Abstract:
:Recently, a glycoprotein fraction, designated gp10/20, purified from Leishmania mexicana amazonensis was shown to induce a cellular immune response mediated by murine L3T4+ T lymphocytes. This fact led us to pursue further the characterization of this fraction. The present study demonstrated that gp10/20 is a degradation product of a 17-kilodalton antigen present in promastigotes and amastigotes of L. mexicana amazonensis. This antigen was easily detected in promastigotes of L. mexicana mexicana, L. donovani, L. chagasi, L. major, and L. tropica. However, culture forms of L. braziliensis complex expressed either low amounts of the 17-kilodalton antigen or an antigenically unrelated antigen. The recognition of gp10/20 by several serum samples of patients with kala-azar was also shown.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Rodrigues MM,Xavier MT,Mendonça-Previato L,Barcinski MAdoi
10.1128/IAI.56.7.1766-1770.1988subject
Has Abstractpub_date
1988-07-01 00:00:00pages
1766-70issue
7eissn
0019-9567issn
1098-5522journal_volume
56pub_type
杂志文章abstract::Candida albicans is a common opportunistic fungal pathogen and is the leading cause of invasive fungal diseases in immunocompromised individuals. The induction of cell-mediated immunity to C. albicans is one of the main tasks of cells of the innate immune system, and in vitro evidence suggests that integrin α(M)β₂ (CR...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00650-10
更新日期:2011-04-01 00:00:00
abstract::Onchocerca volvulus, a human parasitic nematode, is the third leading cause of preventable blindness worldwide. This study describes the molecular cloning of a novel superoxide dismutase (SOD) from the parasite. This putative O. volvulus extracellular SOD (OvEcSOD) is 628 nucleotides (nt) long, including a 22-nt 5' sp...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.2.713-716.1994
更新日期:1994-02-01 00:00:00
abstract::The complete sequence analysis of the 210-kb Shigella flexneri 5a virulence plasmid was determined. Shigella spp. cause dysentery and diarrhea by invasion and spread through the colonic mucosa. Most of the known Shigella virulence determinants are encoded on a large plasmid that is unique to virulent strains of Shigel...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.5.3271-3285.2001
更新日期:2001-05-01 00:00:00
abstract::Mucosa-associated invariant T (MAIT) cells are an innate-like T cell subset in mammals that recognize microbial vitamin B metabolites presented by the evolutionarily conserved major histocompatibility complex class I (MHC I)-related molecule, MR1. Emerging data suggest that MAIT cells may be an attractive target for v...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00524-20
更新日期:2020-12-15 00:00:00
abstract::We evaluated sexual recombination in the apicomplexan parasite Theileria parva using genome-wide marker analysis of haploid sporozoite populations obtained from infected Rhipicephalus appendiculatus ticks. Analysis of 231 parasite clones derived by in vitro infection of bovine lymphocytes revealed 48 distinct combinat...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00472-06
更新日期:2006-10-01 00:00:00
abstract::Lipopolysaccharide (LPS) binding protein (LBP) is an acute-phase protein that enhances the responsiveness of immune cells to LPS by virtue of its capacity to transfer LPS to CD14. To determine the role of LBP in the innate immune response to peritonitis, LBP gene-deficient (LBP(-/-)) and normal wild-type mice were int...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.12.6747-6753.2003
更新日期:2003-12-01 00:00:00
abstract::Random minitransposon mutagenesis was used to identify genes involved in the survival of Bordetella bronchiseptica within eukaryotic cells. One of the mutants which exhibited a reduced ability to survive intracellularly harbored a minitransposon insertion in a locus (ris) which displays a high degree of homology to tw...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.10.4640-4650.1998
更新日期:1998-10-01 00:00:00
abstract::Borrelia burgdorferi produces potent cell-activating molecules capable of stimulating polyclonal proliferation and immunoglobulin production by murine B lymphocytes and cytokine production by a variety of cell types. These stimulatory molecules function in infected mice, resulting in elevated levels of circulating imm...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.2.520-528.1994
更新日期:1994-02-01 00:00:00
