. The role that a p82-specific immune response might play in human immunity to the parasite is not known. To d...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.7.2960-2965.1993
更新日期:1993-07-01 00:00:00
abstract::Merozoite surface protein 2 (MSP2) is an abundant glycosylphosphatidylinositol (GPI)-anchored protein of Plasmodium falciparum, which is a potential component of a malaria vaccine. As all forms of MSP2 can be categorized into two allelic families, a vaccine containing two representative forms of MSP2 may overcome the ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00665-12
更新日期:2012-12-01 00:00:00
abstract::Although the opportunistic bacterial pathogen Enterococcus faecium is a leading source of nosocomial infections, it appears to lack many of the overt virulence factors produced by other bacterial pathogens, and the underlying mechanism of pathogenesis is not clear. Using E. faecium-mediated killing of the nematode wor...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.8.4512-4520.2004
更新日期:2004-08-01 00:00:00
abstract::The antiphagocytic effect of the Staphylococcus aureus capsule is known to be related to its ability to interfere with opsonization by normal human serum. In this study, evidence is presented with isolated cell surface components which indicates that the capsule hinders opsonization by masking cell wall peptidoglycan....
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.23.2.502-508.1979
更新日期:1979-02-01 00:00:00
abstract::Binding of Escherichia coli strain 431 heat-stable enterotoxin (STa) and activation of intestinal particulate guanylate cyclase by E. coli STa were studied with rat intestinal epithelial cells and brush border membranes (BBMs). The rates of guanylate cyclase stimulation by 431 STa in cells and BBMs were rapid, with ma...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.46.2.537-543.1984
更新日期:1984-11-01 00:00:00
abstract::When rabbit peritoneal exudate cells were incubated for 24 and 48 h with phytohemagglutinin-activated lymphocytes or their culture supernatants, two times as many cells remained adherent to culture slides as in the controls. More spreading cells were found among the adherent cells in the stimulated cultures. Eighty pe...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.13.5.1442-1448.1976
更新日期:1976-05-01 00:00:00
abstract::Intimate attachment to the host cell leading to the formation of attaching and effacing (A/E) lesions is an essential feature of enterohemorrhagic Escherichia coli (EHEC) O157:H7 pathogenesis. In a related pathogen, enteropathogenic E. coli (EPEC), this activity is dependent upon translocation of the intimin receptor,...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.5.2389-2398.1999
更新日期:1999-05-01 00:00:00
abstract::Porphyromonas gingivalis is reportedly capable of stimulating the expression of host cell matrix metalloproteinases (MMP), contributing to tissue destruction. However, the impact of this bacterium on specific molecules remains to be determined. In this study, we evaluate the effect of P. gingivalis on regulation of MM...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.12.4940-4945.1996
更新日期:1996-12-01 00:00:00