Abstract:
:Although periodontal treatment by scaling and root planing (SCRP) is known to induce bacteremia, the effect of this procedure on the host immune response is not known. We have determined pre- and post-SCRP immunoglobulin G antibody titers to antigens of Actinobacillus actinomycetemcomitans in the sera of 22 patients with rapidly progressive periodontitis. We also assessed the ability of these sera to enhance phagocytosis and killing of A. actinomycetemcomitans by human polymorphonuclear leukocytes by using a polymorphonuclear leukocyte chemiluminescence (CL) assay. Specific anti-A. actinomycetemcomitans antibody titers were significantly increased at 6 and 12 months after beginning treatment, and CL values were significantly increased at 12 months, whereas mean interproximal pocket depths were significantly decreased at 12 months after beginning treatment. When patients were classified as either seropositive (twice the median titer of control subjects; n = 10) or seronegative (n = 12), both median titers and CL values were significantly increased for the seronegative group at 6 and 12 months after treatment. In the seropositive group, only the median titer was significantly increased at 12 months. Western blot (immunoblot) patterns for six seronegative and six seropositive patients differed remarkably at the baseline. Before treatment, all of the seropositive patients recognized high-molecular-mass lipopolysaccharide (LPS) and a large number of protein components. Patterns were virtually unaffected by therapy. Before treatment, only one of the seronegative patients recognized the LPS smear and none reacted strongly with protein components. Following treatment, slight LPS staining was observed for five of six seronegative patients and detection of protein bands was enhanced in all cases. We conclude that treatment by SCRP induces a humoral immune response, especially in seronegative patients, and that response may play a role in the observed beneficial effects of periodontal treatment.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Sjöström K,Ou J,Whitney C,Johnson B,Darveau R,Engel D,Page RCdoi
10.1128/IAI.62.1.145-151.1994subject
Has Abstractpub_date
1994-01-01 00:00:00pages
145-51issue
1eissn
0019-9567issn
1098-5522journal_volume
62pub_type
杂志文章abstract::The antigenicities of Mycobacterium bovis strain BCG and an isoniazid (INH) - resistant mutant were compared. Sonic extracts of heat-killed, washed bacteria were injected into rabbits, and antisera were produced (anti-BCG and anti-BCG-R). The sonic extracts were also subjected to ultracentrifugation, and test antigens...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.3.4.524-529.1971
更新日期:1971-04-01 00:00:00
abstract::In this study, we investigated a potential requirement of two-component signal transduction systems for acid resistance in Helicobacter pylori. In comparison to a wild-type strain, isogenic strains with null mutations in either HP0165 or HP1364 histidine kinases were impaired in their ability to grow at pH 5.0. The gr...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.74.5.3052-3059.2006
更新日期:2006-05-01 00:00:00
abstract::The genes encoding alpha-hemolysin and mannose-resistant hemagglutination were shown to be closely linked in cloned DNA from two Escherichia coli urinary tract isolates of serotypes O4 (J96) and O6 (C1212). DNA hybridization experiments demonstrated that the hly and mrh gene clusters of other E. coli O6 serotypes were...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.43.1.353-358.1984
更新日期:1984-01-01 00:00:00
abstract::The nitrate dissimilation pathway is important for anaerobic growth in Pseudomonas aeruginosa. In addition, this pathway contributes to P. aeruginosa virulence by using the nematode Caenorhabditis elegans as a model host, as well as biofilm formation and motility. We used a set of nitrate dissimilation pathway mutants...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00822-09
更新日期:2009-10-01 00:00:00
abstract::The compositions of lipopolysaccharides I and II, isolated from Coxiella burnetii phase I and pure phase II cells, respectively, showed drastic and clear-cut differences. Lipopolysaccharide II exhibited a comparatively simple composition. It contained, in addition to glucosamine (from lipid A) and a 2-keto-3-deoxyoctu...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.38.1.53-57.1982
更新日期:1982-10-01 00:00:00
abstract::Encapsulated Streptococcus pneumoniae of serotypes 2, 9N, 14, 21, and 23F and an unencapsulated variant of type 2 pneumococci were efficiently phagocytosed by both aerobically and anaerobically incubated human leukocytes. In the presence of O2, the pneumococci rapidly lost their viability, whereas during anaerobiosis,...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.47.1.277-281.1985
更新日期:1985-01-01 00:00:00
