Abstract:
:We have developed sensitive and specific solid-phase radioimmunoassays to quantitate the distribution and persistence of bacterial antigen in rats developing arthritis in response to a single injection of streptococcal cell wall material. Three separate assays were specific for either the A polysaccharide (N-acetyl-D-glucosamine), A-variant polysaccharide (polyrhamnose), or peptidoglycan (D-ala-D-ala) moieties of the streptococcal cell wall. Antigen was detected in all tissues surveyed, although the greatest amount was in the liver and spleen. By using three fractions of cell wall separated by size, we have shown that the development of arthritis correlates with the degree of cell wall deposited and persisting in the joints. Further statistical analyses suggested differences in metabolism by different tissues and differential metabolism of different antigenic epitopes in some cases.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Eisenberg R,Fox A,Greenblatt JJ,Anderle SK,Cromartie WJ,Schwab JHdoi
10.1128/IAI.38.1.127-135.1982subject
Has Abstractpub_date
1982-10-01 00:00:00pages
127-35issue
1eissn
0019-9567issn
1098-5522journal_volume
38pub_type
杂志文章abstract::The major merozoite surface protein of Plasmodium falciparum (PfMSP1) is a candidate antigen for a malaria vaccine. A 19-kDa C-terminal processing product of PfMSP1 (PfMSP1(19)) is composed of two domains sharing a cysteine-rich motif with epidermal growth factor (EGF) and is the target of monoclonal antibodies which ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.2.456-466.1995
更新日期:1995-02-01 00:00:00
abstract::Oral or intravenous inoculation of previously unexposed juvenile and adult ferrets with Campylobacter jejuni uniformly resulted in intestinal colonization lasting 2 to 12 days. Disease varied from mild to moderate diarrhea, which resolved in 2 to 3 days. Orally infected animals developed agglutinin titers of 8 to 256 ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.6.1848-1852.1990
更新日期:1990-06-01 00:00:00
abstract::We have isolated three genes, ARG57, SER57, and LYS1, on the basis of their function in Candida albicans. A C. albicans transformation vector containing the C. albicans URA3 gene, a Candida ARS sequence, and a portion of the Saccharomyces cerevisiae 2 microns circle containing the replication origin was constructed. C...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.3.876-884.1992
更新日期:1992-03-01 00:00:00
abstract::The ScpC protease of Streptococcus pyogenes degrades interleukin-8 (IL-8), a chemokine that mediates neutrophil transmigration and activation. The ability to degrade IL-8 differs dramatically among clinical isolates of S. pyogenes. Bacteria expressing ScpC overcome immune clearance by preventing the recruitment of neu...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00128-08
更新日期:2008-09-01 00:00:00
abstract::Each of the serotypes of Haemophilus influenzae (types a to f) may colonize the respiratory tract of humans, but only type b strains commonly cause invasive systemic infections. To investigate the role of complement in immunity to encapsulated non-type b strains, rats were depleted of C3 with cobra venom factor and ch...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.35.3.759-763.1982
更新日期:1982-03-01 00:00:00
abstract::In the murine model of urinary tract infections (UTI), cystitis by uropathogenic Escherichia coli (UPEC) occurs through an intimate relationship with the bladder superficial umbrella cell entailing cycles of adherence, invasion, intracellular bacterial community (IBC) formation, and dispersal (fluxing) from the intrac...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.11.7657-7668.2005
更新日期:2005-11-01 00:00:00
abstract::The bacterium Neisseria meningitidis is the causative agent of meningitis and sepsis. A generally effective vaccine against N. meningitidis serogroup B is not yet available, but outer membrane vesicle vaccines are in development. These vaccines contain lipopolysaccharide (LPS). The inclusion of N. meningitidis wild-ty...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00846-07
更新日期:2007-12-01 00:00:00
abstract::Periodontitis is a disease of polymicrobial etiology characterized by inflammation, degradation of host tissue, and bone that irreversibly destroys the supporting apparatus of teeth. Porphyromonas gingivalis contains lipid A with structural heterogeneity that has been postulated to contribute to the initiation of dysb...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01136-13
更新日期:2014-02-01 00:00:00
