Characterization of binding of human lactoferrin to pneumococcal surface protein A.

abstract：:The mechanisms for acquisition of iron by Haemophilus influenzae and their role in pathogenesis are not known. Heme and nonheme sources of iron were evaluated for their effect on growth of type b and nontypable strains of H. influenzae in an iron-restricted, defined medium. All 13 strains acquired iron from heme, hemo...

journal_title：Infection and immunity

authors： Pidcock KA,Wooten JA,Daley BA,Stull TL

更新日期：1988-04-01 00:00:00

abstract：:We developed an in vitro culture method to characterize the expression of bacterial genes under conditions mimicking the colonic environment. Our culture system (the intestinal simulator) comprised a continuous-flow anaerobic culture which was inoculated with fecal samples from healthy volunteers. As a test organism, ...

journal_title：Infection and immunity

authors： Ruiz-Perez F,Sheikh J,Davis S,Boedeker EC,Nataro JP

更新日期：2004-07-01 00:00:00

abstract：:We used the Salmonella typhi galactose epimerase (galE) mutant strain Ty21a, shown to be a safe, effective, living, attenuated oral typhoid vaccine, as a recipient for a recombinant plasmid containing the gene for production of the nontoxic B subunit of the heat-labile enterotoxin of Escherichia coli. The S. typhi der...

journal_title：Infection and immunity

authors： Clements JD,El-Morshidy S

更新日期：1984-11-01 00:00:00

abstract：:Guinea pigs were treated with anti-CD18 antibody (M8), and subsequently middle ears (ME) were infected with nontypeable Haemophilus influenzae. Forty-eight hours after infection, the ME washes of these animals had significantly lower polymorphonuclear leukocyte numbers but higher bacterial counts compared with washes ...

journal_title：Infection and immunity

authors： Patel J,Chonmaitree T,Schmalstieg F

更新日期：1993-03-01 00:00:00

abstract：:Rabbits were immunized with the synthetic peptide EENVEHDA or (EENV)2, corresponding to a tandemly repeated sequence in the C-terminal part of the Plasmodium falciparum antigen Pf155/RESA, or with Escherichia coli-derived fusion proteins containing the corresponding repeats. For all sera, the capacity of the total imm...

journal_title：Infection and immunity

authors： Wåhlin B,Berzins K,Perlmann H,Anders RF,Perlmann P

更新日期：1990-09-01 00:00:00

abstract：:Localized juvenile periodontosis is associated with a defect of neutrophil chemotaxis that is characterized by selective depletion of a surface protein with a molecular mass of 110 kDa (GP110). Data on partial characterization of GP110 suggest that it is a glycoprotein which is enriched in Lys, Glu, His, Leu, and Ala ...

journal_title：Infection and immunity

authors： Tripathi SC,Van Dyke TE

更新日期：1992-07-01 00:00:00

abstract：:The genes for outer membrane protein P2 of four nontypeable Haemophilus influenzae strains were cloned and sequenced. The derived amino acid sequences were compared with the outer membrane protein P2 sequence from H. influenzae type b MinnA and the sequences of P2 from three additional nontypeable H. influenzae strain...

journal_title：Infection and immunity

authors： Bell J,Grass S,Jeanteur D,Munson RS Jr

更新日期：1994-06-01 00:00:00

abstract：:Small-colony variants (SCVs) are slow-growing variants of human bacterial pathogens. They are associated with chronic persistent infections, and their biochemical identification and antimicrobial treatment are impaired by altered metabolic properties. To contribute to the understanding of SCV-mediated infections, we a...

journal_title：Infection and immunity

authors： Roggenkamp A,Hoffmann H,Hornef MW

更新日期：2004-04-01 00:00:00

abstract：:We performed ex vivo experiments with Plasmodium falciparum-infected human placentas from primi- and multigravida women from Cameroon. All women, independent of their gravida status, had anti-chondroitin sulfate A (CSA) adhesion antibodies which cross-reacted with heterologous strains, such as FCR3 and Palo-Alto(FUP)1...

journal_title：Infection and immunity

authors： Gysin J,Pouvelle B,Fievet N,Scherf A,Lépolard C

更新日期：1999-12-01 00:00:00

abstract：:Pseudomonas aeruginosa is considered an extracellular pathogen. Using assays to determine intracellular survival in the presence of gentamicin, we have demonstrated that some strains of P. aeruginosa are able to invade corneal cells during experimental bacterial keratitis in mice. Although intracellular bacteria were ...

