Abstract:
:Chronic actinomycetoma associated with grain production was induced in BALB/c mice by subcutaneous inoculation of live Nocardia brasiliensis in Freund incomplete adjuvant into the hind footpads. Similar inoculation of N. asteroides and N. caviae resulted in local tumor formation which healed spontaneously after 5 months, the disease disseminating into the peritoneum, where masses or organisms could be detected. Grains were recovered from superficial skin lesions of N. caviae, but not from the N. asteroides-infected mice. Mycetoma lesions, appearing as early as 1 month after inoculation of 1.2 X 10(7) colony-forming units of N. brasiliensis per ml or as late as 3 months with inoculation of 1.0 X 10(5) colony-forming units per ml, became persistent and were readily detectable even 6 months after inoculation. No spontaneous healing occurred, and grains were recovered at different stages of the disease. Saline suspensions of N. brasiliensis also produced typical mycetoma lesions, although the incubation period was ca. 6 months. Adjuvant addition appeared to accelerate the onset of the disease. Experimental production of actinomycetoma in laboratory animals allows the study of many unanswered aspects of the disease and also provides a suitable model for therapeutic trials in the search for new and more effective chemotherapeutic agents.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Zlotnik H,Buckley HRsubject
Has Abstractpub_date
1980-09-01 00:00:00pages
1141-5issue
3eissn
0019-9567issn
1098-5522journal_volume
29pub_type
杂志文章abstract::Thrombospondin-related anonymous protein (TRAP) of the malaria parasite Plasmodium falciparum shares two sequence motifs with other proteins which possess adhesive properties. Recently, findings indicate that TRAP is an antigen which contributes to antisporozoite immunity. We have cloned and expressed the TRAP coding ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.8.3490-3495.1993
更新日期:1993-08-01 00:00:00
abstract::NF-κB is a critical regulator of gene expression during severe infections. NF-κB comprises homo- and heterodimers of proteins from the Rel family. Among them, p50 and p65 have been clearly implicated in the pathophysiology of sepsis. In contrast, the role of cRel in sepsis is still controversial and has been poorly st...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00021-11
更新日期:2011-05-01 00:00:00
abstract::Genetic defects in the Rab27a or Munc13-4 gene lead to immunodeficiencies in humans, characterized by frequent viral and bacterial infections. However, the role of Rab27a and Munc13-4 in the regulation of systemic inflammation initiated by Gram-negative bacterium-derived pathogenic molecules is currently unknown. Usin...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.05043-11
更新日期:2011-09-01 00:00:00
abstract::Attachment and ingestion of Mycobacterium avium subsp. paratuberculosis by two epithelial cell lines were enhanced by soluble fibronectin (FN). Peptide blocking of the FN attachment protein (FAP-P) inhibited the internalization of M. avium subsp. paratuberculosis. Disruption of FAP-P expression significantly reduced a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.5.2670-2675.2002
更新日期:2002-05-01 00:00:00
abstract::To test the importance of lipopolysaccharide (LPS) and adhesin as major antigens in vaccination against rabbit enteropathogenic Escherichia coli (EPEC)-like E. coli O103 infection, we used two nonpathogenic wild-type strains to immunize rabbits at weaning. One of these strains (C127) harbors the O103 LPS but does not ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.7.2702-2709.1992
更新日期:1992-07-01 00:00:00
abstract::The surface antigen makeup of metacyclic trypomastigote forms of strain G of Trypanosoma cruzi, which produce a subpatent infection in mice, differed from those of the virulent strains Y and CL. A 100,000-molecular-weight protein, barely detectable on the Y or CL cell surface, appeared as the main surface antigen of t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.40.2.836-839.1983
更新日期:1983-05-01 00:00:00
abstract::Our previous work suggests that one mechanism through which connective tissue breakdown might occur in periodontal diseases is the production of metalloproteinases, including collagenase, by gingival fibroblasts. In this study we investigated whether highly purified preparations of lipopolysaccharide (LPS) and lipotei...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.9.2148-2154.1987
更新日期:1987-09-01 00:00:00
