Characterization of echinocandin-resistant mutants of Candida albicans: genetic, biochemical, and virulence studies.

abstract：:Salmonella spp. and Shigella spp. are responsible for millions of cases of enteric disease each year worldwide. While these pathogens have evolved distinct strategies for interacting with the human intestinal epithelium, they both induce significant proinflammatory responses that result in massive transepithelial migr...

journal_title：Infection and immunity

authors： Mumy KL,Bien JD,Pazos MA,Gronert K,Hurley BP,McCormick BA

更新日期：2008-08-01 00:00:00

abstract：:Recent studies have shown that probiotics are beneficial in T-cell-mediated inflammatory diseases. The molecular mechanism by which probiotics work remains elusive, but accumulating evidence indicates that probiotics can modulate immune cell responses. Since T cells express receptors for bacterial products or componen...

journal_title：Infection and immunity

authors： Peluso I,Fina D,Caruso R,Stolfi C,Caprioli F,Fantini MC,Caspani G,Grossi E,Di Iorio L,Paone FM,Pallone F,Monteleone G

更新日期：2007-04-01 00:00:00

abstract：:The extracellular adherence protein (Eap) is a multifunctional Staphylococcus aureus protein and broad-spectrum adhesin for several host matrix and plasma proteins. We investigated the interactions of full-length Eap and five recombinant tandem repeat domains with host proteins by use of surface plasmon resonance (BIA...

journal_title：Infection and immunity

authors： Hussain M,Haggar A,Peters G,Chhatwal GS,Herrmann M,Flock JI,Sinha B

更新日期：2008-12-01 00:00:00

abstract：:We show here that Helicobacter pylori broth culture supernatants disrupt the actin cytoskeleton of epithelial cell lines, leading to cell rounding and apoptosis through anoikis. We demonstrate that there are marked quantitative differences between strains and that there are different cell line sensitivities. By constr...

journal_title：Infection and immunity

authors： Bebb JR,Letley DP,Rhead JL,Atherton JC

更新日期：2003-06-01 00:00:00

abstract：:Intestinal segmented filamentous bacteria (SFB) protect from ameba infection, and protection is transferable with bone marrow dendritic cells (BMDCs). SFB cause an increase in serum amyloid A (SAA), suggesting that SAA might mediate SFB's effects on BMDCs. Here we further explored the role of bone marrow in SFB-mediat...

journal_title：Infection and immunity

authors： Burgess SL,Saleh M,Cowardin CA,Buonomo E,Noor Z,Watanabe K,Abhyankar M,Lajoie S,Wills-Karp M,Petri WA Jr

更新日期：2016-09-19 00:00:00

abstract：:A 10-amino-acid repeating sequence of the hemagglutinating portion of Clostridium difficile toxin A has been synthesized and used to produce antisera in rabbits. Antipeptide antibody inhibited toxin A-mediated hemagglutination and neutralized cytotoxic activity. Immunoblot analysis with the antipeptide antibody reveal...

journal_title：Infection and immunity

authors： Wren BW,Russell RR,Tabaqchali S

更新日期：1991-09-01 00:00:00

abstract：:Cytotoxic necrotizing factor type 1 (CNF1) and CNF2 are toxins of pathogenic Escherichia coli that share 85% identity over 1,014 amino acids. Although both of these toxins modify GTPases, CNF1 is a more potent inducer of multinucleation in HEp-2 cells, binds more efficiently to HEp-2 cells, and, despite the conservati...

journal_title：Infection and immunity

authors： Grande KK,Meysick KC,Rasmussen SB,O'Brien AD

更新日期：2009-01-01 00:00:00

abstract：:Recently, a glycoprotein fraction, designated gp10/20, purified from Leishmania mexicana amazonensis was shown to induce a cellular immune response mediated by murine L3T4+ T lymphocytes. This fact led us to pursue further the characterization of this fraction. The present study demonstrated that gp10/20 is a degradat...

journal_title：Infection and immunity

authors： Rodrigues MM,Xavier MT,Mendonça-Previato L,Barcinski MA

更新日期：1988-07-01 00:00:00

abstract：:Regulation of the synthesis of Vi polysaccharide, a major virulence determinant in Salmonella enterica serotype Typhi, is under the control of two regulatory systems, ompR-envZ and rscB-rscC, which respond to changes in osmolarity. Some serotype Typhi strains exhibit overexpression of Vi polysaccharide, which masks cl...

journal_title：Infection and immunity

authors： Santander J,Wanda SY,Nickerson CA,Curtiss R 3rd

更新日期：2007-03-01 00:00:00

abstract：:A major ceramide monohexoside (CMH) was purified from lipidic extracts of Cryptococcus neoformans. This molecule was analyzed by high-performance thin-layer chromatography (HPTLC), gas chromatography coupled with mass spectrometry, and fast atom bombardment-mass spectrometry. The cryptococcal CMH is a beta-glucosylcer...

