Abstract:
:Bacteroides fragilis with enterotoxin-like activity (BFEL) was isolated from the feces of 24- to 48-h-old lambs with acute diarrheal disease on three different sheep ranches in the Northern Rocky Mountain region of the United States. The lamb intestinal loop test was used to enrich for the bacterium before its initial isolation. Pure cultures of B. fragilis from the feces of diarrheic lambs caused fluid accumulation in five of five lamb intestinal loop tests and in three of three calf intestinal loop tests. Two different serogroups of BFEL were found in diarrheic lambs, and a third serogroups was found in the feces of a diarrheic ewe. Enteric disease characterized by diarrhea, depression, and inappetence occurred in three of eight newborn, colostrum-fed lambs after oral challenge inoculation with viable BFEL. One of the three lambs died 32 h after challenge. Clinical signs of disease were similar to those observed in the naturally occurring disease. B. fragilis is an obligately anaerobic bacterium found in the intestinal tract of most animals and humans. It is a serious cause of extraintestinal infection in humans. The bacterium has not been reported to cause fluid accumulation in the intestine or to cause diarrhea in any species of animal.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Myers LL,Firehammer BD,Shoop DS,Border MMdoi
10.1128/IAI.44.2.241-244.1984subject
Has Abstractpub_date
1984-05-01 00:00:00pages
241-4issue
2eissn
0019-9567issn
1098-5522journal_volume
44pub_type
杂志文章abstract::The surface antigen makeup of metacyclic trypomastigote forms of strain G of Trypanosoma cruzi, which produce a subpatent infection in mice, differed from those of the virulent strains Y and CL. A 100,000-molecular-weight protein, barely detectable on the Y or CL cell surface, appeared as the main surface antigen of t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.40.2.836-839.1983
更新日期:1983-05-01 00:00:00
abstract::Helicobacter pylori secretes a pore-forming VacA toxin that has structural features and activities substantially different from those of other known bacterial toxins. VacA can assemble into multiple types of water-soluble flower-shaped oligomeric structures, and most VacA activities are dependent on its capacity to ol...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00254-16
更新日期:2016-08-19 00:00:00
abstract::CD14, the leukocyte receptor for lipopolysaccharide (LPS), is important in the response of human polymorphonuclear leukocytes (PMNs) to infection with gram-negative bacteria. The level of CD14 on the PMN surface increases after exposure to some inflammatory stimuli such as N-formyl-methionyl-leucyl-phenylalanine (fMLP...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.11.4747-4753.1997
更新日期:1997-11-01 00:00:00
abstract::A murine monoclonal antibody was raised against the B95-8 strain of Epstein-Barr virus (EBV), which was isolated from a case of mononucleosis after blood transfusion (Hoffman et al. Proc. Natl. Acad. Sci. U.S.A. 77:2979, 1980). We provide evidence that neutralization of immortalization by this monoclonal antibody is v...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.37.3.1028-1031.1982
更新日期:1982-09-01 00:00:00
abstract::Pseudomonas aeruginosa, an important opportunistic pathogen of humans, exploits epithelial damage to establish infection. We have rigorously explored the role of N-glycoproteins and heparan sulfate proteoglycans (HSPGs) in P. aeruginosa-mediated attachment and subsequent downstream events at the apical (AP) and basola...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01215-09
更新日期:2010-03-01 00:00:00
abstract::Since 1984, it has been known that spotted fever group rickettsiosis exists in Japan. We isolated three strains of the causative rickettsiae, designated Katayama, Misaka, and Abe, from patients with the disease and studied the characteristics of the isolates. Nude mice and cyclophosphamide-treated mice died after infe...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.4.887-892.1990
更新日期:1990-04-01 00:00:00
abstract::The mechanisms that govern the initial interaction between Paracoccidioides brasiliensis, a primary dimorphic fungal pathogen, and cells of the innate immunity need to be clarified. Our previous studies showed that Toll-like receptor 2 (TLR2) and TLR4 regulate the initial interaction of fungal cells with macrophages a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00375-10
更新日期:2011-06-01 00:00:00
abstract::Ureaplasma urealyticum is a common commensal of the female lower urogenital tract, yet it has been shown to be an important cause of chorioamnion infection, respiratory and central nervous system disease, and death in premature infants. It has been suggested that only certain serovars are capable of producing invasive...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.3.891-898.1995