abstract::We constructed hha derivatives from both a clinical uropathogenic Escherichia coli isolate (strain FVL4) and a wild E. coli strain causing bovine diarrhea (strain CCB21) and analyzed the effect of the hha allele on the expression of the different virulence factors exhibited by these strains. Expression of hemolysin an...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.7.2881-2884.1996
更新日期:1996-07-01 00:00:00
abstract::Studies of meningococcal pathogenesis have been severely restricted due to the absence of an adequate animal model. Given the significance of iron in meningococcal pathogenesis, we developed a model of Neisseria meningitidis colonization in outbred adult mice that included daily administration of iron dextran. While r...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.4.1849-1855.2003
更新日期:2003-04-01 00:00:00
abstract::Streptococcus pneumoniae is a major cause of illness and death in children in developing countries. In these children, zinc deficiency is associated with an increased risk of acute respiratory tract infections, which can be reduced by daily zinc administration. Severe infections decrease zinc levels in plasma and may ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.4.2009-2013.2003
更新日期:2003-04-01 00:00:00
abstract::Normal bacteria can translocate (migrate) across an intact intestinal mucosa, but the anatomical site of bacterial translocation has not been defined. Gastrointestinal (GI) cross-sections were obtained from mice monoassociated with high cecal concentrations of Escherichia coli, Proteus mirabilis, or Enterococcus faeca...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.12.4693-4697.1991
更新日期:1991-12-01 00:00:00
abstract::Antibody responses against proteins located on the surface or in the apical organelles of merozoites are presumed to be important components of naturally acquired protective immune responses against the malaria parasite Plasmodium falciparum. However, many merozoite antigens are highly polymorphic, and antibodies indu...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.1.422-430.2005
更新日期:2005-01-01 00:00:00
abstract::Studies conducted with F1 and F2 progeny of crosses between strains of inbred mice that differ greatly in their capacity to make an antibody response to type III pneumococcal polysaccharide, dextran B-1355, and lipopolysaccharide from Escherichia coli 0113 have shown that multiple genes influence the magnitude of the ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.45.1.56-61.1984
更新日期:1984-07-01 00:00:00
abstract::Group B streptococci (GBS) are the major cause of neonatal pneumonia, sepsis, and meningitis. Steps considered to be important in the pathogenesis of this infection include colonization of the rectum and vagina of the mother, aspiration of GBS into the fetal lung during or just prior to delivery, and invasion of GBS i...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.6.2450-2458.1994
更新日期:1994-06-01 00:00:00
abstract::The human gastric pathogen Helicobacter pylori modifies host cholesterol via glycosylation and incorporates the glycosylated cholesterol into its membrane; however, the benefits of cholesterol to H. pylori are largely unknown. We speculated that cholesterol in the H. pylori membrane might alter the susceptibility of t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00974-09
更新日期:2011-01-01 00:00:00
abstract::The blood-stage development of malaria parasites is initiated by the invasion of merozoites into susceptible erythrocytes. Specific receptor-ligand interactions must occur for the merozoites to first attach to and then invade erythrocytes. Because the invasion process is essential for the parasite's survival and the m...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.12.5581-5586.1994
更新日期:1994-12-01 00:00:00
abstract::Although periodontal treatment by scaling and root planing (SCRP) is known to induce bacteremia, the effect of this procedure on the host immune response is not known. We have determined pre- and post-SCRP immunoglobulin G antibody titers to antigens of Actinobacillus actinomycetemcomitans in the sera of 22 patients w...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.1.145-151.1994
更新日期:1994-01-01 00:00:00
abstract::Four monoclonal antibodies against Escherichia coli J5 were studied. Each of these monoclonal antibodies reacted with purified lipopolysaccharides from E. coli J5, the deep rough mutant Salmonella minnesota Re595, Agrobacterium tumefaciens, and Pseudomonas aeruginosa PAO1 as well as with the purified lipid A of P. aer...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.45.3.631-636.1984
更新日期:1984-09-01 00:00:00