journal_title：Infection and immunity

authors： Rodrigues ML,Travassos LR,Miranda KR,Franzen AJ,Rozental S,de Souza W,Alviano CS,Barreto-Bergter E

更新日期：2000-12-01 00:00:00

abstract：:Nonviable Mycobacterium tuberculosis strain Jamaica suspended in oil-droplet emulsions was used to enhance resistance of mice against encephalomyocarditis virus (EMCV). The mycobacteria-injected mice were significantly resistant to 50,000 50% lethal doses of EMCV. Similar concentrations of virus in plasma of normal an...

journal_title：Infection and immunity

authors： Lodmell DL,Ewalt LC

更新日期：1978-12-01 00:00:00

abstract：:Bartonella bacilliformis is the etiologic agent of Oroya fever in humans. Flagellum-mediated motility has been postulated as a major virulence factor for invasion of host cells. To address this hypothesis, we purified and characterized flagella from strain KC584 and then assessed their role in human erythrocyte associ...

journal_title：Infection and immunity

authors： Scherer DC,DeBuron-Connors I,Minnick MF

更新日期：1993-12-01 00:00:00

abstract：:Hemolytic-uremic syndrome (HUS) is defined as the triad of anemia, thrombocytopenia, and acute kidney injury. Enterohemorrhagic Shiga toxin (Stx)-producing Escherichia coli (EHEC), which causes a prodromal hemorrhagic enteritis, remains the most common etiology of the typical or epidemic form of HUS. Because no licens...

journal_title：Infection and immunity

authors： Mejias MP,Cabrera G,Fernández-Brando RJ,Baschkier A,Ghersi G,Abrey-Recalde MJ,Miliwebsky E,Meiss R,Goldbaum F,Zylberman V,Rivas M,Palermo MS

更新日期：2014-04-01 00:00:00

abstract：:Phagocytosis and killing by alveolar macrophages from humans, rabbits, rats, and hamsters, were compared in vitro. In the absence of serum opsonins, human alveolar macrophages could phagocytize Staphylococcus aureus Cowan I (protein A positive), but not S. aureus EMS (protein A negative) or Pseudomonas aeruginosa MN. ...

journal_title：Infection and immunity

authors： Nguyen BY,Peterson PK,Verbrugh HA,Quie PG,Hoidal JR

更新日期：1982-05-01 00:00:00

abstract：:Streptococcus sanguis 804 (NCTC 10904) was grown ih batch culture at constant pH. and the glucosyltransferase activity of the supernatant was assayed over a 40-h growth period. The optimum pH for enzyme production was 7.0 to 7.2. During growth of the culture, three reproducible phases of enzyme activity were observed....

journal_title：Infection and immunity

authors： Beeley JA,Black PM

更新日期：1977-01-01 00:00:00

abstract：:Escherichia coli F-18 is a human fecal isolate that makes type 1 fimbriae, encoded by the fim gene cluster, and is an excellent colonizer of the streptomycin-treated mouse intestine. E. coli F-18 fimA::tet, lacking type 1 fimbriae, was constructed by bacteriophage P1 transduction of the fim region of the E. coli K-12 ...

journal_title：Infection and immunity

authors： Sweeney NJ,Klemm P,McCormick BA,Moller-Nielsen E,Utley M,Schembri MA,Laux DC,Cohen PS

更新日期：1996-09-01 00:00:00

abstract：:Chlamydia trachomatis infections can lead to severe chronic complications, including trachoma, ectopic pregnancy, and infertility. The only effective approach to disease control is vaccination. The goal of this work was to identify new potential vaccine candidates through a proteomics approach. We constructed a protei...

journal_title：Infection and immunity

authors： Cruz-Fisher MI,Cheng C,Sun G,Pal S,Teng A,Molina DM,Kayala MA,Vigil A,Baldi P,Felgner PL,Liang X,de la Maza LM

更新日期：2011-01-01 00:00:00

abstract：:The antigenic relationship of glucosyltransferases (GTF) produced by different serotypes of Streptococcus mutans was studied by using a functional inhibition assay. Rat, rabbit, or hamster immune fluids, directed to cell-associated or supernatant-derived GTF, were tested against ammonium sulfate-precipitated culture s...

journal_title：Infection and immunity

authors： Smith DJ,Taubman MA

更新日期：1977-01-01 00:00:00

abstract：:Toll-like receptors (TLRs) are a group of highly conserved molecules that initiate the innate immune response to pathogens by recognizing structural motifs expressed by microbes. We have identified a novel TLR, TLR15, by bioinformatic analysis of the chicken genome, which is distinct from any known vertebrate TLR and ...

journal_title：Infection and immunity

authors： Higgs R,Cormican P,Cahalane S,Allan B,Lloyd AT,Meade K,James T,Lynn DJ,Babiuk LA,O'farrelly C