更新日期:1995-03-01 00:00:00
abstract::After oral feeding of mice with avirulent Salmonella, Escherichia coli, or hybrid strains, only certain bacterial strains were able to multiply and persist within the small intestinal Peyer's patches. After oral vaccination alone, or oral priming and subsequent parenteral boosting, antibody class and titers were detec...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.25.1.27-33.1979
更新日期:1979-07-01 00:00:00
abstract::Streptococcus pneumoniae is the most frequent microbe causing middle ear infection. The pathophysiology of pneumococcal otitis media has been characterized by measurement of local inflammatory mediators such as inflammatory cells, lysozyme, oxidative metabolic products, and inflammatory cytokines. The role of cytokine...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1999-04-01 00:00:00
abstract::Length and restriction site polymorphism within a 2.8-kb threonine-rich open reading frame from Cryptosporidium parvum was identified and used to determine the genotypes of isolates from calves and humans. In agreement with observations of other genetic loci, all calf isolates were identical at this locus. In contrast...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.9.3958-3960.1997
更新日期:1997-09-01 00:00:00
abstract::The ability to bind and utilize hemin is a trait common to many human pathogens. Nevertheless, the relationship between Legionella pneumophila, the agent of Legionnaires' disease, and hemin has received little attention. Thus, we explored the capacity of a virulent, serogroup 1 strain of L. pneumophila to bind hemin a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.3.842-848.1996
更新日期:1996-03-01 00:00:00
abstract::Streptococcus pneumoniae infection leads to multifold increases in sialyltransferase, galactosyltransferase, alpha 2-fucosyltransferase, and alpha 3-fucosyltransferase activity of rat liver. Such changes may reflect an increased demand for glycosylation of acute-phase proteins synthesized and secreted by the liver dur...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.29.1.114-118.1980
更新日期:1980-07-01 00:00:00
abstract::Bactericidal activity and binding of a 57,000-dalton cationic antimicrobial neutrophil granule protein (CAP57) are determined by the presence on bacteria of O-antigen polysaccharide chains and the availability of negatively charged groups in the lipid A region, the inner core region, or both regions of lipopolysacchar...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.56.6.1589-1592.1988
更新日期:1988-06-01 00:00:00
abstract::Lack of efficacious vaccines against Mycobacterium tuberculosis (MTB) infection is a limiting factor in the prevention and control of tuberculosis (TB), the leading cause of death from an infectious agent. Improvement or replacement of the BCG vaccine with one that reliably protects all age-groups is urgent. Concerns ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00585-20
更新日期:2020-12-14 00:00:00
abstract::Persistent infection with Borrelia burgdorferi in the presence of a vigorous host immune response has been demonstrated in humans and in animal models of Lyme disease. Long-term persistence of B. burgdorferi was documented recently in our studies of BALB/c and C3H mice infected with cloned and uncloned strains of B. b...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.8.3521-3527.1994
更新日期:1994-08-01 00:00:00
abstract::The need for agents designed to modify immune response in the treatment of patients with viral infection, immunodeficiency, or cancer prompted the present study on the mechanisms of action of isoprinosine, a compound developed for antiviral use and whose therapeutic activity may involve the immune system. The effect o...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.13.2.382-387.1976
更新日期:1976-02-01 00:00:00
abstract::The Mycobacterium tuberculosis exported repetitive protein (Erp) is a virulence determinant required for growth in cultured macrophages and in vivo. To better understand the role of Erp in Mycobacterium pathogenesis, we generated a mutation in the erp homologue of Mycobacterium marinum, a close genetic relative of M. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02061-05
更新日期:2006-06-01 00:00:00
abstract::Oral inoculation of 5-day-old gnotobiotic pigs with Salmonella enterica serovar Typhimurium strain F98 resulted in severe enteritis and invasive disease. Preinoculation 24 h earlier with an avirulent mutant of Salmonella enterica serovar Infantis (1326/28) completely prevented disease for up to 14 days (when the exper...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.4.2182-2191.2003
