Congenital abnormalities in newborn lambs after infection of pregnant sheep with Akabane virus.

abstract：:Mycobacterium bovis BCG is widely used as a vaccine against tuberculosis (TB), despite its variable protective efficacy. Relatively little is known about the immune response profiles following BCG vaccination in relation to protection against TB. Here we tested whether BCG vaccination results in immune responses to Do...

journal_title：Infection and immunity

authors： Lin MY,Geluk A,Smith SG,Stewart AL,Friggen AH,Franken KL,Verduyn MJ,van Meijgaarden KE,Voskuil MI,Dockrell HM,Huygen K,Ottenhoff TH,Klein MR

更新日期：2007-07-01 00:00:00

abstract：:Splenic lymphocytes from cytomegalovirus-infected mice lost their in vitro proliferative responses to cytomegalovirus antigen within 3 h after in vivo treatment with antilymphocyte globulin and prednisolone. The response was inhibited when the agents were administered separately or together, and inhibition persisted t...

journal_title：Infection and immunity

authors： Mattsson DM,Howard RJ,Balfour HH Jr

更新日期：1980-12-01 00:00:00

abstract：:In vitro experimentation indicates that periodontitis-associated bacteria contain potent polyclonal B-cell activators (PBA). We reasoned that if PBA were operative in vivo, plasma cells specific for nonoral antigens should be present in the inflamed gingival tissues, which are characterized by a plasma cell infiltrate...

journal_title：Infection and immunity

authors： Mallison SM 3rd,Szakal AK,Ranney RR,Tew JG

更新日期：1988-04-01 00:00:00

abstract：:Histophilus somni is capable of intracellular survival within professional phagocytic cells, but the mechanism of survival is not understood. The Fic motif within the direct repeat (DR1)/DR2 domains of the IbpA fibrillary network protein of H. somni is cytotoxic to epithelial and phagocytic cells, which may interfere ...

journal_title：Infection and immunity

authors： Pan Y,Tagawa Y,Champion A,Sandal I,Inzana TJ

更新日期：2018-11-20 00:00:00

abstract：:Chromosomes from Cryptococcus neoformans, an encapsulated yeast pathogen, were separated by contour-clamped homogeneous field gel electrophoresis. Seven strains representing all four serotypes were studied. It was found that each strain had a unique, reproducible pattern of chromosome bands which could potentially be ...

journal_title：Infection and immunity

authors： Perfect JR,Magee BB,Magee PT

更新日期：1989-09-01 00:00:00

abstract：:We show in this study that toxin production in Clostridium difficile is altered in cells which can no longer form flagellar filaments. The impact of inactivation of fliC, CD0240, fliF, fliG, fliM, and flhB-fliR flagellar genes upon toxin levels in culture supernatants was assessed using cell-based cytotoxicity assay, ...

journal_title：Infection and immunity

authors： Aubry A,Hussack G,Chen W,KuoLee R,Twine SM,Fulton KM,Foote S,Carrillo CD,Tanha J,Logan SM

更新日期：2012-10-01 00:00:00

abstract：:The C-terminal 19-kDa domain of merozoite surface protein 1 (MSP1₁₉) is the target of protective antibodies but alone is poorly immunogenic. Previously, using the Plasmodium yoelii murine model, we fused P. yoelii MSP1₁₉ (PyMSP1₁₉) with full-length P. yoelii merozoite surface protein 8 (MSP8). Upon immunization, the M...

journal_title：Infection and immunity

authors： Alaro JR,Angov E,Lopez AM,Zhou H,Long CA,Burns JM Jr

更新日期：2012-07-01 00:00:00

abstract：:Vitamin D is an important regulator of the expression of antimicrobial peptides, and vitamin D deficiency is associated with respiratory infections. Regulating expression of antimicrobial peptides, such as the human cathelicidin antimicrobial peptide 18 (hCAP18)/LL-37, by vitamin D in bronchial epithelial cells requir...

journal_title：Infection and immunity

authors： Schrumpf JA,van Sterkenburg MA,Verhoosel RM,Zuyderduyn S,Hiemstra PS

更新日期：2012-12-01 00:00:00

abstract：:Gardnerella vaginalis, the bacterial species most frequently isolated from women with bacterial vaginosis (BV), produces a cholesterol-dependent cytolysin (CDC), vaginolysin (VLY). At sublytic concentrations, CDCs may initiate complex signaling cascades crucial to target cell survival. Using live-cell imaging, we obse...

journal_title：Infection and immunity

authors： Randis TM,Zaklama J,LaRocca TJ,Los FC,Lewis EL,Desai P,Rampersaud R,Amaral FE,Ratner AJ

更新日期：2013-12-01 00:00:00

abstract：:Murine monoclonal and rabbit, murine, and human polyclonal antibodies against chlamydial lipopolysaccharide (LPS) were characterized by the passive hemolysis and passive hemolysis inhibition assays and by absorption experiments with LPSs of Chlamydia psittaci, Chlamydia trachomatis, and a recombinant strain of Salmone...

