Abstract:
:Administration of free muramyl tripeptide phosphatidylethanolamide (MTPPE) or liposome-encapsulated MTPPE (LE-MTPPE) in a twofold-lower dose at 24 h before bacterial inoculation resulted in clearance of intravenously inoculated Klebsiella pneumoniae by tissue macrophages, whereas in control mice, bacteria were not effectively cleared from the blood. In addition, MTPPE and LE-MTPPE led to increased numbers of leukocytes in the blood, which could compensate for the leukopenia in mice resulting from infection with K. pneumoniae. In an attempt to elucidate the relative contributions of the activation of tissue macrophages and the recruitment of leukocytes to the antibacterial resistance induced by MTPPE and LE-MTPPE, mice were infected intraperitoneally with K. pneumoniae. In these MTPPE- and LE-MTPPE treated mice, intraperitoneal influx of leukocytes and the phagocytic capacity of leukocytes were not higher than in untreated control mice. However, MTPPE- and LE-MTPPE-treated mice survived much longer; eventually 33% of the LE-MTPPE-treated mice survived, whereas all untreated control mice died as a result of bacterial septicemia. This prevention of early death appeared to be the result of an increased clearance of bacteria from the blood by activated tissue macrophages. It was observed that depletion of these tissue macrophages in liver and spleen abrogates the effect of LE-MTPPE treatment, indicating that tissue macrophages are of major importance in the LE-MTPPE-induced resistance against K. pneumoniae infection.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Melissen PM,van Vianen W,Bakker-Woudenberg IAdoi
10.1128/IAI.60.11.4891-4897.1992keywords:
subject
Has Abstractpub_date
1992-11-01 00:00:00pages
4891-7issue
11eissn
0019-9567issn
1098-5522journal_volume
60pub_type
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journal_title:Infection and immunity
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doi:10.1128/IAI.60.12.5078-5084.1992
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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doi:10.1128/IAI.19.2.411-415.1978
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更新日期:1973-04-01 00:00:00
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pub_type: 杂志文章,收录出版
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更新日期:2012-06-01 00:00:00
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journal_title:Infection and immunity
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更新日期:2014-03-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.1.253-260.1991
更新日期:1991-01-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.9.3134-3142.1991
更新日期:1991-09-01 00:00:00
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更新日期:1975-05-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
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更新日期:1992-02-01 00:00:00
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更新日期:2001-12-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:1975-10-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:1983-07-01 00:00:00
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journal_title:Infection and immunity
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更新日期:2011-08-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:2010-01-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:1999-05-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:1979-10-01 00:00:00