abstract::Colonization of the large bowel of healthy infants by Clostridium difficile was studied. Feces were collected from five breast-fed aand five formula-fed infants throughout the first year of life, and levels of C. difficile were quantitated. Three breast-fed and five formula-fed infants were colonized for periods of be...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.35.3.895-899.1982
更新日期:1982-03-01 00:00:00
abstract::In the present study, the roles of interleukin 12 (IL-12) and IL-18 and their possible interaction during superantigen-induced responses were studied by injection of staphylococcal enterotoxin B (SEB) into mice. These data suggest that the role of IL-12 in SEB-induced responses is limited to sustaining gamma interfero...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.69.9.5949-5952.2001
更新日期:2001-09-01 00:00:00
abstract::Borrelia burgdorferi, the causative agent of Lyme arthritis, does not produce any exported proteases capable of degrading extracellular matrix despite the fact that it is able to disseminate from a skin insertion site to infect multiple organs. Prior studies have shown that B. burgdorferi induces the host protease, ma...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00214-09
更新日期:2009-07-01 00:00:00
abstract::A Gram-negative, filamentous, rod-shaped bacillus which failed to grow in cell-free media was isolated in apparently pure culture from the bronchial scraping and washing of a laboratory rat suffering from chronic respiratory disease by inoculating embryonated chicken eggs via the allantoic route. None of the embryos d...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.47.2.472-479.1985
更新日期:1985-02-01 00:00:00
abstract::Peripheral leukocytes from 16 Thai children with dengue hemorrhagic fever were examined to determine the leukocyte composition on the day of presentation and on convalescent days 15 and 30. Mononuclear cells were isolated each time, and the concentrations of T, B, Fc receptor-bearing, and "null" cells were determined....
journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1980-05-01 00:00:00
abstract::We report the immunizing capacity of Salmonella enteritidis AL1192, a strain that has been cured of a 36-megadalton plasmid, to protect ddY mice against subsequent challenge with virulent salmonellas. This strain, which was given subcutaneously at a dose of 10(6) organisms, provided significant protection against oral...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.50.2.586-587.1985
更新日期:1985-11-01 00:00:00
abstract::Peptic ulcer disease (PUD) occurs after a long-term Helicobacter pylori infection. However, the disease can develop earlier, and rare cases have been observed in children, suggesting that these H. pylori strains may be more virulent. We used suppressive subtractive hybridization for comparative genomics between H. pyl...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00123-06
更新日期:2006-07-01 00:00:00
abstract::Endocarditis was induced in the rabbit by the placement of a polyethylene catheter in the right heart. The catheter was filled with stable L-phase variants of Staphylococcus aureus to determine if the variant form would colonize the damaged endocardium and produce further tissue injury similar to that produced by the ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.7.5.725-730.1973
更新日期:1973-05-01 00:00:00
abstract::Akabane virus (a Bunyavirus) has been associated with epizootics of congenital deformities in cattle, sheep, and goats. Experimental studies using mouse-adapted virus inoculated intravenously into pregnant sheep gave an inapparent infection. Neutralizing antibodies were detected on day 5, and peaks in the titer were s...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.15.1.254-262.1977
更新日期:1977-01-01 00:00:00
abstract::It was shown that a strain of Serratia liquefaciens harbors a conjugative R-plasmid responsible for reistance to the following 14 antibiotics: ampicillin, carbenicillin, cephalothin, butirosin, neomycin, paramomycin, kanamycin, lividomycin, gentamicin, tobramycin, streptomycin, tetracycline, sulfonamide, and chloramph...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1980-06-01 00:00:00
abstract::Two weeks after mice had been infected in the footpad with cells of Nocardia brasiliensis, immunoglobulin and C3 deposits were observed in tissue from the inoculation site. Both immunoglobulin and C3 were found in the actinomycotic granules that characterize the mycetoma and in the surrounding inflammatory zones, in w...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.40.3.1218-1222.1983
更新日期:1983-06-01 00:00:00
abstract::Pasteurella multocida is the causative agent of fowl cholera in birds. In a previous study using signature-tagged mutagenesis, we identified a mutant, AL251, which was attenuated for virulence in mice and in the natural chicken host. Sequence analysis indicated that AL251 had an insertional inactivation of the gene wa...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.6.3436-3443.2004
