Enhanced effect of repeated administration of bacterial vaccine against viral respiratory infection.

abstract：:Chronic pulmonary infection with Pseudomonas aeruginosa is common in cystic fibrosis (CF) patients. P. aeruginosa lipopolysaccharide (LPS), phosholipase C (PLC), and exotoxin A (ETA) were evaluated for their ability to induce pulmonary inflammation in mice following intranasal inoculation. Both LPS and PLC induced hig...

journal_title：Infection and immunity

authors： Wieland CW,Siegmund B,Senaldi G,Vasil ML,Dinarello CA,Fantuzzi G

更新日期：2002-03-01 00:00:00

abstract：:Staphylococcus aureus fibronectin-binding proteins (FnBPs) play a critical role in S. aureus pathogenesis. FnBPs mediate adhesion to fibronectin and invasion of mammalian cells, including epithelial, endothelial, and fibroblastic cells, by fibronectin bridging to the host cell fibronectin receptor integrin (alpha(5))b...

journal_title：Infection and immunity

authors： Grundmeier M,Hussain M,Becker P,Heilmann C,Peters G,Sinha B

更新日期：2004-12-01 00:00:00

abstract：:Acinetobacter baumannii is a pathogen of increasing medical importance with a propensity to be multidrug resistant, thereby making treatment challenging. Little is known of virulence traits in A. baumannii. To identify virulence factors and potential drug targets, random transposon (Tn) mutants derived from the A. bau...

journal_title：Infection and immunity

authors： Russo TA,Luke NR,Beanan JM,Olson R,Sauberan SL,MacDonald U,Schultz LW,Umland TC,Campagnari AA

更新日期：2010-09-01 00:00:00

abstract：:Pathogenicities of 10 temperature-sensitive mutants of Venezuelan encephalitis virus were studied using the hamster model of human virulence. The parental strain and nine of the temperature-sensitive mutants produced lethal infections in hamsters. Strain ts 126 showed reduced hamster virulence. Deaths with the lethal ...

journal_title：Infection and immunity

authors： Krieger JN,Scherer WF,Wiebe ME,Pancake BA,Harsanyi ZP

更新日期：1979-09-01 00:00:00

abstract：:Toxin B from Clostridium difficile is cytopathic in vitro for various types of cells, including polymorphonuclear cells, lymphocytes, and monocytes. Since intestine lamina propria is rich in macrophages, we studied the effect of toxin B on human monocytes and on human macrophages generated in vitro by long-term cultur...

journal_title：Infection and immunity

authors： Siffert JC,Baldacini O,Kuhry JG,Wachsmann D,Benabdelmoumene S,Faradji A,Monteil H,Poindron P

更新日期：1993-03-01 00:00:00

abstract：:A peptidoglycan layer of Treponema pallidum kazan was isolated by solubilization of whole cells with 1% warm sodium dodecyl sulfate and subsequent digestion of an insoluble residue with proteases. Electron microscopy revealed that the peptidoglycan was isolated as a single-layered sacculus of less than 5 nm in thickne...

journal_title：Infection and immunity

authors： Umemoto T,Ota T,Sagawa H,Kato K,Takada H,Tsujimoto M,Kawasaki A,Ogawa T,Harada K,Kotani S

更新日期：1981-02-01 00:00:00

abstract：:Numerous investigations have shown that 70-kDa heat shock protein (Hsp70) homologs interact tightly with hydrophobic proteins and functionally assist proteins in membranous organelles and environments. One such protein is the Chlamydia trachomatis Hsp70 that is associated with isolated outer membrane complexes of infe...

journal_title：Infection and immunity

authors： Raulston JE,Davis CH,Paul TR,Hobbs JD,Wyrick PB

更新日期：2002-02-01 00:00:00

abstract：:We show here that Helicobacter pylori broth culture supernatants disrupt the actin cytoskeleton of epithelial cell lines, leading to cell rounding and apoptosis through anoikis. We demonstrate that there are marked quantitative differences between strains and that there are different cell line sensitivities. By constr...

journal_title：Infection and immunity

authors： Bebb JR,Letley DP,Rhead JL,Atherton JC

更新日期：2003-06-01 00:00:00

abstract：:The in vitro effects of pneumolysin, a sulfhydryl-activated toxin produced by Streptococcus pneumoniae, on various functions of human polymorphonuclear leukocytes (PMNLs) was investigated. Treatment of PMNLs with highly purified toxin significantly inhibited respiratory burst (in response to stimulation), ability to k...

journal_title：Infection and immunity

authors： Paton JC,Ferrante A

更新日期：1983-09-01 00:00:00

abstract：:Influenza A/Scotland/74 (H3N2) and A/Victoria/75 (H3N2) cold-adapted (ca) recombinant viruses, prepared by mating the A/Ann Arbor/6/60 (H2N2) ca donor virus and influenza A wild-type virus, were evaluated in adult seronegative volunteers (serum hemagglutination-inhibiting antibody titer,

journal_title：Infection and immunity

authors： Murphy BR,Holley HP Jr,Berquist EJ,Levine MM,Spring SB,Maassab HF,Kendal AP,Chanock RM