journal_title：Infection and immunity

authors： Fleiszig SM,Zaidi TS,Fletcher EL,Preston MJ,Pier GB

更新日期：1994-08-01 00:00:00

abstract：:Defensins are antibiotic peptides expressed in human and animal myeloid and epithelial cells. Due to the limited availability of natural peptides, the properties of human epithelial defensins have not been studied. We assayed the microbicidal activity of recombinant human intestinal defensin 5 (rHD-5) in the presence ...

journal_title：Infection and immunity

authors： Porter EM,van Dam E,Valore EV,Ganz T

更新日期：1997-06-01 00:00:00

abstract：:Science has a critical role to play in addressing humanity's most important challenges in the twenty-first century. However, the contemporary scientific enterprise has developed in ways that prevent it from reaching maximum effectiveness and detract from the appeal of a research career. To be effective, the methodolog...

journal_title：Infection and immunity

authors： Fang FC,Casadevall A

更新日期：2012-03-01 00:00:00

abstract：:Thirty-two clinical isolates of Shiga-like toxin (SLT)-producing Escherichia coli associated with single cases or outbreaks of bloody diarrhea, hemorrhagic colitis, the hemolytic uremic syndrome, or edema disease of swine were examined for multiple copies of genes belonging to the slt-I or slt-II toxin families. Five ...

journal_title：Infection and immunity

authors： Schmitt CK,McKee ML,O'Brien AD

更新日期：1991-03-01 00:00:00

abstract：:Inbred mouse strains differ in their susceptibility to infection with the facultative intracellular bacterium Listeria monocytogenes, largely due to delayed or deficient innate immune responses. Previous antibody depletion studies suggested that neutrophils (polymorphonuclear leukocytes [PMN]) were particularly import...

journal_title：Infection and immunity

authors： Pitts MG,Combs TA,D'Orazio SEF

更新日期：2018-03-22 00:00:00

abstract：:In experimental visceral leishmaniasis, in which the tissue macrophage is the target, in vivo responsiveness to conventional chemotherapy (pentavalent antimony [Sb]) requires a T-cell-dependent mechanism. To determine if this mechanism involves gamma interferon (IFN-gamma)-induced activation and/or specific IFN-gamma-...

journal_title：Infection and immunity

authors： Murray HW,Delph-Etienne S

更新日期：2000-01-01 00:00:00

abstract：:Helicobacter pylori vacuolating cytotoxin (VacA) is a secreted protein that induces vacuolation of epithelial cells. To study VacA structure and function, we immunized mice with purified type s1-m1 VacA from H. pylori strain 60190 and generated a panel of 10 immunoglobulin G1kappa anti-VacA monoclonal antibodies. All ...

journal_title：Infection and immunity

authors： Vinion-Dubiel AD,McClain MS,Cao P,Mernaugh RL,Cover TL

更新日期：2001-07-01 00:00:00

abstract：:We used an in vitro opsonophagocytic killing assay to measure the functional activity of antibody directed at the mucoid exopolysaccharide (MEP) antigen expressed by Pseudomonas aeruginosa strains isolated from cystic fibrosis patients. Rabbit antibodies raised to purified MEP were able to mediate phagocytic killing i...

journal_title：Infection and immunity

authors： Ames P,DesJardins D,Pier GB

更新日期：1985-08-01 00:00:00

abstract：:Pathogenic species of the spotted fever group Rickettsia are subjected to repeated exposures to the host complement system through cyclic infections of mammalian and tick hosts. The serum complement machinery is a formidable obstacle for bacteria to overcome if they endeavor to endure this endozoonotic cycle. We have ...

journal_title：Infection and immunity

authors： Riley SP,Patterson JL,Martinez JJ

更新日期：2012-08-01 00:00:00

abstract：:The outcome of coccidioidomycosis depends to a large extent on the effectiveness of the T-cell-mediated immune (CMI) response to the fungal pathogen. For this reason, identification of Coccidioides immitis antigens which stimulate T cells is important for understanding the nature of host defense against the organism a...

journal_title：Infection and immunity

authors： Kirkland TN,Thomas PW,Finley F,Cole GT

更新日期：1998-02-01 00:00:00

abstract：:An antigenically distinct serotype, type IV, has recently been added to the recognized serotypes of group B streptococci (GBS). We isolated and purified the capsular polysaccharide antigen from a prototype type IV GBS strain. The type IV capsular polysaccharide formed a precipitin line with rabbit antiserum to type IV...

journal_title：Infection and immunity

authors： Wessels MR,Benedí WJ,Jennings HJ,Michon F,DiFabio JL,Kasper DL

更新日期：1989-04-01 00:00:00

abstract：:The level of type-specific antigen (that covalently associated with the cell wall peptidoglycan and that released extracellularly) synthesized by virulent and avirulent strains of type III group B streptococci was quantitated and compared. Additionally, the effect of the physiological age of the cells and the influenc...

