Role of endogenous interleukin-12 in immune response to staphylococcal enterotoxin B in mice.

abstract：:To assess the humoral immunological responses at the subclass level in shigellosis, specific antibody responses against Shigella dysenteriae 1 lipopolysaccharide (LPS), S. flexneri Y LPS, invasion plasmid-coded protein antigens (Ipa), and Shiga toxin were analyzed. Antibody responses of 41 patients with S. dysenteriae...

journal_title：Infection and immunity

authors： Islam D,Wretlind B,Ryd M,Lindberg AA,Christensson B

更新日期：1995-05-01 00:00:00

abstract：:An asd-stabilized plasmid carrying enterotoxigenic Escherichia coli cfaABCE genes was constructed and called pJGX15C-asd+. Expression of colonization factor antigen I (CFA/I) by this plasmid occurs independently of the cfaABCE positive regulator cfaR in attenuated Salmonella delta aro delta asd strain H683 and nonpath...

journal_title：Infection and immunity

authors： Wu S,Pascual DW,VanCott JL,McGhee JR,Maneval DR Jr,Levine MM,Hone DM

更新日期：1995-12-01 00:00:00

abstract：:The action of injected bacterial lipopolysaccharide upon the uptake of cytophilic antibodies by macrophages was found to be unrelated either to changes in surface charge or to the rate of anaerobic glycolysis of these cells. It is apparently mediated by alterations in the levels of material in the serum which enhances...

journal_title：Infection and immunity

authors： Tizard IR

更新日期：1971-10-01 00:00:00

abstract：:Mice were inoculated with Legionella pneumophila via an intratracheal route to establish an experimental model of infection. Lung lavage fluid obtained from infected mice contained a cytolytic factor identified as tumor necrosis factor (TNF). Peak levels of TNF were produced at about 24 h postinfection and rapidly dec...

journal_title：Infection and immunity

authors： Blanchard DK,Djeu JY,Klein TW,Friedman H,Stewart WE 2nd

更新日期：1987-02-01 00:00:00

abstract：:In previous work, we identified xanthine oxidase (XO) as an important enzyme in the interaction between the host and enteropathogenic Escherichia coli(EPEC) and Shiga-toxigenic E. coli(STEC). Many of the biological effects of XO were due to the hydrogen peroxide produced by the enzyme. We wondered, however, if uric ac...

journal_title：Infection and immunity

authors： Crane JK,Broome JE,Lis A

更新日期：2016-03-24 00:00:00

abstract：:Legionella pneumophila is a facultative intracellular bacterium which readily grows in cultures of guinea pig and human mononuclear phagocytes. In this report, we demonstrate that the Legionella sp. also grows in thioglycolate-elicited macrophages obtained from A/J mice but not in cells from other mouse strains tested...

journal_title：Infection and immunity

authors： Yamamoto Y,Klein TW,Newton CA,Widen R,Friedman H

更新日期：1988-02-01 00:00:00

abstract：:Helicobacter pylori secretes a pore-forming VacA toxin that has structural features and activities substantially different from those of other known bacterial toxins. VacA can assemble into multiple types of water-soluble flower-shaped oligomeric structures, and most VacA activities are dependent on its capacity to ol...

journal_title：Infection and immunity

authors： González-Rivera C,Campbell AM,Rutherford SA,Pyburn TM,Foegeding NJ,Barke TL,Spiller BW,McClain MS,Ohi MD,Lacy DB,Cover TL

更新日期：2016-08-19 00:00:00

abstract：:The mouse system provides an excellent model for studying host resistance to Naegleria fowleri, the agent of primary amoebic meningoencephalitis. Innate resistance to infection with N. fowleri was examined with respect to infecting dose and the age, sex, and strain of mice. Intravenous inoculation with 10(7) amoebae p...

journal_title：Infection and immunity

authors： Haggerty RM,John DT

更新日期：1978-04-01 00:00:00

abstract：:The mechanism(s) of interaction between Mycoplasma pulmonis and eucaryotic cells was studied by adherence to and hemagglutination of erythrocytes. Simple and complex carbohydrates and glycoproteins were unable to inhibit either adherence or hemagglutination, indicating that neither was a lectin activity. Both interact...

journal_title：Infection and immunity

authors： Minion FC,Cassell GH,Pnini S,Kahane I

更新日期：1984-05-01 00:00:00

abstract：:Memory CD8+ T cells are essential for protective immunity against many intracellular pathogens; therefore, stimulation of this population of cells is an important goal of vaccination. We have previously shown that a detoxified derivative of Bacillus anthracis anthrax lethal toxin (LT) can deliver heterologous CD8+ T-c...

journal_title：Infection and immunity

authors： Shaw CA,Starnbach MN

更新日期：2008-03-01 00:00:00

abstract：:Nasopharyngeal colonization is a necessary first step in the pathogenesis of Streptococcus pneumoniae. Using isolates containing defined mutations in the S. pneumoniae capsule locus, we found that expression of the capsular polysaccharide is essential for colonization by the type 2 strain D39 and the type 3 strains A6...

