Plasmid-cured Salmonella enteritidis AL1192 as a candidate for a live vaccine.

abstract：:The EUO gene (for early upstream open reading frame) of Chlamydia psittaci was previously found to be transcribed better at 1 than at 24 h postinfection. We found that the EUO gene encodes a minor protein that is expressed within 1 h of infection of host cells with C. psittaci 6BC but that protein quantity peaks durin...

journal_title：Infection and immunity

authors： Zhang L,Douglas AL,Hatch TP

更新日期：1998-03-01 00:00:00

abstract：:Acquisition of immunity to Plasmodium falciparum sexual stages is a key determinant for reducing human-mosquito transmission by preventing the fertilization and the development of the parasite in the mosquito midgut. Naturally acquired immunity against sexual stages may therefore form the basis for the development of ...

journal_title：Infection and immunity

authors： Ouédraogo AL,Roeffen W,Luty AJ,de Vlas SJ,Nebie I,Ilboudo-Sanogo E,Cuzin-Ouattara N,Teleen K,Tiono AB,Sirima SB,Verhave JP,Bousema T,Sauerwein R

更新日期：2011-12-01 00:00:00

abstract：:The type-specific antigens of group B type Ic (old designation type Ii) streptococci were extracted, purified, and characterized by serological and chemical methods. The Ia antigen, shared by types Ia and Ic, is a polysaccharide composed of 69% galactose and 25% glucosamine (i.e., 31% N-acetyl-glucosamine). However, t...

journal_title：Infection and immunity

authors： Wilkinson HW,Eagon RG

更新日期：1971-11-01 00:00:00

abstract：:Cord factor (trehalose 6,6'-dimycolate[TDM] ), a mixture of 6,6'-diesters of alpha, alpha-D-trehalose with natural mycolic acids, has been described as having immunoregulatory and antitumor activities in vivo, although the relevant mechanisms of action remain unelucidated. In this work, we measured the effects of TDM ...

journal_title：Infection and immunity

authors： Kierszenbaum F,Zenian A,Wirth JJ

更新日期：1984-02-01 00:00:00

abstract：:Polyamines such as putrescine, spermidine, and cadaverine are small, polycationic molecules that are required for optimal growth in all cells. The intracellular concentrations of these molecules are maintained by de novo synthesis and transport pathways. The human pathogen Streptococcus pneumoniae possesses a putative...

journal_title：Infection and immunity

authors： Ware D,Jiang Y,Lin W,Swiatlo E

更新日期：2006-01-01 00:00:00

abstract：:Recent studies have shown that children with blood group A have increased susceptibility to enterotoxigenic Escherichia coli (ETEC) diarrhea and that Lewis blood group "a" antigen (Le(a)) may be a candidate receptor for ETEC colonization factor (CF) antigen I (CFA/I) fimbriae. Based on these findings, we have attempte...

journal_title：Infection and immunity

authors： Ahmed T,Lundgren A,Arifuzzaman M,Qadri F,Teneberg S,Svennerholm AM

更新日期：2009-05-01 00:00:00

abstract：:Infection of mice with the murine sarcoma virus (Moloney) markedly suppressed the humoral antibody response to sheep erythrocyte antigen injected 10 days after infection, when tumor size was maximal, and on day 26, when primary tumors had partially regressed. Humoral antibody response was also inhibited when antigen w...

journal_title：Infection and immunity

authors： Chan SP,Hook WA,Turner W,Chirigos MA

更新日期：1970-03-01 00:00:00

abstract：:In this work we immunized mice with DNA encoding full-length Tc52 or its amino- or carboxy-terminal (N- and C-term, respectively) domain carried by attenuated Salmonella as a DNA delivery system. As expected, Salmonella-mediated DNA delivery resulted in low antibody titers and a predominantly Th1 response, as shown by...

journal_title：Infection and immunity

authors： Matos MN,Cazorla SI,Bivona AE,Morales C,Guzmán CA,Malchiodi EL

更新日期：2014-10-01 00:00:00

abstract：:The protective efficacy of Mycobacterium bovis BCG can be markedly augmented by stable integration of Mycobacterium tuberculosis genomic region RD1. BCG complemented with RD1 (BCG::RD1) encodes nine additional proteins. Among them, 10-kDa culture filtrate protein (CFP-10) and ESAT-6 (6-kDa early secreted antigenic tar...

journal_title：Infection and immunity

authors： Demangel C,Brodin P,Cockle PJ,Brosch R,Majlessi L,Leclerc C,Cole ST

更新日期：2004-04-01 00:00:00

abstract：:The two-component regulatory system, GraRS, appears to be involved in staphylococcal responses to cationic antimicrobial peptides (CAPs). However, the mechanism(s) by which GraRS is induced, regulated, and modulated remain undefined. In this study, we used two well-characterized MRSA strains (Mu50 and COL) and their r...

journal_title：Infection and immunity

authors： Yang SJ,Bayer AS,Mishra NN,Meehl M,Ledala N,Yeaman MR,Xiong YQ,Cheung AL