abstract::Delayed-type hypersensitivity (DTH) is the standard measure of T-cell responsiveness to infectious organisms. For leprosy, the Mitsuda reaction, a local immune response to cutaneous challenge with Mycobacterium leprae, is considered to represent a measure of DTH against the pathogen. We analyzed the diversity of the T...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.11.4542-4548.1992
更新日期:1992-11-01 00:00:00
abstract::Attachment of Fusobacterium nucleatum to various oral surfaces is mediated by several adhesins anchored on its outer surface. Monoclonal antibodies (MAbs) were prepared and used to identify the putative galactose-binding adhesin of F. nucleatum PK1594. Four unique MAbs, 8G7, 26B9, 28G11, and 29D4, were isolated on the...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.12.5231-5237.1997
更新日期:1997-12-01 00:00:00
abstract::The protective efficacy of antibodies to the Staphylococcus aureus type 5 capsular polysaccharide (CP5) was examined in a modified model of catheter-induced endocarditis. Rats were catheterized by surgically passing a polyethylene catheter through the right carotid artery and aortic valve into the left ventricle. The ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.10.4146-4151.1997
更新日期:1997-10-01 00:00:00
abstract::Trypanosoma brucei subsp. brucei and T. congolense incubated in homologous antibody at 0 degrees C for 30 min were lysed by subsequent addition of guinea pig complement. Trypanosomes incubated in antibody at 37 degrees C before complement treatment remained intact. Parasites bearing adsorbed antibody also remained int...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.24.3.617-627.1979
更新日期:1979-06-01 00:00:00
abstract::The hallmarks of pulmonary Mycobacterium tuberculosis infection are lung granulomas. These organized structures are composed of host immune cells whose purpose is to contain or clear infection, creating a complex hub of immune and bacterial cell activity, as well as limiting pathology in the lungs. Yet, given cellular...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00426-18
更新日期:2018-08-22 00:00:00
abstract::PtlH is an essential component of the Ptl system, the type IV transporter responsible for secretion of pertussis toxin (PT) across the outer membrane of Bordetella pertussis. The nine Ptl proteins are believed to interact to form a membrane-spanning apparatus through which the toxin is secreted. In this study, we moni...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00008-07
更新日期:2007-05-01 00:00:00
abstract::A 30-amino-acid peptide corresponding to variable domain IV (VD IV) of the major outer membrane protein of Chlamydia trachomatis serovar E was conjugated to keyhole limpet hemocyanin (KLH) and used to immunize mice. The resulting antisera (anti-KLH-VD IV sera) recognized all 15 serovars of C. trachomatis when assayed ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.8.3428-3432.1992
更新日期:1992-08-01 00:00:00
abstract::gammaG-globulin from nonimmunized rabbits and from rabbits immunized with various bacteria reacted in the immunofluorescence technique with protein A-containing Staphylococcus aureus. Pepsin digestion of most immunoglobulin preparations eliminated the reaction, thus showing that the Fc fragment is involved and that th...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.2.4.387-391.1970
更新日期:1970-10-01 00:00:00
abstract::Addition of a monoclonal antibody which binds the Cryptococcus neoformans capsule to suspensions of human monocytes, T lymphocytes, and cryptococcal cells (i) enhances interleukin-1beta (IL-1beta), tumor necrosis factor alpha, and IL-2 production; (ii) reduces IL-10 secretion; and (iii) promotes T-cell proliferation. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.3.1244-1247.1998
更新日期:1998-03-01 00:00:00
abstract::Little data are available regarding L-form phagocyte interactions. Due to difficulty with more conventional methods, a serum-free technique of surface phagocytosis employing cellulose ester micropore filters, fluorochrome staining, and reflecting fluorescence microscopy was developed. Intracellular localization of L-f...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.5.6.976-981.1972
更新日期:1972-06-01 00:00:00
abstract::An attenuated influenza A candidate vaccine virus, derived from the A/Ann Arbor/6/60 (H2N2) cold-adapted (ca) donor virus and the A/Alaska/6/77 (H3N2) wild-type virus, was evaluated in adult seronegative volunteers (serum hemagglutination-inhibiting antibody titer, less than or equal to 1:8) for level of attenuation, ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.40.3.1044-1051.1983
更新日期:1983-06-01 00:00:00