更新日期:2003-04-01 00:00:00
abstract::The method of hemagglutination inhibition was used to investigate the antigenic diversity of lipopolysaccharide (LPS) from Neisseria meningitidis and to develop a serotyping systems based on this antigen. The system uses outer membrane complex prepared by a simple extraction procedure to inhibit homologous hemagglutin...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.16.2.471-475.1977
更新日期:1977-05-01 00:00:00
abstract::The leukotrienes and tumor necrosis factor (TNF) play an important role in the pathophysiology of septic shock, in which hypotension, leukopenia, thrombocytopenia, and hemoconcentration are observed. This study was performed to examine the effects of a 5-lipoxygenase inhibitor (AA-861), a selective leukotriene recepto...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.6.2432-2437.1992
更新日期:1992-06-01 00:00:00
abstract::The polysaccharide antigen preparations from serotype a and serotype d strains of Streptococcus mutans contained both a serotype-specific antigenic determinant and a common a-d antigenic determinant, as demonstrated by agar gel diffusion studies and a quantitative cross-precipitin assay. The chromatographically purifi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.12.4.791-798.1975
更新日期:1975-10-01 00:00:00
abstract::Expression of virulence determinants by Bordetella pertussis, the primary etiological agent of whooping cough, is regulated by the BvgAS two-component regulatory system. The role of a second two-component regulatory system, encoded by risAS, in this process is not defined. Here, we show that mutation of B. pertussis r...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.9.5995-6004.2005
更新日期:2005-09-01 00:00:00
abstract::The ultrastructural appearance of the "halozone" formed at the interface between the spotted fever agent Rickettsia rickettsii and the cytoplasm of persistently infected cultured vole cells (Microtus pennsylvanicus) was studied by transmission electron microscopy. In sections of epoxy-embedded specimens stained with u...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.41.3.1252-1260.1983
更新日期:1983-09-01 00:00:00
abstract::Conditions are described for the production of an extracellular cytotoxin or CHO cell-killing factor by Vibrio fluvialis, a recently recognized enteric pathogen. The cell-killing factor was ammonium sulfate precipitable, heat labile, and inactivated by proteases, and had an isoelectric point (estimated by sucrose dens...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.46.3.773-777.1984
更新日期:1984-12-01 00:00:00
abstract::Monoclonal antibodies have been generated to the unique distal sugar epitopes on the oligosaccharide haptens of the glycopeptidolipid antigens of clinically prominent members of the Mycobacterium avium serocomplex. Thus, antibodies are described that recognize the distal O-acetyl-alpha-L-rhamnopyranosyl residue of the...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.10.3147-3158.1989
更新日期:1989-10-01 00:00:00
abstract::A clone expressing a 58-kDa protein reactive with human convalescent-phase serum was isolated from a recombinant library of Ehrlichia chaffeensis, the etiologic agent of human ehrlichiosis. Sequencing identified two open reading frames, one encoding a 10.3-kDa polypeptide consisting of 94 amino acids and another encod...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.8.3536-3539.1993
更新日期:1993-08-01 00:00:00
abstract::Corynebacteriophage 782, a phage highly related to the beta family of corynebacteriophages but lacking a tox allele, was isolated from a nontoxinogenic clinical isolate of Corynebacterium diphtheriae. Phage 782 exhibits beta immunity but has a wider host range than beta, forming plaques on strains of C. ulcerans and C...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.49.1.32-35.1985
更新日期:1985-07-01 00:00:00
abstract::The ethanol-insoluble product formed from sucrose by purified enzyme encoded by the gtfA gene from Streptococcus mutans, expressed in recombinant Escherichia coli, was analyzed by 13C and 31P nuclear magnetic resonance. The product was identified as alpha-D-glucose-1-phosphate, and it was concluded that the GTF-A enzy...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.56.10.2763-2765.1988
更新日期:1988-10-01 00:00:00
abstract::A fibronectin-binding protein (FnBP) adhesin of Staphylococcus aureus possesses three 37- or 38-amino-acid motifs (D1, D2, and D3) that can each bind fibronectin (Fn) with low affinity and that in tandem comprise D1-3, a high-affinity Fn-binding domain. To identify epitopes for the generation of adhesion-blocking anti...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.2.537-543.1997
更新日期:1997-02-01 00:00:00