Role of bacterial phospholipases in serum-mediated killing of Escherichia coli.

abstract：:In the present study, the role of virulence factors in and the effect of opsonization on the interactions between Bordetella pertussis and human monocytes were investigated. The methods used facilitated the distinction between attachment and ingestion of bacteria by monocytes. Nonopsonized virulent B. pertussis cells ...

journal_title：Infection and immunity

authors： Hazenbos WL,van den Berg BM,van't Wout JW,Mooi FR,van Furth R

更新日期：1994-11-01 00:00:00

abstract：:The coexistence of bacteria in natural environments can often be explained in terms of competition for a growth-limiting substrate(s), and the outcome of such competition depends upon relevant growth parameters such as substrate affinity and yield. Dental plaque bacteria are frequently carbon and energy limited. Growt...

journal_title：Infection and immunity

authors： Rogers AH,de Jong MH,Zilm PS,van der Hoeven JS

更新日期：1986-06-01 00:00:00

abstract：:Infection of inbred mouse strains with Borrelia burgdorferi results in the development of experimental Lyme arthritis. The degree of arthritic pathology has been suggested to correlate with the level of spirochete burden within tissues. To investigate this further, we infected resistant DBA/2 (DBA) and susceptible C3H...

journal_title：Infection and immunity

authors： Brown CR,Reiner SL

更新日期：1998-05-01 00:00:00

abstract：:Escherichia coli strains that cause nonbloody diarrhea in infants are known to present three distinct patterns of adherence to epithelial cells, namely, localized (LA), diffuse (DA), and aggregative (AA) adherence. Strains with LA (typical Enteropathogenic Escherichia coli [EPEC]) are well recognized as a cause of sec...

journal_title：Infection and immunity

authors： Scaletsky IC,Pedroso MZ,Oliva CA,Carvalho RL,Morais MB,Fagundes-Neto U

更新日期：1999-07-01 00:00:00

abstract：:Tox-+ staphylococcal strains, as opposed to Tox-minus strains, produce epidermal exfoliation within 18 h after direct subcutaneous or intraperitoneal injection into newborn mice. The extracellular product responsible for exfoliation is termed exfoliative toxin (ET). When culture supernatant fluid from the plasmid-cure...

journal_title：Infection and immunity

authors： Keyhani M,Rogolsky M,Wiley BB,Glasgow LA

更新日期：1975-07-01 00:00:00

abstract：:Patients with chronic bronchitis are colonized by and may develop acute bronchopulmonary infection due to nontypable Haemophilus influenzae (NTHI) despite the presence of bactericidal and opsonizing antibody to the infecting organism. To test the hypothesis that secretory immunoglobulin A (IgA) interferes with host de...

journal_title：Infection and immunity

authors： Musher DM,Goree A,Baughn RE,Birdsall HH

更新日期：1984-07-01 00:00:00

abstract：:Virulent strains of Yersinia enterocolitica and their plasmidless, avirulent derivatives were examined for their cell surface properties. Increased surface charge and hydrophobicity of Y. enterocolitica were found to be associated with the possession of a 40- to 48-megadalton plasmid. These surface properties were exp...

journal_title：Infection and immunity

authors： Lachica RV,Zink DL

更新日期：1984-05-01 00:00:00

abstract：:C4BP (C4b-binding protein) is a high-molecular-weight plasma protein that inhibits the classical pathway of complement activation. Recent experiments have demonstrated that C4BP binds to many strains of the gram-positive bacterium Streptococcus pyogenes, a major respiratory tract pathogen. Binding to S. pyogenes was s...

journal_title：Infection and immunity

authors： Berggård K,Johnsson E,Mooi FR,Lindahl G

更新日期：1997-09-01 00:00:00

abstract：:The interaction between human neutrophils and wild-type Bordetella pertussis or mutants expressing altered lipopolysaccharide or lacking virulence factors-pertussis toxin, adenylate cyclase toxin, dermonecrotic toxin, filamentous hemagglutinin (FHA), pertactin, or BrkA-was examined. In the absence of antibodies, the w...

journal_title：Infection and immunity

authors： Weingart CL,Weiss AA

更新日期：2000-03-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) glycoprotein gC was purified by affinity chromatography with an immunosorbent column containing monoclonal antibody to HSV-1 gC, and its reactivity with rabbit antisera was measured by enzyme-linked immunosorbent assay and sodium dodecyl sulfate-polyacrylamide gel electrophoretic an...

journal_title：Infection and immunity

authors： Zweig M,Heilman CJ Jr,Bladen SV,Showalter SD,Hampar B

更新日期：1983-08-01 00:00:00

abstract：:Purified cell walls representing a wide variety in teichoic acid and peptidoglycan structure prepared from eight different gram-positive bacterial species induced the production of tumor necrosis factor alpha (TNF-alpha) and interleukin-6 from human monocytes in the presence of 10% plasma or serum. Significant amounts...