abstract::Humoral immunity does not play a prominent role during experimental cryptococcosis. However, previous studies have shown that immunoglobulin G (IgG) anti-Cryptococcus neoformans antibodies can mediate cell-dependent yeast killing in vitro. Therefore, the protective effect of a previously described monoclonal IgG1 anti...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.3.749-752.1987
更新日期:1987-03-01 00:00:00
abstract::Vesicular stomatitis virus (VSV) infection of beige (bg/bg) mice induced levels of natural killer cytolytic activity comparable to that of uninfected normal bg/+ controls, but considerably less than natural killer activity in VSV-infected bg/+ mice. In contrast, VSV-infected bg/bg and bg/+ mice had essentially equival...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.32.1.204-210.1981
更新日期:1981-04-01 00:00:00
abstract::Relapsing fever (RF) is a spirochetal infection characterized by periods of sickness with fever at time of high bacteremia that alternate with afebrile periods of relative well being during low bacteremia. Patients with epidemic RF who are doing relatively well have extraordinarily high levels of interleukin-10 (IL-10...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00587-08
更新日期:2008-12-01 00:00:00
abstract::Enterohemorrhagic Escherichia coli (EHEC) is a prominent, food-borne cause of diarrhea, bloody diarrhea, and the hemolytic uremic syndrome in industrialized countries. Most strains of EHEC carry the locus for enterocyte effacement (LEE) pathogenicity island, but a proportion of isolates from patients with severe disea...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.11.6307-6319.2003
更新日期:2003-11-01 00:00:00
abstract::Localized juvenile periodontosis is associated with a defect of neutrophil chemotaxis that is characterized by selective depletion of a surface protein with a molecular mass of 110 kDa (GP110). Data on partial characterization of GP110 suggest that it is a glycoprotein which is enriched in Lys, Glu, His, Leu, and Ala ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.7.3015-3016.1992
更新日期:1992-07-01 00:00:00
abstract::Vibrio cholerae is a monoflagellated gram-negative bacterium that causes the severe diarrheal disease cholera. In contrast to Salmonella enterica serovar Typhimurium infection, which is accompanied by both acute diarrhea and high-level inflammation, V. cholerae infection is largely noninflammatory in human hosts. Bact...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00736-07
更新日期:2008-03-01 00:00:00
abstract::Significant resistance against influenza virus and Mycobacterium tuberculosis infections was induced when trehalose dimycolate from M. tuberculosis or M. bovis but not M. avium was combined with muramyl dipeptide. Trehalose dimycolate from M. tuberculosis, in contrast to that from M. avium, could confer resistance aga...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.50.3.938-940.1985
更新日期:1985-12-01 00:00:00
abstract::Immunization of BALB/c mice with a plasmid containing the gene for Trypanosoma cruzi trans-sialidase (TS) induced antibodies that inhibited TS enzymatic activity, CD4+ Th1 and CD8+ Tc1 cells, and protective immunity against infection. We used this model to obtain basic information on the requirement of CD4 or CD8 or B...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.69.9.5477-5486.2001
更新日期:2001-09-01 00:00:00
abstract::Vaccine antigen-specific antibody-secreting cell (ASC) responses in peripheral blood of healthy adult volunteers were studied after oral immunization with a prototype enterotoxigenic Escherichia coli (ETEC) vaccine by means of the enzyme-linked immunospot technique. Three doses of vaccine consisting of formalin-killed...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.7.2605-2611.1992
更新日期:1992-07-01 00:00:00
abstract::Yersinia enterocolitica, Yersinia pseudotuberculosis, and Yersinia pestis deliver different Yop (Yersinia outer proteins) effector proteins into mammalian cells by a type III secretion mechanism. Recently, it was shown that Yersinia producing YopT leads to disruption of the actin cytoskeleton of HeLa cells (M. Iriarte...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.12.7535-7543.2001
更新日期:2001-12-01 00:00:00
abstract::The adherence protein (P1 protein) of Mycoplasma pneumoniae was purified by electroelution and cleaved with cyanogen bromide. The resulting peptides were separated by two-dimensional electrophoresis. Spots reacting in Western immunoblots with two attachment-inhibiting monoclonal antibodies were isolated, and the amino...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.3.685-688.1989
更新日期:1989-03-01 00:00:00