journal_title：Infection and immunity

authors： Magee AD,Yother J

更新日期：2001-06-01 00:00:00

abstract：:The important veterinary pathogen Clostridium perfringens type B is unique for producing the two most lethal C. perfringens toxins, i.e., epsilon-toxin and beta-toxin. Our recent study (K. Miyamoto, J. Li, S. Sayeed, S. Akimoto, and B. A. McClane, J. Bacteriol. 190:7178-7188, 2008) showed that most, if not all, type B...

journal_title：Infection and immunity

authors： Sayeed S,Li J,McClane BA

更新日期：2010-01-01 00:00:00

abstract：:This study focuses on the interaction of the three components of the Bacillus cereus Nhe enterotoxin with particular emphasis on the functional roles of NheB and NheC. The results demonstrated that both NheB and NheC were able to bind to Vero cells directly while NheA lacked this ability. It was also shown that Nhe-in...

journal_title：Infection and immunity

authors： Lindbäck T,Hardy SP,Dietrich R,Sødring M,Didier A,Moravek M,Fagerlund A,Bock S,Nielsen C,Casteel M,Granum PE,Märtlbauer E

更新日期：2010-09-01 00:00:00

abstract：:Escherichia coli O157:H7 is an important pathogen of humans. Cattle are most frequently identified as the primary source of infection, and therefore, reduction in E. coli O157:H7 prevalence in cattle by vaccination represents an attractive strategy for reducing the incidence of human disease. H7 flagella have been imp...

journal_title：Infection and immunity

authors： McNeilly TN,Naylor SW,Mahajan A,Mitchell MC,McAteer S,Deane D,Smith DG,Low JC,Gally DL,Huntley JF

更新日期：2008-06-01 00:00:00

abstract：:Actinobacillus actinomycetemcomitans SUNY 465, the invasion prototype strain, enters epithelial cells by an actin-dependent mechanism, escapes from the host cell vacuole, and spreads intracellularly and to adjacent epithelial cells via intercellular protrusions. Internalized organisms also egress from host cells into ...

journal_title：Infection and immunity

authors： Meyer DH,Rose JE,Lippmann JE,Fives-Taylor PM

更新日期：1999-12-01 00:00:00

abstract：:Infection by Shigella flexneri is characterized by infiltration of neutrophils in the intestinal mucosa and by a strong inflammatory reaction. Although neutrophils are constitutively programmed to die by apoptosis, we show that isolated human neutrophils undergo necrosis 2 h after infection with virulent S. flexneri s...

journal_title：Infection and immunity

authors： François M,Le Cabec V,Dupont MA,Sansonetti PJ,Maridonneau-Parini I

更新日期：2000-03-01 00:00:00

abstract：:Several monoclonal antibodies directed against gonococcal pili have been used to investigate the potential contribution of anti-pilus antibodies to host defense against gonococcal infection. Included were two antibodies (SM1 and SM2) which reacted with conserved determinants present on pili from all strains tested and...

journal_title：Infection and immunity

authors： Virji M,Heckels JE

更新日期：1985-09-01 00:00:00

abstract：:To characterize the roles of Porphyromonas gingivalis and its components in disease processes, we investigated the cytokine profiles induced by live P. gingivalis, its lipopolysaccharide (LPS), and its major fimbrial protein, fimbrillin (FimA). A cytokine antibody array revealed that human monocyte-derived macrophages...

journal_title：Infection and immunity

authors： Zhou Q,Amar S

更新日期：2006-02-01 00:00:00

abstract：:BCG, the attenuated strain of Mycobacterium bovis, has been widely used as a vaccine against tuberculosis and is thus an important candidate as a live carrier for multiple antigens. With the aim of developing a recombinant BCG (rBCG) vaccine against diphtheria, pertussis, and tetanus (DPT), we analyzed the potential o...

journal_title：Infection and immunity

authors： Miyaji EN,Mazzantini RP,Dias WO,Nascimento AL,Marcovistz R,Matos DS,Raw I,Winter N,Gicquel B,Rappuoli R,Leite LC

更新日期：2001-02-01 00:00:00

abstract：:The cytokine response to the agent of human granulocytic ehrlichiosis (HGE) was assessed in a murine infection model and the role of gamma interferon (IFN-gamma), a cytokine that is crucial for host defenses against intracellular pathogens, was investigated by using IFN-gamma-deficient mice. The agent of HGE (aoHGE) i...

journal_title：Infection and immunity

authors： Akkoyunlu M,Fikrig E

更新日期：2000-04-01 00:00:00

abstract：:As part of a study of virulence gene regulation in Streptococcus pneumoniae, we have identified a gene encoding a homologue of the staphylococcal catabolite control protein CcpA in the pneumococcal genome sequence. The pneumococcal protein, designated RegM, has significant similarity to members of the LacI/GalR family...