journal_title：Infection and immunity

authors： Heumann D,Barras C,Severin A,Glauser MP,Tomasz A

更新日期：1994-07-01 00:00:00

abstract：:An experimental model of coxsackievirus B3 infection in newborn mice was utilized to examine the protective role of antiviral antibodies and an interferon inducer, polyinosinic acid-polycytidylic acid [poly(I:C)]. Subcutaneous administration to the infected mice of specific antiviral antibodies resulted in significant...

journal_title：Infection and immunity

authors： Cho CT,Feng KK,McCarthy VP,Lenahan MF

更新日期：1982-08-01 00:00:00

abstract：:Bordetella pertussis extract that contained adenylate cyclase toxin produced large increases in human neutrophil cyclic AMP levels and inhibited their oxidative burst, as reflected by luminol-enhanced chemiluminescence and superoxide release. The adenylate cyclase toxin-containing extract blocked neutrophil-mediated i...

journal_title：Infection and immunity

authors： Galgiani JN,Hewlett EL,Friedman RL

更新日期：1988-04-01 00:00:00

abstract：:Pools of rat antiserum to Plasmodium berghei had different levels of protective activity as assessed by a passive transfer test. Preincubation of parasite inocula with an effective pool before injection did not significantly enhance protective activity. Removal of the antiserum from preincubated parasite inocula aboli...

journal_title：Infection and immunity

authors： Brown IN,Phillips RS

更新日期：1974-12-01 00:00:00

abstract：:In mice infected with virulent blood (trypomastigote) forms of Trypanosoma cruzi, complement depletion with cobra venom factor caused a marked exacerbation of the disease evidenced by significantly increased parasitemia levels and early mortality as compared with those of untreated infected animals. The effect was gre...

journal_title：Infection and immunity

authors： Budzko DB,Pizzimenti MC,Kierszenbaum F

更新日期：1975-01-01 00:00:00

abstract：:Rhodococcus equi is a facultative intracellular pathogen of macrophages, relying on the presence of a conjugative virulence plasmid harboring a 21-kb pathogenicity island (PAI) for growth in host macrophages. The PAI encodes a family of 6 virulence-associated proteins (Vaps) in addition to 20 other proteins. The contr...

journal_title：Infection and immunity

authors： Coulson GB,Miranda-CasoLuengo AA,Miranda-CasoLuengo R,Wang X,Oliver J,Willingham-Lane JM,Meijer WG,Hondalus MK

更新日期：2015-08-01 00:00:00

abstract：:Infection with Trypanosoma cruzi, the agent of Chagas' disease, may induce antibodies and T cells reactive with self antigens (autoimmunity). Because autoimmunity is generally thought to develop during the chronic phase of infection, one hypothesis is that autoimmunity develops only after long-term, low-level stimulat...

journal_title：Infection and immunity

authors： Leon JS,Godsel LM,Wang K,Engman DM

更新日期：2001-09-01 00:00:00

abstract：:The pneumocandins are potent antifungal agents of the echinocandin class which are under development for use as broad-spectrum antimycotic therapy. One important consideration for any new therapeutic class for treating serious fungal infections is the potential for drug resistance development. In this study we have is...

journal_title：Infection and immunity

authors： Kurtz MB,Abruzzo G,Flattery A,Bartizal K,Marrinan JA,Li W,Milligan J,Nollstadt K,Douglas CM

更新日期：1996-08-01 00:00:00

abstract：:Various invasive pathogens attach to host tissues via the extracellular matrix component laminin, the major glycoprotein found within basement membranes. Previous investigations identified the laminin-binding adhesin Tp0751 within the spirochete bacterium Treponema pallidum. In the current study, Tp0751 was shown to a...

journal_title：Infection and immunity

authors： Cameron CE,Brouwer NL,Tisch LM,Kuroiwa JM

更新日期：2005-11-01 00:00:00

abstract：:Pseudomonas aeruginosa is a leading cause of hospital-acquired pneumonia and chronic lung infections in cystic fibrosis patients. Iron is essential for bacterial growth, and P. aeruginosa expresses multiple iron uptake systems, whose role in lung infection deserves further investigation. P. aeruginosa Fe(3+) uptake sy...

journal_title：Infection and immunity

authors： Minandri F,Imperi F,Frangipani E,Bonchi C,Visaggio D,Facchini M,Pasquali P,Bragonzi A,Visca P