更新日期：2012-01-01 00:00:00

abstract：:The effects of treatment with live or inactivated Shope fibroma virus on host cell deoxyribonucleic acid (DNA) synthesis were determined. The incorporation of (3)H-thymidine into nuclear DNA was suppressed by both active and inactivated virus, although live virus was more effective. During the early phase of infection...

journal_title：Infection and immunity

authors： Chan JC,Hodes ME

更新日期：1973-04-01 00:00:00

abstract：:Endotoxin-treated mice exhibit a rapid rise in the level of the serum amyloid A (SAA) protein, but this effect is not observed in endotoxin-resistant C3H/HeJ mice. To evaluate the role of lymphoid cells in the production of SAA protein, C3H/HeJ mice were adoptively transfused with endotoxin-sensitive (C3H/HeN) bone ma...

journal_title：Infection and immunity

authors： Rosenstreich DL,McAdam KP

更新日期：1979-01-01 00:00:00

abstract：:Female mice infected at birth with 10(7) 50% tissue culture infective doses of polyoma virus were mated when at least 6 weeks old. Polyoma was not detected in any tissues of 27 female mice before mating except for trace amounts in the kidneys of 2 mice, but late in gestation polyoma virus could be found in the kidneys...

journal_title：Infection and immunity

authors： McCance DJ,Mims CA

更新日期：1979-09-01 00:00:00

abstract：:A concentrated bacterial culture supernatant from the hemolytic Moraxella bovis strain UQV 148NF was used to immunize mice and generate monoclonal antibodies (MAbs). One, MAb G3/D7, neutralized the hemolytic activity of M. bovis and recognized a 94-kDa protein by Western blot analysis in hemolytic M. bovis strains rep...

journal_title：Infection and immunity

authors： Billson FM,Harbour C,Michalski WP,Tennent JM,Egerton JR,Hodgson JL

更新日期：2000-06-01 00:00:00

abstract：:The complete sequence analysis of the 210-kb Shigella flexneri 5a virulence plasmid was determined. Shigella spp. cause dysentery and diarrhea by invasion and spread through the colonic mucosa. Most of the known Shigella virulence determinants are encoded on a large plasmid that is unique to virulent strains of Shigel...

journal_title：Infection and immunity

authors： Venkatesan MM,Goldberg MB,Rose DJ,Grotbeck EJ,Burland V,Blattner FR

更新日期：2001-05-01 00:00:00

abstract：:One of the first steps in the development of cerebral toxoplasmosis is the penetration of the blood-brain barrier, which is comprised of microvascular endothelial cells. We examined the capacity of human brain microvascular endothelial cells (HBMEC) to interact with Toxoplasma gondii. We found that stimulation of HBME...

journal_title：Infection and immunity

authors： Däubener W,Spors B,Hucke C,Adam R,Stins M,Kim KS,Schroten H

更新日期：2001-10-01 00:00:00

abstract：:The major merozoite surface protein of Plasmodium falciparum (PfMSP1) is a candidate antigen for a malaria vaccine. A 19-kDa C-terminal processing product of PfMSP1 (PfMSP1(19)) is composed of two domains sharing a cysteine-rich motif with epidermal growth factor (EGF) and is the target of monoclonal antibodies which ...

journal_title：Infection and immunity

authors： Egan AF,Chappel JA,Burghaus PA,Morris JS,McBride JS,Holder AA,Kaslow DC,Riley EM

更新日期：1995-02-01 00:00:00

abstract：:Cytoadherence-linked asexual gene 9 (Clag9), a conserved Plasmodium protein expressed during the asexual blood stages, is involved in the cytoadherence of infected red blood cells (RBCs) to the endothelial lining of blood vessels. Here, we show that Plasmodium falciparum Clag9 (PfClag9) is a component of the PfClag9-R...

journal_title：Infection and immunity

authors： Chourasia BK,Deshmukh A,Kaur I,Paul G,Panda A,Rathore S,Singh SK,Theisen M,Mohmmed A,Malhotra P

更新日期：2020-01-22 00:00:00

abstract：:The opportunistic pathogen Pseudomonas aeruginosa is a major cause of sepsis in severely burned patients. If it is not eradicated from the wound, it translocates to the bloodstream, causing sepsis, multiorgan failure, and death. We recently described the P. aeruginosa heparinase-encoding gene, hepP, whose expression w...

journal_title：Infection and immunity

authors： Dzvova N,Colmer-Hamood JA,Griswold JA,Hamood AN

更新日期：2017-12-19 00:00:00

abstract：:Our previous studies identified two iron-regulated cytoplasmic membrane proteins of 32 and 36 kDa expressed by both Staphylococcus epidermidis and Staphylococcus aureus. In this study we show by Triton X-114 phase partitioning and tritiated palmitic acid labelling that these proteins are lipoproteins which are anchore...