journal_title：Infection and immunity

authors： Giammarinaro P,Paton JC

更新日期：2002-10-01 00:00:00

abstract：:In the murine model of urinary tract infections (UTI), cystitis by uropathogenic Escherichia coli (UPEC) occurs through an intimate relationship with the bladder superficial umbrella cell entailing cycles of adherence, invasion, intracellular bacterial community (IBC) formation, and dispersal (fluxing) from the intrac...

journal_title：Infection and immunity

authors： Wright KJ,Seed PC,Hultgren SJ

更新日期：2005-11-01 00:00:00

abstract：:Suppression of the host defense is one of the hallmarks of Yersinia enterocolitica infection. This enteric pathogen resists phagocytosis and interferes with macrophage functions from an extracellular localization (oxidative-burst generation and tumor necrosis factor alpha production). In this study, we investigated th...

journal_title：Infection and immunity

authors： Ruckdeschel K,Roggenkamp A,Lafont V,Mangeat P,Heesemann J,Rouot B

更新日期：1997-11-01 00:00:00

abstract：:Cryptococcal meningoencephalitis develops as a result of hematogenous dissemination of inhaled Cryptococcus neoformans from the lung to the brain. The mechanism(s) by which C. neoformans crosses the blood-brain barrier (BBB) is a key unresolved issue in cryptococcosis. We used both an in vivo mouse model and an in vit...

journal_title：Infection and immunity

authors： Chang YC,Stins MF,McCaffery MJ,Miller GF,Pare DR,Dam T,Paul-Satyaseela M,Kim KS,Kwon-Chung KJ

更新日期：2004-09-01 00:00:00

abstract：:Glaesserella (Haemophilus) parasuis is a commensal bacterium of the upper respiratory tract in pigs and also the causative agent of Glässer's disease, which causes significant morbidity and mortality in pigs worldwide. Isolates are characterized into 15 serovars by their capsular polysaccharide, which has shown a corr...

journal_title：Infection and immunity

authors： Eberle KC,Hau SJ,Luan SL,Weinert LA,Stasko JA,Wang J,Peters SE,Langford PR,Rycroft AN,Wren BW,Maskell DJ,Tucker AW,Brockmeier SL

更新日期：2020-04-20 00:00:00

abstract：:The outer membrane of pathogenic Leptospira species grown in culture media contains lipopolysaccharide (LPS), a porin (OmpL1), and several lipoproteins, including LipL36 and LipL41. The purpose of this study was to characterize the expression and distribution of these outer membrane antigens during renal infection. Ha...

journal_title：Infection and immunity

authors： Barnett JK,Barnett D,Bolin CA,Summers TA,Wagar EA,Cheville NF,Hartskeerl RA,Haake DA

更新日期：1999-02-01 00:00:00

abstract：:Salivary proline-rich proteins (PRPs), which were purified from parotid saliva, were adsorbed onto 15-nm-diameter gold particles to visualize specific binding of the salivary molecules to Actinomyces viscosus type 1 fimbriae. Negatively stained preparations incubated with PRP-gold conjugates but not bovine serum album...

journal_title：Infection and immunity

authors： Leung KP,Nesbitt WE,Fischlschweiger W,Hay DI,Clark WB

更新日期：1990-06-01 00:00:00

abstract：:Human peripheral blood monocytes become apoptotic following phagocytosis of Staphylococcus aureus. In this study, we investigated the mechanisms involved in this phenomenon. Cells exposed to bacteria were examined for the surface expression of Fas and Fas ligand (FasL). The level of soluble form of FasL was also measu...

journal_title：Infection and immunity

authors： Baran J,Weglarczyk K,Mysiak M,Guzik K,Ernst M,Flad HD,Pryjma J

更新日期：2001-03-01 00:00:00

abstract：:Toxigenic Vibrio cholerae strains are lysogens of CTXPhi, a filamentous phage which encodes cholera toxin. The receptor for CTXPhi for invading V. cholerae cells is the toxin-coregulated pilus (TCP), the genes for which reside in a larger genetic element, the TCP pathogenicity island. We analyzed 146 CTX-negative stra...

journal_title：Infection and immunity

authors： Faruque SM,Asadulghani,Saha MN,Alim AR,Albert MJ,Islam KM,Mekalanos JJ

更新日期：1998-12-01 00:00:00

abstract：:Attention has recently been focused on immunoglobulin A1 (IgA1) protease production as a possible virulence factor of bacteria implicated in meningitis and gonorrhea. This report demonstrates that suspected principal etiological agents in destructive periodontal disease include bacteria capable of degrading IgA1, IgA2...

journal_title：Infection and immunity

authors： Kilian M

更新日期：1981-12-01 00:00:00