Abstract:
:Thrombospondin-related anonymous protein (TRAP) of the malaria parasite Plasmodium falciparum shares two sequence motifs with other proteins which possess adhesive properties. Recently, findings indicate that TRAP is an antigen which contributes to antisporozoite immunity. We have cloned and expressed the TRAP coding sequences in Escherichia coli to investigate the human humoral immune response against this protein in a region of malaria endemicity of West Africa characterized by a seasonal transmission. Our results show that antibodies against TRAP are present in infected individuals. The anti-TRAP antibodies were analyzed in both a longitudinal and a prospective study. The longitudinal analysis shows seasonal fluctuations of the levels of specific antibodies as well as age-dependent quantitative differences. The immune response is long-lived in most of the adults and some of the older children but short-lived in young children. More importantly, the prospective analysis suggests that the presence of anti-TRAP antibodies in older children before the beginning of malaria transmission correlates with the subsequent control of parasite densities.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Scarselli E,Tolle R,Koita O,Diallo M,Müller HM,Früh K,Doumbo O,Crisanti A,Bujard Hdoi
10.1128/IAI.61.8.3490-3495.1993subject
Has Abstractpub_date
1993-08-01 00:00:00pages
3490-5issue
8eissn
0019-9567issn
1098-5522journal_volume
61pub_type
杂志文章abstract::Because combined administration of intramuscular and intravenous interferon has been partially successful in the incubationary treatment of rabies, the effect of direct interferon administration into the cerebrospinal fluid space was tested. After injecting 1,800 U of interferon into the cisterna magna or the lateral ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.2.286-293.1974
更新日期:1974-02-01 00:00:00
abstract::Chlamydia trachomatis is a strict human pathogen producing infections that cause medically important chronic inflammatory diseases, such as blinding trachoma and tubal factor infertility. Isolates exist as serotypes that fall into distinct biologic and pathological groups corresponding to differences in infection tiss...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.12.7063-7072.2004
更新日期:2004-12-01 00:00:00
abstract::The biological response to endotoxin mediated through the Toll-like receptor 4 (TLR4)-MD-2 receptor complex is directly related to lipid A structure or configuration. Endotoxin structure may also influence activation of the MyD88-dependent and -independent signaling pathways of TLR4. To address this possibility, human...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.5.2940-2950.2005
更新日期:2005-05-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.15.1.124-131.1977
更新日期:1977-01-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.12.7293-7203.2001
更新日期:2001-12-01 00:00:00
abstract::Monoclonal antibody MASC1-MR9 of isotype immunoglobulin M was generated in LOU/C rats by immunization with heat-killed Salmonella thompson (serogroup C1, O-antigen 6,7 lipopolysaccharide) bacteria which had been further enriched for O-antigen by coating with homologous lipopolysaccharide. Eight monoclonal antibodies w...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.1.229-233.1991
更新日期:1991-01-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.8.4661-4668.2002
更新日期:2002-08-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.10.6058-6062.2003
更新日期:2003-10-01 00:00:00
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journal_title:Infection and immunity
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doi:10.1128/IAI.00027-14
更新日期:2014-04-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.10.5901-5907.2000
更新日期:2000-10-01 00:00:00
abstract::Streptococcus pneumoniae infections of the lung are associated with significant damage to the alveolar epithelium. Host phagocytes and pneumolysin, a cytolytic toxin of S. pneumoniae, are believed to contribute to this cellular damage, yet experiments in which these elements are absent demonstrate the presence of an a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.10.4392-4397.1993
更新日期:1993-10-01 00:00:00
abstract::The role of a plasmid in the virulence activity of an enteropathogenic Escherichia coli (EPEC) strain belonging to serotype 0111:NM was examined. EPEC strain B171, which is resistant to chloramphenicol, streptomycin, sulfathiazole, and tetracycline, harbors a 54-megadalton plasmid, pYR111, and exhibits localized adher...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.9.2052-2056.1987
更新日期:1987-09-01 00:00:00
abstract::Adoptive immunity is poorly expressed in normal syngeneic mice. This phenomenon was studied by using experimental antituberculosis immunity as a model system representing pure cell-mediated immunity. Expression of adoptive immunity was facilitated by pretreating recipients with sublethal ionizing radiation (500 rads) ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.41.1.257-263.1983
更新日期:1983-07-01 00:00:00
abstract::The effect of splenectomy on animals infected with Trypanosoma lewisi is unclear, and previous reports are inconclusive or conflictive. We splenectomized rats of different ages after they had been infected with T. lewisi. Female Sprague-Dawley rats, Hemobartonella-free, were assigned to four groups according to weight...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.40.3.1127-1133.1983
更新日期:1983-06-01 00:00:00
abstract::We studied seven strains of group G streptococci isolated from clinically severe bacteremic infections in six intravenous drug abusers. These group G strains multiplied luxuriantly in fresh human blood. On electron microscopy, they exhibited surface fibrillae similar to those observed in M-protein-rich group A strepto...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.3.753-757.1987
更新日期:1987-03-01 00:00:00
abstract::We used a murine model to determine whether chronic corticosteroid therapy has uniform effects on bacterial clearance processes in different tissues. After a 2-week regimen of oral prednisolone, Swiss Webster mice were challenged with Pseudomonas aeruginosa strain PAO1 or virulent derivatives of PAO1 (IP-8 and IT-10)....
