Recombinant V antigen protects mice against pneumonic and bubonic plague caused by F1-capsule-positive and -negative strains of Yersinia pestis.

Abstract:

:The purified recombinant V antigen from Yersinia pestis, expressed in Escherichia coli and adsorbed to aluminum hydroxide, an adjuvant approved for human use, was used to immunize outbred Hsd:ND4 mice subcutaneously. Immunization protected mice from lethal bubonic and pneumonic plague caused by CO92, a wild-type F1+ strain, or by the isogenic F1- strain C12. This work demonstrates that a subunit plague vaccine formulated for human use provides significant protection against bubonic plague caused by an F1- strain (C12) or against substantial aerosol challenges from either F1+ (CO92) or F1-(C12) Y. pestis.

journal_name

Infect Immun

journal_title

Infection and immunity

authors

Anderson GW Jr,Leary SE,Williamson ED,Titball RW,Welkos SL,Worsham PL,Friedlander AM

doi

10.1128/IAI.64.11.4580-4585.1996

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

4580-5

issue

11

eissn

0019-9567

issn

1098-5522

journal_volume

64

pub_type

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