更新日期：1979-02-01 00:00:00

abstract：:Colonization by Bordetella bronchiseptica results in a variety of inflammatory respiratory infections, including canine kennel cough, porcine atrophic rhinitis, and a whooping cough-like disease in humans. For successful colonization, B. bronchiseptica must acquire iron (Fe) from the infected host. A vast amount of Fe...

journal_title：Infection and immunity

authors： Mocny JC,Olson JS,Connell TD

更新日期：2007-10-01 00:00:00

abstract：:We used inhibitors of receptor-mediated endocytosis to study the mechanisms of infectivity, especially the uptake mechanism, of Chlamydia trachomatis for cultured cells. The effect of methylamine and monodansylcadaverine on the different stages of the chlamydial growth cycle in McCoy cells was examined. There was a do...

journal_title：Infection and immunity

authors： Söderlund G,Kihlström E

更新日期：1983-05-01 00:00:00

abstract：:Mutant analysis was used to identify Moraxella catarrhalis gene products necessary for biofilm development in a crystal violet-based assay involving 24-well tissue culture plates. The wild-type M. catarrhalis strains that formed the most extensive biofilms in this system proved to be refractory to transposon mutagenes...

journal_title：Infection and immunity

authors： Pearson MM,Laurence CA,Guinn SE,Hansen EJ

更新日期：2006-03-01 00:00:00

abstract：:Inactivated Marek's disease virus-infected chicken kidney cells and inactivated MSB-1 lymphoblastoid Marek's disease tumor cells were used to immunize chickens as virus- and tumor-associated antigens, respectively. Immune and nonimmune birds were then challenged by exposure to live virulent Marek's disease virus. Both...

journal_title：Infection and immunity

authors： Murthy KK,Calnek BW

更新日期：1979-11-01 00:00:00

abstract：:Antigens were extracted from a virulent isolate of Pasteurella multocida (serotype 3, 12, 15:D) with potassium thiocyanate, and a vaccine was prepared. Pasteurella-free rabbits were vaccinated intranasally and intraconjuctivally twice with a 2-week interval and challenged intranasally with the homologous P. multocida ...

journal_title：Infection and immunity

authors： Ringler DH,Peter GK,Chrisp CE,Keren DF

更新日期：1985-09-01 00:00:00

abstract：:Peptidoglycan (PG) turnover in exponentially growing Neisseria gonorrhoeae RD5 type 4 was accompanied by release of soluble PG fragments into the medium. Turnover of the D-[14C]glucosamine-labeled glycan moiety and of the meso-[3H]diaminopimelic acid (DAP)-labeled peptide region occurred at similar rates (ca. 35% per ...

journal_title：Infection and immunity

authors： Rosenthal RS

更新日期：1979-06-01 00:00:00

abstract：:Pseudomonas aeruginosa utilizes a number of distinct pathways to secrete proteins that play various roles during infection. These include the type II secretion system, which is responsible for the secretion of the majority of exoproducts into the surrounding environment, including toxins and degradative enzymes. In co...

journal_title：Infection and immunity

authors： Lee VT,Smith RS,Tümmler B,Lory S

更新日期：2005-03-01 00:00:00

abstract：:We have previously shown that infection by Trypanosoma cruzi, a parasitic protozoan, is reduced by injection of CD40 ligand (CD40L)-transfected 3T3 fibroblasts (D. Chaussabel, F. Jacobs, J. de Jonge, M. de Veerman, Y. Carlier, K. Thielemans, M. Goldman, and B. Vray, Infect. Immun. 67:1929-1934, 1999). This prompted us...

journal_title：Infection and immunity

authors： Chamekh M,Vercruysse V,Habib M,Lorent M,Goldman M,Allaoui A,Vray B

更新日期：2005-10-01 00:00:00

abstract：:The development of immunological responsiveness to a soluble cercarial antigenic preparation (CAP) from Schistosoma mansoni was analyzed in inbred CBA/J mice infected with cercariae, one or multiple times, or sensitized using CAP. Repeated exposure to 75 cercariae at three weekly intervals (3X-75) or subcutaneous admi...

journal_title：Infection and immunity

authors： Katz SP,Colley DG

更新日期：1976-08-01 00:00:00

abstract：:A purified human granulocyte colony-stimulating factor (hG-CSF) was studied for its protective effect on the induction of neutropenia and enhanced susceptibility to microbial infections in mice receiving cyclophosphamide (CPA). A severe reduction in peripheral blood neutrophils was induced 4 days after injection with ...

journal_title：Infection and immunity

authors： Matsumoto M,Matsubara S,Matsuno T,Tamura M,Hattori K,Nomura H,Ono M,Yokota T