更新日期：2006-03-01 00:00:00

abstract：:Nasopharyngeal colonization represents the initial interaction between Haemophilus influenzae and its human host. Factors that influence bacterial carriage likely affect transmission and incidence of infection. Therefore, we investigated host factors involved in limiting H. influenzae colonization in BALB/c mice, as c...

journal_title：Infection and immunity

authors： Zola TA,Lysenko ES,Weiser JN

更新日期：2009-08-01 00:00:00

abstract：:We assessed cell-mediated immunity to herpes simplex virus type 1 antigen in patients suffering from recurrent cold sores and in a series of healthy controls. Paradoxically, all those subject to recurrent herpetic infections had, without exception, evidence of cell-mediated immunity to herpes antigens. This was demons...

journal_title：Infection and immunity

authors： Russell AS,Percy JS,Kovithavongs T

更新日期：1975-02-01 00:00:00

abstract：:Escherichia coli O157:H7, a major Shiga toxin-producing pathogen, has a low infectious dose and causes serious illness in humans. The gastrointestinal tract of cattle is the primary reservoir of E. coli O157:H7, and thus, it is critical to eliminate or reduce E. coli O157:H7 gut colonization. Given that E. coli O157:H...

journal_title：Infection and immunity

authors： Xue Y,Zhang H,Wang H,Hu J,Du M,Zhu MJ

更新日期：2014-05-01 00:00:00

abstract：:This study was undertaken to ascertain the relationship between complement-derived chemotactic factors and complement component 1 inactivator (C1INA) enhancement of neutrophil chemotaxis. Studies were also designed to determine whether the C1s- reactive or binding site on C1INA was functional in altering chemotactic r...

journal_title：Infection and immunity

authors： Patrick RA,Hollers JC,Liu DY,Giese BH,Smith CW

更新日期：1980-06-01 00:00:00

abstract：:D-Amino acid oxidase (DAO) is a hydrogen peroxide-generating enzyme that uses a D-amino acid as a substrate. We hypothesized that DAO may protect against bacterial infection, because hydrogen peroxide is one of the most important molecules in the antibacterial defense systems in mammals. We show here that DAO suppress...

journal_title：Infection and immunity

authors： Nakamura H,Fang J,Maeda H

更新日期：2012-04-01 00:00:00

abstract：:Whole cells, morphological components, and various extracts of Candida albicans were tested for toxicity by methods involving biological activities ordinarily used to characterize bacterial endotoxin. Fungal preparations exerted several of these activities, but only at much higher dose levels than those required for b...

journal_title：Infection and immunity

authors： Cutler JE,Friedman L,Milner KC

更新日期：1972-10-01 00:00:00

abstract：:FcRgamma and interleukin-10 (IL-10) are both required for chronic disease in C57BL/6 mice with Leishmania mexicana parasite infection. FcRgamma is a component of several different FcRs and may be a component of some T-cell receptors. The initial antibody response to L. mexicana is an immunoglobulin G1 (IgG1) response,...

journal_title：Infection and immunity

authors： Thomas BN,Buxbaum LU

更新日期：2008-02-01 00:00:00

abstract：:Exoenzyme Y (ExoY) is a type III secretion system effector found in 90% of the Pseudomonas aeruginosa isolates. Although it is known that ExoY is a soluble nucleotidyl cyclase that increases the cytoplasmic levels of nucleoside 3',5'-cyclic monophosphates (cNMPs) to mediate endothelial Tau phosphorylation and permeabi...

journal_title：Infection and immunity

authors： He C,Zhou Y,Liu F,Liu H,Tan H,Jin S,Wu W,Ge B

更新日期：2017-08-18 00:00:00

abstract：:The role of type 1 pili in promoting bladder colonization was examined by constructing two mutant strains of a clinical Escherichia coli isolate. One mutant was isogenic to the parental strain save for a lesion in a gene required for pilus receptor binding; the other mutant was isogenic save for a lesion in the gene e...

journal_title：Infection and immunity

authors： Keith BR,Maurer L,Spears PA,Orndorff PE

更新日期：1986-09-01 00:00:00

abstract：:We identified a T-cell determinant of the 35-kDa antigen of Mycobacterium leprae which is discriminatory against cross-sensitization by its closely related homologue in Mycobacterium avium. From synthetic peptides covering the entire sequence, those with the highest affinity and permissive binding to purified HLA-DR m...

journal_title：Infection and immunity

authors： Wilkinson RJ,Wilkinson KA,Jurcevic S,Hills A,Sinha S,Sengupta U,Lockwood DN,Katoch K,Altman D,Ivanyi J

更新日期：1999-03-01 00:00:00

abstract：:Human lactoferrin is an iron-binding glycoprotein that is particularly prominent in exocrine secretions and leukocytes and is also found in serum, especially during inflammation. It is able to sequester iron from microbes and has immunomodulatory functions, including inhibition of both complement activation and cytoki...

journal_title：Infection and immunity

authors： Håkansson A,Roche H,Mirza S,McDaniel LS,Brooks-Walter A,Briles DE

更新日期：2001-05-01 00:00:00