abstract::The role of the hypothalamus-pituitary-adrenal (HPA) axis in regulating the growth of Mycobacterium avium in Mycobacterium bovis BCG-resistant and -susceptible congenic mice was evaluated. Restraint was used to activate the HPA axis, which resulted in an increase in the level of corticosterone in the plasma. Activatio...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.11.4793-4800.1993
更新日期:1993-11-01 00:00:00
abstract::Mouse fibroblasts (L cells) infected with the 6BC strain of Chlamydia psittaci released potassium ion (K(+)) into the extracellular milieu in a way that depended on size of inoculum and time after infection. When the multiplicity of infection was 500 to 1,000 50% infectious units (ID(50)) per L cell, loss of intracell...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.19.3.827-832.1978
更新日期:1978-03-01 00:00:00
abstract::FcRgamma and interleukin-10 (IL-10) are both required for chronic disease in C57BL/6 mice with Leishmania mexicana parasite infection. FcRgamma is a component of several different FcRs and may be a component of some T-cell receptors. The initial antibody response to L. mexicana is an immunoglobulin G1 (IgG1) response,...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00316-07
更新日期:2008-02-01 00:00:00
abstract::Defensins are antibiotic peptides expressed in human and animal myeloid and epithelial cells. Due to the limited availability of natural peptides, the properties of human epithelial defensins have not been studied. We assayed the microbicidal activity of recombinant human intestinal defensin 5 (rHD-5) in the presence ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.6.2396-2401.1997
更新日期:1997-06-01 00:00:00
abstract::Citrobacter rodentium, an attaching-effacing bacterial pathogen, establishes an acute infection of the murine colonic epithelium and induces a mild colitis in immunocompetent mice. This study describes the role of T-cell subsets and B lymphocytes in immunity to C. rodentium. C57Bl/6 mice orally infected with C. rodent...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.9.5077-5086.2003
更新日期:2003-09-01 00:00:00
abstract::Listeria monocytogenes, isolated from outbreaks in either human or nonhuman primate populations, was administered orally at doses ranging from 10(6) to 10(10) CFU. Four of 10 treated animals delivered stillborn infants. L. monocytogenes was isolated from fetal tissue, and the pathology was consistent with L. monocytog...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.3.1574-1579.2003
更新日期:2003-03-01 00:00:00
abstract::We examined the intracellular growth of 20 strains within six species of Legionella in thioglycolate-elicited peritoneal macrophages from A/J and C57BL/6 mice and a congenic strain derived from them (A.B Lgn1). With the exception of Legionella pneumophila Togus-1 and Bloomington-2, the intracellular growth of the 15 L...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.5.1842-1845.1996
更新日期:1996-05-01 00:00:00
abstract::Several studies have demonstrated roles for eosinophils during innate and adaptive immune responses to helminth infections. However, evidence that eosinophils are capable of initiating an immune response to parasite antigens is lacking. The goal of the present in vitro study was to investigate the potential of eosinop...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02067-05
更新日期:2006-06-01 00:00:00
abstract::Botulinum neurotoxins (BoNTs) and tetanus toxin (TeNT) are the most potent toxins for humans and elicit unique pathologies due to their ability to traffic within motor neurons. BoNTs act locally within motor neurons to elicit flaccid paralysis, while retrograde TeNT traffics to inhibitory neurons within the central ne...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00477-15
更新日期:2015-07-01 00:00:00
abstract::Intestinal mucus is postulated to play a role in preventing colonization of the gastrointestinal tract by microbial pathogens. To evaluate the ability of both crude mucus and purified mucin, a glycoprotein of goblet cell origin, to inhibit mucosal adherence of enteric pathogens, we examined whether mucus and mucin der...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.56.9.2437-2442.1988
更新日期:1988-09-01 00:00:00
abstract::Cell-mediated immunity to herpes simplex virus type 1 (HSV-1) was assessed by a lymphocytotoxicity 51-Cr-release microassay procedure, using the MA-160 human prostatic adenoma cell line chronically infected with HSV-1 and its parent cell line as control. The specific immune release mean plus or minus standard deviatio...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.12.1.76-80.1975
更新日期:1975-07-01 00:00:00
abstract::In vivo administration of Porphyromonas gingivalis lipopolysaccharide (Pg-LPS) to mice induced apoptosis before a specific immune response. Apoptosis was associated with the expression of immunoglobulin and Ia on B cells and of CD5 and several markers on T cells. Apoptosis peaked in the spleen and lymph nodes on day 2...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.4.1461-1466.1996
更新日期:1996-04-01 00:00:00