更新日期:2004-06-01 00:00:00
abstract::Group B streptococci (GBS) adhere to surface receptors present on epithelial cells; these receptors include fibronectin and laminin. To identify other possible receptors, plasma membranes from A549 cells, a respiratory tract epithelial cell line, were prepared. These plasma membranes were tested in a protein blot anal...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.4.2129-2134.2000
更新日期:2000-04-01 00:00:00
abstract::The effect of infection with low-virulence, tissue culture-propagated strains of reticuloendotheliosis virus (REV) on protective vaccinal immunity against Marek's disease (MD) lymphomas was investigated. Vaccinated chickens inoculated at hatching with greater than 10(4) focus-forming units of REV and challenged with M...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.26.1.90-98.1979
更新日期:1979-10-01 00:00:00
abstract::We have previously identified two K88ac adhesion receptors (210 and 240 kDa) which are present in membrane preparations from adhesive but not nonadhesive porcine intestinal brush border cells; these adhesin receptors are postulated to be important determinants of the susceptibility of pigs to K88ac+ enterotoxigenic Es...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.12.5404-5410.1994
更新日期:1994-12-01 00:00:00
abstract::The effects of tolerance to Escherichia coli endotoxin on the phagocytic and bactericidal activity of the hepatic reticuloendothelial system against viable E. coli were examined using ex vivo perfused rat livers. Livers were isolated from control and endotoxin-tolerant rats and perfused with a medium containing 5% hom...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.27.3.798-803.1980
更新日期:1980-03-01 00:00:00
abstract::Legionella pneumophila, the gram-negative agent of Legionnaires' disease, possesses type IV pili and a type II protein secretion (Lsp) system, both of which are dependent upon the PilD prepilin peptidase. By analyzing multiple pilD mutants and various types of Lsp mutants as well as performing trans-complementation of...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.72.1.310-321.2004
更新日期:2004-01-01 00:00:00
abstract::LipL32 is the major outer membrane protein in pathogenic Leptospira. It is highly conserved throughout pathogenic species and is expressed in vivo during human infection. While these data suggest a role in pathogenesis, a function for LipL32 has not been defined. Outer membrane proteins of gram-negative bacteria are t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01643-07
更新日期:2008-05-01 00:00:00
abstract::Legionella pneumophila is the predominant cause of Legionnaires' disease in the United States and Europe, while Legionella longbeachae is the common cause of the disease in Western Australia. Although clinical manifestations by both intracellular pathogens are very similar, recent studies have shown that phagosome bio...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00025-07
更新日期:2007-04-01 00:00:00
abstract::Pyolysin (PLO), a cholesterol-dependent cytolysin expressed by Arcanobacterium pyogenes, is an important host-protective antigen. However, this molecule is toxic and requires inactivation prior to its use as a vaccine. Three genetically toxoided, nonhemolytic PLO molecules, HIS-PLO.F(497), HIS-PLO.Delta P(499), and HI...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.5.2966-2969.2003
更新日期:2003-05-01 00:00:00
abstract::A hemolysin that appears to be responsible for the zones of beta-hemolysis surrounding colonies of group B streptococci (Streptococcus agalactiae) on blood agar plates has been isolated and partially purified. No soluble hemolysin was detectable in the supernatants of streptococcal cultures grown in several types of m...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1980-12-01 00:00:00
abstract::Mycobacterium leprae are killed by myeloperoxidase (or eosinophil peroxidase), H2O2, and a halide, thus suggesting a mechanism for their destruction by peroxidase-containing phagocytes. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.44.2.534-536.1984
更新日期:1984-05-01 00:00:00
abstract::In this analysis we have examined in detail the effects of low concentrations of zinc on the growth and dimorphism of Candida albicans. Evidence is presented that micromolar concentrations of zinc added to growth cultures grown at 25 degrees C (i) cause a twofold increase in the final concentration of spheres at satio...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.26.1.348-354.1979
更新日期:1979-10-01 00:00:00