journal_title：Infection and immunity

authors： Brade L,Holst O,Kosma P,Zhang YX,Paulsen H,Krausse R,Brade H

更新日期：1990-01-01 00:00:00

abstract：:Brucella organisms are intracellular stealth pathogens of animals and humans. The bacteria overcome the assault of innate immunity at early stages of an infection. Removal of polymorphonuclear neutrophils (PMNs) at the onset of adaptive immunity against Brucella abortus favored bacterial elimination in mice. This was ...

journal_title：Infection and immunity

authors： Mora-Cartín R,Gutiérrez-Jiménez C,Alfaro-Alarcón A,Chaves-Olarte E,Chacón-Díaz C,Barquero-Calvo E,Moreno E

更新日期：2019-04-23 00:00:00

abstract：:In pathogenic bacteria, iron acquisition is important for colonization and proliferation in the host under iron-limited conditions. The ability of Vibrio spp. to acquire iron is often critical to their virulence, causing gastroenteritis or excessive watery diarrhea in humans. In the study described here, we cloned the...

journal_title：Infection and immunity

authors： Ahn SH,Han JH,Lee JH,Park KJ,Kong IS

更新日期：2005-02-01 00:00:00

abstract：:A heterogeneous subset of extraintestinal pathogenic Escherichia coli (ExPEC) strains, referred to as uropathogenic E. coli (UPEC), causes most uncomplicated urinary tract infections. However, no core set of virulence factors exists among UPEC strains. Instead, the focus of the analysis of urovirulence has shifted to ...

journal_title：Infection and immunity

authors： Engstrom MD,Alteri CJ,Mobley HL

更新日期：2014-09-01 00:00:00

abstract：:Protective immunity against Babesia bigemina is hypothesized to involve antibodies directed against merozoite surface-exposed epitopes. Levels of antibody against a rhoptry-associated protein 1 (RAP-1) B-lymphocyte epitope, defined by surface-reactive and inhibitory monoclonal antibodies, in immune cattle sera were de...

journal_title：Infection and immunity

authors： Ushe TC,Palmer GH,Sotomayor L,Figueroa JV,Buening GM,Perryman LE,McElwain TF

更新日期：1994-12-01 00:00:00

abstract：:Chlamydia pneumoniae is a causative agent for many respiratory infections and has been associated with cardiovascular diseases in humans. The pathogenicity of C. pneumoniae is thought to depend on its ability to cause persistent infection and to evade host defense. Genome sequence analysis indicates that C. pneumoniae...

journal_title：Infection and immunity

authors： Fan P,Dong F,Huang Y,Zhong G

更新日期：2002-01-01 00:00:00

abstract：:Previous attempts to induce mucosal antibodies in rhesus monkeys by enteric immunization have resulted in only modest and short-lived responses, dominated by immunoglobulin M (IgM) antibodies in the plasma. In this study, two groups of rhesus monkeys were immunized intranasally three times at 2-week intervals with a b...

journal_title：Infection and immunity

authors： Russell MW,Moldoveanu Z,White PL,Sibert GJ,Mestecky J,Michalek S M

更新日期：1996-04-01 00:00:00

abstract：:We determined the diphtheria toxin phenotype of specially selected isolates of Corynebacterium ulcerans and Corynebacterium pseudotuberculosis (C. ovis). All produced proteins similar in size and immunological structure to diphtheria toxin. As with diphtheria toxin, they exhibited ADP-ribosylating activity, and their ...

journal_title：Infection and immunity

authors： Wong TP,Groman N

更新日期：1984-03-01 00:00:00

abstract：:Toll-like receptors (TLRs) play a critical role in early immune recognition of Aspergillus, which can regulate host defense during invasive pulmonary Aspergillosis (IPA). However, the role of TLR7 in the pathogenesis of IPA remains unknown. In this study, an in vivo model of IPA was established to investigate the cont...

journal_title：Infection and immunity

authors： Xu B,Luo Q,Gong Y,Li J,Cao J

更新日期：2021-01-25 00:00:00

abstract：:The ability of intracellular pathogens to sense and adapt to the hostile environment of the host is an important factor governing virulence. We have sequenced the operon encoding the major heat shock proteins GroES and GroEL in the gram-positive food-borne pathogen Listeria monocytogenes. The operon has a conserved or...

journal_title：Infection and immunity

authors： Gahan CG,O'Mahony J,Hill C

更新日期：2001-06-01 00:00:00

abstract：:Urease activity has recently been shown to be an important virulence determinant for Helicobacter pylori, allowing it to survive the low pH of the stomach during colonization. Experimental murine infection with Helicobacter felis is now being used as a model for H. pylori infection to study the effects of vaccines, an...