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.43.3.901-905.1984
更新日期:1984-03-01 00:00:00
abstract::The microfilament inhibitors cytochalasins B and D have been traditionally used to indirectly evaluate the requirement for actin in the uptake of invasive bacterial pathogens by nonprofessional phagocytes. Through their effects on microfilaments, both cytochalasins also impart profound alterations in cellular morpholo...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.10.3187-3193.1990
更新日期:1990-10-01 00:00:00
abstract::Salmonella choleraesuis chi 3781, an attenuated [delta cya-12 delta(crp-cdt)19] mutant, was electroporated with the plasmid pBA31-R7, which codes for the expression of a 31-kDa protein from Brucella abortus (BCSP31). Recombinant S. choleraesuis chi 3781 stably maintained the pBA31-R7 plasmid and continued to express t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.2.610-618.1993
更新日期:1993-02-01 00:00:00
abstract::The immunoprotective activity of Klebsiella pneumoniae K2 cell surface preparations and purified capsular polysaccharide was tested in mice. The 50% protective dose (PD50), expressed as capsular polysaccharide content, was 2 ng for cell surface preparations and 50 ng for purified capsular polysaccharide. Both preparat...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.54.2.365-370.1986
更新日期:1986-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.10.4222-4228.1997
更新日期:1997-10-01 00:00:00
abstract::Thrombin-induced platelet microbicidal protein 1 (tPMP-1) is a small, cationic peptide generated from rabbit platelets when they are exposed to thrombin in vitro. It has potent microbicidal activity against a broad spectrum of bacterial and fungal pathogens, including Staphylococcus aureus. Previous in vitro studies i...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.5.2475-2481.1999
更新日期:1999-05-01 00:00:00
abstract::In vitro, Clostridium perfringens enterotoxin (CPE) binds to human ileal epithelium and induces morphological damage concurrently with reduced short-circuit current, transepithelial resistance, and net water absorption. CPE also binds to the human colon in vitro but causes only slight morphological and transport chang...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.12.8407-8410.2005
更新日期:2005-12-01 00:00:00
abstract::The hagfish, Eptatretus stoutii, has been shown to synthesize bactericidal antibodies after injections of gram-negative organisms. These bactericidins could be detected as early as 2 days after the primary injection. Secondary responses were accelerated, although titers were not significantly higher than those reached...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.4.2.160-166.1971
更新日期:1971-08-01 00:00:00
abstract::Ehrlichia chaffeensis, a tick-transmitted rickettsial, is the causative agent of human monocytic ehrlichiosis. To examine protein expression patterns, we analyzed total, membrane, and immunogenic proteomes of E. chaffeensis originating from macrophage and tick cell cultures. Total proteins resolved by one-dimensional ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00484-08
更新日期:2008-11-01 00:00:00
abstract::Mice immunized with a killed vaccine of phase I Bordetella bronchiseptica were challenged with various numbers of virulent B. bronchiseptica by intraperitoneal, intracerebral, or intranasal routes. The course of infection was compared among these routes, and the protective effect of vaccination was quantitatively anal...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.41.2.598-603.1983
更新日期:1983-08-01 00:00:00
abstract::To look for a possible correlation between the virulence of Rhodococcus equi and its cytokine-inducing capacity, we evaluated intracellular survival and measured cytokine induction by mouse macrophages infected with a virulent strain containing an 85-kb plasmid and expressing VapA (103+), its avirulent plasmid-cured d...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.5.1848-1854.1998
更新日期:1998-05-01 00:00:00
abstract::Two inbred mouse strains, derived from feral founders, are susceptible to experimental leishmaniasis due to Leishmania major and support a disease of a severity intermediate between those observed in strains C57BL/6 and BALB/c. Mice of the MAI strain develop a severe, nonhealing, but nonfatal disease with no resistanc...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.8.4603-4611.2004
更新日期:2004-08-01 00:00:00
abstract::A soluble hemagglutinin/protease produced by Vibrio cholerae, which has previously been shown to hydrolyze fibronectin and ovomucin and to cleave lactoferrin and the A subunit of the heat-labile enterotoxin of Escherichia coli, appears to be a zinc metalloendopeptidase. Both its hemagglutinative and protease functions...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.42.2.639-644.1983
更新日期:1983-11-01 00:00:00
abstract::Previous studies have suggested that interleukin-4 (IL-4) has a protective effect in host defense to Borrelia burgdorferi infection, both in limiting the severity of arthritis and in controlling spirochete numbers in tissues, and a mapping study revealed suggestive linkage to a cluster of genes on mouse chromosome 11,...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.10.5603-5609.2000
更新日期:2000-10-01 00:00:00
abstract::Total-cell DNA isolated from a highly virulent serotype Ic strain of a group B streptococcus was used to construct a gene bank with bacteriophage lambda L47.1 in Escherichia coli K-12. Recombinant phage plaques in the bank were immunoblotted by using anti-alpha- and anti-beta-specific antibodies directed towards the I...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.5.1151-1155.1987
更新日期:1987-05-01 00:00:00