更新日期：1987-11-01 00:00:00

abstract：:An immunogenic aminopeptidase was purified from Brucella melitensis strain VTRM1. The purification procedure consisted of ammonium sulfate fractionation and three chromatographic steps. This procedure resulted in a yield of 29% and a 144-fold increase in specific activity. The aminopeptidase appeared to be a monomeric...

journal_title：Infection and immunity

authors： Contreras-Rodriguez A,Ramirez-Zavala B,Contreras A,Schurig GG,Sriranganathan N,Lopez-Merino A

更新日期：2003-09-01 00:00:00

abstract：:A total of 32 patients with Plasmodium falciparum malaria were studied. Of these, 23 had benign infections, and 9 had typical cerebral malaria. Cryoglobulins, circulating immune complexes detected by a C1q-binding assay, and hypocomplementemia were found in eight of nine patients with cerebral malaria. Raised levels o...

journal_title：Infection and immunity

authors： Adam C,Géniteau M,Gougerot-Pocidalo M,Verroust P,Lebras J,Gibert C,Morel-Maroger L

更新日期：1981-02-01 00:00:00

abstract：:We have isolated full-length cDNAs encoding two distinct types of CuZn superoxide dismutases (SODs) from the filarial nematode parasite Brugia pahangi. The derived amino acid sequences suggested that one class of cDNAs represented a cytoplasmic form of SOD and the second class represented an extracellular (EC) variant...

journal_title：Infection and immunity

authors： Tang L,Ou X,Henkle-Dührsen K,Selkirk ME

更新日期：1994-03-01 00:00:00

abstract：:Help from CD4 T cells is often important for the establishment of primary and memory CD8 T-cell responses. However, it has yet to be determined whether T helper polarization affects the delivery of help and/or whether responding CD8 T cells helped by Th1 or Th2 cells express distinct effector properties. To address th...

journal_title：Infection and immunity

authors： Ekkens MJ,Shedlock DJ,Jung E,Troy A,Pearce EL,Shen H,Pearce EJ

更新日期：2007-05-01 00:00:00

abstract：:Glaesserella (Haemophilus) parasuis is a commensal bacterium of the upper respiratory tract in pigs and also the causative agent of Glässer's disease, which causes significant morbidity and mortality in pigs worldwide. Isolates are characterized into 15 serovars by their capsular polysaccharide, which has shown a corr...

journal_title：Infection and immunity

authors： Eberle KC,Hau SJ,Luan SL,Weinert LA,Stasko JA,Wang J,Peters SE,Langford PR,Rycroft AN,Wren BW,Maskell DJ,Tucker AW,Brockmeier SL

更新日期：2020-04-20 00:00:00

abstract：:A unique enzyme-linked immunosorbent assay was developed to detect soluble peptidoglycans in biological fluids. It makes use of the similar affinities of vancomycin and purified rabbit antibodies to peptidoglycan precursor sequences found in soluble peptidoglycans. This assay has been used to detect as little as 500 p...

journal_title：Infection and immunity

authors： Park H,Zeiger AR,Schumacher HR

更新日期：1984-01-01 00:00:00

abstract：:Group A streptococcal pyrogenic exotoxins A, B, and C (also known as scarlet fever toxins and erythrogenic toxins) were evaluated for relatedness to another streptococcus-derived lymphocyte mitogen, blastogen A. Streptococcal pyrogenic exotoxin A and blastogen A were immunologically cross-reactive and shared the same ...

journal_title：Infection and immunity

authors： Schlievert PM,Gray ED

更新日期：1989-06-01 00:00:00

abstract：:Eperythrozoon coccoides is a common blood parasite of rodents and the etiological agent of a chronic infection present in many mouse colonies. After primary infection, mice develop a parasitemia and anemia followed by a chronic, latent infection. During the acute phase of infection, mice manifest a striking suppressio...

journal_title：Infection and immunity

authors： Glasgow LA,Odugbemi T,Dwyer P,Ritterson AL

更新日期：1971-10-01 00:00:00

abstract：:It has been proposed that a multivalent malaria vaccine is necessary to mimic the naturally acquired resistance to this disease observed in humans. A major experimental challenge is to identify the optimal components to be used in such a multivalent vaccine. Expression library immunization (ELI) is a method for screen...

journal_title：Infection and immunity

authors： Rainczuk A,Scorza T,Smooker PM,Spithill TW

更新日期：2003-08-01 00:00:00

abstract：:Macrophage-dependent killing of facultative intracellular bacteria was markedly impaired by overt erythrocytic Plasmodium yoelii or Plasmodium berghei infection of mice. P. yoelii infection was capable of ablating not only the macrophage microbicidal capacity of "normal" animals but also the bactericidal capacities of...

journal_title：Infection and immunity

authors： Murphy JR

更新日期：1981-01-01 00:00:00