更新日期：2016-07-21 00:00:00

abstract：:Bactericidal activity and binding of a 57,000-dalton cationic antimicrobial neutrophil granule protein (CAP57) are determined by the presence on bacteria of O-antigen polysaccharide chains and the availability of negatively charged groups in the lipid A region, the inner core region, or both regions of lipopolysacchar...

journal_title：Infection and immunity

authors： Farley MM,Shafer WM,Spitznagel JK

更新日期：1988-06-01 00:00:00

abstract：:Mucosal immune responses to fungal infection range from T helper type 2 (Th2) cell-directed allergic inflammation to Th1-predominant neutrophilic inflammation, but the mechanisms directing these divergent mucosal immune outcomes and the role of T cells in host defense against mucosal fungal infections are not known. H...

journal_title：Infection and immunity

authors： Porter PC,Roberts L,Fields A,Knight M,Qian Y,Delclos GL,Han S,Kheradmand F,Corry DB

更新日期：2011-11-01 00:00:00

abstract：:We compared the susceptibilities of Chlamydia trachomatis elementary bodies (EBs) to human defensin HNP-2 and porcine protegrin PG-1, cysteine-rich beta-sheet antimicrobial peptides produced by mammalian leukocytes. Although both peptides protected McCoy cell monolayers from infection by chlamydial EBs, protegrins wer...

journal_title：Infection and immunity

authors： Yasin B,Harwig SS,Lehrer RI,Wagar EA

更新日期：1996-03-01 00:00:00

abstract：:The antiphagocytic effect of the Staphylococcus aureus capsule is known to be related to its ability to interfere with opsonization by normal human serum. In this study, evidence is presented with isolated cell surface components which indicates that the capsule hinders opsonization by masking cell wall peptidoglycan....

journal_title：Infection and immunity

authors： Wilkinson BJ,Peterson PK,Quie PG

更新日期：1979-02-01 00:00:00

abstract：:Evidence that the bactericidal ability and the stimulated oxidative metabolism of leukocytes appear in parallel during fetal development of the Minnesota Miniature pig has been obtained by application of the techniques applied to studies of human cells. It was demonstrated that leukocytes from 87- to 90-day fetuses we...

journal_title：Infection and immunity

authors： Holmes B,Day N,Haseman J,Good RA

更新日期：1972-02-01 00:00:00

abstract：:Oral treponemes are considered to be important in the development and progression of periodontal diseases. We investigated the mechanisms of recognition and activation of human gingival epithelial cells (HGEC) with the oral treponemes Treponema denticola, Treponema vincentii, and Treponema medium and their outer membr...

journal_title：Infection and immunity

authors： Asai Y,Jinno T,Ogawa T

更新日期：2003-02-01 00:00:00

abstract：:Ehrlichia chaffeensis, a tick-transmitted rickettsial, is the causative agent of human monocytic ehrlichiosis. To examine protein expression patterns, we analyzed total, membrane, and immunogenic proteomes of E. chaffeensis originating from macrophage and tick cell cultures. Total proteins resolved by one-dimensional ...

journal_title：Infection and immunity

authors： Seo GM,Cheng C,Tomich J,Ganta RR

更新日期：2008-11-01 00:00:00

abstract：:Host-adapted Gram-negative bacterial pathogens from the Pasteurellaceae, Neisseriaceae, and Moraxellaceae families normally reside in the upper respiratory or genitourinary tracts of their hosts and rely on utilizing iron from host transferrin (Tf) for growth and survival. The surface receptor proteins that mediate th...

journal_title：Infection and immunity

authors： Frandoloso R,Martínez-Martínez S,Calmettes C,Fegan J,Costa E,Curran D,Yu RH,Gutiérrez-Martín CB,Rodríguez-Ferri EF,Moraes TF,Schryvers AB

更新日期：2015-03-01 00:00:00

abstract：:Differences in molecular composition of lipopolysaccharides (LPS) between serum-sensitive (S) clinical isolates of Escherichia coli and serum-resistant (R) clones derived by serial passage in serum were demonstrated to determine sensitivity or resistance to killing by normal human serum (NHS). LPS from R clones had a ...

journal_title：Infection and immunity

authors： Porat R,Johns MA,McCabe WR

更新日期：1987-02-01 00:00:00

abstract：:A nonhuman primate model for malaria vaccine development allowing reliable, stringent sporozoite challenge and evaluation of both cellular and antibody responses is needed. We therefore constructed a multicomponent, multistage DNA vaccine for the simian malaria species Plasmodium knowlesi including two preerythrocytic...

journal_title：Infection and immunity

authors： Rogers WO,Baird JK,Kumar A,Tine JA,Weiss W,Aguiar JC,Gowda K,Gwadz R,Kumar S,Gold M,Hoffman SL

更新日期：2001-09-01 00:00:00