abstract::gamma delta T cells have variously been implicated in the protection against, and the pathogenesis of, malaria, but few studies have examined the gamma delta T-cell response to malaria in African children, who suffer the large majority of malaria-associated morbidity and mortality. This is unfortunate, since available...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.5.3190-3196.2001
更新日期:2001-05-01 00:00:00
abstract::Vibrio cholerae is the causative bacteria of the diarrheal disease cholera, but it also persists in aquatic environments, where it displays an expression profile that is distinct from that during infection. Upon entry into the host, a tightly regulated circuit coordinates the induction of two major virulence factors: ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00707-16
更新日期:2016-12-29 00:00:00
abstract::Aerobic microorganisms were isolated and identified from 9 of 10 malignant tissues aseptically obtained from surgical patients. The organisms isolated are species commonly associated with the flora of the human body. When these cancer-associated organisms were grown in Trypticase soy broth (BBL Microbiology Systems), ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.32.3.1211-1215.1981
更新日期:1981-06-01 00:00:00
abstract::Biofilm formation by the periodontal pathogen Aggregatibacter actinomycetemcomitans is dependent upon autoinducer-2 (AI-2)-mediated quorum sensing. However, the components that link the detection of the AI-2 signal to downstream gene expression have not been determined. One potential regulator is the QseBC two-compone...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01376-09
更新日期:2010-07-01 00:00:00
abstract::Antimicrobial fatty acids (AFAs) protect the human epidermis against invasion by pathogenic bacteria. In this study, we questioned whether human skin fatty acids (FAs) can be incorporated into the lipid moiety of lipoproteins and whether such incorporation would have an impact on innate immune stimulation in the model...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00822-15
更新日期:2015-10-26 00:00:00
abstract::Attaching and effacing adhesion to epithelial cells is a pathognomonic feature of infection by both enteropathogenic Escherichia coli (EPEC) and certain strains of verocytotoxin-producing E. coli (VTEC). EPEC adhesion to tissue culture epithelial cells results in activation of the phosphatidylinositol pathway, with el...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.9.3316-3326.1995
更新日期:1995-09-01 00:00:00
abstract::The chemotactic behavior of Campylobacter jejuni was determined in the presence of different amino acids, carbohydrates, organic acids, and preparations and constituents of mucin and bile. L-Fucose was the only carbohydrate and L-aspartate, L-cysteine, L-glutamate, and L-serine were the only amino acids producing a ch...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.56.6.1560-1566.1988
更新日期:1988-06-01 00:00:00
abstract::Toll-like receptors (TLRs) play a critical role in early immune recognition of Aspergillus, which can regulate host defense during invasive pulmonary Aspergillosis (IPA). However, the role of TLR7 in the pathogenesis of IPA remains unknown. In this study, an in vivo model of IPA was established to investigate the cont...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00019-21
更新日期:2021-01-25 00:00:00
abstract::A family of high-molecular-weight (HMW) surface-exposed proteins important in the attachment of nontypeable Haemophilus influenzae (NTHi) to human epithelial cells was previously identified (J. W. St. Geme III, S. Falkow, and S. J. Barenkamp, Proc. Natl. Acad. Sci. USA 90:2875-2879, 1993). In the present investigation...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.10.4460-4468.1994
更新日期:1994-10-01 00:00:00
abstract::The mechanism of enhanced resistance of Mycobacterium bovis BCG-treated mice to ectromelia virus infection was investigated by determining the effect of splenectomy, antithymocyte serum, and antimacrophage serum on resistance. It was greatly reduced by these treatments, not only in normal mice, but also in mice treate...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.42.2.567-573.1983
更新日期:1983-11-01 00:00:00
abstract::Lewis (Le) antigens have been implicated in the pathogenesis of atrophic gastritis and gastric cancer in the setting of Helicobacter pylori infection, and H. pylori-induced anti-Le antibodies have been described that cross-react with the gastric mucosa of both mice and humans. The aim of this study was to examine the ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.8.4774-4781.2001
更新日期:2001-08-01 00:00:00
abstract::Antibody to Pseudomonas aeruginosa exotoxin was detected in human sera by using a cytotoxicity-neutralization assay. Serum antitoxin was present in high titer in all 14 patients who recovered from serious pseudomonas infections (log2 of 50% neutralization titer, mean +/- standard deviation = 6.0 +/- 1.2). In contrast,...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.14.4.942-947.1976
更新日期:1976-10-01 00:00:00