journal_title：Infection and immunity

authors： Yeung MK,Mattingly SJ

更新日期：1984-05-01 00:00:00

abstract：:We have developed sensitive and specific solid-phase radioimmunoassays to quantitate the distribution and persistence of bacterial antigen in rats developing arthritis in response to a single injection of streptococcal cell wall material. Three separate assays were specific for either the A polysaccharide (N-acetyl-D-...

journal_title：Infection and immunity

authors： Eisenberg R,Fox A,Greenblatt JJ,Anderle SK,Cromartie WJ,Schwab JH

更新日期：1982-10-01 00:00:00

abstract：:Campylobacter jejuni is the leading cause of infectious gastroenteritis in industrialized nations. Its ability to enter and survive within nonphagocytic cells is thought to be very important for pathogenesis. However, little is known about the C. jejuni determinants that mediate these processes. Through an extensive t...

journal_title：Infection and immunity

authors： Novik V,Hofreuter D,Galán JE

更新日期：2010-08-01 00:00:00

abstract：:Bordetella bronchiseptica secreted a hydroxamate siderophore when grown in Fe-depleted medium. A Tn5lac insertion mutant of B. bronchiseptica, DBB22, did not produce this hydroxamate siderophore and was incapable of using lactoferrin as an Fe source. Our data suggest that B. bronchiseptica uses a siderophore for remov...

journal_title：Infection and immunity

authors： Foster LA,Dyer DW

更新日期：1993-06-01 00:00:00

abstract：:Neonatal animals are generally very susceptible to infection with bacterial pathogens. However, we recently reported that neonatal mice are highly resistant to orogastric infection with Yersinia enterocolitica. Here, we show that proinflammatory responses greatly exceeding those in adults arise very rapidly in the mes...

journal_title：Infection and immunity

authors： Siefker DT,Echeverry A,Brambilla R,Fukata M,Schesser K,Adkins B

更新日期：2014-02-01 00:00:00

abstract：:In the mouse model of Lyme borreliosis, the host immune response during infection with Borrelia burgdorferi results in the remission of carditis and arthritis, as well as global reduction of spirochete numbers in tissues, without elimination of infection. These events were recapitulated by passive transfer of immune s...

journal_title：Infection and immunity

authors： Barthold SW,Hodzic E,Tunev S,Feng S

更新日期：2006-08-01 00:00:00

abstract：:A variant enterotoxin gene, referred to as sezA+, has been identified. Staphylococcus aureus FRI1106, a staphylococcal enterotoxin type D producer (Sed+), contained HindIII fragments of 3.8 and 9.4 kilobase pairs (kbp) that hybridized in Southern blot analysis to a probe containing only staphylococcal enterotoxin type...

journal_title：Infection and immunity

authors： Soltis MT,Mekalanos JJ,Betley MJ

更新日期：1990-06-01 00:00:00

abstract：:Interleukin-18 (IL-18) is a proinflammatory cytokine that plays an important role in natural killer cell activation and the T helper 1 (Th1) cell response, particularly in collaboration with IL-12. Since Th1 cells play a pivotal role in the host defense against infection with intracellular microbes, such as Leishmania...

journal_title：Infection and immunity

authors： Ohkusu K,Yoshimoto T,Takeda K,Ogura T,Kashiwamura S,Iwakura Y,Akira S,Okamura H,Nakanishi K

更新日期：2000-05-01 00:00:00

abstract：:Streptococcus pneumoniae is the most common pathogen associated with otitis media. To examine the role of Toll-like receptor 2 (TLR2) in host defense against Streptococcus pneumoniae infection in the middle ear, wild-type (WT; C57BL/6) and TLR2-deficient (TLR2(-/-)) mice were inoculated with Streptococcus pneumoniae (...

journal_title：Infection and immunity

authors： Han F,Yu H,Tian C,Li S,Jacobs MR,Benedict-Alderfer C,Zheng QY

更新日期：2009-07-01 00:00:00

abstract：:Fibronectin binds to Streptococcus pyogenes, and this binding is inhibited by lipoteichoic acid (LTA). Previous studies have shown that LTA can be released from S. pyogenes by treatment with penicillin. Penicillin released LTA from both S. pyogenes and Staphylococcus aureus; however, the binding of fibronectin correla...

journal_title：Infection and immunity

authors： Nealon TJ,Beachey EH,Courtney HS,Simpson WA

更新日期：1986-02-01 00:00:00