abstract::The ultrastructural organization of Mycoplasma pneumoniae membranes and spatial relationships of this pathogen to epithelial cells in tracheal organ cultures were examined ultrastructurally by freeze-fracture techniques. Areas of morphologically distinct cell membrane variability characterized by membrane blebs and al...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1980-09-01 00:00:00
abstract::Chromatin modification triggered by bacteria is a newly described mechanism by which pathogens impact host transcription. Listeria monocytogenes dephosphorylates histone H3 through the action of listeriolysin O (LLO); however, the underlying mechanism is unknown. Here we show that an unrelated pore-forming toxin, Aero...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01243-10
更新日期:2011-07-01 00:00:00
abstract::Tuberculosis (TB) remains an enormous global health problem, and a new vaccine against TB more potent than the current inadequate vaccine, Mycobacterium bovis BCG, is urgently needed. We describe a recombinant BCG vaccine (rBCG30) expressing and secreting the 30-kDa major secretory protein of Mycobacterium tuberculosi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.4.1672-1679.2003
更新日期:2003-04-01 00:00:00
abstract::Our previous work suggests that one mechanism through which connective tissue breakdown might occur in periodontal diseases is the production of metalloproteinases, including collagenase, by gingival fibroblasts. In this study we investigated whether highly purified preparations of lipopolysaccharide (LPS) and lipotei...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.9.2148-2154.1987
更新日期:1987-09-01 00:00:00
abstract::Bordetella parapertussis, a respiratory tract pathogen commonly regarded as noninvasive, was found to invade HeLa 229 cell monolayers. Following treatment of the monolayers with gentamicin, numbers of viable B. parapertussis recovered were comparable to those of invasive Salmonella and Shigella isolates. Invasion occu...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.4.1240-1247.1989
更新日期:1989-04-01 00:00:00
abstract::A cohort of 111 children from Bangui, Central African Republic, was surveyed for enteric Campylobacter infections from birth to the age of 2 years; stools were examined biweekly in these children until 6 months of age and at least four times per year thereafter until 2 years of age and after each diarrheal episode. Bl...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.8.2542-2546.1989
更新日期:1989-08-01 00:00:00
abstract::Growth in colonies with type 1 morphology and the presence of pili are characteristics that have been associated with virulence of gonococci for humans. To determine whether the presence of pili per se might be responsible for colony type 1 morphology, the relationship of pili to colony type was examined in various sp...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.15.2.594-600.1977
更新日期:1977-02-01 00:00:00
abstract::The goal of this study is to evaluate the contribution of mast cells to Helicobacter pylori immunity in a model of vaccine-induced protection. Mast cell-deficient Kitl(Sl)/Kitl(Sl-d) and control mice were immunized with H. pylori sonicate plus cholera toxin and challenged with H. pylori, and the bacterial loads, infla...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00532-09
更新日期:2009-12-01 00:00:00
abstract::A preparation procedure for scanning electron microscopy was developed by which gononcoccal colonies can be studied directly on the agar surface. After glutaraldehyde fixation directly in petri dishes, small agar pieces were cut out and dehydrated stepwise in increasing concentrations of ethanol. The blocks were there...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.12.3.630-637.1975
更新日期:1975-09-01 00:00:00
abstract::Antigens were extracted from a virulent isolate of Pasteurella multocida (serotype 3, 12, 15:D) with potassium thiocyanate, and a vaccine was prepared. Pasteurella-free rabbits were vaccinated intranasally and intraconjuctivally twice with a 2-week interval and challenged intranasally with the homologous P. multocida ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.49.3.498-504.1985
更新日期:1985-09-01 00:00:00
abstract::Streptococcus iniae causes systemic infection characterized by meningitis and sepsis. Here, we report a larval zebrafish model of S. iniae infection. Injection of wild-type S. iniae into the otic vesicle induced a lethal infection by 24 h postinfection. In contrast, an S. iniae mutant deficient in polysaccharide capsu...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00642-12
更新日期:2013-01-01 00:00:00