journal_title：Infection and immunity

authors： Gootz TD,Perez-Perez GI,Clancy J,Martin BA,Tait-Kamradt A,Blaser MJ

更新日期：1994-03-01 00:00:00

abstract：:Virulence of the fungal pathogen Aspergillus fumigatus is in part based on the saprophytic lifestyle that this mold has evolved. A crucial function for saprophytism resides in secreted proteases that allow assimilation of proteinaceous substrates. The impact of extracellular proteolytic activities on the pathogenesis ...

journal_title：Infection and immunity

authors： Bergmann A,Hartmann T,Cairns T,Bignell EM,Krappmann S

更新日期：2009-09-01 00:00:00

abstract：:The enteric pathogen Shigella is one of the leading causes of moderate-to-severe diarrhea and death in young children in developing countries. Transformed cell lines and animal models have been widely used to study Shigella pathogenesis. In addition to altered physiology, transformed cell lines are composed of a singl...

journal_title：Infection and immunity

authors： Ranganathan S,Doucet M,Grassel CL,Delaine-Elias B,Zachos NC,Barry EM

更新日期：2019-03-25 00:00:00

abstract：:Administration of free muramyl tripeptide phosphatidylethanolamide (MTPPE) or liposome-encapsulated MTPPE (LE-MTPPE) in a twofold-lower dose at 24 h before bacterial inoculation resulted in clearance of intravenously inoculated Klebsiella pneumoniae by tissue macrophages, whereas in control mice, bacteria were not eff...

journal_title：Infection and immunity

authors： Melissen PM,van Vianen W,Bakker-Woudenberg IA

更新日期：1992-11-01 00:00:00

abstract：:Trypanosoma cruzi is a protozoan parasite that causes human Chagas' disease, a leading source of congestive heart failure in Central and South America. CD8+ T cells are critical for control of T. cruzi infection, and CD8+ T cells recognizing the immunodominant trans-sialidase gene-encoded peptide TSKB20 (ANYKFTLV) acc...

journal_title：Infection and immunity

authors： Martin DL,Murali-Krishna K,Tarleton RL

更新日期：2010-07-01 00:00:00

abstract：:The virulence of Neisseria gonorrhoeae for chicken embryos can be modified in a predictable manner by the addition of microbial siderophores to the inoculum. "Meningobactin" and "gonobactin," siderophores isolated from iron-limited cultures of meningococci and gonococci, respectively, enhance the virulence of the rela...

journal_title：Infection and immunity

authors： Finkelstein RA,Yancey RJ

更新日期：1981-05-01 00:00:00

abstract：:Alveolar bone resorption can be induced in specific-pathogen-free mice by oral infection with Porphyromonas gingivalis (P. J. Baker, R. T. Evans, and D. C. Roopenian, Arch. Oral Biol. 39:1035-1040, 1994). Here we used a mouse strain, C57BL/6J, which is relatively resistant to P. gingivalis-induced bone loss to examine...

journal_title：Infection and immunity

authors： Baker PJ,DuFour L,Dixon M,Roopenian DC

更新日期：2000-06-01 00:00:00

abstract：:By screening a genomic lambda library of Streptococcus equi subsp. zooepidemicus, we have cloned and sequenced a gene, termed fnz, encoding a fibronectin (Fn)-binding protein called FNZ. On the basis of the deduced amino acid sequence of FNZ, the mature protein has a molecular mass of approximately 61 kDa. Analysis of...

journal_title：Infection and immunity

authors： Lindmark H,Jacobsson K,Frykberg L,Guss B

更新日期：1996-10-01 00:00:00

abstract：:Macrophage-dependent killing of facultative intracellular bacteria was markedly impaired by overt erythrocytic Plasmodium yoelii or Plasmodium berghei infection of mice. P. yoelii infection was capable of ablating not only the macrophage microbicidal capacity of "normal" animals but also the bactericidal capacities of...

journal_title：Infection and immunity

authors： Murphy JR

更新日期：1981-01-01 00:00:00

abstract：:The 25-kb linear plasmid lp25 and one of the 28-kb linear plasmids (lp28-1) are required for experimental infection in Borrelia burgdorferi, the etiologic agent of Lyme disease. The loss of these plasmids either eliminates infectivity (lp25) or significantly increases the 50% infective dose during a 2-week infection p...

journal_title：Infection and immunity

authors： Labandeira-Rey M,Seshu J,Skare JT

更新日期：2003-08-01 00:00:00

abstract：:Exposure to bacterial superantigens such as staphylococcal enterotoxin B (SEB) leads to the induction of toxic shock syndrome which results in multiorgan failure, including liver damage. In the present study, we investigated the role of CD44 in SEB-induced liver injury. Injection of SEB into d-galactosamine-sensitized...

journal_title：Infection and immunity

authors： McKallip RJ,Fisher M,Gunthert U,Szakal AK,Nagarkatti PS,Nagarkatti M

更新日期：2005-01-01 00:00:00