journal_title：Infection and immunity

authors： Cockayne A,Hill PJ,Powell NB,Bishop K,Sims C,Williams P

更新日期：1998-08-01 00:00:00

abstract：:Moraxella catarrhalis expresses surface receptor proteins that specifically bind host transferrin (Tf) and lactoferrin (Lf) in the first step of the iron acquisition pathway. Acute- and convalescent-phase antisera from a series of patients with M. catarrhalis pulmonary infections were tested against Tf and Lf receptor...

journal_title：Infection and immunity

authors： Yu RH,Bonnah RA,Ainsworth S,Schryvers AB

更新日期：1999-08-01 00:00:00

abstract：:The orotidine-5'-monophosphate decarboxylase (OMPDC) gene, encoding the final enzyme of the de novo pyrimidine biosynthesis pathway, was deleted using Toxoplasma gondii KU80 knockouts to develop an avirulent nonreverting pyrimidine auxotroph strain. Additionally, to functionally address the role of the pyrimidine salv...

journal_title：Infection and immunity

authors： Fox BA,Bzik DJ

更新日期：2010-09-01 00:00:00

abstract：:Streptococcus pneumoniae is a fermentative microorganism and causes serious diseases in humans, including otitis media, bacteremia, meningitis, and pneumonia. However, the mechanisms enabling pneumococcal survival in the host and causing disease in different tissues are incompletely understood. The available evidence ...

journal_title：Infection and immunity

authors： Gaspar P,Al-Bayati FA,Andrew PW,Neves AR,Yesilkaya H

更新日期：2014-12-01 00:00:00

abstract：:Salmonella enterica serovar Pullorum is worldwide a poultry pathogen of considerable economic importance, particularly in those countries with a developing poultry industry. In addition to the characteristic high mortality rates among young chicks, one of the features of Salmonella serovar Pullorum infection is that i...

journal_title：Infection and immunity

authors： Wigley P,Berchieri A Jr,Page KL,Smith AL,Barrow PA

更新日期：2001-12-01 00:00:00

abstract：:Toll-like receptors (TLRs) are a major component of the pattern recognition receptor repertoire that detect invading microorganisms and direct the vertebrate immune system to eliminate infection. In chickens, the differential biology of Salmonella serovars (systemic versus gut-restricted localization) correlates with ...

journal_title：Infection and immunity

authors： Iqbal M,Philbin VJ,Withanage GS,Wigley P,Beal RK,Goodchild MJ,Barrow P,McConnell I,Maskell DJ,Young J,Bumstead N,Boyd Y,Smith AL

更新日期：2005-04-01 00:00:00

abstract：:Strains of Bacteroides fragilis that produce a ca. 20-kDa heat-labile protein toxin (termed B. fragilis toxin [BFT]) have been associated with diarrheal disease of animals and humans. BFT alters the morphology of intestinal epithelial cells both in vitro and in vivo and stimulates secretion in ligated intestinal segme...

journal_title：Infection and immunity

authors： Franco AA,Mundy LM,Trucksis M,Wu S,Kaper JB,Sears CL

更新日期：1997-03-01 00:00:00

abstract：:The skin microenvironment at the site of infection plays a role in the early events that determine protective T helper 1/type 1 immune responses during cutaneous leishmaniasis (CL) infection. During CL in nonhealing BALB/c mice, early interleukin-4 (IL-4) can instruct dendritic cells for protective Th1 immunity. Addit...

journal_title：Infection and immunity

authors： Govender M,Hurdayal R,Martinez-Salazar B,Gqada K,Pillay S,Gcanga L,Passelli K,Nieuwenhuizen NE,Tacchini-Cottier F,Guler R,Brombacher F

更新日期：2018-11-20 00:00:00

abstract：:Clostridium perfringens type B and type C isolates, which produce beta-toxin (CPB), cause fatal diseases originating in the intestines of humans or livestock. Our previous studies demonstrated that CPB is necessary for type C isolate CN3685 to cause bloody necrotic enteritis in a rabbit ileal loop model and also showe...

journal_title：Infection and immunity

authors： Vidal JE,McClane BA,Saputo J,Parker J,Uzal FA

更新日期：2008-10-01 00:00:00

abstract：:Strategies to limit complement deposition on Streptococcus pneumoniae are established as virulence features for invasive disease, but their role in respiratory tract infection requires further analysis. We evaluated complement C3 protein deposition on discordant S. pneumoniae isolates of the same serotype (6A) and the...

journal_title：Infection and immunity

authors： Sabharwal V,Ram S,Figueira M,Park IH,Pelton SI

更新日期：2009-03-01 00:00:00

abstract：:Serotype b-specific polysaccharide antigen (SPA) was extracted from whole cells of Actinobacillus actinomycetemcomitans Y4 by autoclaving and purified by chromatography on DEAE-Sephadex A-25 and Sephacryl S-300. SPA induced the release of monocyte and leukocyte chemotactic factors by human monocytes. Polymyxin B had a...

journal_title：Infection and immunity

authors： Yamaguchi N,Yamashita Y,Ikeda D,Koga T

更新日期：1996-07-01 00:00:00